Patents by Inventor Manik Reddy Pullagurla

Manik Reddy Pullagurla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Process for the Preparation of Gadolinium Complex of (4S)-4-(4-Ethoxybenzyl)-3,6,9-Tris(Carboxylatomethyl)-3,6,9-Triazaundecanedioic Acid Disodium (Gadoxetate Disodium)
    Publication number: 20200123178
    Abstract: The present invention discloses a novel process for the preparation of gadolinium complex of (4 S)-4-(4-Ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9-triazaundecanedioic acid disodium of formula 1 and novel intermediates thereof.
    Type: Application
    Filed: May 30, 2017
    Publication date: April 23, 2020
    Applicant: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy PULLAGURLA, Bhaskar Reddy PITTA, Suresh Babu NAMANI, Jagadeesh Babu RANGISETTY
  • Process for the synthesis of dimethyl fumarate
    Patent number: 10626076
    Abstract: The present invention describes an improved process for the industrial scale production of dimethyl fumarate. The process involves a one-pot ring opening reaction of maleic anhydride to monomethyl maleate and isomerization into the corresponding monomethyl fumarate in presence of a Lewis acid. Finally the mono methyl fumarate was converted into the dimethyl fumarate by an acid catalyzed esterification reaction.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: April 21, 2020
    Assignee: BIOPHORE INDIA PHARMAEUTICALS PVT. LTD.
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar, Nagarapu Radha
  • IMPROVED METHOD FOR THE PREPARATION OF SULFOBUTYLETHER BETA CYCLODEXTRIN SODIUM
    Publication number: 20200095343
    Abstract: The present invention relates to an improved method for the synthesis of sulfobutylether beta cyclodextrin sodium and to provide an amorphous form of sulfobutylether beta cyclodextrin sodium having a 1,4-butane sultone content less than 0.5 ppm. The present invention further provides sulfobutylether beta cyclodextrin sodium containing less than 35 IU/g of Bacterial endotoxins.
    Type: Application
    Filed: February 7, 2018
    Publication date: March 26, 2020
    Inventors: Manik Reddy Pullagurla, Bhaskar Reddy Pitta, Suresh Babu Namana, Radha Nagarapu, Jagadeesh Babu Rangisetty
  • Novel Process for the Preparation of Tavaborole, Its Novel Polymorphic Forms and the Polymorphs Thereof
    Publication number: 20200087325
    Abstract: The invention relates to novel process for preparation of Tavaborole. The invention also relates to novel polymorphic forms of Tavaborole and process for preparation of those polymorphic forms. The invention also relates to process for purification of Tavaborole to obtain the Tavaborole in significantly high yield and substantially pure form.
    Type: Application
    Filed: September 24, 2019
    Publication date: March 19, 2020
    Inventors: Manik Reddy PULLAGURLA, Mecheril Valsan NANDA KUMAR, Bhaskar Reddy PITTA, Jagadeesh Babu RANGISETTY
  • NOVEL PROCESS FOR THE PREPARATION OF 4-[(1-HYDROXY-1,3-DIHYDRO-2,1-BENZOXABOROL-5-YL) OXY] BENZONITRILE (CRISABOROLE)
    Publication number: 20200062785
    Abstract: The present invention relates to a novel process for the preparation of substantially pure Crisaborole (I).
    Type: Application
    Filed: May 12, 2018
    Publication date: February 27, 2020
    Inventors: Manik Reddy Pullagurla, Bhaskar Reddy Pitta, Suresh Babu Namana, Jagadeesh Babu Rangisetty
  • Process for the preparation of pasireotide
    Patent number: 10556924
    Abstract: The present invention relates to a novel process for the preparation of Pasireotide of formula 11 [Cyclo [Phe-{4-(OCO—NH—CH2—CH2—NH2)) Pro}-Phg-DTrp-Lys-Tyr(Bzl)]]. The invention also relates to a novel intermediate compound of formula 8 and process thereof which is used for preparation of compound of formula 11.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: February 11, 2020
    Assignee: BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.
