Patents by Inventor Manal Ahmed Gasmelseed Awad

Manal Ahmed Gasmelseed Awad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10703641
    Abstract: A method for synthesizing metal nanoparticles can include combining a metallic nitrate with an extract of Kalanchoe blossfeldiana to form the metal nanoparticles. The method can include adding an aqueous solution of silver nitrate (AgNO3) to the extract of Kalanchoe blossfeldiana to form silver nanoparticles. The method can include dissolving zinc nitrate hexahydrate (Zn(NO3)2.6H2O) in an extract of Kalanchoe blossfeldiana to provide a zinc nitrate extract solution, stirring the zinc nitrate extract solution, and adding an aqueous solution of sodium hydroxide (NaOH) to the zinc nitrate extract solution to form zinc oxide nanoparticles.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: July 7, 2020
    Assignee: King Saud University
    Inventors: Ali Kanakhir Aldalbahi, Seham Soliman Alterary, Ruba Ali Abdullrahman Almoghim, Manal Ahmed Gasmelseed Awad, Noura Saleem Aldosari, Shoog Fahad Abdullah Algannam, Alhanouf Nasser Abdulaziz Alabdan, Shaden Abdullah Alharbi, Bedoor Ali Al-Ateeq, Atheer Abdulrahman Al-Mohssen, Munirah Abdulaziz Abdullah Alkathri, Raghad Abdulrahman Alrashed
  • Patent number: 10689257
    Abstract: A bio buckypaper synthesized with fish scales may be manufactured by mixing carrageenan with a bio waste solution to provide a first mixture, adding carbon nanotubes to the first mixture produce a second mixture, sonicating the second mixture, and evaporative-casting the second mixture to produce the bio buckypaper. In an embodiment, the carrageenan may be ?-carrageenan. In an embodiment, the carbon nanotubes may be single walled carbon nanotubes (SWCNTs) or multi-walled carbon nanotubes (MWCNTs). In an embodiment, the bio waste solution may be derived from fish scales.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: June 23, 2020
    Assignee: King Saud University
    Inventors: Ali Kanakhir Aldalbahi, Manal Ahmed Gasmelseed Awad, Khalid Mustafa Osman Ortashi, Shaykha Mohammed Alzahly
  • Patent number: 10588929
    Abstract: The watermelon seed nanoparticles may be synthesized by dissolving powdered watermelon seeds in a solvent to produce a first mixture, adding the first mixture dropwise to boiling water under ultrasonic conditions to produce a second mixture, sonicating the second mixture and drying the second mixture to produce watermelon seed nanoparticles. In an embodiment, the watermelon seeds may be Citrullus lanatus seeds. In an embodiment, the watermelon seed nanoparticles may be included in a pharmaceutical composition, such as an antimicrobial or anti-cancer composition.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: March 17, 2020
    Assignee: King Saud University
    Inventors: Khalid Mustafa Osman Ortashi, Manal Ahmed Gasmelseed Awad
  • Patent number: 10542758
    Abstract: The methanol extract of grape seed nanoparticles is prepared from grape seeds washed in distilled water and oven-dried at 60° C. for 12 hours. The seeds are milled or ground to a powder and sieved to a maximum size of 0.355 mm. The powder is added to concentrated HCl and stirred at 3000 rpm at 30° C. for one hour, and then distilled water is added with stirring for an additional 2 hours. The mixture is filtered, and the marc is dried to recover grape seed nanoparticles. The nanoparticles are added to methanol at the rate of 100 mg/ml, left in a shaker for 24 hours at room temperature, centrifuged, filtered, and the resulting extract (the supernatant) is recovered. Agar well diffusion testing showed that the nanoparticle extract exhibited greater antibacterial activity than a methanol extract of grape seeds alone, and testing showed greater antioxidant levels in the nanoparticle extract as well.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: January 28, 2020
    Assignee: King Saud University
    Inventors: Hany Mohamed Yehia, Reem Atta Alajmi, Hatem Salama Mohamed Ali, Manal Fawzy Elkhadragy, Dina Mahmoud Metwally Hasanin, Mohamed Fekry Serag El-Din, Manal Ahmed Gasmelseed Awad
  • Patent number: 10517905
