Abstract: An adjustable length strut includes two joints, a threaded rod extending between the joints, and a tube adapted to receive the threaded rod. An actuation mechanism with gear teeth extending radially outward of the strut axis is rotatably fixed to the threaded rod. A protrusion may be coupled to an end of the threaded rod by a rotatable collar, with the protrusion extending through a slot in the tube to mark the length of the strut. A modular attachment member may be adapted to be couple to the first joint and include a worm gear adapted to engage gear teeth of the actuation mechanism. The modular attachment member may include a radiofrequency identity tag mechanism adapted to be read by a tag reader of a tool, the tool adapted to couple to the attachment member to rotate the worm gear to increase or decrease the effective length of the strut.

Abstract: A system for guiding a cutting tool in an osteotomy procedure includes a cutting block. The cutting block includes an aperture extending through a thickness of the cutting block and having a length and a width. The width of the aperture is defined between a first interior surface of the cutting block and a second interior surface of the cutting block opposing the first interior surface. The system further includes a sleeve. The sleeve includes a slot configured for receiving a sawblade and configured for insertion into the aperture of the cutting block such that the sleeve contacts either the first interior surface or the second interior surface without contacting the other interior surface.

Abstract: A system for processing patient data associated with a joint of a patient. The system comprising a computing device executing instructions to generate a 3D patient bone model of the joint in a non-weighted pose. The instructions rearrange 3D first and second bone models in order to mimic a weighted pose of the joint of the patient from a 2D image of the joint of the patient in a weighted pose by performing the steps of: generating a plurality of 2D projections of poses of the 3D patient bone model; comparing the plurality of 2D projections to contour lines of the first bone and the second bone in the 2D image; identifying particular 2D projections that best-fit a shape and size of the contour lines; and arranging the 3D first and second bone models relative to each other according to orientations represented by the particular 2D projections that were identified.

Abstract: The present application relates to a process for the preparation of semaglutide. The present application also relates to a recombinant process for the preparation of semapeptide. The present invention is related to a process for producing semapeptide, the process comprising the steps of, a) culturing a host cell comprising a nucleotide sequence encoding of Formula (II) under suitable conditions for expression, wherein, insoluble tag is a nucleotide sequence of Alanine-Valine; b) recovering semapeptide, wherein semapeptide amino acid sequence is Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly.

Abstract: A system for processing patient data associated with a joint of a patient. The system comprising a computing device executing instructions to generate a 3D patient bone model of the joint in a non-weighted pose. The instructions rearrange 3D first and second bone models in order to mimic a weighted pose of the joint of the patient from a 2D image of the joint of the patient in a weighted pose by performing the steps of: generating a plurality of 2D projections of poses of the 3D patient bone model; comparing the plurality of 2D projections to contour lines of the first bone and the second bone in the 2D image; identifying particular 2D projections that best-fit a shape and size of the contour lines; and arranging the 3D first and second bone models relative to each other according to orientations represented by the particular 2D projections that were identified.

Abstract: Robotic system and methods for robotic arthroplasty are provided. The robotic system includes a machining system and a guidance system. The guidance station tracks movement of one or more of various objects in the operating room, such as a surgical tool, a tibia of a patient, a talus of the patient, or a component of an implant. The guidance system tracks these objects for purposes of displaying their relative positions and orientations to the surgeon and, in some cases, for purposes of controlling movement of the surgical tool of the machining system relative to virtual cutting boundaries or other virtual objects associated with the tibia and talus to facilitate preparation of bone to receive an ankle implant system.

Abstract: Disclosed herein are systems and methods for manipulating the orientation of a plurality of bone fragments with respect to one another. A bone transport frame including first and second rings, a plurality of elongate struts, and a plurality of ring transport assemblies for orienting a first bone segment with respect to a second bone segment is disclosed. A third ring may be included in the bone transport frame for orienting a third bone segment with respect to the first and second bone segments. Manipulation of an adjustable member of the bone transport frame can transport a ring in either a proximal or distal direction with respect to other rings of the frame. Manipulation of another adjustable member of the bone transport frame can translate a central axis of one of the rings either toward or away from the central axes of the plurality of elongate struts.

Abstract: Robotic system and methods for robotic arthroplasty are provided. The robotic system includes a machining system and a guidance system. The guidance station tracks movement of one or more of various objects in the operating room, such as a surgical tool, a tibia of a patient, a talus of the patient, or a component of an implant. The guidance system tracks these objects for purposes of displaying their relative positions and orientations to the surgeon and, in some cases, for purposes of controlling movement of the surgical tool of the machining system relative to virtual cutting boundaries or other virtual objects associated with the tibia and talus to facilitate preparation of bone to receive an ankle implant system.

Abstract: An adjustable length strut includes two joints, a threaded rod extending between the joints, and a tube adapted to receive the threaded rod. An actuation mechanism with gear teeth extending radially outward of the strut axis is rotatably fixed to the threaded rod. A protrusion may be coupled to an end of the threaded rod by a rotatable collar, with the protrusion extending through a slot in the tube to mark the length of the strut. A modular attachment member may be adapted to be couple to the first joint and include a worm gear adapted to engage gear teeth of the actuation mechanism. The modular attachment member may include a radiofrequency identity tag mechanism adapted to be read by a tag reader of a tool, the tool adapted to couple to the attachment member to rotate the worm gear to increase or decrease the effective length of the strut.

Abstract: A medical device navigation system includes a medical device assembly and a navigation device. The medical device assembly includes an adhesive patch configured to adhere to an outer surface of a patient and a tracking assembly coupled to the adhesive patch. The tracking assembly includes one or more reference markers. The navigation device is configured to receive image data representing one or more images from an imaging device. The one or more images indicate a relative position between the one or more reference markers and a treatment site in the patient. The navigation device is configured to determine, based on the image data, a percutaneous insertion path for an injection needle from an insertion point to the treatment site of the patient and output one or more parameters corresponding to the percutaneous insertion path.

