Patents by Inventor Manojit Pal

Manojit Pal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic Compounds as Lipoxygenase Inhibitors
    Publication number: 20220356162
    Abstract: The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or a stereoisomer thereof, wherein X, R1, R2, R3, R4, R5, R6, m and n are as defined in the detailed description. The present invention also relates to pharmaceutical compositions containing one or more compounds of the formula (I), as well as methods of treating or preventing diseases and/or disorders mediated by aberrant or undesired expression of one or more lipoxygenases (LOXs) using such compounds or compositions.
    Type: Application
    Filed: May 20, 2020
    Publication date: November 10, 2022
    Applicants: Dr. Reddy's Institute of Life Sciences, University of Hyderabad
    Inventors: Reddanna Pallu, Kumar Reddy Kakularam, Nooruddin Khan, Harshavardhan Dattarao Bhuktar, Manojit Pal, Sharda Shukla, Naireen Fatima
  • Pyrimidine compounds, process for their preparation and compositions containing them
    Patent number: 7820654
    Abstract: The present invention is directed to a compounds, methods and compositions for making the compounds and methods of treating a variety of diseases and disease states including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan, comprising the administration of new heterocyclic compounds, particularly substituted pyrimidines.
    Type: Grant
    Filed: September 23, 2005
    Date of Patent: October 26, 2010
    Assignee: Dr. Reddy's Laboratories Ltd.
    Inventors: Manojit Pal, Srinivas Kalleda, Srinivas Padakanti, Nalivela Kumara Swamy, Koteswar Rao Yeleswarapu, Christopher W. Alexander, Ish Khanna, Javed Iqbal, Sivaram Pillarisetti, Deepak Barange
  • Pyridine compounds, process for their preparation and compositions containing them
    Patent number: 7622486
    Abstract: The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
    Type: Grant
    Filed: September 23, 2005
    Date of Patent: November 24, 2009
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Manojit Pal, Christopher W. Alexander, Ish Khanna, Javed Iqbal, Ram Pillarisetti, Santanu Maitra, Gayla W. Roberts, Lavanya Sagi, Chintakunta Vamsee Krishna, Jennepalli Sreenu
  • Heterocyclic compounds and methods of making and using thereof
    Patent number: 7456288
    Abstract: Compounds of formula (I), and methods and/or compositions comprising compounds that are effective in modulating inflammatory responses, such as those resulting from AGE and glycated protein accumulation are provided. Methods and/or compositions comprising compounds that are effective in modulating smooth muscle cell proliferation and the diseases or conditions related thereto are also provided.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: November 25, 2008
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Yeleswarapu Koteswar Rao, Manojit Pal, Vedula Manohar Sharma, Akella Venkateswarlu, Ram Pillarisetti, Srinivas Padakanti, Kalleda Srinivasa Rao
  • Medical devices employing triazine compounds and compositions thereof
    Patent number: 7335656
    Abstract: The present invention relates to methods, compounds, and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses, and is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention also relates to compounds that inhibit smooth muscle proliferation, for example, by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis. This invention also relates to medical devices, such as a stent, comprising a compound or composition of this invention disposed on or within the medical device.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: February 26, 2008
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Sesha Sridevi Alluri, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Triazine compounds and their analogs, compositions, and methods
    Patent number: 7335770
    Abstract: The present invention relates to triazine compounds and their analogs and derivatives, and methods and compositions comprising these compounds. The compounds and compositions of this invention are useful for, among other things, treating pathophysiological conditions arising from inflammatory responses, inhibiting or blocking glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells, inhibiting smooth muscle proliferation, treating vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis, and the like.
    Type: Grant
    Filed: March 24, 2004
    Date of Patent: February 26, 2008
    Assignee: Reddy U5 Therapeutics, Inc.
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Sesha Sridevi Alluri, Velagala Venkata Rama Murali Krishna Reddy, Manojit Pal, Jangalgar Tirupathy Reddy, Koteswar Rao Yeleswarapu, Gaddam Om Reddy, Potlapally Rajender Kumar
  • Methods and compositions of novel triazine compounds
    Patent number: 7332488
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: February 19, 2008
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Methods and compositions of novel triazine compounds
    Patent number: 7332490
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: February 19, 2008
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Methods and compositions of novel triazine compounds
    Patent number: 7332489
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: February 19, 2008
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Medical devices employing triazine compounds and compositions thereof
    Patent number: 7268134
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: September 11, 2007
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Methods and compositions of novel triazine compounds
    Patent number: 7265114
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Grant
    Filed: November 22, 2005
    Date of Patent: September 4, 2007
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Yeleswarapu Koteswar Rao, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Medical devices employing triazine compounds and compositions thereof
    Patent number: 7238692
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: July 3, 2007
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krisha Reddy, Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Medical devices employing triazine compounds and compositions thereof
    Publication number: 20070122444
    Abstract: The present invention relates to methods, compounds, and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses, and is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention also relates to compounds that inhibit smooth muscle proliferation, for example, by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis. This invention also relates to medical devices, such as a stent, comprising a compound or composition of this invention disposed on or within the medical device.
    Type: Application
    Filed: August 30, 2006
    Publication date: May 31, 2007
    Inventors: Richard Timmer, Christopher Alexander, Sivaram Pillarisetti, Uday Saxena, Sesha Alluri, Koteswar Yeleswarapu, Manojit Pal, Jangalgar Reddy, Velagala Rama Murali Krishna Reddy, Potlapally Kumar, Gaddam Reddy
  • Methods and compositions of novel triazine compounds
    Publication number: 20070117795
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Application
    Filed: August 28, 2006
    Publication date: May 24, 2007
    Inventors: Richard Timmer, Christopher Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Yeleswarapu, Manojit Pal, Jangalgar Reddy, Velagala Venkata Rama Krishna Reddy, Sesha Alluri, Potlapally Kumar, Gaddam Reddy
  • Methods and compositions of novel triazine compounds
    Publication number: 20070099874
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Application
    Filed: March 26, 2003
    Publication date: May 3, 2007
    Applicant: Reddy US Therapeutics, Inc.
    Inventors: Richard Timmer, Christopher Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Yeleswarapu, Manojit Pal, Jangalgar Reddy, Velagala Venkata Rama Reddy, Sesha Alluri, Potlapally Kumar, Gaddam Reddy
  • Methods and compositions of novel triazine compounds
    Patent number: 7169785
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: January 30, 2007
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishma Reddy, Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Medical devices employing triazine compounds and compositions thereof
    Patent number: 7169784
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: January 30, 2007
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalger Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Bhatlapenumarthy Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Methods and compositions of novel triazine compounds
    Patent number: 7163943
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: January 16, 2007
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Bhatlapenumarthy Sesha Sridevi, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Methods and compositions of novel triazine compounds
    Publication number: 20070004729
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Application
    Filed: June 20, 2006
    Publication date: January 4, 2007
    Inventors: Richard Timmer, Christopher Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Yeleswarapu, Manojit Pal, Jangalgar Reddy, Velagala Venkata Rama Reddy, Sesha Alluri, Potlapally Kumar, Gaddam Reddy
  • Methods and compositions of novel triazine compounds
    Publication number: 20060258641
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Application
    Filed: May 25, 2006
    Publication date: November 16, 2006
    Inventors: Richard Timmer, Christopher Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Yeleswarapu, Manojit Pal, Jangalgar Reddy, Velagala Venkata Rama Reddy, Sesha Alluri, Potlapally Kumar, Gaddam Reddy