    Abstract: A method of fabricating probiotics nanowhiskers using cheese comprises cutting and grinding cheese to produce cheese powder; mixing the cheese powder with sulfuric acid to produce a solution; stirring the solution to produce a stirred solution; and filtering the stirred solution to produce the probiotics nanowhiskers. The fabricated probiotics nanowhiskers possess antioxidant, anti-inflammatory, antitumor, and antimicrobial properties. The probiotics nanowhiskers may reduce cadmium concentration in a patient's liver. The probiotics nanowhiskers may also ameliorate the oxidative stress assessed as a decrease in the serum MDA levels in a patient.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: December 31, 2019
    Assignee: King Saud University
    Inventors: Promy Virk, Manal Ahmed Gasmelseed Awad, Mai Abdelrahman Elobeid, Khalid Mustafa Osman Ortashi, Awatif Ahmed Hendi
  • Patent number: 10500244
    Abstract: The black eggplant skin antioxidant nanoparticles may be manufactured by extracting black eggplant skins in a solvent, spraying the black eggplant skin extracts into boiling water under ultrasonic conditions to produce a first mixture, sonicating the mixture, stirring the mixture, and drying the mixture to obtain black eggplant skin antioxidant nanoparticles. In an embodiment, the black eggplant skin may be skin of Solanum melongena. In an embodiment, the black eggplant skin nanoparticles may have improved antibacterial or antioxidant properties.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: December 10, 2019
    Assignee: King Saud University
    Inventors: Hany Mohamed Yehia, Mohamed Fekry Serag El-Din, Hatem Salama Mohamed Ali, Mohamed Saleh Alamri, Wafa Abdullah Al-Megrin, Manal Fawzy Elkhadragy, Manal Ahmed Gasmelseed Awad
  • Patent number: 10442833
    Abstract: The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: October 15, 2019
    Assignee: King Saud University
    Inventors: Rabab Abd El Moneim Khalil El Dib, Shaza Mohamed Adel Al-Massarani, Manal Ahmed Gasmelseed Awad, Ali Ali Hasan El Gamal
  • Patent number: 10398744
    Abstract: The mustard seed nanoparticles may be synthesized by washing mustard seeds, drying and crushing the washed mustard seeds, extracting the crushed mustard seeds to produce a mustard seed extract, spraying the mustard seed extract into boiling water, sonicating the mustard seed extract and boiling water mixture, and centrifuging the mustard seed extract and boiling water mixture to obtain mustard seed nanoparticles. The mustard seed nanoparticles may be used in a pharmaceutical composition.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: September 3, 2019
    Assignee: King Saud University
    Inventors: Manal Ahmed Gasmelseed Awad, Promy Virk, Rabia Qindeel, Khalid Mustafa Osman Ortashi, Mai Abdelrahman Elobeid
  • Patent number: 10384945
    Abstract: A method of producing silica nanoparticles using sand can include mixing white sand with H2SO4 and H3PO4 to form a mixture. The mixture can be stirred in an ice bath. KMnO4 can then be added to the mixture while maintaining the temperature of the mixture below 5° C. The resulting suspension can be reacted for about 3 hours to about 5 hours on ice. The suspension is stirred in an ice bath and then maintained in a water bath at a temperature of 40° C. for about 90 minutes to about 120 minutes. Afterwards, the temperature is adjusted to and maintained at 98° C. for another period of about 90 minutes to about 120 minutes while adding water. H2O2 can be added to the suspension after adding the water to produce a reaction product with a precipitate. The reaction product can then be dried and calcinated to provide the silica nanoparticles.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: August 20, 2019
    Assignee: King Saud University
    Inventors: Manal Ahmed Gasmelseed Awad, Rabia Qindeel, Khalid Mustafa Osman Ortashi, Awatif Ahmed Hendi
  • Patent number: 10363218
    Abstract: A method of preparing probiotic nanoparticles can include dissolving formulated probiotics in methanol, spraying the methanol solution into boiling water under ultrasonic conditions to provide a sonicated solution, and stirring the sonicated solution to obtain probiotic nanoparticles. The probiotic nanoparticles may be cluster or rod-shaped. The probiotic nanoparticles may be administered to a subject to reduce oxidative stress or to treat diseases associated with oxidative stress.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: July 30, 2019
    Assignee: King Saud University
    Inventors: Promy Virk, Manal Ahmed Gasmelseed Awad, Amnah El-Enazy, Awatif Ahmed Hendi, Mai Abdelrahman Elobeid Wagealla, Rabia Qindeel
  • Patent number: 10358356
