Abstract: Described here are methods and compositions for treating tumors and metastases that improve anti-angiogenesis therapy. By inhibiting these mechanisms in a biological system with an anti-beta one integrin composition in combination with an antiangiogenic composition, tumors and metastases may be deprived of an adequate blood supply, thereby resulting in tumor cell growth arrest and possibly regression, including tumor cell death. The present compositions comprise an anti-beta one integrin agent in combination with an anti-VEGF agent, in a pharmaceutical composition or compositions. Methods of treatment and of imaging are also described.

Abstract: In some embodiments, the present disclosure relates to a resistive random access memory (RRAM) memory circuit. The memory circuit has a word-line decoder operably coupled to a first RRAM device and a second RRAM device by a word-line. A bit-line decoder is coupled to the first RRAM device by a first bit-line and to the second RRAM device by a second bit-line. A bias element is configured to apply a first non-zero bias voltage to the second bit-line concurrent to the bit-line decoder applying a non-zero voltage to the first bit-line.

Abstract: A method and a system for providing alerts at a computing device are provided. The method as executed by the system includes determining usage of the computing device based on a user interaction. Ascertaining whether the user is exhibiting a foot movement. Displaying an overlay of a predetermined size for a predetermined amount of time to cause an alert, in response to the ascertainment and the determination. Incrementing a size of the displayed overlay linearly with time, based on persistence of the usage and said exhibition of the foot movement beyond an extended time duration.

Abstract: The disclosure describes a method of forming highly ordered membrane protein crystals. The forming process is done in the presence of a magnetic field to exploit the diamagnetic anisotropy of the membrane protein. Further described is a method of magnetic alignment and crystallization of membrane proteins in two-dimensional (2D) sheets for protein structural characterization and applications in functional devices. Block co-copolymers are used in alternative embodiments to assist with the crystallization process.

Abstract: A combustor has a trailing edge duct (110) that has a trailing edge (120) that is adapted to be connected to an adjacent trailing edge (120) of a trailing edge duct (110). The connections between the adjacent trailing edges may be formed along the lengthwise direction of the trailing edges and/or using interfacing components.

Abstract: In certain aspects, the disclosure relates to compositions comprising modified Cas9 polyribonucleotides and methods of use, as well as Cas9 polynucleotides and polyribonucleotides.

Abstract: In one embodiment, a device in a network maintains first and second routing tables associated with a virtual private network (VPN) tunnel. The first and second routing tables comprise routing information used to route packets external to a particular routing domain. The device routes a first packet in the network via the VPN tunnel and a second tunnel that encapsulates the VPN tunnel, using the routing information in the first routing table. The device receives a second packet via the VPN tunnel that was routed to the device using the routing information in the second routing table and bypasses the second tunnel.

Abstract: The present invention contains a printing apparatus and a method, e.g., for ejecting inks (i.e., pure liquids, mixtures, colloids, etc.) for a very broad range of physical properties (such as viscosity). Acoustic forces 3a may be generated by an emitter 1 and a reflector 2 to detach droplets 10 from a nozzle 6. The ink may be advanced through the nozzle 6 by a standard back pressure system 5. A reflectorless chamber 7 may enhance acoustic forces 8a and the droplets 10 may be ejected at a bottom 9 of said chamber 7, so that droplets 10 may be deposited on any substrate 11.

Abstract: Dynamic motion path blur techniques are described. In one or more implementations, paths may be specified to constrain a motion blur effect to be applied to a single image. A variety of different techniques may be employed as part of the motion blur effects, including use of curved blur kernel shapes, use of a mesh representation of blur kernel parameter fields to support real time output of the motion blur effect to an image, use of flash effects, blur kernel positioning to support centered or directional blurring, tapered exposure modeling, and null paths.

Abstract: The present disclosure relates to an integrated circuit, which includes a semiconductor substrate and an interconnect structure disposed over the semiconductor substrate. The interconnect structure includes a lower metal layer, an intermediate metal layer disposed over the lower metal layer, and an upper metal layer disposed over the intermediate metal layer. An upper surface of the lower metal layer and a lower surface of the intermediate metal layer are spaced vertically apart by a first distance. A resistive random access memory (RRAM) cell is arranged between the lower metal layer and the upper metal layer. The RRAM cell includes a bottom electrode and a top electrode which are separated by a data storage layer having a variable resistance. The data storage layer vertically spans a second distance that is greater than the first distance.

Abstract: The present disclosure relates to a method and apparatus for performing a read operation of an RRAM cell, which applies a non-zero bias voltage to unselected bit-lines and select-lines to increase a read current window without damaging corresponding access transistors. In some embodiments, the method may be performed by activating a word-line coupled to a row of RRAM cells comprising a selected RRAM device by applying a first read voltage to the word-line. A second read voltage is applied to a bit-line coupled to a first electrode of the selected RRAM device. One or more non-zero bias voltages are applied to bit-lines and select-lines coupled to RRAM cells, within the row of RRAM cells, having unselected RRAM devices.