    Inventors: Manik Reddy Pullagurla, Radha Nagarapu, Jagadeesh Babu Rangisetty
  • NOVEL PROCESS FOR THE PREPARATION OF INDIGOTINDISULFONATE SODIUM (INDIGO CARMINE)
    Publication number: 20200017689
    Abstract: This invention relates to an improved method for the preparation of highly or substantially pure Indigotindisulfonate sodium (1). It further relates to the novel crystalline form I of Indigotindisulfonate sodium (1) and the process for its preparation.
    Type: Application
    Filed: December 23, 2017
    Publication date: January 16, 2020
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty
  • PROCESS FOR THE PREPARATION OF CETRORELIX ACETATE
    Publication number: 20190382447
    Abstract: The present invention relates to an improved process for the preparation of Cetrorelix acetate (1). More particularly, the present invention relates to the purification of Cetrorelix acetate (1) by simple method.
    Type: Application
    Filed: June 14, 2019
    Publication date: December 19, 2019
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty
  • PROCESS FOR THE PREPARATION OF SODIUM 4-(2-((1E,3E,5E,7Z)-7-(1,1-DIMETHYL-3-(4-SULFONATOBUTYL)-1H-BENZO[e]INDOL-2(3H)-YLIDENE) HEPTA-1,3,5-TRIENYL)-1,1-DIMETHYL-1H-BENZO[e]INDOLIUM-3-YL) BUTANE-1-SULFONATE (INDOCYANINE GREEN)
    Publication number: 20190337896
    Abstract: A process for the preparation of substantially pure Indocyanine green of formula with purity greater than 99.0% is provided. More particularly, the embodiments relate to the process for the preparation of Indocyanine green of formula and its intermediates thereof. It further provides crystalline form I of Indocyanine green of formula and process thereof.
    Type: Application
    Filed: April 30, 2019
    Publication date: November 7, 2019
    Inventors: MANIK REDDY PULLAGURLA, JAGADEESH BABU RANGISETTY
  • Process for the preparation of tavaborole, its novel polymorphic forms and the polymorphs thereof
    Patent number: 10435419
    Abstract: The invention relates to novel process for preparation of Tavaborole. The invention also relates to novel polymorphic forms of Tavaborole and process for preparation of those polymorphic forms. The invention also relates to process for purification of Tavaborole to obtain the Tavaborole in significantly high yield and substantially pure form.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: October 8, 2019
    Assignee: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy Pullagurla, Mecheril Valsan Nanda Kumar, Bhaskar Reddy Pitta, Jagadeesh Babu Rangisetty
  • NOVEL PROCESS FOR THE PREPARATION OF BELINOSTAT
    Publication number: 20190256459
    Abstract: The present invention provides a novel and commercially viable process with high yield for the preparation of (E)-N-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide, also known as Belinostat (I). The invention also provides process for purification and novel crystalline form of Belinostat in substantially pure form.
    Type: Application
    Filed: May 1, 2017
    Publication date: August 22, 2019
    Inventors: Manik Reddy PULLAGURLA, Mecheril Valsan NANDA KUMAR, Bhaskar Reddy PITTA, Jagadeesh Babu RANGISETTY
  • ISOSULFAN BLUE, ITS CRYSTALLINE FORM AND PROCESS FOR PREPARATION THEREOF
    Publication number: 20190225626
    Abstract: Provided is an improved process for the preparation N-[4-[[4-(diethyl amino) phenyl](2,5-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N-ethylethanaminium inner salt sodium salt (Isosulfan blue) of formula I. It also relates to highly pure novel crystalline form of Isosulfan blue hydrate and its process for the preparation thereof. It also relates to an improved process for the preparation of Isosulfan blue sodium hydrate having not more than 0.2% of desethyl impurity of formula A.
    Type: Application
    Filed: September 6, 2016
    Publication date: July 25, 2019
    Inventors: MANIK REDDY PULLAGURLA, MECHERIL VALSAN NANDA KUMAR, BHASKAR REDDY PITTA, SURESH BABU NAMANA, JAGADEESH BABU RANGISETTY, SADASHIV CHOPPARI
  • IMPROVED METHOD FOR THE SYNTHESIS OF PERMETHRIN
    Publication number: 20190194118
    Abstract: The present invention describes an improved method for the synthesis of substantially pure Permethrin (1) having purity greater than 99.5% by Gas Chromatography (GC). The invention also relates to a purification process of Permethrin by recrystallization from methanol-water mixture.