    Abstract: A method of synthesizing zinc oxide nanoparticles includes preparing a liquid extract of Cymbopogon proximus, dissolving zinc salt in the liquid extract to provide an extract with zinc salt, adding a base to the extract with zinc salt to form a precipitate including zinc oxide nanoparticles. The method overcomes the drawbacks associated with prior chemical methods of synthesizing nanoparticles, while providing increased yield of the nanoparticles.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: July 23, 2019
    Assignee: King Saud University
    Inventors: Manal Ahmed Gasmelseed Awad, Awatif Ahmed Hendi, Khalid Mustafa Osman Ortashi, Ali Kanakhir Aldalbahi, Reema Abdullah Alnamlah
  • Patent number: 10301187
    Abstract: Synthesis of titanium dioxide (TiO2) nanoparticles (NPs) includes mixing Cymbopogon proximis (Maharayb) grass extract with Titanium (IV) isopropoxide (TTIP). The synthesis is simple and occurs at a rapid rate. The synthesized TiO2 nanoparticles can be effective in degrading Rhodamine B dye under UV light irradiation. Accordingly, the TiO2 nanoparticles can be useful in purifying drinking water.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: May 28, 2019
    Assignee: King Saud University
    Inventors: Manal Ahmed Gasmelseed Awad, Khalid Mustafa Osman Ortashi, Awatif Ahmed Hendi, Wadha Khalaf Alenazi, Ali Aldalbahi
  • Patent number: 10278999
    Abstract: In one embodiment, synthesis of Nuxia oppositifolia nanoparticles includes providing a Nuxia oppositifolia powder; dissolving the powder in a first alcohol to provide a first alcohol extract; concentrating a filtrate from the first alcohol extract under reduced pressure to provide a dried alcohol extract; dissolving the dried alcohol extract in the first alcohol to provide a second alcohol extract; successively partitioning the second alcohol extract using n-hexane to provide an n-hexane extract; dissolving the n-hexane extract in a second alcohol and water to provide a first solution; and adding an acidic solution to the first solution to form a final solution including Nuxia oppositifolia nanoparticles.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: May 7, 2019
    Assignee: King Saud University
    Inventors: Ali Ali El-Gamal, Adnan Jathlan Al-Rehaily, Manal Ahmed Gasmelseed Awad, Rabab Abd El Moneim Khalil El Dib, Shaza Mohamed Adel Al-Massarani
  • Patent number: 10206417
    Abstract: The guava seed (Psidium guajava) nanoparticles as an antibacterial agent are prepared from guava seeds that have been washed, dried, and ground to powder of less than 1 mm diameter. The powder is reduced to nanoparticle size (less than 100 nm diameter) by adding the powder to a solution of concentrated hydrochloric acid (38% w/w) and stirring the mixture at 3000 rpm at room temperature. The resulting nanoparticles are filtered through a Millipore membrane filter and dried. Agar well diffusion studies showed significant antibacterial activity against various Gram positive and negative species commonly implicated in food contamination. Further testing showed the guava seed nanoparticles have significant antioxidant and radical scavenging content, suggesting that guava seed nanoparticles may serve as an antibacterial agent.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: February 19, 2019
    Assignee: King Saud University
    Inventors: Hatem Salama Mohamed Ali, Reem Atta Alajmi, Hany Mohamed Yehia, Mohamed Fekry Serag El-Din, Manal Fawzy Elkhadragy, Manal Ahmed Gasmelseed Awad, Dina Mahmoud Metwally Hasanin
  • Patent number: 10202415
    Abstract: A method for synthesizing 3-oxolupenal nanoparticles including isolating 3-oxolupenal from a fraction of Nuxia oppositifolia plant, reducing the 3-oxolupenal to obtain a powder of 3-oxolupenal, dissolving the powder of 3-oxolupenal in methanol to form a first solution, adding the first solution to boiling water to form a second solution, sonicating the second solution, and freeze-drying after sonication to obtain the synthesized 3-oxolupenal nanoparticles. The synthesized 3-oxolupenal nanoparticles exhibited cytotoxic effects and antimicrobial effects.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: February 12, 2019
    Assignee: King Saud University
    Inventors: Rabab Abd El Moneim Khalil El Dib, Shaza Mohamed Adel Al-Massarani, Manal Ahmed Gasmelseed Awad, Ali Ali El-Gamal
  • Patent number: 10188116
