Patents by Inventor Manfred Reiter

Manfred Reiter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELL CULTURE MEDIUM FOR ADAMTS PROTEIN EXPRESSION
    Publication number: 20150329848
    Abstract: The present invention provides culture mediums that are useful for the expression of ADAMTS proteins, such as ADAMTS13. Methods for the expression and purification of ADAMTS proteins are also provided. In some embodiments, the mediums and methods of the invention are useful for the expression of ADAMTS proteins having high specific activities. Also provided are ADAMTS, e.g., ADAMTS13, protein compositions with high specific activities, which are expressed and purified according to the methods provided herein.
    Type: Application
    Filed: July 23, 2015
    Publication date: November 19, 2015
    Inventors: Leopold Grillberger, Alexandra Spenger, Meinhard Hasslacher, Rana Grillberger, Manfred Reiter
  • Animal protein free media for cultivation of cells
    Patent number: 9163211
    Abstract: The present invention relates to animal protein free cell culture media comprising a combination of non-animal derived peptides derived from soy hydrolysate and yeast hydrolysate. The invention also provides an animal protein free culture process, wherein cells are cultivated, propagated and passaged without animal-derived components. This process is useful for cultivating cells, such as recombinant cells or cells infected with a virus, and for production biological products by cell culture processes under conditions devoid of animal protein components.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: October 20, 2015
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Manfred Reiter, Wolfgang Mundt, Leopold Grillberger, Barbara Kraus
  • Cell culture medium for ADAMTS protein expression
    Patent number: 9127265
    Abstract: The present invention provides culture mediums that are useful for the expression of ADAMTS proteins, such as ADAMTS13. Methods for the expression and purification of ADAMTS proteins are also provided. In some embodiments, the mediums and methods of the invention are useful for the expression of ADAMTS proteins having high specific activities. Also provided are ADAMTS, e.g., ADAMTS13, protein compositions with high specific activities, which are expressed and purified according to the methods provided herein.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: September 8, 2015
    Assignees: Baxalta Incorporated, Baxalta GmbH
    Inventors: Leopold Grillberger, Alexandra Spenger, Meinhard Hasslacher, Rana Grillberger, Manfred Reiter
  • Substantially animal protein-free recombinant furin and methods for producing the same
    Patent number: 9127264
    Abstract: The present invention relates to recombinant furin (rFurin) and methods for producing rFurin. More specifically, the invention relates to substantially animal protein-free rFurin and methods for producing substantially animal protein-free rFurin.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: September 8, 2015
    Assignees: BAXALTA INCORPORATED, BAXALTA GMBH
    Inventors: Barbara Plaimauer, Simone Von Fircks, Leopold Grillberger, Meinhard Hasslacher, Roland Geyer, Artur Mitterer, Manfred Reiter
  • ANIMAL PROTEIN-FREE MEDIA FOR CULTIVATION OF CELLS
    Publication number: 20150104867
    Abstract: The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating cells, such as recombinant cells or cells infected with a virus, and for producing biological products by cell culture processes.
    Type: Application
    Filed: May 2, 2014
    Publication date: April 16, 2015
    Applicants: Baxter International Inc., Baxter Healthcare SA
    Inventors: Leopold Grillberger, Manfred Reiter, Wolfgang Mundt, Friedrich Dorner
  • MEDIUM FOR THE PROTEIN-FREE AND SERUM-FREE CULTIVATION OF CELLS
    Publication number: 20150072415
    Abstract: A medium is described for the protein-free and serum-free cultivation of cells, especially mammalian cells, whereby the medium contains a proportion of soy hydrolysate.
    Type: Application
    Filed: March 31, 2014
    Publication date: March 12, 2015
    Applicant: Baxter Innovations GmbH
    Inventors: Manfred Reiter, Wolfgang Mundt, Friedrich Dorner, Leopold Grillberger, Artur Mitterer
  • METHOD FOR PRODUCING CONTINUOUS CELL LINES
    Publication number: 20150072414
    Abstract: The present invention relates to a method for production of continuous cell lines comprising providing living cells of an animal or a human, irradiating said cells with UV light, proliferating said cells and selecting multiplying cells as cells of a continuous cell line.
    Type: Application
    Filed: September 17, 2014
    Publication date: March 12, 2015
    Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.
