Abstract: A belt tensioning device includes a first tensioning arm mounted on a base body pivotably about a first pivot axis and includes a rotatable first tensioning roller. A second tensioning arm is pivotably mounted relative to the base body about a second pivot axis and includes a rotatable second tensioning roller. Via a spring arrangement between the first tensioning arm and the second tensioning arm, the first and second tensioning arms are resiliently supported against one another in the circumferential direction. A damping mechanism is operatively arranged between the base body and the first tensioning arm for damping relative rotational movement between the first tensioning arm and the base body. The damping mechanism generates a varying damping torque dependent on the rotational position and/or rotational direction of the first tensioning arm relative to the base body upon pivoting of the first tensioning arm relative to the base body.

Abstract: The present invention is inter alia concerned with an inhibitor selected from the group consisting of a selective KMT9-inhibitor, a selective METTL21A-inhibitor and a selective METTL21B-inhibitor for use in the treatment of cancer. KMT9, METTL21A and METTL21B are characterized herein for the first time as histone methyl transferases, and inhibitors of the same can be used for treating cancer.

Abstract: A belt tensioning device includes a base body. A first tensioning arm is mounted on the base body such that it can pivot about a first pivot axis and which has a rotatable first tensioning roller. A second tensioning arm is pivotably mounted relative to the base body about a second pivot axis and which has a rotatable second tensioning roller. A spring arrangement is arranged between the first tensioning arm and the second tensioning arm and via which the first tensioning arm and the second tensioning arm are resiliently supported against one another in the circumferential direction. A damping mechanism is operatively arranged between the base body and the first tensioning arm for damping relative rotational movement between the first tensioning arm and the base body. The damping mechanism generates a varying damping torque dependent on the rotational position and/or rotational direction of the first tensioning arm relative to the base body upon pivoting of the first tensioning arm relative to the base body.

Abstract: A hollow cylindrical carbon fiber construction, including a carbon fiber nonwoven, which is continuous between the inner lateral surface and the outer lateral surface of the carbon fiber construction all around. The hollow cylindrical carbon fiber construction can be obtained by a method in which a hollow cylindrical starting fiber construction, which includes a nonwoven that is continuous between the inner lateral surface and the outer lateral surface of the starting fiber construction all around, is subjected to a pyrolysis process.

Abstract: The invention relates to a filter medium comprising a reinforced non-woven fabric, to a method for the production thereof, and to the use thereof.

Abstract: A belt tensioning device comprises: a base member; a first tensioning arm, which is pivotably supported by a bearing sleeve on the base member around a first pivot axis and which comprises a first tensioning roller, wherein the bearing sleeve is configured radially elastically and is connected to one of the components, the base member and the first tensioning arm in a rotationally fixed manner, and which is rotatable relative to the other of the components, the base member and the tensioning arm a second tensioning arm, which is pivotably supported on the base member around a second pivot axis and comprises a second tensioning roller; a spring arrangement that pre-tensions the first tensioning arm and the second tensioning arm in circumferential direction relative to each other; pre-tensioning means, which that are arranged radially between a circumferential face of the bearing sleeve and a circumferential face of the component connected to the bearing sleeve to exert a radial force in direction relative to t

Abstract: A compound of formula (1), (1?), (1?) or (1??) or a pharmaceutically acceptable salt thereof, for use in the treatment of diseases or conditions for which a bromodomain inhibitor is indicated.

Abstract: A belt tensioning device comprises: a base member; a first tensioning arm, which is pivotably supported by a bearing sleeve on the base member around a first pivot axis and which comprises a first tensioning roller, wherein the bearing sleeve is configured radially elastically and is connected to one of the components, the base member and the first tensioning arm in a rotationally fixed manner, and which is rotatable relative to the other of the components, the base member and the tensioning arm a second tensioning arm, which is pivotably supported on the base member around a second pivot axis and comprises a second tensioning roller; a spring arrangement that pre-tensions the first tensioning arm and the second tensioning arm in circumferential direction relative to each other; pre-tensioning means, which that are arranged radially between a circumferential face of the bearing sleeve and a circumferential face of the component connected to the bearing sleeve to exert a radial force in direction relative to t

Abstract: A belt tensioning device for a belt drive which comprises a driving machine with a driving belt pulley drivable by a driveshaft around a driving axis, and a plurality of further belt pulleys and with an infinite belt which is wrapped around the driving belt pulley and the further belt pulleys wherein the belt tensioning device comprises a housing in which two tensioning arms are supported so as to be pivotable around a common pivot axis, in which tensioning arms there are supported tensioning rollers with axes of rotation extending parallel to the driving axis, wherein the tensioning arms are supported relative to one another by spring means, wherein, with the driving belt pulley mounted at the driving machine, the housing can be mounted in that, in an annular region surrounding the driveshaft of the driving belt pulley, the housing is contact-free relative to the driving machine.

Abstract: A belt tensioning device for a belt drive having at least one apparatus with a housing, a driveshaft and a belt pulley, as well as an infinite belt for driving the belt pulley. The belt tensioning device includes a base that can be or is firmly connected to the apparatus, exactly one tensioning arm that, relative to the base, is supported so as to be pivotable around a pivot axis and that, via a torsion spring, is supported in the circumferential direction against the base. The belt tensioning device also includes a tensioning roller that, at the tensioning arm, is supported so as to be rotatable around an axis of rotation and serves to tension the belt. When the belt tensioning device is mounted at the apparatus, the pivot axis of the tensioning arm is arranged inside the outer diameter of the belt pulley of the apparatus.