    Abstract: Doum nanoparticles can be synthesized by drying Doum fruit, reducing the dried Doum fruit to a powder or flour, and subjecting the powder to acid hydrolysis or alcohol hydrolysis to provide Doum nanoparticles. The Doum nanoparticles can be used as a food preservative. When compared to bulk Doum particles, the Doum nanoparticles can provide substantially increased antibacterial activity.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: January 29, 2019
    Assignee: King Saud University
    Inventors: Manal Ahmed Gasmelseed Awad, Awatif Ahmed Hendi, Khalid Mustafa Osman Ortashi, Hany Mohamed Yehia, Mohamed Mahmoud Hafez Ahmed, Hatem Salama Mohamed Ali, Mohamed Fekry Serag El-Din, Zeinab Korany Mohamed Hassan
  • Patent number: 10184033
    Abstract: The synthesis of a silver-PMMA nanocomposite film includes mixing an aqueous extract of Trigonella foenum-graecum (also known as Helba and fenugreek) seeds with an aqueous solution of silver nitrate, thereby reducing the silver ions to silver metal nanoparticles. A solution of the silver nanoparticles is added to a solution of PMMA [poly (methyl methacrylate)] in N?N-dimethylformamide (DMF) with stirring at 90° C. A light brown solution of silver colloids develops, which is cast in a glass plate and the DMF is evaporated at room temperature, leaving a silver-PMMA nanocomposite film. Testing on water shows the silver-PMMA nanocomposite film prevents or inhibits growth of microbes, suggesting use as an antimicrobial or antibacterial agent, e.g., in water purification.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: January 22, 2019
    Assignee: King Saud University
    Inventors: Manal Ahmed Gasmelseed Awad, Awatif Ahmed Hendi, Khalid Mustafa Osman Ortashi, Amnah Bader Alanazi, Batool Ali Marzouq Alzhrani, Dina Wafiq Awad Soliman
  • Patent number: 10138135
    Abstract: Synthesis of titanium dioxide nanoparticles using Origanum majorana (O. majorana) herbal extracts may be achieved by mixing Titanium (IV) isopropoxide (TTIP) with O. majorana extracts. The O. majorana herbal extracts may be extracts obtained using boiled water. The TTIP may be mixed with the O. majorana extract at a ratio of 2:1. The resulting paste may be heated and pounded into a powder. The powder may then be calcinated in a muffle furnace, producing O. majorana titanium dioxide nanoparticles. The O. majorana titanium dioxide nanoparticles may be efficient photocatalysts.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: November 27, 2018
    Assignee: King Saud University
    Inventors: Manal Ahmed Gasmelseed Awad, Awatif Ahmed Hendi, Khalid Mustafa Osman Ortashi, Wadha Khalaf Alenazi
  • Patent number: 10111441
    Abstract: The synthesis of a silver-PMMA nanocomposite film using herbal extract includes mixing an aqueous extract of Aristolochia bracteolate buds with an aqueous solution of silver nitrate, thereby reducing the silver ions to silver metal nanoparticles. A solution of the silver nanoparticles is added to a solution of PMMA [poly (methyl methacrylate)] in N?N-dimethylformamide (DMF) with stirring at 80° C. A brown solution of silver colloids develops, which is cast in a glass plate and the DMF is evaporated at room temperature, leaving a silver-PMMA nanocomposite film. Testing on water shows the silver-PMMA nanocomposite film prevents or inhibits growth of microbes, suggesting use as an antimicrobial or antibacterial agent, e.g., in water purification. In addition, testing by disc diffusion against E. coli and Bacillus cereus showed zones of inhibition, also suggesting use as an antimicrobial or antibacterial agent.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: October 30, 2018
    Assignee: KING SAUD UNIVERSITY
    Inventors: Manal Ahmed Gasmelseed Awad, Awatif Ahmed Hendi, Khalid Mustafa Osman Ortashi, Dina Wafiq Awad Soliman
  • Patent number: 10086027
    Abstract: The synthesis of katononic acid nanosheets is a method of extraction of katononic acid from the n-hexane fraction of Nuxia oppositifolia. The katononic acid isolated from N. oppositifolia may be suspended in methanol and added dropwise to boiling water, sonicated, stirred, and freeze dried to form katononic acid nanosheets. These katononic acid nanosheets may be used to kill cancer cells or microorganisms.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: October 2, 2018
    Assignee: KING SAUD UNIVERSITY
    Inventors: Ali Ali Hassan Elgamal, Manal Ahmed Gasmelseed Awad, Rabab El Dib, Shaza Mohamed Adel Al-Massarani, Omer Ahmed Basudan