    Inventors: Manfred Reiter, Wolfgang Mundt, Simone Feigl, Simone Von Fircks
  • Formulation of sugar solutions for continuous ultracentrifugation for virus purification
    Patent number: 8969533
    Abstract: The present invention provides a method for purification of a virus or virus antigen comprising providing a virus preparation and centrifugation of said virus preparation in a gradient of a sugar established by the addition of two or more buffered sugar layers of different concentration. The method leads to higher yields and reduces unwanted aggregation of the virus or virus antigen by increasing the volume of the peak pool.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: March 3, 2015
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Manfred Reiter, Leopold Grillberger, Wolfgang Mundt, Artur Mitterer, Horst Schafhauser
  • METHOD OF PRODUCING RECOMBINANT HIGH MOLECULAR WEIGHT vWF IN CELL CULTURE
    Publication number: 20150056657
    Abstract: Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with a high specific activity and ADAMTS13 with a high specific activity. The cell culture conditions of the present invention can include, for example, a cell culture medium with an increased copper concentration and/or cell culture supernatant with a low ammonium (NH4+) concentration. The present invention also provides methods for cultivating cells in the cell culture conditions to express high molecular weight vWF and rA13 having high specific activities.
    Type: Application
    Filed: September 3, 2014
    Publication date: February 26, 2015
    Inventors: Leopold Grillberger, Manfred Reiter, Wolfgang Mundt, Daniel Fleischanderl, Gregor Bramberger
  • METHOD OF PRODUCING RECOMBINANT HIGH MOLECULAR WEIGHT vWF IN CELL CULTURE
    Publication number: 20150018525
    Abstract: Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with a high specific activity and ADAMTS13 with a high specific activity. The cell culture conditions of the present invention can include, for example, a cell culture medium with an increased copper concentration and/or cell culture supernatant with a low ammonium (NH4+) concentration. The present invention also provides methods for cultivating cells in the cell culture conditions to express high molecular weight vWF and rA13 having high specific activities.
    Type: Application
    Filed: July 23, 2014
    Publication date: January 15, 2015
    Inventors: Leopold Grillberger, Manfred Reiter, Wolfgang Mundt
  • CELL CULTURE MEDIUM FOR ADAMTS PROTEIN EXPRESSION
    Publication number: 20140329294
    Abstract: The present invention provides culture mediums that are useful for the expression of ADAMTS proteins, such as ADAMTS13. Methods for the expression and purification of ADAMTS proteins are also provided. In some embodiments, the mediums and methods of the invention are useful for the expression of ADAMTS proteins having high specific activities. Also provided are ADAMTS, e.g., ADAMTS13, protein compositions with high specific activities, which are expressed and purified according to the methods provided herein.
    Type: Application
    Filed: May 13, 2014
    Publication date: November 6, 2014
    Applicants: Baxter International Inc., Baxter Healthcare SA
    Inventors: Leopold Grillberger, Alexandra Spenger, Meinhard Hasslacher, Rana Grillberger, Manfred Reiter
  • Method for producing continuous cell lines
    Patent number: 8865450
    Abstract: The present invention relates to a method for production of continuous cell lines comprising providing living cells of an animal or a human, irradiating said cells with UV light, proliferating said cells and selecting multiplying cells as cells of a continuous cell line.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: October 21, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Manfred Reiter, Wolfgang Mundt, Simone Feigl, Simone Von Fircks
  • Method of producing recombinant high molecular weight vWF in cell culture
    Patent number: 8852888
    Abstract: Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vWF, in particular, highly multimericWF with a high specific activity and ADAMTS13 with a high specific activity. The cell culture conditions of the present invention can include, for example, a cell culture medium with an increased copper concentration and/or cell culture supernatant with a low ammonium (NH4+) concentration. The present invention also provides methods for cultivating cells in the cell culture conditions to express high molecular weight vWF and rA13 having high specific activities.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: October 7, 2014
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Leopold Grillberger, Manfred Reiter, Wolfgang Mundt
  • Methods for increasing recovery of an ADAMTS activity from a cell culture supernatant
    Patent number: 8759026
