Abstract: Provided herein are long circulating material free (LCMF) poloxamer compositions and uses thereof. In particular, provided are LCMF poloxamer 188 compositions and uses thereof. Also provided are supercritical fluid extraction (SFE) methods and high pressure (subcritical) methods for preparing poloxamer compositions, particularly the LCMF poloxamer compositions.

Abstract: Provided herein are long circulating material free (LCMF) poloxamer compositions and uses thereof. In particular, provided are LCMF poloxamer 188 compositions and uses thereof. Also provided are supercritical fluid extraction (SFE) methods and high pressure (subcritical) methods for preparing poloxamer compositions, particularly the LCMF poloxamer compositions.

Abstract: Provided herein are long circulating material free (LCMF) poloxamer compositions and uses thereof. In particular, provided are LCMF poloxamer 188 compositions and uses thereof. Also provided are supercritical fluid extraction (SFE) methods and high pressure (subcritical) methods for preparing poloxamer compositions, particularly the LCMF poloxamer compositions.

Abstract: A multi-purpose food grinding machine having springs for exerting compressive force upon grinding rollers having various surfaces and configurations and including apparatus for adjusting and monitoring the compressive force.

Abstract: A multi-purpose food grinding machine having an open topped cylindrical vessel that is rotated by a gear reduced motor. The motor is located within a hollow housing. A keyed motor shaft engages a mating aperture in the bottom of the cylinder. A frame holds the housing in place under the vessel. A central shaft is held by the frame and extends downward into the vessel. Rotatable grinding members are attached to the bottom of the shaft so that as the vessel is rotated by the gear motor, the grinding members rotate at the bottom of the vessel causing any food items trapped between the grinding members and the floor of the vessel to be crushed. The grinding members are forced downward by a spring biased mechanism. A spring biased inside wall scraper forces food to drop back down into the vessel.

Abstract: Provided herein are long circulating material free (LCMF) poloxamer compositions and uses thereof. In particular, provided are LCMF poloxamer 188 compositions and uses thereof. Also provided are supercritical fluid extraction (SFE) methods and high pressure (subcritical) methods for preparing poloxamer compositions, particularly the LCMF poloxamer compositions.

Abstract: Provided herein are long circulating material free (LCMF) poloxamer compositions and uses thereof. In particular, provided are LCMF poloxamer 188 compositions and uses thereof. Also provided are supercritical fluid extraction (SFE) methods and high pressure (subcritical) methods for preparing poloxamer compositions, particularly the LCMF poloxamer compositions.

Abstract: Provided herein are long circulating material free (LCMF) poloxamer compositions and uses thereof. In particular, provided are LCMF poloxamer 188 compositions and uses thereof. Also provided are supercritical fluid extraction (SFE) methods and high pressure (subcritical) methods for preparing poloxamer compositions, particularly the LCMF poloxamer compositions.

Abstract: A multi-purpose food grinding machine having an open topped cylindrical vessel that is rotated by a gear reduced motor. The motor is located within a hollow housing. A keyed motor shaft engages a mating aperture in the bottom of the cylinder. A frame holds the housing in place under the vessel. A central shaft is held by the frame and extends downward into the vessel. Rotatable grinding members are attached to the bottom of the shaft so that as the vessel is rotated by the gear motor, the grinding members rotate at the bottom of the vessel causing any food items trapped between the grinding members and the floor of the vessel to be crushed. The grinding members are forced downward by a spring biased mechanism. A spring biased inside wall scraper forces food to drop back down into the vessel.

Abstract: The present invention comprises novel polyoxyethylene/polyoxypropylene block copolymers compositions and compounds. The compositions comprise block copolymers that are useful in gene therapy methods.

Abstract: The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene octablock copolymers which retain the growth-promoting and immunity-enhancing activity of commercially-available preparations, but are free from the undesirable effects which are inherent in the prior art preparations. Because the polyoxypropylene/polyoxyethylene copolymers which comprise the present invention have a more homogenous population of molecules with fewer low molecular weight species than prior art preparations, the biological activity of the copolymer is better defined and more predictable. Moreover, the polyoxypropylene/polyoxyethylene copolymer of the present invention substantially reduces any risk to human health through the consumption of food animals since the copolymer hereof is not absorbed into the animal's edible tissue. Methods for preparation of the polyoxypropylene/polyoxyethylene copolymer of the present invention are also provided.

Abstract: The present invention includes novel polyoxyethylene/polyoxypropylene block copolymers as well as methods for making the block copolymers. The block copolymers are high molecular weight molecules and are useful as general surfactants and display enhanced biological efficacy as vaccine adjuvants.

Abstract: The present invention comprises novel polyoxyethylene/polyoxypropylene block copolymer compositions and compounds. The compositions comprise block copolymers that are high molecular weight molecules, and are useful in gene therapy methods.

Abstract: The present invention includes novel polyoxyethylene/polyoxypropylene block copolymers as well as methods for making the block copolymers. The block copolymers are high molecular weight molecules and are useful as general surfactants and display enhanced biological efficacy as vaccine adjuvants.

Abstract: The present invention includes novel polyoxyethylene/polyoxypropylene block copolymers as well as methods for making the block copolymers. The block copolymers are high molecular weight molecules and are useful as general surfactants and display enhanced biological efficacy as vaccine adjuvants.

Abstract: The present invention includes novel polyoxyethylene/polyoxypropylene block copolymers as well as methods for making the block copolymers. The block copolymers are high molecular weight molecules and are useful as general surfactants and display enhanced biological efficacy as vaccine adjuvants.

Abstract: The present invention includes novel polyoxyethylene/polyoxypropylene block copolymers as well as methods for making the block copolymers. The block copolymers are high molecular weight molecules and are useful as general surfactants and display enhanced biological efficacy as vaccine adjuvants.

Abstract: The present invention includes compositions and methods using biologically active nonionic reverse block copolymers. The reverse copolymers have an inner core of polyoxypropylene (POP) that is flanked on either end by polyoxyethylene (POE). The reverse block copolymers have the following formula: ##STR1## wherein "b" represents a number such that the molecular weight of the hydrophobe (C.sub.3 H.sub.6 O).sub.b is between approximately 2,000 and 10,000, and "a" represents a number such that the percentage of hydrophile (C.sub.2 H.sub.4 O).sub.a is between approximately 5% and 30%. The reverse block copolymers stimulate the immune response, can suppress immune responses such as those in autoimmune diseases, promote the growth of animals, and stimulate hormone production.

Abstract: The present invention comprises methods and compositions for reducing or eliminating multidrug resistance in cancers or certain infections by drug resistant microorganisms in patients. According to the method and composition of the present invention, a non-ionic amphipathic diester of fatty acids or a reverse poloxmer is administered to a patient in which a cancer or microorganism exhibits multidrug resistance to the chemotherapeutic agent. The method and composition of the present invention may be employed with particular efficacy where multidrug resistance to any chemotherapeutic agent has been conferred upon a cancer.

Abstract: The present invention comprises methods and compositions for reducing or eliminating multidrug resistance in cancers or certain infections by drug resistant microorganisms in patients. According to the method and composition of the present invention, a non-ionic amphipathic diester of fatty acids or a reverse poloxmer is administered to a patient in which a cancer or microorganism exhibits multidrug resistance to the chemotherapeutic agent. The method and composition of the present invention may be employed with particular efficacy where multidrug resistance to any chemotherapeutic agent has been conferred upon a cancer.