Patents by Inventor Mannarsamy Balasubramanian

Mannarsamy Balasubramanian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiinfective polyoxypropylene/polyoxyethylene copolymers and methods of use
    Patent number: 5674911
    Abstract: The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but substantially reduce the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable and the cardiotoxicity inherent in the native copolymers is substantially reduced.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 7, 1997
    Assignee: Cytrx Corporation
    Inventors: R. Martin Emanuele, Mannarsamy Balasubramanian, Hameedsulthan S. Allaudeen
  • Methods and compositions for reducing multidrug resistance
    Patent number: 5591715
    Abstract: The present invention comprises methods and compositions for reducing or eliminating multidrug resistance in cancers or certain infections by drug resistant microorganisms in patients. According to the method and composition of the present invention, a non-ionic amphipathic diester of fatty acids or a reverse poloxmer is administered to a patient in which a cancer or microorganism exhibits multidrug resistance to the chemotherapeutic agent. The method and composition of the present invention may be employed with particular efficacy where multidrug resistance to any chemotherapeutic agent has been conferred upon a cancer.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 7, 1997
    Assignee: Rush Presbyterian-St. Luke's Medical Center
    Inventors: John S. Coon, Mannarsamy Balasubramanian, R. Martin Emanuele, Himanshu Shah
  • Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
    Patent number: 5567859
    Abstract: The present invention comprises novel preparations of polyoxypropylene/polyoxyethylene copolymers which retain the therapeutic activity of the commercial preparations, but substantially reduce the undesirable effects which are inherent in the prior art preparations. Because the preparations of polyoxypropylene/polyoxyethylene copolymers which comprise the present invention are a less polydisperse population of molecules than the prior art polyoxypropylene/polyoxyethylene copolymers, the biological activity of the copolymers is better defined and more predictable and the cardiotoxicity inherent in the native copolymers is substantially reduced.
    Type: Grant
    Filed: August 9, 1994
    Date of Patent: October 22, 1996
    Assignee: CytRx Corporation
    Inventors: R. Martin Emanuele, Mannarsamy Balasubramanian, Hameedsulthan S. Allaudeen
  • Gel composition for implant prosthesis and method of use
    Patent number: 5407445
    Abstract: In accordance with the present invention, a composition and method is provided for a biocompatible filler for prostheses. The composition and method relate to certain polyoxyethylene/polyoxypropylene block copolymers which have gelling properties at body temperature and are ideally suited for use as fillers for a soft tissue prosthesis such as a breast implant.
    Type: Grant
    Filed: May 19, 1993
    Date of Patent: April 18, 1995
    Assignee: Cytrx Corporation
    Inventors: Daiva K. Tautvydas, Mannarsamy Balasubramanian, R. Martin Emanuele
  • Process for preparing organosilazanes
    Patent number: 5010157
    Abstract: Organosilazanes having higher prepolymerization molecular weights are prepared by subjecting to elevated temperatures in a dry atmosphere the total reaction mixture resulting from the ammonolysis of an organohalosilane in an organic solvent. Their higher molecular weights expedite the polymerization of the organosilazanes to preceramic polysilazanes.
    Type: Grant
    Filed: June 30, 1989
    Date of Patent: April 23, 1991
    Assignee: Ethyl Corporation
    Inventors: Mannarsamy Balasubramanian, Pranab Choudhury
  • Process for preparing organosilazanes
    Patent number: 5006625
    Abstract: Organosilazanes having higher prepolymerization molecular weights are prepared by the ammonolysis of organohalosilanes at a temperature of about 15.degree.-23.degree. C. Their higher molecular weights facilitate the polymerization of the organosilazanes to preceramic polysilazanes.
    Type: Grant
    Filed: June 30, 1989
    Date of Patent: April 9, 1991
    Assignee: Ethyl Corporation
    Inventors: Mannarsamy Balasubramanian, Martin E. Gluckstein, Edwin D. Hornbaker