Abstract: A stabilizer bar has a first connected position and a second disconnected position. One side-bar is fixed to a housing while the other side-bar is fixed to a tulip within the housing. The housing has a plurality of axial grooves. The tulip defines a plurality of slots which are aligned with the grooves when the vehicle is level. A nut has a plurality of pins that extend radially such that the nut is torsionally coupled to the housing. In a first connected position, the pins fit within the slots of the tulip to torsionally couple the nut and the housing to the tulip. To facilitate a second disconnected position, a motor driven actuator moves the nut axially such that the pins no longer engage the slots. When motor power is withdrawn, a spring pushes the nut back to the first connected position.

Abstract: A wheel module (14) for a motor vehicle has a wheel rotatable about a center of rotation and serves for the propulsion of the motor vehicle, and having a swing arm attachable to a supporting frame of the motor vehicle so as to be articulated about a pivot axis and by which forces which act on the wheel are supported on the supporting frame. The center of rotation of the wheel and the pivot axis of the swing arm lie on an imaginary radial line beginning at the center of rotation of the wheel. The radial line runs at an angle ? of ?40°???35° with respect to an X-Y plane of the motor vehicle.

Abstract: A stabilizer bar has a first connected position and a second disconnected position. One side-bar is fixed to a housing while the other side-bar is fixed to a tulip within the housing. The housing has a plurality of axial grooves. The tulip defines a plurality of slots which are aligned with the grooves when the vehicle is level. A nut has a plurality of pins that extend radially such that the nut is torsionally coupled to the housing. In a first connected position, the pins fit within the slots of the tulip to torsionally couple the nut and the housing to the tulip. To facilitate a second disconnected position, a motor driven actuator moves the nut axially such that the pins no longer engage the slots. When motor power is withdrawn, a spring pushes the nut back to the first connected position.

Abstract: This invention relates to combination therapies comprising an EZH2 inhibitor and a chemotherapeutic agent, and associated pharmaceutical compositions, methods of treatment, and pharmaceutical uses.

Abstract: A wheel module (10) for a motor vehicle includes a wheel (12) and a wheel guide (14) for guiding the wheel (12). The wheel guide (14) includes a wheel carrier unit (16) for supporting the wheel (12); a wheel fork (24) supporting the wheel carrier unit (16); a steering actuator (18) for adjusting the steering angle of the wheel (12); a spring-damper unit (28); and a level adjustment unit (36) for adjusting the height of the vehicle body (32) of the motor vehicle. The spring-damper unit (28) is arranged in a region of the wheel guide (14) between the wheel fork (24) and the wheel carrier unit (16).

Abstract: A hybrid connection element, in particular a bearing outer element of a wheel bearing, includes a core part made of steel and a reinforcement part made of plastic. The reinforcement part at least partially encases the core part. The core part includes a hollow cylindrical bearing unit extending in an axial direction and a flange extending in a radial direction. The reinforcement part includes at least one reinforcement rib which transmits force between the bearing unit and the flange of the core part.

Abstract: A wheel module (10) for a motor vehicle includes a wheel (12) and a wheel guide (14) for guiding the wheel (12). The wheel guide (14) includes a wheel carrier unit (16) for supporting the wheel (12); a wheel fork (24) supporting the wheel carrier unit (16); a steering actuator (18) for adjusting the steering angle of the wheel (12); a spring-damper unit (28); and a level adjustment unit (36) for adjusting the height of the vehicle body (32) of the motor vehicle. The spring-damper unit (28) is arranged in a region of the wheel guide (14) between the wheel fork (24) and the wheel carrier unit (16).

Abstract: A motor vehicle (10), in particular an autonomous motor vehicle, includes a steering system (38, 30), a plurality of wheels (18, 20) that can be steered by means of the steering system (28, 30), and wheel housings (24, 26) for said wheels (18, 20). The steering system (28, 30) is designed such that the steering system steers the steerable wheels (18, 20) of a wheel pair in question in the same direction, in the case of joint steering to the left or right at a steering angle a up to a limit angle ag defined by the shape of the corresponding wheel housings (24, 26), and in opposite directions, in the case of steering to the left or right at a steering angle a exceeding the limit angle ?g.

Abstract: A steering head bearing arrangement for mounting a wheel module for a motor vehicle is provided with a steering rod connectable to a steering actuator and a wishbone, and a bearing flange connectable with a support frame of the motor vehicle, first and second roller bearings arranged in the bearing flange for mounting the steering rod, and a retaining ring screwed onto the steering rod for biasing the second roller bearing against the first roller bearing. By biasing the substantially spaced apart roller bearings against each other by means of the screwed-on retaining ring, radial and axial play of the steering rod in the bearing flange can be largely eliminated, thereby allowing to avoid wear-intensive peak stresses and allowing robust mounting of a steering rod of a motor vehicle.

