Patents by Inventor Manish Deshpande
Manish Deshpande has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110201981Abstract: A compression garment assembly comprises a compression garment adapted for placement on a body part in a self-retaining configuration and for removal from the body part. The compression garment has at least one inflatable bladder for applying compression to the body part. A portable controller unit is adapted for fluid connection to the inflatable bladder and is configured for cyclically inflating the bladder. The compression garment and portable controller unit are configured so that the portable controller unit must be disconnected from the compression garment before the compression garment can be removed from the body part. Loss of the portable controller unit by, for example, accidental disposal with the compression garment is thus prevented.Type: ApplicationFiled: February 12, 2010Publication date: August 18, 2011Applicant: TYCO HEALTHCARE GROUP LPInventors: Manish Deshpande, Ross Kanter
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Patent number: 7997831Abstract: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.Type: GrantFiled: November 2, 2009Date of Patent: August 16, 2011Assignee: Cytonome/St, LLCInventors: John R. Gilbert, Manish Deshpande, Bernard Bunner
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Publication number: 20110168871Abstract: An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.Type: ApplicationFiled: December 13, 2010Publication date: July 14, 2011Inventors: John R. Gilbert, Edward Sinofsky, Manish Deshpande
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Patent number: 7963399Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.Type: GrantFiled: August 7, 2009Date of Patent: June 21, 2011Assignee: Cytonome/ST, LLCInventors: Sebastian Böhm, John R. Gilbert, Manish Deshpande
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Patent number: 7870964Abstract: A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. An infusion pump for delivering a fluid from a fluid source may be integrated in a microfluidic chip using a capping module having pumping components formed therein.Type: GrantFiled: November 24, 2008Date of Patent: January 18, 2011Assignee: Cytonome / St, LLCInventors: John R. Gilbert, Manish Deshpande
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Publication number: 20110005978Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.Type: ApplicationFiled: June 23, 2010Publication date: January 13, 2011Applicant: Cytonome/ST, LLCInventors: Sebastian Böhm, John R. Gilbert, Manish Deshpande
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Publication number: 20100133151Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.Type: ApplicationFiled: August 7, 2009Publication date: June 3, 2010Applicant: CYTONOME/ST, LLCInventors: Sebastian Bohm, John R. Gilbert, Manish Deshpande
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Publication number: 20100111616Abstract: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.Type: ApplicationFiled: November 2, 2009Publication date: May 6, 2010Applicant: CYTONOME, INC.Inventors: John R. Gilbert, Manish Deshpande, Bernard Bunner
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Publication number: 20100032350Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.Type: ApplicationFiled: July 8, 2009Publication date: February 11, 2010Applicant: CYTONOME/ST, LLCInventors: Manish DESHPANDE, John R. GILBERT
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Publication number: 20090291463Abstract: A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. The microfluidic element may comprise a matrix having an affinity for selected molecules in a sample. The matrix binds, reacts with and/or retains the selected molecules without affecting other molecules in the sample.Type: ApplicationFiled: March 27, 2009Publication date: November 26, 2009Applicant: Cytonome, Inc.Inventors: John R. Gilbert, Manish Deshpande, Jaishree Trikha
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Patent number: 7611309Abstract: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.Type: GrantFiled: November 30, 2007Date of Patent: November 3, 2009Assignee: Cytonome/ST, LLCInventors: John R. Gilbert, Manish Deshpande, Bernard Bunner
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Patent number: 7584857Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.Type: GrantFiled: August 7, 2006Date of Patent: September 8, 2009Assignee: Cytonome/ST, LLCInventors: Sebastian Böhm, John R. Gilbert, Manish Deshpande
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Patent number: 7576861Abstract: An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.Type: GrantFiled: March 27, 2008Date of Patent: August 18, 2009Assignee: Cytonome/ST, LLCInventors: John R. Gilbert, Edward Sinofsky, Manish Deshpande
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Patent number: 7569788Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.Type: GrantFiled: April 6, 2005Date of Patent: August 4, 2009Assignee: Cytonome/ST, LLCInventors: Manish Deshpande, John R. Gilbert
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Publication number: 20090168053Abstract: An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.Type: ApplicationFiled: February 12, 2009Publication date: July 2, 2009Applicant: Cytonome, Inc.Inventors: John R. GILBERT, Edward SINOFSKY, Manish DESHPANDE
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Patent number: 7514000Abstract: A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. The microfluidic element may comprise a matrix having an affinity for selected molecules in a sample. The matrix binds, reacts with and/or retains the selected molecules without affecting other molecules in the sample.Type: GrantFiled: June 30, 2006Date of Patent: April 7, 2009Assignee: Cytonome, Inc.Inventors: John R. Gilbert, Manish Deshpande, Jaishree Trikha
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Publication number: 20090071541Abstract: A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. An infusion pump for delivering a fluid from a fluid source may be integrated in a microfluidic chip using a capping module having pumping components formed therein.Type: ApplicationFiled: November 24, 2008Publication date: March 19, 2009Applicant: Cytonome, Inc.Inventors: John R. Gilbert, Manish Deshpande
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Patent number: 7492522Abstract: An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.Type: GrantFiled: October 3, 2007Date of Patent: February 17, 2009Assignee: Cytonome, Inc.Inventors: John R. Gilbert, Edward Sinofsky, Manish Deshpande
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Patent number: 7455770Abstract: A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. An infusion pump for delivering a fluid from a fluid source may be integrated in a microfluidic chip using a capping module having pumping components formed therein.Type: GrantFiled: September 27, 2004Date of Patent: November 25, 2008Assignee: Cytonome, Inc.Inventors: John R. Gilbert, Manish Deshpande
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Publication number: 20080277615Abstract: An on-chip chemical compound dilution system for providing dilution of a chemical compound in a microfluidic application includes at least one sample well for providing a selected chemical compound to be diluted, a dilution well for providing a diluent for diluting the chemical compound, a network of channels for carrying the chemical compound and diluent, a first syringe pump for effecting dilution, a second syringe pump, a detector and a plurality of valves for selectively controlling the flow of liquid through the channels. The dilution system may be a multiple-stage dilution system for precisely mixing a plurality of chemical compounds in a diluent. The dilution system allows for accurate calibration to compensate for variations due to manufacturing, thereby providing precise dilution ratios. The dilution system further enables flushing to allow re-use of the system with another chemical compound.Type: ApplicationFiled: July 21, 2008Publication date: November 13, 2008Applicant: Cytonome, Inc.Inventors: John Gilbert, Manish Deshpande