Abstract: An adjustable length strut includes two joints, a threaded rod extending between the joints, and a tube adapted to receive the threaded rod. An actuation mechanism with gear teeth extending radially outward of the strut axis is rotatably fixed to the threaded rod. A protrusion may be coupled to an end of the threaded rod by a rotatable collar, with the protrusion extending through a slot in the tube to mark the length of the strut. A modular attachment member may be adapted to be couple to the first joint and include a worm gear adapted to engage gear teeth of the actuation mechanism. The modular attachment member may include a radiofrequency identity tag mechanism adapted to be read by a tag reader of a tool, the tool adapted to couple to the attachment member to rotate the worm gear to increase or decrease the effective length of the strut.

Abstract: Disclosed herein are a bone plating system and a method for utilizing the same. The bone plating system may include first and second bone plates in contact with respective first and second bones, a cross-connector, a cutting guide and a targeter device. The cross-connector may have a first end and an opposite second extending along a longitudinal axis from the first bone plate to the second bone plate. The cutting guide may have an elongate body placed on one of the first or second bones. The targeter device may have a drill guide to align the cross-connector with the first and second bone plates. A method for fixing the bone plating system to the first and second bone may include using the targeter device.

Abstract: A base member of a prosthetic stemless shoulder implant may include a proximal collar, a central anchor, and at least one peripheral anchor. The proximal collar may have a proximal surface and a distal bone-engaging surface opposite the proximal surface. The central anchor may extend distally from the bone-engaging surface and define an opening extending from the bone-engaging surface into the central anchor for receiving a humeral head component of the prosthetic stemless shoulder implant. The at least one peripheral anchor may be positioned radially outwardly of the central anchor and extend distally from the bone-engaging surface. The peripheral anchor may be frangibly connected to the proximal collar.

Abstract: Disclosed herein are apparatuses and methods for intraoperative on-demand implant customization in a surgical setting. An apparatus may include a storage portion, an implant customization portion and an interface. The storage portion may house implant blanks and implant accessories. The implant customization portion may customize the implant blanks. The interface may be configured to receive implant customization information and utilize the same to intraoperatively manipulate the implant blank to a patient-specific implant within a sterile environment. A method to customize an implant in a surgical care environment may include the steps of obtaining information related to the implant location, selecting an implant blank based on the information, and customizing the implant blank in a surgical care setting with a customization apparatus.

Abstract: A tissue repair apparatus includes a housing, a rotatable shaft at least partially disposed within the housing, and first and second curved needles coupled to the shaft. The housing defines a gap between a first edge of the housing and a second edge of the housing, the gap adapted to receive tissue. The first and second needles curved needles being articulable within the housing from a delivery position, at which the first and second needles are spaced from the gap, to a deployed position, at which the first and second needles extend through the gap. Actuation of the shaft simultaneously articulates the first and second needles and the first needle enters the gap before the second needle enters the gap.

Abstract: Disclosed herein are apparatuses and methods for intraoperative on-demand implant customization in a surgical setting. An apparatus may include a storage portion, an implant customization portion and an interface. The storage portion may house implant blanks and implant accessories. The implant customization portion may customize the implant blanks. The interface may be configured to receive implant customization information and utilize the same to intraoperatively manipulate the implant blank to a patient-specific implant within a sterile environment. A method to customize an implant in a surgical care environment may include the steps of obtaining information related to the implant location, selecting an implant blank based on the information, and customizing the implant blank in a surgical care setting with a customization apparatus.

Abstract: A bone implant includes a proximal end, a distal end, a first portion extending between the proximal and distal ends having a maximum and minimum portion height, and a second portion extending between the proximal and distal ends having a maximum and minimum portion height. The second portion is connected to the first portion at the proximal end and the distal end and at least one of the first portion and the second portion is moveable relative to the other of the first portion and the second portion so as to transition the bone implant between a relaxed state wherein the first and second portions are separated by a first distance and a contracted state wherein the first and second portions are separated by a second distance different from the first distance. At least one of the proximal end and the distal end have the minimum portion height.

Abstract: A tissue repair apparatus includes a housing, a rotatable shaft at least partially disposed within the housing, and first and second curved needles coupled to the shaft. The housing defines a gap between a first edge of the housing and a second edge of the housing, the gap adapted to receive tissue. The first and second needles curved needles being articulable within the housing from a delivery position, at which the first and second needles are spaced from the gap, to a deployed position, at which the first and second needles extend through the gap. Actuation of the shaft simultaneously articulates the first and second needles and the first needle enters the gap before the second needle enters the gap.

Abstract: A bone implant includes a proximal end, a distal end, a first portion extending between the proximal and distal ends having a maximum and minimum portion height, and a second portion extending between the proximal and distal ends having a maximum and minimum portion height. The second portion is connected to the first portion at the proximal end and the distal end and at least one of the first portion and the second portion is moveable relative to the other of the first portion and the second portion so as to transition the bone implant between a relaxed state wherein the first and second portions are separated by a first distance and a contracted state wherein the first and second portions are separated by a second distance different from the first distance. At least one of the proximal end and the distal end have the minimum portion height.

Abstract: Disclosed herein are external fixation frames for correcting bone deformities. The external fixation frames include a top fixation ring and a bottom fixation ring coupled to one another by at least two struts. A half ring is coupled to bottom fixation ring. The bottom fixation ring is u-shaped. One or more rocker members may be coupled to the bottom fixation ring. The half ring may be hingedly coupled to the bottom fixation ring such that it can rotate with respect to the bottom fixation ring from a first position to a second position.