Patents by Inventor Manami Shizuka

Manami Shizuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20200405870
    Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
    Type: Application
    Filed: June 15, 2020
    Publication date: December 31, 2020
    Inventors: Ravi V.J. Chari, Michael Louis Miller, Manami Shizuka
  • BENZODIAZEPINE DERIVATIVES
    Publication number: 20200397914
    Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formulae (I), (II) and (III). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
    Type: Application
    Filed: December 27, 2018
    Publication date: December 24, 2020
    Inventors: Michael Louis Miller, Manami Shizuka, Ravi V.J. Chari
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10844078
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: November 24, 2020
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10787463
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: September 29, 2020
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • Cytotoxic benzodiazepine derivatives
    Patent number: 10722588
    Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: July 28, 2020
    Assignee: IMMUNOGEN, INC.
    Inventors: Ravi V. J. Chari, Michael Louis Miller, Manami Shizuka
  • METHODS OF PREPARING INDOLINOBENZODIAZEPINE DERIVATIVES
    Publication number: 20200109145
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds and their synthetic precursors.
    Type: Application
    Filed: September 4, 2019
    Publication date: April 9, 2020
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20200017526
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: June 21, 2019
    Publication date: January 16, 2020
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20200002360
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: June 17, 2019
    Publication date: January 2, 2020
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20190389883
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: June 6, 2019
    Publication date: December 26, 2019
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • Methods for preparing substituted 12a,13-dihydro-6H-benzo[5,6][1,4]diazepino[1,2-a]indol-6-ones
    Patent number: 10442809
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds and their synthetic precursors.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: October 15, 2019
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20190269786
    Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
    Type: Application
    Filed: February 13, 2019
    Publication date: September 5, 2019
    Inventors: Ravi V.J. Chari, Michael Louis Miller, Manami Shizuka
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10392407
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: August 27, 2019
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10385071
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: August 20, 2019
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10370389
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: August 6, 2019
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20190112320
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: September 12, 2018
    Publication date: April 18, 2019
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • Cytotoxic benzodiazepine derivatives
    Patent number: 10238751
    Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: March 26, 2019
    Assignee: IMMUNOGEN, INC.
    Inventors: Ravi V. J. Chari, Michael Louis Miller, Manami Shizuka
  • METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES
    Publication number: 20190010169
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Application
    Filed: January 3, 2018
    Publication date: January 10, 2019
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva
  • CYTOTOXIC BENZODIAZEPINE DERIVATIVES AND CONJUGATES THEREOF
    Publication number: 20180346488
    Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formulae (I) and (II). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
    Type: Application
    Filed: April 19, 2018
    Publication date: December 6, 2018
    Inventors: Michael Louis Miller, Manami Shizuka
  • METHODS OF PREPARING INDOLINOBENZODIAZEPINE DERIVATIVES
    Publication number: 20180339989
    Abstract: The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds and their synthetic precursors.
    Type: Application
    Filed: April 19, 2018
    Publication date: November 29, 2018
    Inventors: Baudouin Gérard, Richard A. Silva, Michael Louis Miller, Manami Shizuka
  • Methods of preparing cytotoxic benzodiazepine derivatives
    Patent number: 10081640
    Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: September 25, 2018
    Assignee: IMMUNOGEN, INC.
    Inventors: Baudouin Gérard, Manami Shizuka, Michael Louis Miller, Richard A. Silva