Patents by Inventor Manami Shizuka

Manami Shizuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF PREPARING INDOLINOBENZODIAZEPINE DERIVATIVES
    Publication number: 20240067652
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds and their synthetic precursors.
    Type: Application
    Filed: August 2, 2023
    Publication date: February 29, 2024
    Applicant: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders
    Patent number: 11793885
    Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formulae (I), (II) and (III). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: October 24, 2023
    Assignee: IMMUNOGEN, INC.
    Inventors: Michael Louis Miller, Manami Shizuka, Ravi V. J. Chari
  • Process for preparing substituted indolines
    Patent number: 11760759
    Abstract: The invention provides novel methods for preparing substituted indoline compounds and their synthetic precursors.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: September 19, 2023
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • Conjugates comprising cell-binding agents and cytotoxic agents
    Patent number: 11732038
    Abstract: The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: August 22, 2023
    Assignee: IMMUNOGEN, INC.
    Inventors: Nathan Elliott Fishkin, Daniel J. Tavares, Lingyun Rui, Luke B. Harris, Manami Shizuka, Michael Louis Miller, Ravi V. J. Chari
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20230257400
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: December 14, 2022
    Publication date: August 17, 2023
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20230233697
    Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
    Type: Application
    Filed: October 25, 2022
    Publication date: July 27, 2023
    Inventors: Ravi V.J. Chari, Michael Louis Miller, Manami Shizuka
  • CYTOTOXIC BIS-BENZODIAZEPINE DERIVATIVES AND CONJUGATES THEREOF WITH CELL-BINDING AGENTS FOR INHIBITING ABNORMAL CELL GROWTH OR FOR TREATING PROLIFERATIVE DISEASES
    Publication number: 20230094471
    Abstract: The invention relates to benzodiazepine derivatives with antiproliferative activity and more specifically to benzodiazepine compounds of formulae (I), (II), (TI) and (T2). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
    Type: Application
    Filed: March 27, 2020
    Publication date: March 30, 2023
    Applicant: IMMUNOGEN, INC.
    Inventors: Ravi V.J. Chari, Michael Louis Miller, Manami Shizuka, Katie Elizabeth Archer, Emily Elizabeth Reid
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20230039161
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: June 15, 2022
    Publication date: February 9, 2023
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 11420982
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: August 23, 2022
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 11390633
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: July 19, 2022
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS
    Publication number: 20210299271
    Abstract: The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.
    Type: Application
    Filed: February 12, 2021
    Publication date: September 30, 2021
    Inventors: Nathan Elliott Fishkin, Daniel J. Tavares, Lingyun Rui, Luke B. Harris, Manami Shizuka, Michael Louis Miller, Ravi V.J. Chari
  • METHODS OF PREPARING INDOLINOBENZODIAZEPINE DERIVATIVES
    Publication number: 20210292329
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds and their synthetic precursors.
    Type: Application
    Filed: February 26, 2021
    Publication date: September 23, 2021
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • Cytotoxic benzodiazepine derivatives
    Patent number: 11116845
    Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
    Type: Grant
    Filed: June 15, 2020
    Date of Patent: September 14, 2021
    Assignee: IMMUNOGEN, INC.
    Inventors: Ravi V. J. Chari, Michael Louis Miller, Manami Shizuka
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20210171547
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: November 23, 2020
    Publication date: June 10, 2021
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20210171546
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: August 12, 2020
    Publication date: June 10, 2021
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20210139510
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: October 22, 2020
    Publication date: May 13, 2021
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • Conjugates comprising cell-binding agents and cytotoxic agents
    Patent number: 10988531
    Abstract: The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: April 27, 2021
    Assignee: IMMUNOGEN, INC.
    Inventors: Nathan Elliott Fishkin, Daniel Tavares, Lingyun Rui, Luke B. Harris, Manami Shizuka, Michael Louis Miller, Ravi V. J. Chari
  • Methods of preparing substituted 12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indoles
    Patent number: 10968228
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds of formula (I) below and their synthetic precursors:
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: April 6, 2021
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10899775
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: January 26, 2021
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20200405870
    Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
    Type: Application
    Filed: June 15, 2020
    Publication date: December 31, 2020
    Inventors: Ravi V.J. Chari, Michael Louis Miller, Manami Shizuka