    Type: Application
    Filed: September 1, 2017
    Publication date: June 27, 2019
    Inventors: MANIK REDDY PULLAGURLA, MECHERIL VALSAN NANDA KUMAR, Madhusudhana Rao VELIGETLA, JAGADEESH BABU RANGISETTY
  • Process for the preparation of (S)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxo-pentan-2-yl) amino)-1-oxo-3-phenylpropan-2-yl)-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido) pentanamide
    Patent number: 10329325
    Abstract: Novel methods for preparation of Carfilzomib and intermediates thereof with high stereo selection are reported. The synthetic procedures result in substantially pure Carfilzomib (I).
    Type: Grant
    Filed: August 29, 2015
    Date of Patent: June 25, 2019
    Assignee: Biophore India Pharmaceuticals Pvt. Ltd
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nanda Kumar, Surya Bala Subrahmanyam Pendyala, Bhaskar Reddy Pitta
  • Method of Preparing Solid Dispersions of Active Pharmaceutical Ingredients
    Publication number: 20190160005
    Abstract: The present invention provides solid dispersions of active pharmaceutical ingredients (APIs). It further relates to a process for the preparation of solid dispersions of active pharmaceutical ingredients (APIs) using pharmaceutically acceptable excipients.
    Type: Application
    Filed: November 26, 2018
    Publication date: May 30, 2019
    Inventors: Manik Reddy PULLAGURLA, Bhaskar Reddy PITTA, Rajesham BOGE, Suresh Babu NAMANA, Jagadeesh Babu RANGISETTY
  • Novel Process for the Synthesis of Docosanol
    Publication number: 20190161425
    Abstract: The present invention relates to a novel process for the preparation of Docosanol (I). More particularly, the invention relates to a novel process for the preparation of Docosanol (I) in a substantially pure form with a purity level of greater than 99.5%. The invention also relates to novel crystalline forms of Docosanol (I) and process for preparation thereof.
    Type: Application
    Filed: November 22, 2018
    Publication date: May 30, 2019
    Inventors: Manik Reddy PULLAGURLA, Jagadeesh Babu RANGISETTY
  • Novel Process for the Preparation of Tavaborole, Its Novel Polymorphic Forms and the Polymorphs Thereof
    Publication number: 20190119306
    Abstract: The invention relates to novel process for preparation of Tavaborole. The invention also relates to novel polymorphic forms of Tavaborole and process for preparation of those polymorphic forms. The invention also relates to process for purification of Tavaborole to obtain the Tavaborole in significantly high yield and substantially pure form.
    Type: Application
    Filed: July 21, 2016
    Publication date: April 25, 2019
    Applicant: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy PULLAGURLA, Mecheril Valsan NANDA KUMAR, Bhasakar Reddy PITTA, Jagadeesh Babu RANGISETTY
  • Method for the Synthesis of Ferric Oraganic Compounds
    Publication number: 20190047934
    Abstract: The present invention relates to an improved method for the synthesis of Ferric Citrate and also to provide an amorphous form of Ferric Citrate having an active surface area less than 14 sq.m/g.
    Type: Application
    Filed: December 17, 2015
    Publication date: February 14, 2019
    Inventors: Manik Reddy Pullagurla, Mecheril Valsan Nanda Kumar, Jagadeesh Babu Rangisetty, Rajesh Bhudeti, Radha Nagarapu
  • Process for the synthesis of Dabigatran Etexilate and its intermediates
    Patent number: 10077251
    Abstract: The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: September 18, 2018
    Assignee: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar
  • Process for the Synthesis of Melphalan and the Hydrochloride Salt
    Publication number: 20180237377
    Abstract: The present invention relates to an improved process for the preparation of Melphalan, more specifically the invention relates to an efficient process for the preparation of substantially pure Melphalan hydrochloride (I).
    Type: Application
    Filed: April 24, 2018
    Publication date: August 23, 2018
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar, Madhava Reddy Vedururi, Sreenu Samireddi