Patents by Inventor Manoj Desai
Manoj Desai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20110023184Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 3, or 4, the nucleotide sequence set forth in SEQ ID NO:1, 9, 10, or 11, as well as variants and fragments thereof.Type: ApplicationFiled: July 1, 2010Publication date: January 27, 2011Inventors: Nalini Manoj Desai, Jill Hinson, Deepa Balasubramanian, Kimberly S. Sampson, Daniel J. Tomso, Duane Alan Lehtinen, Nicholas Duck, Rong Guo
-
Patent number: 7645747Abstract: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.Type: GrantFiled: October 25, 2005Date of Patent: January 12, 2010Assignee: Gilead Sciences, Inc.Inventors: Constantine G. Boojamra, Carina E. Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Craig S. Gibbs, Ralph F. Hirschmann, Alan X. Huang, Haolun Jin, Choung U. Kim, Thorsten A. Kirschberg, Steven Krawczyk, Christopher P. Lee, William A. Lee, Kuei-Ying Lin, Richard L. Mackman, David Y. Markevitch, Peter H. Nelson, David A. Oare, Vidya K. Prasad, Hyung-Jung Pyun, Adrian S. Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang, Lijun Zhang
-
Publication number: 20090227543Abstract: The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.Type: ApplicationFiled: July 1, 2008Publication date: September 10, 2009Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Alan X. Huang, Thorsten Kirschberg, Christopher P. Lee, Richard L. Mackman, Peter H. Nelson, Hyung-Jung Pyun, Adrian S. Ray, William J. Watkins, Jennifer R. Zhang, Sundaramoorthi Swaminathan
-
Publication number: 20090181930Abstract: The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.Type: ApplicationFiled: July 2, 2008Publication date: July 16, 2009Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Thorsten Kirschberg, Richard L. Mackman, Sundaramoorthi Swaminathan, William J. Watkins
-
Patent number: 7470724Abstract: The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.Type: GrantFiled: April 26, 2004Date of Patent: December 30, 2008Assignee: Gilead Sciences, Inc.Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Alan X. Huang, Thorsten Kirschberg, Christopher P. Lee, Richard L. Mackman, Peter H. Nelson, Hyung-Jung Pyun, Adrian S. Ray, William J. Watkins, Jennifer R. Zhang, Sundaramoorthi Swaminathan
-
Patent number: 7417055Abstract: The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.Type: GrantFiled: April 26, 2004Date of Patent: August 26, 2008Assignee: Gilead Sciences, Inc.Inventors: Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Manoj Desai, Maria Fardis, Thorsten Kirschberg, Richard L. Mackman, Sundaramoorthi Swaminathan, William J. Watkins
-
Publication number: 20080108617Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.Type: ApplicationFiled: July 6, 2007Publication date: May 8, 2008Inventors: Manoj Desai, Allen Hong, Hongtao Liu, Randall Vivian, Lianhong Xu
-
Publication number: 20080070910Abstract: The present invention provides compounds of Formula (I): wherein A, X, Q, R2-R6, m, and W have the values described herein, as well as compositions comprising such compounds. The compounds are protease inhibitors and are useful for inhibiting the development of drug resistance in animals.Type: ApplicationFiled: July 24, 2007Publication date: March 20, 2008Inventors: Manoj Desai, Christopher Lee, Hongtao Liu, Sundaramoorthi Swaminathan, Lianhong Xu
-
Publication number: 20080008682Abstract: The present application provides for a compound of Formula I or II: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that include the administration of such compounds with at least one additional active agent.Type: ApplicationFiled: July 6, 2007Publication date: January 10, 2008Inventors: Lee Chong, Manoj Desai, Brian Gallagher, Michael Graupe, Randall Halcomb, Hong Yang, Jennifer Zhang
-
Publication number: 20070244109Abstract: New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.Type: ApplicationFiled: June 12, 2007Publication date: October 18, 2007Applicant: NOVARTIS VACCINES AND DIAGNOSTICS, INC.Inventors: Manoj Desai, Simon Ng, Zhi-Jie Ni, Keith Pfister, Savithri Ramurthy, Sharadha Subramanian, Allan Wagman
-
Publication number: 20060264404Abstract: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.Type: ApplicationFiled: October 25, 2005Publication date: November 23, 2006Inventors: Constantine Boojamra, Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Manoj Desai, Maria Fardis, Craig Gibbs, Ralph Hirschmann, Alan Huang, Haolun Jin, Choung Kim, Thorsten Kirschberg, Steven Krawczyk, Christopher Lee, William Lee, Kuei-Ying Lin, Richard Mackman, David Markevitch, Peter Nelson, David Oare, Vidya Prasad, Hyung-Jung Pyun, Adrian Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang, Lijun Zhang
