Abstract: A belt tensioning device for a belt drive which comprises a driving machine with a driving belt pulley drivable by a driveshaft around a driving axis, and a plurality of further belt pulleys and with an infinite belt which is wrapped around the driving belt pulley and the further belt pulleys wherein the belt tensioning device comprises a housing in which two tensioning arms are supported so as to be pivotable around a common pivot axis, in which tensioning arms there are supported tensioning rollers with axes of rotation extending parallel to the driving axis, wherein the tensioning arms are supported relative to one another by spring means, wherein, with the driving belt pulley mounted at the driving machine, the housing can be mounted in that, in an annular region surrounding the driveshaft of the driving belt pulley, the housing is contact-free relative to the driving machine.

Abstract: A magnetic field sensor device comprising a substrate having at least a first tilted planar section having a surface normal at a first angle with respect to a surface normal of the substrate, and at least a first magnetoresistive layered structure positioned at the at least first tilted section. Methods for manufacturing magnetic field sensor devices are also presented.

Abstract: The present invention provides treatment methods involving modulating a sirtuin activity and/or a sirtuin mRNA and/or a sirtuin polypeptide level. In some embodiments, the present invention provides treatment methods involving modulating SIRT1 activity and/or SIRT mRNA and/or polypeptide level. The present invention provides methods of inhibiting SIRT1 Tat deacetylase activity. Methods of inhibiting SIRT1 Tat deacetylase activity are useful for treating immunodeficiency virus infections, particularly human immunodeficiency virus (HIV) infection. Thus, the present invention provides methods of treating an immunodeficiency virus infection, generally involving inhibiting SIRT1 Tat deacetylase activity. The present invention further provides methods of identifying agents that modulate sirtuin activity (e.g., SIRT1 activity), particularly ability of sirtuins to interact with (e.g., bind and/or deacetylate) a substrate, e.g., a viral substrate such as a Tat polypeptide.

Abstract: A belt tensioning device for a continuous belt drive. The device includes a torsion spring assembly (20) with a longitudinal axis (A2) and with at least one torsion bar or torsion tube (32). The torsion spring assembly (20) can be clamped axially and in a rotationally fixed way into a rack. A tensioning arm (19), at one end, is arranged at the torsion spring assembly (20) so as to be aligned approximately radially relative to the longitudinal axis (A2). A tensioning roller (15) is rotatably fixed at the other end of the tensioning arm (19). The axis of rotation (A1) of the tensioning roller (15) extends substantially parallel relative to the longitudinal axis (A2) of the torsion spring assembly (20), and the tensioning arm (19) can be resiliently supported relative to the rack so as to oscillate around the longitudinal axis (A2).

Abstract: A roller for belt tensioning systems or wrap drives having a hollow hub and a cylindrical running ring. The hollow hub and the running ring are connected to one another by an annular web and wherein, on both sides of the annular web, the hollow hub and the running ring are supported relative to one another by circumferentially distributed radially arranged ribs. The number of ribs on both sides of the annular web can be a prime number. In addition, or in the alternative, the ribs on both sides of the annular web can be arranged so as to be non-centrically circumferentially offset. In addition, or in the alternative, the number of ribs on both sides of the annular web can deviate from one another. In addition, or in the alternative, the rib assembly can be provided with variable pitch angles around the circumference.

Abstract: A method of manufacturing a magnetic field sensor device in one embodiment includes applying a mask on a substrate, performing a wet etching procedure on the substrate for generating at least a first groove having tilted side walls, and depositing at least one layer of magnetoresistive material onto a section of the surface of at least a first tilted side wall of the groove. A method of manufacturing a magnetic field sensor device on a substrate having a plurality of tilted planar sections, each of the tilted planar sections having a surface normal angled with respect to a surface normal of the substrate is also provided.

Abstract: A belt tensioning device for a continuous belt drive. The device includes a torsion spring assembly (20) with a longitudinal axis (A2) and with at least one torsion bar or torsion tube (32). The torsion spring assembly (20) can be clamped axially and in a rotationally fast way into a rack. A tensioning arm (19), at one end, is arranged at the torsion spring assembly (20) so as to be aligned approximately radially relative to the longitudinal axis (A2). A tensioning roller (15) is rotatably fixed at the other end of the tensioning arm (19). The axis of rotation (A1) of the tensioning roller (15) extends substantially parallel relative to the longitudinal axis (A2) of the torsion spring assembly (20), and the tensioning arm (19) can be resiliently supported relative to the rack so as to oscillate around the longitudinal axis (A2).

Abstract: Embodiments of the present invention provide a thin-film coil assembly. The coil assembly includes a substrate, at least two layers of conductive material on top of the substrate, and one layer of insulating material between the two layers of conductive material, wherein the two layers of conductive material are in contact with two interconnects, respectively, which extends substantially vertical to the substrate.

Abstract: A belt tensioning device fixable to a unit has a torsion spring assembly. A housing is provided with a longitudinal axis A and a torsion spring is positioned in the housing so as to extend coaxially relative to the longitudinal axis A. One of the ends of the torsion spring is secured to the housing in a rotationally fixed way. A tensioning arm is supported relative to the housing so as to be oscillatingly rotatable around the longitudinal axis A. The tensioning arm is connected to the other end of the torsion spring in a rotationally fixed way. A tensioning roller is supported at a free end of the tensioning arm supported so as to be rotatable around an axis of rotation B extending parallel relative to the longitudinal axis A. The housing has a flange for being fixed to the unit, whose flange plane is passed through by the longitudinal axis A.

