Patents by Inventor Manfred Herold
Manfred Herold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8563253Abstract: The present invention relates to a method for diagnosing hemolytic anemia or a predisposition thereof. It also relates to a method of determining whether a compound is capable of inducing hemolytic anemia in a subject and to a method of identifying a drug for treating hemolytic anemia. Furthermore, the present invention relates to a data collection comprising characteristic values of metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing hemolytic anemia. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing hemolytic anemia in a subject.Type: GrantFiled: June 4, 2007Date of Patent: October 22, 2013Assignee: Metanomics GmbHInventors: Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine, Edgar Leibold, Bennard van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunha, Eric Fabian, Volker Strauss
-
Patent number: 8349186Abstract: The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture.Type: GrantFiled: July 18, 2011Date of Patent: January 8, 2013Assignee: Metanomics GmbHInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
-
Publication number: 20120209535Abstract: The present invention relates to methods for evaluating biomarkers. In particular, the invention relates to a method for establishing at least one pattern for at least one pre-defined effector having at least one effect on a biological system, which effect is capable of being determined, to a method of establishing a class of effectors for a pre-defined effect or group of effects, to a method for identifying at least one effect of a pre-defined effector and to a computer program and a computer adapted to carry out these methods.Type: ApplicationFiled: October 14, 2010Publication date: August 16, 2012Applicant: BASF Plant Science Company GmbHInventors: Alexandre Prokoudine, Tilmann B. Walk, Jan C. Wiemer, Ralf Looser, Michael Manfred Herold, Bennard van Ravenzwaay, Werner Mellert, Eric Fabian, Volker Strauss, Hennicke Kamp
-
Publication number: 20120132797Abstract: The present invention relates to a method for diagnosing thyroid disorders. It also relates to a method of determining whether a compound is capable of inducing a thyroid disorder in a subject and to a method of identifying a drug for treating a thyroid disorder. Furthermore, the present invention relates a device for diagnosing a thyroid disorder and diagnostic uses.Type: ApplicationFiled: July 13, 2010Publication date: May 31, 2012Applicant: BASF SEInventors: Volker Strauss, Hennicke Kamp, Eric Fabian, Georgia Coelho Palermo Cunha, Werner Mellert, Bennard van Ravenzwaay, Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C. Weimer, Alexandre Prokoudine, Edgar Leibold
-
Publication number: 20110272353Abstract: The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture.Type: ApplicationFiled: July 18, 2011Publication date: November 10, 2011Applicant: Metanomics GmbH and Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
-
Publication number: 20110252509Abstract: This invention relates generally to a method for producing a transgenic cell with increased gamma-aminobutyric acid (GABA) content as compared to a corresponding non-transformed wild type cell.Type: ApplicationFiled: October 23, 2009Publication date: October 13, 2011Applicant: BASF Plant Sceince GmbHInventors: Janneke Hendriks, Hardy Schön, Oliver Thimm, Volker Haake, Gunnar Plesch, Piotr Puzio, Astrid Blau, Michael Manfred Herold, Birgit Wendel, Beate Kamlage, Florian Schauwecker
-
Patent number: 7981294Abstract: The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture.Type: GrantFiled: October 1, 2008Date of Patent: July 19, 2011Assignee: Metanomics GmbH and Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
-
Publication number: 20110163226Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed.Type: ApplicationFiled: May 26, 2009Publication date: July 7, 2011Applicant: BASF SEInventors: Bennard van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunha, Eric Fabian, Volker Strauss, Hennicke Kamp, Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine, Edgar Leibold
-
Publication number: 20110129933Abstract: The present invention pertains to the field of toxicological as for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosis. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of diagnostic devices or compositions.Type: ApplicationFiled: May 26, 2009Publication date: June 2, 2011Applicant: BASF SEInventors: Bennard Van Ravenzwaay, Werner Mellert, Eric Fabian, Volker Strauss, Tilmann B. Walk, Ralf Looser, Edgar Leibold, Hennicke Kamp, Georgia Coelho Palermo Cunha, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine
-