-
Publication number: 20060089369Abstract: New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.Type: ApplicationFiled: September 6, 2005Publication date: April 27, 2006Applicant: Chiron CorporationInventors: John Nuss, Stephen Harrison, David Ring, Rustum Boyce, Kirk Johnson, Keith Pfister, Savithri Ramurthy, Lynn Seely, Allan Wagman, Manoj Desai, Barry Levine
-
Publication number: 20060035866Abstract: The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.Type: ApplicationFiled: April 26, 2004Publication date: February 16, 2006Inventors: Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Manoj Desai, Maria Fardis, Alan Huang, Thorsten Kirschberg, Christopher Lee, Richard Mackman, Peter Nelson, Hyung-Jung Pyun, Adrian Ray, William Watkins, Jennifer Zhang, Sundaramoorthi Swaminathan
-
Publication number: 20060030545Abstract: Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1; RX1 is RX; RX2 is alkenyl of 2 to 18 carbon atoms or alkynyl of 2 to 18 carbon atoms; Y1 is ?O, —O(RX), ?S, —N(RX), —N(O)(RX), —N(ORX), —N(O)(ORX), or —N(N(RX)(RX)); RX is independently R1, R2, R4, W3, or a protecting group; R1 is independently —H or alkyl of 1 to 18 carbon atoms; R2 is independently R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R3 groups; R3 is R3a, R3b, R3c or R3d, provided that when R3 is bound to a heteroatom, then R3 is R3c or R3d; R3a is —H, —F, —Cl, —Br, —I, —CF3, —CN, N3, —NO2, or —OR4; R3b is ?O, —O(R4), ?S, —N(R4), —N(O)(R4), —N(OR4), —N(O)(OR4), or —N(N(R4)(R4)); R3c is —R4, —N(R4)(R4), —SR4, —S(O)R4, —S(O)2R4, —S(O)(OR4), —S(O)2(OR4), —OC(R3b)R4,Type: ApplicationFiled: June 29, 2005Publication date: February 9, 2006Inventors: Xiaoqin Cheng, Gary Cook, Manoj Desai, Edward Doerffler, Gong-Xin He, Choung Kim, William Lee, John Rohloff, Jianying Wang, Zheng-Yu Yang
-
Publication number: 20050261253Abstract: The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.Type: ApplicationFiled: April 26, 2004Publication date: November 24, 2005Inventors: Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Manoj Desai, Maria Fardis, Thorsten Kirschberg, Richard Mackman, Sundaramoorthi Swaminathan, William Watkins
-
Publication number: 20050222090Abstract: Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1; RX1 and RX2 are independently RX; Y1 is ?O, —O(RX), ?S, —N(RX), —N(O)(RX), —N(ORX), —N(O)(ORX), or —N(N(RX)(RX)); RX is independently R1, R2, R4, W3, or a protecting group; R1 is independently —H or alkyl of 1 to 18 carbon atoms; R2 is independently R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R3 groups; R3 is R3a, R3b, R3c or R3d, provided that when R3 is bound to a heteroatom, then R3 is R3c or R3d; R3a is —H, —F, —Cl, —Br, —I, —CF3, —CN, N3, —NO2, or —OR4; R3b is ?O, —O(R4), ?S, —N(R4), —N(O)(R4), —N(OR4), —N(O)(OR4), or —N(N(R4)(R4)); R3c is —R4, —N(R4)(R4), —SR4, —S(O)R4, —S(O)2R4, —S(O)(OR4), —S(O)2(OR4), —OC(R3b)R4, —OC(R3b)OR4, —OC(R3b)(N(R4)(R4)), —SC(R3b)R4, —SC(R3b)OR4,Type: ApplicationFiled: December 29, 2004Publication date: October 6, 2005Inventors: Xiaqin Cheng, Gary Cook, Manoj Desai, Edward Doerffler, Gong-Xin He, Choung Kim, William Lee, John Rohloff, Jianying Wang, Zheng-Yu Yang
-
Publication number: 20050209254Abstract: Quinazolinone compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the quinazolinone compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the quinazolinone compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.Type: ApplicationFiled: November 24, 2004Publication date: September 22, 2005Inventors: Weibo Wang, Liana Lagniton, Ryan Constantine, Manoj Desai
-
Publication number: 20050085490Abstract: Pyridin[1,2-a]pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the pyridino[1,2-a]pyrimidinyl compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the pyridino[1,2-a]pyrimidinyl compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.Type: ApplicationFiled: June 17, 2004Publication date: April 21, 2005Inventors: Weibo Wang, Ryan Constantine, Liana Lagniton, Sabina Pecchi, Matthew Burger, Manoj Desai
-
Patent number: 6869969Abstract: Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.Type: GrantFiled: November 13, 2003Date of Patent: March 22, 2005Assignee: Chiron CorporationInventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Jennifer C. Moore, Beata Krywult, Thayalan Navaratnam, Rajinder Singh, Rob Trainor, Liang Wang
-
Patent number: 6743815Abstract: Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.Type: GrantFiled: April 25, 2002Date of Patent: June 1, 2004Assignee: Chiron CorporationInventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Jennifer C. Moore, Beata Krywult, Thayalan Navaratnam, Rajinder Singh, Rob Trainor, Liang Wang