Patents by Inventor Manojit Pal

Manojit Pal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions of novel triazine compounds
    Patent number: 7132423
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: November 7, 2006
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Sesha Sridevi Alluri, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Methods and compositions of novel triazine compounds
    Patent number: 7112587
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: September 26, 2006
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Bhatlapenumarthy Sesha Sridevi, Potlapally Rajendar Kumar, Gaddam Om Reddy
  • Methods and compositions of novel triazine compounds
    Publication number: 20060172984
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Application
    Filed: November 22, 2005
    Publication date: August 3, 2006
    Inventors: Richard Timmer, Christopher Alexander, Sivaram Pillarisetti, Uday Saxena, Yeleswarapu Rao, Manojit Pal, Jangalgar Reddy, Velagala Venkata Rama Reddy, Sesha Alluri, Potlapally Kumar, Gaddam Reddy
  • Heterocyclic and bicyclic compounds, compositions and methods
    Publication number: 20060128702
    Abstract: The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.
    Type: Application
    Filed: November 23, 2005
    Publication date: June 15, 2006
    Inventors: Manojit Pal, Ish Khanna, Venkataraman Subramanian, Srinivas Padakanti, Sivaram Pillarisetti
  • Novel bicyclic heterocyclic compounds, process for their preparation and compositions containing them
    Publication number: 20060128729
    Abstract: The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.
    Type: Application
    Filed: November 23, 2005
    Publication date: June 15, 2006
    Inventors: Manojit Pal, Yeleswarapu Rao, Ish Khanna, Nalivela Swamy, Venkataraman Subramanian, Venkateswara Batchu, Javed Iqbal, Sivaram Pillarisetti
  • Novel pyrimidine compounds, process for their preparation and compositions containing them
    Publication number: 20060084645
    Abstract: The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
    Type: Application
    Filed: September 23, 2005
    Publication date: April 20, 2006
    Inventors: Manojit Pal, Srinivas Kalleda, Srinivas Padakanti, Nalivela Swamy, Koteswar Yeleswarapu, Christopher Alexander, Ish Khanna, Javed Iqbal, Sivaram Pillarisetti, Deepak Barange
  • Novel pyridine compounds, process for their preparation and compositions containing them
    Publication number: 20060084644
    Abstract: The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
    Type: Application
    Filed: September 23, 2005
    Publication date: April 20, 2006
    Inventors: Manojit Pal, Christopher Alexander, Ish Khanna, Javed Iqbal, Ram Pillarisetti, Santanu Maitra, Gayla Roberts, Lavanya Sagi, Chintakunta Krishna, Jennepalli Sreenu
  • Triazine compounds and their analogs, compositions, and methods
    Publication number: 20050227983
    Abstract: The present invention relates to triazine compounds and their analogs and derivatives, and methods and compositions comprising these compounds. The compounds and compositions of this invention are useful for, among other things, treating pathophysiological conditions arising from inflammatory responses, inhibiting or blocking glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells, inhibiting smooth muscle proliferation, treating vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis, and the like.
    Type: Application
    Filed: March 24, 2004
    Publication date: October 13, 2005
    Inventors: Richard Timmer, Christopher Alexander, Sivaram Pillarisetti, Uday Saxena, Sesha Alluri, Velagala Venkata Krishna Reddy, Manojit Pal, Jangalgar Reddy, Koteswar Yeleswarapu, Gaddam Reddy, Potlapally Kumar
  • Medical devices employing triazine compounds and compositions thereof
    Publication number: 20050137196
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Application
    Filed: September 27, 2004
    Publication date: June 23, 2005
    Inventors: Richard Timmer, Christopher Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Yeleswarapu, Manojit Pal, Jangalgar Reddy, Velagala Venkata Krishna Reddy, Bhatlapenumarthy Sesha Sridevi, Potlapally Kumar, Gaddam Reddy
  • Medical devices employing triazine compounds and compositions thereof
    Publication number: 20050124619
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Application
    Filed: September 27, 2004
    Publication date: June 9, 2005
    Inventors: Richard Timmer, Christopher Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Yeleswarapu, Manojit Pal, Jangalgar Reddy, Velagala Venkata Krisha Reddy, Bhatlapenumarthy Sesha Sridevi, Potlapally Kumar, Gaddam Reddy
  • Heterocyclic compounds and methods of making and using thereof
    Publication number: 20050119269
    Abstract: Compounds of formula (I), and methods and/or compositions comprising compounds that are effective in modulating inflammatory responses, such as those resulting from AGE and glycated protein accumulation are provided. Methods and/or compositions comprising compounds that are effective in modulating smooth muscle cell proliferation and the diseases or conditions related thereto are also provided.
    Type: Application
    Filed: October 28, 2004
    Publication date: June 2, 2005
    Inventors: Yeleswarapu Rao, Manojit Pal, Vedula Sharma, Akella Venkateswarlu, Ram Pillarisetti
  • Medical devices employing triazine compounds and compositions thereof
    Publication number: 20050113341
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Application
    Filed: September 27, 2004
    Publication date: May 26, 2005
    Inventors: Richard Timmer, Christopher Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Yeleswarapu, Manojit Pal, Jangalgar Reddy, Velagala Murali Krishna Reddy, Bhatlapenumarthy Sridevi, Potlapally Kumar, Gaddam Reddy
  • Methods and compositions of novel triazine compounds
    Publication number: 20040224950
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Application
    Filed: March 26, 2003
    Publication date: November 11, 2004
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkira Rama Murali Krishna Reddy, Bhatlapenumarphy Shesha Sridevi, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Methods and compositions of novel triazine compounds
    Publication number: 20040209881
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Application
    Filed: March 26, 2003
    Publication date: October 21, 2004
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishna Reddy, Bhatlapenumarthy Sesha Sridevi, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Methods and compositions of novel triazine compounds
    Publication number: 20040209880
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Application
    Filed: March 26, 2003
    Publication date: October 21, 2004
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krlshna Reddy, Bhatlapenumarthy Sesha Sridevi, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Methods and compositions of novel triazine compounds
    Publication number: 20040209882
    Abstract: The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
    Type: Application
    Filed: March 26, 2003
    Publication date: October 21, 2004
    Inventors: Richard T. Timmer, Christopher W. Alexander, Sivaram Pillarisetti, Uday Saxena, Koteswar Rao Yeleswarapu, Manojit Pal, Jangalgar Tirupathy Reddy, Velagala Venkata Rama Murali Krishma Reddy, Bhatlapenumarthy Sesila Sridevi, Potlapally Rajender Kumar, Gaddam Om Reddy
  • Compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them
    Patent number: 6686390
    Abstract: The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their regioisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: February 3, 2004
    Assignee: Dr. Reddy's Laboratories Limited
    Inventors: Manojit Pal, Koteswar Rao Yeleswarapu, Rajagopalan Ramanujam, Parimal Misra, Prem Kumar Mamnoor, Seshagiri Rao Casturi
  • Novel compounds having antiinflamatory activity: process for their preparation and pharmaceutical compositions containing them
    Publication number: 20020032230
    Abstract: The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their regioisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
    Type: Application
    Filed: May 21, 2001
    Publication date: March 14, 2002
    Applicant: DR. REDDY'S LABORATORIES LTD.
    Inventors: Manojit Pal, Koteswar Rao Yeleswarapu, Rajagopalan Ramanujam, Parimal Misra, Prem Kumar Mamnoor, Seshagiri Rao Casturi