Publication number: 20110113863Abstract: The present invention relates to the field of diagnostic measures. Specifically, it contemplates a method for assessing whether gastric bypass therapy was successful in a subject, a method of predicting whether gastric bypass therapy will be beneficial for a subject in need thereof, and a method of diagnosing whether a supportive therapy accompanying gastric bypass has beneficial effects on a subject in need thereof. Further provided are diagnostic methods for diabetes and body lean mass. Furthermore, the invention relates to a method for identifying a treatment against diabetes and/or obesity.Type: ApplicationFiled: July 15, 2009Publication date: May 19, 2011Applicants: Metanomics Health GmbH, INSERM Institute National de la Sante' et de la Recherche MedicaleInventors: Jens Fuhrmann, Dietrich Rein, Beate Kamlage, Jan C. Wiemer, Michael Manfred Herold, Karine Clément, David M. Mutch
-
Publication number: 20110091929Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological effects on the liver by enzyme induction in a subject and to a method of identifying a drug for treating the pro-pathological effect of liver enzyme induction. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five analytes, a data storage medium comprising said data collection, and a system and a device for diagnosing the pro-pathological effect of liver enzyme induction.Type: ApplicationFiled: May 25, 2009Publication date: April 21, 2011Applicant: BASF SEInventors: Bennard van Ravenzwaay, Werner Mellert, Georgia CoelhoPalermo Cunha, Eric Fabian, Volker Strauss, Hennicke Kamp, Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine, Edgar Leibold
-
Publication number: 20110035841Abstract: Described herein are inventions in the field of genetic engineering of plants, including combinations of polynucleotides encoding LMPs to improve agronomic, horticultural, and quality traits. This invention also relates to the combination of polynucleotides encoding proteins that are related to the presence of seed storage compounds in plants. More specifically, the present invention relates to LMP polynucleotides encoding lipid metabolism proteins (LMP) and the use of these combinations of these sequences, their order and direction in the combination, and the regulatory elements used to control expression and transcript termination in these combinations in transgenic plants. In particular, the invention is directed to methods for manipulating fatty acid-related compounds and for increasing oil and starch levels and altering the fatty acid composition in plants and seeds.Type: ApplicationFiled: December 10, 2008Publication date: February 10, 2011Applicant: BASF Plant Science GmbHInventors: Gunnar Plesch, Piotr Puzio, Astrid Blau, Michael Manfred Herold, Birgit Wendel, Beate Kamlage, Florian Schauwecker, Thorsten Zank, Oliver Oswald, Tom Wetjen
-
Patent number: 7873481Abstract: A method for analyzing a test sample is disclosed, the test sample comprising at least one compound. A test sample comprising at least one compound is provided. Next, the at least one compound in the test sample is determined, thereby generating raw results. The generated raw results are analyzed, wherein the analysis of the test sample is accompanied by an analysis of at least one reference sample. The test sample and the reference sample are analyzed in an identical sequence in each step of the method. A system for carrying out the method is also disclosed.Type: GrantFiled: July 25, 2006Date of Patent: January 18, 2011Assignee: Metanomics GmbHInventors: Tilmann B. Walk, Ralf Looser, Bianca Bethan, Michael Manfred Herold, Beate Kamlage, Oliver Schmitz, Jan C. Wiemer, Alexandre Prokoudine, Bennard Van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunha, Thomas Ehrhardt, Gerhard Krennrich
-
Publication number: 20090263826Abstract: The present invention relates to a method for diagnosing hemolytic anemia or a predis-position thereof. It also relates to a method of determining whether a compound is capable of inducing hemolytic anemia in a subject and to a method of identifying a drug for treating hemolytic anemia. Furthermore, the present invention relates to a data collection comprising characteristic values of metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing hemolytic anemia. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing hemolytic anemia in a subject.Type: ApplicationFiled: June 4, 2007Publication date: October 22, 2009Applicant: Metanomics GmbHInventors: Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine, Edgar Leibold, Bennard van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunha, Eric Fabian, Volker Strauss
-