    Abstract: The present invention provides culture mediums that are useful for the expression of ADAMTS proteins, such as ADAMTS13. Methods for the expression and purification of ADAMTS proteins are also provided. In some embodiments, the mediums and methods of the invention are useful for the expression of ADAMTS proteins having high specific activities. Also provided are ADAMTS, e.g., ADAMTS13, protein compositions with high specific activities, which are expressed and purified according to the methods provided herein.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: June 24, 2014
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Leopold Grillberger, Alexandra Spenger, Meinhard Hasslacher, Rana Grillberger, Manfred Reiter
  • Animal protein-free media for cultivation of cells
    Patent number: 8748156
    Abstract: The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating cells, such as recombinant cells or cells infected with a virus, and for producing biological products by cell culture processes.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: June 10, 2014
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Leopold Grillberger, Manfred Reiter, Wolfgang Mundt, Friedrich Dorner
  • Medium for the protein-free and serum-free cultivation of cells
    Patent number: 8722406
    Abstract: A medium is described for the protein-free and serum-free cultivation of cells, especially mammalian cells, whereby the medium contains a proportion of soy hydrolysate.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: May 13, 2014
    Assignee: Baxter Innovations GmbH
    Inventors: Manfred Reiter, Wolfgang Mundt, Friedrich Dorner, Leopold Grillberger, Artur Mitterer
  • Inactivation of a pathogen in a sample by a treatment with formalin and UV light
    Patent number: 8703467
    Abstract: The present invention relates to a method for inactivating virus in a sample by treating a virus containing sample with an effective concentration of formalin and by treating the sample with an effective dose of UV light in a flow-through apparatus.
    Type: Grant
    Filed: May 26, 2005
    Date of Patent: April 22, 2014
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Manfred Reiter, Wolfgang Mundt, Noel Barrett, Otfried Kistner
  • METHOD OF PRODUCING A POLYPEPTIDE OR VIRUS OF INTEREST IN A CONTINUOUS CELL CULTURE
    Publication number: 20140038264
    Abstract: Described herein is a chemostat-like continuous cell culture system that combines certain advantages of perfusion open systems and chemostat open systems to improve the culturing of mammalian cells, e.g., genetically modified cells, particularly in serum-free or chemically-defined media. The continuous culture system described herein involves culturing mammalian cells in a continuous cell culture system, which comprises a cell retention device, wherein the cell culture system has a dilution rate (D) of less than about 2 d?1, and a cell density of less than about 2×107 cell/mL.
    Type: Application
    Filed: October 10, 2013
    Publication date: February 6, 2014
    Applicants: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Leopold Grillberger, Manfred Reiter, Daniel Fleischanderl
  • Virus Filtration of Cell Culture Media
    Publication number: 20130344535
    Abstract: The invention relates to a method for removing a viral contaminant from a preparation, being a cell culture medium or at least a component of a cell culture medium. The method comprises subjecting said preparation to filtration for at least about 24 hours through a virus filter having an effective pore size of maximum about 75 nm. Further, the invention relates to the use of a virus filter in filtration of at least about 24 hours, wherein the virus filter has an effective pore size of maximum about 75 nm for the removal of viral contaminant from a preparation, being a cell culture medium or at least a component of a cell culture medium. In some embodiments the filtration according to the invention operates at a volumetric capacity of at least about 2000 L/m2.
    Type: Application
    Filed: June 19, 2013
    Publication date: December 26, 2013
    Applicants: Baxter Healthcare S.A., Baxter International Inc.
    Inventors: Wolfgang Mundt, Artur MITTERER, Manfred REITER, Meinhard HASSLACHER, Leopold GRILLBERGER, Thomas KRElL
  • Animal Protein Free Media for Cultivation of Cells
    Publication number: 20130316434
    Abstract: The present invention relates to animal protein free cell culture media comprising a combination of non-animal derived peptides derived from soy hydrolysate and yeast hydrolysate. The invention also provides an animal protein free culture process, wherein cells are cultivated, propagated and passaged without animal-derived components. This process is useful for cultivating cells, such as recombinant cells or cells infected with a virus, and for production biological products by cell culture processes under conditions devoid of animal protein components.
    Type: Application
    Filed: August 6, 2013
    Publication date: November 28, 2013
    Applicants: Baxter Healthcare S.A., Baxter International Inc.
    Inventors: Manfred Reiter, Wolfgang Mundt, Leopold Grillberger, Barbara Kraus