Abstract: An external fixation system and method for realigning, compressing or distracting broken bones has a planar ring element with an adjustable device having a body releasably mounted on the ring element. The adjustable device includes a first member for movement in a direction generally perpendicular to the ring element. A second member is mounted on the first member for movement in a direction parallel to the first member and with respect to a circumference of the planar ring element. The method includes inserting a k-wire through a first piece of bone and affixing the k-wire to the ring element. Then inserting a second k-wire through a second piece of bone and affixing the k-wire to the adjustable device second member. The pieces of bone are realigned, compressed or distracted by adjusting at least one of a first and second adjustable members forming the device.

Abstract: A tool for implementing a correction plan in an external fixation frame having a plurality of adjustment elements or screws, for example, generally includes a driver, a motor, a controller, and a processor. The driver is adapted to engage and rotate each of the screws. The motor is coupled the driver and adapted to rotate the driver. The controller is connected to the motor and configured to control operation of the motor. The controller may determine whether the tool is engaged with a strut and which strut is engaged, and may determine how much the strut has rotated, taking into account intentional or unintentional manual rotation of the tool. The tool may also include features to help ensure proper engagement between the drive and the strut. Variations may be provided in which similar functionality is provided with manual rotation of a motorless tool.

Abstract: Embodiments of the invention are directed to a system, method, and computer program product for assessing error notifications associated with one or more application functions. An exemplary embodiment includes receiving an indication of an error associated with at least one function in an application; extracting information associated with the application from one or more sources; and initiating a presentation of a second user-interface to enable a user to resolve the error, wherein the second user-interface comprises at least one of an aggregation of the information extracted from the one or more sources.

Abstract: An external fixation frame for correcting a bone deformity includes a first fixation ring and a second fixation ring. A posterior adjustable length strut couples a posterior portion of the first fixation ring to a posterior portion of the second fixation ring and has universal joint. Medial and lateral adjustable length struts couples medial and lateral portions of the first fixation ring to medial and lateral portions of the second fixation ring respectively, each of the medial and lateral adjustable length struts including a constrained hinge joint. The fixation frame also includes a half ring hingedly coupled to the second fixation ring, and an anterior adjustable length strut coupling an anterior portion of the first fixation ring to the half ring.

Abstract: Disclosed herein are systems and methods for manipulating the orientation of a plurality of bone fragments with respect to one another. A bone transport frame including first and second rings, a plurality of elongate struts, and a plurality of ring transport assemblies for orienting a first bone segment with respect to a second bone segment is disclosed. A third ring may be included in the bone transport frame for orienting a third bone segment with respect to the first and second bone segments. Manipulation of an adjustable member of the bone transport frame can transport a ring in either a proximal or distal direction with respect to other rings of the frame. Manipulation of another adjustable member of the bone transport frame can translate a central axis of one of the rings either toward or away from the central axes of the plurality of elongate struts.

Abstract: An external fixation system includes top and bottom fixation plates that may be connected to fragments of a bone. At least one y-shaped strut attaches the two fixation plates. Each y-shaped strut has first, second and third telescopic struts coupled at a connector joint. The first strut member is coupled to the top fixation plate and the second and third strut members are coupled to the bottom fixation plate. Each strut member may include a joint and may also include an actuation unit connecting the particular strut member to the top or bottom fixation plate. Rotation of a head portion of the actuation unit causes rotation of a threaded rod, causing adjustment in the length of the respective strut member. As the lengths of the strut members change, the joints may reposition, leading to the top fixation plate becoming repositioned with respect to the bottom fixation plate.

Abstract: An external fixation frame for correcting a bone deformity includes a first fixation ring and a second fixation ring. A posterior adjustable length strut couples a posterior portion of the first fixation ring to a posterior portion of the second fixation ring and has universal joint. Medial and lateral adjustable length struts couples medial and lateral portions of the first fixation ring to medial and lateral portions of the second fixation ring respectively, each of the medial and lateral adjustable length struts including a constrained hinge joint. The fixation frame also includes a half ring hingedly coupled to the second fixation ring, and an anterior adjustable length strut coupling an anterior portion of the first fixation ring to the half ring.

Abstract: Disclosed herein are systems and methods for manipulating the orientation of a plurality of bone fragments with respect to one another. A bone transport frame including first and second rings, a plurality of elongate struts, and a plurality of ring transport assemblies for orienting a first bone segment with respect to a second bone segment is disclosed. A third ring may be included in the bone transport frame for orienting a third bone segment with respect to the first and second bone segments. Manipulation of an adjustable member of the bone transport frame can transport a ring in either a proximal or distal direction with respect to other rings of the frame. Manipulation of another adjustable member of the bone transport frame can translate a central axis of one of the rings either toward or away from the central axes of the plurality of elongate struts.

Abstract: An external fixation frame for correcting a bone deformity includes a first fixation ring and a second fixation ring. A posterior adjustable length strut couples a posterior portion of the first fixation ring to a posterior portion of the second fixation ring and has universal joint. Medial and lateral adjustable length struts couples medial and lateral portions of the first fixation ring to medial and lateral portions of the second fixation ring respectively, each of the medial and lateral adjustable length struts including a constrained hinge joint. The fixation frame also includes a half ring hingedly coupled to the second fixation ring, and an anterior adjustable length strut coupling an anterior portion of the first fixation ring to the half ring.