Abstract: Systems, methods, and devices for escalating voice-based interactions via speech-controlled devices are described. Speech-controlled devices capture audio, including wakeword portions and payload portions, for sending to a server to relay messages between speech-controlled devices. In response to determining the occurrence of an escalation event, such as repeated messages between the same two devices, the system may automatically change a mode of a speech-controlled device, such as no longer requiring a wakeword, no longer requiring an indication of a desired recipient, or automatically connecting two speech-controlled devices in a voice-chat mode. In response to determining the occurrence of further escalation events, the system may initiate a real-time call between the speech-controlled devices.

Abstract: Systems, methods, and devices for outputting indications regarding voice-based interactions are described. A first speech-controlled device detects spoken audio corresponding to recipient information. The first device captures the audio and sends audio data corresponding to the captured audio to a server. The server determines a second speech-controlled device of the recipient and sends a signal to the recipient's second speech-controlled device representing a message is forthcoming. The recipient's second speech-controlled device outputs and indication representing a message is forthcoming.

Abstract: Systems, methods, and devices for outputting visual indications regarding voice-based interactions are described. A first speech-controlled device detects spoken audio corresponding to a voice message to a second speech-controlled device. The first device captures the audio and sends audio data corresponding to the captured audio to a server. The server performs speech processing on the audio data to determine a recipient and message content. The server then determines a second speech-controlled device associated with the recipient and sends the message content to the recipient's second speech-controlled device. Thereafter, the server receives an indication from the recipient's speech-controlled device that the second device is detecting speech, presumably in response to the original message. The server then causes a visual indication to be output by the first speech-controlled device, with the visual indication representing the recipient-speech controlled device is detecting speech.

Abstract: Disclosed herein is a membrane comprising a bonding layer; and an activation layer disposed on the bonding layer and in contact with it; where the activation layer comprises catalyst nanoparticles that are operative to decompose impurities contained in an aqueous solution to generate gas bubbles that remove a sludge disposed on the membrane. Disclosed herein too is a method of purifying an aqueous solution comprising disposing in the aqueous solution, a membrane that comprises a bonding layer and an activation layer; where the activation layer comprises catalyst nanoparticles; partitioning the aqueous solution into a concentrate portion and a filtrate portion; where the activation layer contacts the concentrate portion; and decomposing impurities contained in the aqueous solution to generate gas bubbles that remove a sludge disposed on the membrane.

Abstract: The described implementations relate to tunable predicate discovery. One implementation is manifest as a method for obtaining a data set and determining anomaly scores for anomalies of an attribute of interest in the data set. The method can also generate a ranked list of predicates based on the anomaly scores and cause at least one of the predicates of the ranked list to be presented.

Abstract: An approach is provided in which a system selects a first processor as a master Time of Day (TOD) processor in a first TOD topology in response to determining that the first processor is directed connected to an oscillator. The system then assigns a second processor as an alternate master TOD processor to a second TOD topology based upon determining that the second processor is on a different node than the first processor. The system configures to the first TOD topology and, when the system detects a TOD failure, the system re-configures to the second TOD topology.

Abstract: An approach is provided in which a system selects a first processor as a master Time of Day (TOD) processor in a first TOD topology. The system then assigns a second processor as an alternate master TOD processor to a second TOD topology based upon determining that the second processor is on a different node than the first processor. The system configures to the first TOD topology and, when the system detects a TOD failure requiring a topology switch, the system re-configures to the second TOD topology.

Abstract: The present invention contains a printing apparatus and a method, e.g., for ejecting inks (i.e. pure liquids, mixtures, colloids, etc.) for a very broad range of physical properties (such as viscosity). Acoustic forces 3a may be generated by an emitter 1 and a reflector 2 to detach droplets 10 from a nozzle 6. The ink may be advanced through the nozzle 6 by a standard back pressure system 5. A reflectorless chamber 7 may enhance acoustic forces 8a and the droplets 10 may be ejected at a bottom 9 of said chamber 7, so that droplets 10 may be deposited on any substrate 11.

Abstract: A system and method for notifying a called party of a call attempt is provided. The method comprises initiating a communication request by a calling party; routing the communication request to an intelligent network via an mobile service center; validating the communication request by the intelligent network; and handing over the communication request to an intelligent platform by the intelligent network in the event of a nonstandard trigger event such as calling party insufficient balance. The processing of communication request by the intelligent platform includes monitoring number of call attempts, introducing a delay in sending notification, monitoring availability of called party and performing one or more actions based on the delay and the availability of the called party.