Patent number: 7606667Abstract: The invention relates to a method and device for analyzing a sample containing a number of substances. The method comprises the following steps: recording one or more mass spectra (mass spectra data D) of the sample (P); deconvoluting the mass spectra in a first evaluating device (A), which assigns the chromatographic peaks (a) and their associated deconvoluted mass spectra of one substance at a time based on the correspondence with a reference spectrum of the substance, and/or determining the intensity of the obtained peaks of the ions of the mass spectra in an evaluating device (B), which assigns the chromatographic peaks (b) of the ions and their associated mass spectra based on the correspondence of selective ions and their retention time ranges of the peaks (b) with the reference values of the substance predetermined for a substance, and verifying the assignments in a validating device (V).Type: GrantFiled: February 1, 2006Date of Patent: October 20, 2009Assignee: Metanomics GmbHInventors: Michael Manfred Herold, Martin Kluttig, Nicole Christiansen, Joachim Kopka, Jörn Quedenau
-
Publication number: 20090032462Abstract: The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture.Type: ApplicationFiled: October 1, 2008Publication date: February 5, 2009Applicant: Metanomics GmbH and Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
-
Patent number: 7431841Abstract: The invention relates to a method for the extraction of components made from organic material, comprising the step of extraction with a single-phase mixture of 50 to 90 vol. % methanol and 50 to 10 vol. % water and optionally 0 to 40 vol. % of a further solvent or solvent mixture.Type: GrantFiled: November 11, 2002Date of Patent: October 7, 2008Assignee: Metanomics GmbH & Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka
-
Publication number: 20080234945Abstract: The present invention relates to a method for analyzing at least one test sample, wherein said test sample comprises at least one compound, said method comprising the steps of: a) providing at least one test sample comprising at least one compound; b) determining said at least one compound in said test sample whereby raw results are generated; and c) analyzing the raw results obtained in step b), wherein the analysis of said at least one test sample is accompanied by an analysis of at least one reference sample; and wherein the test sample and the reference sample are analyzed in an identical sequence in each step of the method.Type: ApplicationFiled: July 25, 2006Publication date: September 25, 2008Applicant: METANOMICS GMBHInventors: Tilmann B. Walk, Ralf Looser, Bianca Bethan, Michael Manfred Herold, Beate Kamlage, Oliver Schmitz, Jan C Wiemer, Alexandre Prokoudine, Bennard van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunba, Thomas Ehrhardt, Gerhard Krennrich
-
Publication number: 20080128607Abstract: The invention relates to a method and device for analyzing a sample containing a number of substances. The method comprises the following steps: recording one or more mass spectra (mass spectra data D) of the sample (P); deconvoluting the mass spectra in a first evaluating device (A), which assigns the chromatographic peaks (a) and their associated deconvoluted mass spectra of one substance at a time based on the correspondence with a reference spectrum of the substance, and/or determining the intensity of the obtained peaks of the ions of the mass spectra in an evaluating device (B), which assigns the chromatographic peaks (b) of the ions and their associated mass spectra based on the correspondence of selective ions and their retention time ranges of the peaks (b) with the reference values of the substance predetermined for a substance, and verifying the assignments in a validating device (V).Type: ApplicationFiled: February 1, 2006Publication date: June 5, 2008Applicant: Metanomics GmbHInventors: Michael Manfred Herold, Martin Kluttig, Nicole Christiansen, Joachim Kopka, Jorn Quedenau
-
Patent number: 7311838Abstract: The present invention relates to a process for isolating constituents from organic material, comprising the following process steps: a) freeze-drying of the organic material; b) extracting the constituents with a polar solvent or solvent mixture (A) and an organic solvent or solvent mixture (B), it being possible for the extracts of the extraction with (A) and (B) to form one phase; c) combining the extracts (A) and (B) to give one phase; and d) carrying out an esterification/transesterification in the unpolar phase with an alcohol, the esterification/transesterification being carried out in the presence of a volatile acid; the process being a high-throughput process.Type: GrantFiled: November 11, 2002Date of Patent: December 25, 2007Assignee: Metanomics GmbH & Co. KGaAInventors: Michael Manfred Herold, Martin Dostler, Ralf Looser, Tilmann B. Walk, Achim Fegert, Martin Kluttig, Britta Lehmann, Silke Heidemann, Annette Hennig, Joachim Kopka