Abstract: A method of correcting a bone deformity includes fixing first and second support members to first and second fragments of a bone, respectively. The first support member may have a receiver connected thereto. First and second tracking devices are connected to the first and second bone fragments, respectively. A deformity correction plan is determined, and a position of the first support member is adjusted relative to the second support member based on the plan. Location data is transmitted from the first and second trackers to the receiver. Based on the tracker location data, a real position of the first and second bone fragments is determined. The real position of the first and second bone fragment is compared to the deformity correction plan, and the deformity correction plan is reprogrammed based on the comparison. The first and second support members may then be adjusted based on the reprogrammed deformity correction plan.

Abstract: An external fixation frame for correcting a bone deformity includes a first fixation ring and a second fixation ring. A posterior adjustable length strut couples a posterior portion of the first fixation ring to a posterior portion of the second fixation ring and has universal joint. Medial and lateral adjustable length struts couples medial and lateral portions of the first fixation ring to medial and lateral portions of the second fixation ring respectively, each of the medial and lateral adjustable length struts including a constrained hinge joint. The fixation frame also includes a half ring hingedly coupled to the second fixation ring, and an anterior adjustable length strut coupling an anterior portion of the first fixation ring to the half ring.

Abstract: The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidne (VP), N-Isopropylactylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.

Abstract: An external fixation system and method for realigning, compressing or distracting broken bones has a planar ring element with an adjustable device having a body releasably mounted on the ring element. The adjustable device includes a first member for movement in a direction generally perpendicular to the ring element. A second member is mounted on the first member for movement in a direction parallel to the first member and with respect to a circumference of the planar ring element. The method includes inserting a k-wire through a first piece of bone and affixing the k-wire to the ring element. Then inserting a second k-wire through a second piece of bone and affixing the k-wire to the adjustable device second member. The pieces of bone are realigned, compressed or distracted by adjusting at least one of a first and second adjustable members forming the device.

Abstract: An external fixation system has a planar ring with an adjustable device having a body releasably mounted on the ring. The adjustable device includes a first member for movement in a direction generally perpendicular to the ring. A second member is mounted on the first member for movement in a direction parallel to a side wall of the planar ring. A method for treating a broken bone includes providing an external fixation system and inserting a first k-wire or half pin through a first piece of the bone and affixing the first k-wire or half pin to the ring, then inserting a second k-wire or half pin through a second piece of bone and affixing the second k-wire or half pin to the adjustable device. The pieces of bone are realigned, compressed, or distracted by adjusting at least one of the first and second adjustable members.

Abstract: An external fixator system comprising at least two fixation plates which are arranged at a distance to each another, at least one adjustable length strut having a first end region and a second end region which are in connection with the fixation plates and at least one actuation unit to adjust the length of the strut in order to adjust the distance and/or orientation between the fixation plates. The actuation unit is in a fixed connection with at least one of the fixation plates as well as with at least one of the end regions of the respective strut in order to connect the strut with the fixation plate. The actuation unit comprises a feedback unit which provides the user with a feedback concerning the degree of the actuation.

Abstract: An external fixation system and method for realigning, compressing or distracting broken bones has a planar ring element with an adjustable device having a body releasably mounted on the ring element. The adjustable device includes a first member for movement in a direction generally perpendicular to the ring element. A second member is pivotally connected to the first member for angular movement with respect to the ring. A third member is mounted on the second member for movement in a direction parallel to the second member and with respect to a circumference of the planar ring element. The method includes inserting k-wires into bone and affixing the k-wires to the ring element and affixing the k-wires to an adjustable device. The pieces of bone are realigned, compressed or distracted by adjusting at least one of a first and second members forming the device.

Abstract: The present invention relates to an improved process for the preparation of substituted Fluticasone derivatives. The invention also reveals the processes for the purification of Fluticasones and related intermediates to provide the highly pure product.

Abstract: An external fixator system comprising at least two fixation plates which are arranged at a distance to each another, at least one adjustable length having a first end region and a second end region which are in connection with the fixation plates and at least one actuation unit to adjust the length of the strut in order to adjust the distance and/or orientation between the fixation plates. The actuation unit is in a fixed connection with at least one of the fixation plates as well as with at least one of the end regions of the respective strut in order to connect the strut with the fixation plate. The actuation unit comprises a feedback unit which provides the user with a feedback concerning the degree of the actuation.

Abstract: The present invention relates to an improved process for the preparation of substituted Fluticasone derivatives. The invention also reveals the processes for the purification of Fluticasones and related intermediates to provide the highly pure product.

Abstract: Disclosed herein are systems and methods for manipulating the orientation of a plurality of bone fragments with respect to one another. A bone transport frame including first and second rings, a plurality of elongate struts, and a plurality of ring transport assemblies for orienting a first bone segment with respect to a second bone segment is disclosed. A third ring may be included in the bone transport frame for orienting a third bone segment with respect to the first and second bone segments. Manipulation of an adjustable member of the bone transport frame can transport a ring in either a proximal or distal direction with respect to other rings of the frame. Manipulation of another adjustable member of the bone transport frame can translate a central axis of one of the rings either toward or away from the central axes of the plurality of elongate struts.