Abstract: A spring, especially for use in a belt tensioning device, with a number of at least 1.25 and at a maximum 2.5 coils, which extend around a spring axis A8, wherein a first coil end 42 has an axial offset Va relative to a first coil region 48, arranged at an angle of 360° around the spring axis A8, and wherein a second coil end 49 has an radial offset Vr relative to a second coil region 50 arranged at an angle of 360° around the spring axis A8. A belt tensioning device and an assembly with such a belt tensioning device include such a spring.

Abstract: A compound of formula (1), (1?), (1?) or (1??) or a pharmaceutically acceptable salt thereof, for use in the treatment of diseases or conditions for which a bromodomain inhibitor is indicated.

Abstract: A belt tensioning device for a belt drive which comprises a driving machine with a driving belt pulley drivable by a driveshaft around a driving axis, and a plurality of further belt pulleys and with an infinite belt which is wrapped around the driving belt pulley and the further belt pulleys wherein the belt tensioning device comprises a housing in which two tensioning arms are supported so as to be pivotable around a common pivot axis, in which tensioning arms there are supported tensioning rollers with axes of rotation extending parallel to the driving axis, wherein the tensioning arms are supported relative to one another by spring means, wherein, with the driving belt pulley mounted at the driving machine, the housing can be mounted in that, in an annular region surrounding the driveshaft of the driving belt pulley, the housing is contact-free relative to the driving machine.

Abstract: A spring, especially for use in a belt tensioning device, with a number of at least 1.25 and at a maximum 2.5 coils, which extend around a spring axis A8, wherein a first coil end 42 has an axial offset Va relative to a first coil region 48, arranged at an angle of 360° around the spring axis A8, and wherein a second coil end 49 has an radial offset Vr relative to a second coil region 50 arranged at an angle of 360° around the spring axis A8. A belt tensioning device and an assembly with such a belt tensioning device include such a spring.

Abstract: A belt tensioning device for a belt drive which comprises a driving machine with a driving belt pulley drivable by a driveshaft around a driving axis, and a plurality of further belt pulleys and with an infinite belt which is wrapped around the driving belt pulley and the further belt pulleys wherein the belt tensioning device comprises a housing in which two tensioning arms are supported so as to be pivotable around a common pivot axis, in which tensioning arms there are supported tensioning rollers with axes of rotation extending parallel to the driving axis, wherein the tensioning arms are supported relative to one another by spring means, wherein, with the driving belt pulley mounted at the driving machine, the housing can be mounted in that, in an annular region surrounding the driveshaft of the driving belt pulley, the housing is contact-free relative to the driving machine.

Abstract: A central device for a control system which controls an energy transfer system that has energy generators and energy consumers. The central device is suitable for determining, by an actual and/or a prognosticated energy consumption, how much energy should be generated by the energy generators. An individual energy bandwidth is assigned to at least one subgroup of the energy consumers connected to the energy transfer system, the bandwidth indicating to what extent the total energy consumption of the subgroup is expected to be able to be raised and/or lowered. The central device is suitable—in view of the energy generating behavior of the energy generators and the individual energy bandwidth of the subgroup—for determining an optimum target energy consumption which lies within the individual energy bandwidth and which the subgroup should achieve in total. The central device further generates a control signal indicating the target energy consumption.

Abstract: A belt tensioning device for a belt drive having at least one apparatus with a housing, a driveshaft and a belt pulley, as well as an infinite belt for driving the belt pulley. The belt tensioning device includes a base that can be or is firmly connected to the apparatus, exactly one tensioning arm that, relative to the base, is supported so as to be pivotable around a pivot axis and that, via a torsion spring, is supported in the circumferential direction against the base. The belt tensioning device also includes a tensioning roller that, at the tensioning arm, is supported so as to be rotatable around an axis of rotation and serves to tension the belt. When the belt tensioning device is mounted at the apparatus, the pivot axis of the tensioning arm is arranged inside the outer diameter of the belt pulley of the apparatus.

Abstract: An arrangement for use in a distributed system for an energy grid includes a processing circuit and a plurality of destination nodes coupled to the processing circuit. The processing circuit is configured to calculate a desired destination index for each of the plurality of destination nodes based on a desired aggregate index for the plurality of destination nodes, wherein the desired aggregate index includes information representative of carbon consumption, and communicate each desired destination index to the corresponding one of the plurality of destination nodes. Each of the plurality of destination nodes is configured to receive the desired destination index from the processing circuit, and display the desired destination index on a display.

Abstract: A method of manufacturing a magnetic field sensor device in one embodiment includes applying a mask on a substrate, performing a wet etching procedure on the substrate for generating at least a first groove having tilted side walls, and depositing at least one layer of magnetoresistive material onto a section of the surface of at least a first tilted side wall of the groove. A method of manufacturing a magnetic field sensor device on a substrate having a plurality of tilted planar sections, each of the tilted planar sections having a surface normal angled with respect to a surface normal of the substrate is also provided.

Abstract: The present invention provides treatment methods involving modulating a sirtuin activity and/or a sirtuin mRNA and/or a sirtuin polypeptide level. In some embodiments, the present invention provides treatment methods involving modulating SIRT1 activity and/or SIRT mRNA and/or polypeptide level. The present invention provides methods of inhibiting SIRT1 Tat deacetylase activity. Methods of inhibiting SIRT1 Tat deacetylase activity are useful for treating immunodeficiency virus infections, particularly human immunodeficiency virus (HIV) infection. Thus, the present invention provides methods of treating an immunodeficiency virus infection, generally involving inhibiting SIRT1 Tat deacetylase activity. The present invention further provides methods of identifying agents that modulate sirtuin activity (e.g., SIRT1 activity), particularly ability of sirtuins to interact with (e.g., bind and/or deacetylate) a substrate, e.g., a viral substrate such as a Tat polypeptide.