Abstract: A belt tensioning device has a torsion spring assembly and a damping assembly with a housing with a longitudinal axis A. A torsion spring is positioned in the housing so as to extend coaxially relative to the longitudinal axis A and which, by means of one of its ends, is secured in the housing in a rotationally fixed way. A tensioning arm is supported relative to the housing so as to be oscillatingly rotatable around the longitudinal axis A and is connected to the other end of the torsion spring in a rotationally fixed way. A tensioning roller is supported at a free end of the tensioning arm so as to be rotatable around an axis of rotation B and extending parallel relative to the longitudinal axis A. The damping assembly surrounds the housing coaxially relative to the longitudinal axis A and comprises cylindrical friction face pairs.

Abstract: Embodiments of the present invention provide a thin-film coil assembly. The coil assembly includes a substrate, at least two layers of conductive material on top of the substrate, and one layer of insulating material between the two layers of conductive material, wherein the two layers of conductive material are in contact with two interconnects, respectively, which extends substantially vertical to the substrate.

Abstract: A magnetic field sensor device comprising a substrate having at least a first tilted planar section having a surface normal at a first angle with respect to a surface normal of the substrate, and at least a first magnetoresistive layered structure positioned at the at least first tilted section. Methods for manufacturing magnetic field sensor devices are also presented.

Abstract: A belt tensioning device having a substantially cylindrical receiving housing and a hub coaxially arranged therein. The receiving housing and the hub are supported so as to be rotatable relative to one another as well as supported by a helical torsion spring so as to be pretensioned relative to one another. A damping device is provided which comprises a circumferentially slotted damping bush and a strip spring adapted to the damping bush, wherein the damping bush rests against the inside of the receiving housing. The strip spring is arranged between the damping bush and the torsion spring. The strip spring and the torsion spring are connected in series, wherein one of the two is supported on the receiving housing and the other one of the two on the hub.

Abstract: A belt tensioning device for traction mechanisms includes a receiving and mounting housing, a pulley carrier pivotally connected to the receiving and mounting housing, a bearing supporting the pulley carrier relative to the receiving and mounting housing, and a spring located between the pulley carrier and the receiving and mounting housing for applying the tensioning force. The belt tensioning device, in normal operation, on the slack side between a generator and a main pulley can also be used when the slack side becomes the load side by a blocking mechanism which enables swinging motion of the pulley carrier relative to the receiving and mounting housing in a first direction, and limits or prevents such motion in a second, opposite direction.

Abstract: The present invention provides treatment methods involving modulating a sirtuin activity and/or a sirtuin mRNA and/or a sirtuin polypeptide level. In some embodiments, the present invention provides treatment methods involving modulating SIRT1 activity and/or SIRT mRNA and/or polypeptide level. The present invention provides methods of inhibiting SIRT1 Tat deacetylase activity. Methods of inhibiting SIRT1 Tat deacetylase activity are useful for treating immunodeficiency virus infections, particularly human immunodeficiency virus (HIV) infection. Thus, the present invention provides methods of treating an immunodeficiency virus infection, generally involving inhibiting SIRT1 Tat deacetylase activity. The present invention further provides methods of identifying agents that modulate sirtuin activity (e.g., SIRT1 activity), particularly ability of sirtuins to interact with (e.g., bind and/or deacetylate) a substrate, e.g., a viral substrate such as a Tat polypeptide.

Abstract: Improved methods for treatment of cancer are provided. The improvements include the administration of one or more synergistic agents, specifically inhibitors of histone deacetylase proteins and complexes. These synergistic agnets increase the effectiveness of radiation therapy and/or chemotherapies by increasing the sensitivity of tumor cells to treatment.

Abstract: A belt tensioning device for a continuous belt drive. The device includes a torsion spring assembly (20) with a longitudinal axis (A2) and with at least one torsion bar or torsion tube (32). The torsion spring assembly (20) can be clamped axially and in a rotationally fast way into a rack. A tensioning arm (19), at one end, is arranged at the torsion spring assembly (20) so as to be aligned approximately radially relative to the longitudinal axis (A2). A tensioning roller (15) is rotatably fixed at the other end of the tensioning arm (19). The axis of rotation (A1) of the tensioning roller (15) extends substantially parallel relative to the longitudinal axis (A2) of the torsion spring assembly (20), and the tensioning arm (19) can be resiliently supported relative to the rack so as to oscillate around the longitudinal axis (A2).

Abstract: A belt tensioning device for traction mechanisms includes a receiving and mounting housing, a pulley carrier pivotally connected to the receiving and mounting housing, a bearing supporting the pulley carrier relative to the receiving and mounting housing, and a spring located between the pulley carrier and the receiving and mounting housing for applying the tensioning force. The belt tensioning device, in normal operation, on the slack side between a generator and a main pulley can also be used when the slack side becomes the load side by a blocking mechanism which enables swinging motion of the pulley carrier relative to the receiving and mounting housing in a first direction, and limits or prevents such motion in a second, opposite direction.

Abstract: A flat semi-finished product includes a filled fluoroplastics substrate in the form of a sheet, which is coated at least partially on at least one surface with a soft, thin coating of fluoroplastics. The substrate material of the sheet has a Shore-D hardness of at least 65 and the average layer thickness of the thin sheet coating is at most 20 &mgr;m. A component, in particular a flat gasket, is made from the semi-finished product. A process for the production thereof is also provided.

Abstract: A metal-reinforced layered composite includes at least one intermediate metal layer. The intermediate metal layer includes at least two at least partially overlapping metal foils which are joined to one another in an overlap region by at least one weld seam. There are no leakage channels and/or no continuous leakage channels at the weld seam of the metal foils in the longitudinal extent of the overlap region. At least one of the weld seams may have a course which at least at one point has a direction component at right angles to the longitudinal extent of the overlap region of the metal foils. The intermediate metal layer may be provided with at least one passage in the overlap region of the metal foils. A gasket, a gasket sheet, a metal layer and a method of manufacturing a layered composite are also provided.