Patents by Inventor Manoj Desai
Manoj Desai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040102498Abstract: Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.Type: ApplicationFiled: November 13, 2003Publication date: May 27, 2004Inventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Jennifer C. Moore, Beata Krywult, Thayalan Navaratnam, Rajinder Singh, Rob Trainor, Liang Wang
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Patent number: 6727273Abstract: Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.Type: GrantFiled: September 18, 2001Date of Patent: April 27, 2004Assignee: Chiron CorporationInventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Beata Krywult, Rajinder Singh, Liang Wang
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Publication number: 20040077701Abstract: Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.Type: ApplicationFiled: June 12, 2003Publication date: April 22, 2004Applicant: CHIRON CORPORATIONInventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Beata Krywult, Rajinder Singh, Liang Wang
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Publication number: 20040038309Abstract: A method is provided for use in solid phase chemical synthesis such as in the synthesis of polypeptides, peptoids, and other molecules synthesized by solid phase methods. The method is used to identify compounds having activity against a selected target, wherein the compounds are present in a mixture obtained from a combinatorial library. A bead distributor probe is also provided. The probe is used to extract beads from a population of beads, and then deliver the bead to a selected location. A capillary bead insert is also provided, as well as a bead distribution system which includes both a bead distributor probe and a capillary bead insert.Type: ApplicationFiled: June 17, 2003Publication date: February 26, 2004Inventors: Ronald Zuckermann, Manoj Desai, Gavin Dollinger, Timothy Dawes, Petar Stojadinovic, Eric Martin
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Publication number: 20040034081Abstract: Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.Type: ApplicationFiled: September 18, 2001Publication date: February 19, 2004Applicant: Chiron CorporationInventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Beata Krywult, Rajinder Singh, Liang Wang
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Publication number: 20030145347Abstract: The invention provides novel methods of processing grain, such as corn and soybeans, utilizing thioredoxin and/or thioredoxin reductase to enhance extractability and recovery of starch and protein. The invention further provides novel transgenic plants expressing thermostable thioredoxin and/or thioredoxin reductase.Type: ApplicationFiled: November 27, 2002Publication date: July 31, 2003Applicant: Syngenta Participations AGInventors: Michael B. Lanahan, Nalini Manoj Desai, Pamela Y. Gasdaska, Stephen Arthur Goff
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Publication number: 20030065012Abstract: Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.Type: ApplicationFiled: April 25, 2002Publication date: April 3, 2003Applicant: Chiron CorporationInventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Jennifer C. Moore, Beata Krywult, Thayalan Navaratnam, Rajinder Singh, Rob Trainor, Liang Wang
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Patent number: 6531648Abstract: The invention provides novel methods of processing grain, such as corn and soybeans, utilizing thioredoxin and/or thioredoxin reductase to enhance extractability and recovery of starch and protein. The invention further provides novel transgenic plants expressing thermostable thioredoxin and/or thioredoxin reductase.Type: GrantFiled: June 21, 2000Date of Patent: March 11, 2003Assignee: Syngenta Participations AGInventors: Michael B. Lanahan, Nalini Manoj Desai, Pamela Y. Gasdaska, Stephen Arthur Goff
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Publication number: 20020111374Abstract: Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.Type: ApplicationFiled: September 18, 2001Publication date: August 15, 2002Applicant: Chiron CorporationInventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Beata Krywult, Rajinder Singh, Liang Wang
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Patent number: 6429360Abstract: The genes encoding a novel class of insecticidal proteins have been isolated and characterized from a strain of Bacillus thuringiensis. Both the nucleic and amino acid sequences for the proteins are disclosed. The nucleic acid molecules are utilized in the transformation of host microorganisms and production of transgenic plants which are resistant to insects. Also, the gene encoding for the insect's receptor of the insecticidal protein has been isolated and characterized. Novel processes and methods for controlling plants pests are provided.Type: GrantFiled: July 12, 2001Date of Patent: August 6, 2002Assignee: Syngenta Investment CorporationInventors: Juan Jose Estruch, Gregory Wayne Warren, Nalini Manoj Desai, Michael Gene Koziel, Gordon James Nye
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Publication number: 20020078473Abstract: The present invention is drawn to a novel class of proteins, and their receptors. Novel processes, assays and methods for controlling plant pests are provided.Type: ApplicationFiled: July 12, 2001Publication date: June 20, 2002Inventors: Juan Jose Estruch, Gregory Wayne Warren, Nalini Manoj Desai, Michael Gene Koziel, Gordon James Nye
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Patent number: 6387920Abstract: Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.Type: GrantFiled: April 11, 2001Date of Patent: May 14, 2002Assignee: Chiron CorporationInventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Jennifer C. Moore, Beata Krywult, Thayalan Navaratnam, Rajinder Singh, Rob Trainor, Liang Wang
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Publication number: 20010039020Abstract: A method is provided for use in solid phase chemical synthesis such as in the synthesis of polypeptides, peptoids, and other molecules synthesized by solid phase methods. The method is used to identify compounds having activity against a selected target, wherein the compounds are present in a mixture obtained from a combinatorial library. A bead distributor probe is also provided. The probe is used to extract beads from a population of beads, and then deliver the bead to a selected location. A capillary bead insert is also provided, as well as a bead distribution system which includes both a bead distributor probe and a capillary bead insert.Type: ApplicationFiled: May 6, 1999Publication date: November 8, 2001Inventors: RONALD ZUCKERMANN, MANOJ DESAI, GAVIN DOLLINGER, TIMOTHY DAWES, PETAR STOJADINOVIC
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Publication number: 20010036956Abstract: Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.Type: ApplicationFiled: April 11, 2001Publication date: November 1, 2001Inventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Jennifer C. Moore, Beata Krywult, Thayalan Navaratnam, Rajinder Singh, Rob Trainor, Liang Wang
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Patent number: 6291505Abstract: Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.Type: GrantFiled: August 6, 1999Date of Patent: September 18, 2001Assignee: Chiron CorporationInventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Beata Krywult, Rajinder Singh, Liang Wang
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Patent number: 6262098Abstract: Isoxazole estrogen receptor agonist and antagonist compounds having unexpected and surprising activity in modulating estrogen receptor activity are described. In addition, methods and compositions for treating or preventing estrogen receptor-mediated disorders are disclosed. The compounds, methods, and compositions of the invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.Type: GrantFiled: August 6, 1999Date of Patent: July 17, 2001Assignee: Chiron CorporationInventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Jennifer C. Moore, Beata Krywult, Thayalan Navaratnam, Rajinder Singh, Rob Trainor, Liang Wang