Abstract: Combinations of an IDO1 inhibitor (e.g., a 3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione compound), with an anti-PD1 antibody or anti-PD-L1 antibody, and an anti-4-1BB antibody, as selected anti-cancer or anti-viral agents are provided. Also provided are use of these combinations for the treatment and/or prevention of cancer and endometriosis.

Abstract: A wheel module for a motor vehicle is provided with a wheel, a steering rod which can be rotatably mounted on a supporting frame of the motor vehicle for transmitting a steering motion to the wheel, a wishbone connected to the steering rod for forming an articulation point radially offset relative to the wheel, a rocker articulated to the articulation point of the wishbone and to the wheel, and a shock absorber connected to the rocker and the wishbone for damping vibration of a relative movement of the wheel. The shock absorber, in particular including a chassis spring, is arranged to be axially offset in the axial direction of the wheel relative to the wheel. With the shock absorber connected to the wheel and the wishbone and arranged next to the wheel, a large steering angle for a motor vehicle is possible with a small installation space.

Abstract: This invention relates to combination therapies comprising an EZH2 inhibitor and a chemotherapeutic agent, and associated pharmaceutical compositions, methods of treatment, and pharmaceutical uses.

Abstract: A hybrid connection element, in particular a bearing outer element of a wheel bearing, includes a core part made of steel and a reinforcement part made of plastic. The reinforcement part at least partially encases the core part. The core part includes a hollow cylindrical bearing unit extending in an axial direction and a flange extending in a radial direction. The reinforcement part includes at least one reinforcement rib which transmits force between the bearing unit and the flange of the core part.

Abstract: An apparatus for toe and/or camber adjustment for a running gear of a motor vehicle, having a tie rod and/or a link which can be fastened at one side to a bearing fixed with respect to the car body and at the other side by a bearing can be fastened to the wheel carrier of a wheel of the motor vehicle, wherein one bearing has an adjustment element which is in the form of an eccentric and which has an eccentric shaft, which eccentric shaft can be adjusted by an adjustment drive and is assigned safety bearings arranged on both sides of the eccentric.

Abstract: Combinations of an IDO1 inhibitor (e.g., a 3-(5-fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione compound), with an anti-PD1 antibody or anti-PD-L1 antibody, and an anti-4-1BB antibody, as selected anti-cancer or anti-viral agents are provided. Also provided are use of these combinations for the treatment and/or prevention of cancer and endometriosis.

Abstract: An apparatus for toe and/or camber adjustment for a running gear of a motor vehicle, having a tie rod and/or a link which can be fastened at one side to a bearing fixed with respect to the car body and at the other side by a bearing can be fastened to the wheel carrier of a wheel of the motor vehicle, wherein one bearing has an adjustment element which is in the form of an eccentric and which has an eccentric shaft, which eccentric shaft can be adjusted by an adjustment drive and is assigned safety bearings arranged on both sides of the eccentric.

Abstract: The invention relates to a rolling bearing having an inner race and an outer race. Between the inner race and the outer race, several rolling bodies are associated with at least one first bearing row between an inner raceway associated with the first bearing row and the outer raceway and several rolling bodies are associated with at least one second bearing row between an inner raceway associated with the second bearing row and the outer raceway. The at least one first bearing row is designed in such a way that several roller bodies are arranged at a distance from the inner raceway and/or the outer raceway of the bearing row when the inner race or outer race is stationary.

Abstract: The instant invention relates to methods for the treatment of B-cell lymphomas and leukemia by administering a SYK inhibitor. In another embodiment, the invention relates to a method for treating a patient diagnosed with a B-cell lymphoma or leukemia, comprising administering a SYK inhibitor, wherein the B-cells of said patient to be treated are characterized by elevated expression levels of CD86.

Abstract: Roll stabilizers as an example for chassis actuators are used for compensating or suppressing rolling movements of a vehicle about its longitudinal axis. Such rolling movements are caused, in particular, when driving around curves due to centrifugal forces. A chassis actuator device is provided, in particular, a roll stabilizer, for a vehicle with a flange connection between an actuator and a stabilization component. A holder-side positive-locking contour is arranged on a holder section of the flange connection and a flange-side positive-locking contour is arranged on a flange. The positive-locking contours together form a positive-locking connection in the circumferential direction about a torsion axis A, and the flange-side positive-locking contour is arranged on a flange-side lateral surface and/or the holder-side positive-locking contour is arranged on a holder-side lateral surface.

Abstract: Split roll stabilizer of a motor vehicle, between the two stabilizer parts (2a) of which an actuator (1) for a torsion of the stabilizer parts (2a) can be effectively disposed, a sensor (11) for determining the torsional moment acting in the stabilizer parts (2a) being provided.