Patents by Inventor Manuel Allen Revez Ferreira

Manuel Allen Revez Ferreira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating metabolic disorders and cardiovascular disease with inhibin subunit beta E (INHBE) inhibitors
    Patent number: 11957704
    Abstract: The present disclosure provides methods of treating a subject having metabolic disorders and/or cardiovascular diseases, methods of identifying subjects having an increased risk of developing a metabolic disorder and/or a cardiovascular disease, and methods of detecting human Inhibin Subunit Beta E variant nucleic acid molecules and variant polypeptides.
    Type: Grant
    Filed: August 31, 2022
    Date of Patent: April 16, 2024
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Luca Andrea Lotta, Parsa Akbari, Olukayode Sosina, Manuel Allen Revez Ferreira, Aris Baras
  • Treatment Of Ophthalmic Conditions With Son of Sevenless 2 (SOS2) Inhibitors
    Publication number: 20240102013
    Abstract: The present disclosure provides methods of treating patients having an ophthalmic condition, methods of identifying subjects having an increased risk of developing an ophthalmic condition, methods of detecting human Son of Sevenless 2 (SOS2) variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: October 12, 2023
    Publication date: March 28, 2024
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Goncalo Abecasis, Aris Baras
  • Treatment of obesity in subjects having variant nucleic acid molecules encoding Calcitonin Receptor (CALCR)
    Patent number: 11939635
    Abstract: The present disclosure provides methods of treating subjects having obesity and/or increased body mass index (BMI), and methods of identifying subjects having an increased risk of developing obesity and/or BMI.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: March 26, 2024
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Luca Andrea Lotta, Parsa Akbari, Manuel Allen Revez Ferreira, Aris Baras
  • Treatment Of Endometriosis With R-Spondin 3 (RSPO3) Inhibitors
    Publication number: 20240084298
    Abstract: The present disclosure relates generally to the treatment of subjects having endometriosis or at risk of developing endometriosis by administering an R-spondin 3 (RSPO3) inhibitor and/or an RSPO3 Receptor blocker to the subject.
    Type: Application
    Filed: September 11, 2023
    Publication date: March 14, 2024
    Inventors: Manuel Allen Revez Ferreira, Maria Cristina Suciu, Courtney Williams
  • Macrophage Stimulating 1 Receptor (MST1R) Variants And Uses Thereof
    Publication number: 20240075102
    Abstract: Methods of treating patients having inflammatory bowel disease (IBD) or primary sclerosing cholangitis (PSC) are provided herein.
    Type: Application
    Filed: July 19, 2023
    Publication date: March 7, 2024
    Inventors: Julie Horowitz, Aris Baras, Manuel Allen Revez Ferreira
  • Treatment of ophthalmic conditions with son of Sevenless 2 (SOS2) inhibitors
    Patent number: 11820982
    Abstract: The present disclosure provides methods of treating patients having an ophthalmic condition, methods of identifying subjects having an increased risk of developing an ophthalmic condition, methods of detecting human Son of Sevenless 2 (SOS2) variant nucleic acid molecules and variant polypeptides.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: November 21, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Goncalo Abecasis, Aris Baras
  • Kelch Domain Containing 7B (KLHDC7B) Variants And Uses Thereof
    Publication number: 20230366024
    Abstract: The present disclosure provides methods of treating subjects having hearing loss, methods of identifying subjects having an increased risk of developing hearing loss, and methods of detecting Kelch Domain Containing 7B (KLHDC7B) variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: April 19, 2023
    Publication date: November 16, 2023
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Aris Baras, Meghan Drummond Samuelson, Goncalo Abecasis
  • Methods of treating metabolic disorders and cardiovascular disease with Inhibin Subunit Beta E (INHBE) inhibitors
    Patent number: 11759476
    Abstract: The present disclosure provides methods of treating a subject having metabolic disorders and/or cardiovascular diseases, methods of identifying subjects having an increased risk of developing a metabolic disorder and/or a cardiovascular disease, and methods of detecting human Inhibin Subunit Beta E variant nucleic acid molecules and variant polypeptides.
    Type: Grant
    Filed: April 1, 2022
    Date of Patent: September 19, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Luca Andrea Lotta, Parsa Akbari, Olukayode Sosina, Manuel Allen Revez Ferreira, Aris Baras
  • Macrophage stimulating 1 receptor (MST1R) variants and uses thereof
    Patent number: 11752197
    Abstract: Methods of treating patients having inflammatory bowel disease (IBD) or primary sclerosing cholangitis (PSC) are provided herein.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: September 12, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Julie Horowitz, Aris Baras, Manuel Allen Revez Ferreira
  • Treatment Of Kidney Diseases With Angiopoietin Like 3 (ANGPTL3) Inhibitors
    Publication number: 20230193271
    Abstract: The present disclosure provides methods of treating a subject having a kidney disease or at risk of developing a kidney disease by administering an Angiopoietin Like 3 (ANGPTL3) inhibitor, and methods of identifying subjects having an increased risk of developing a kidney disease.
    Type: Application
    Filed: December 21, 2022
    Publication date: June 22, 2023
    Inventors: Mary E. Haas, Luca Andrea Lotta, Aris Baras, Manuel Allen Revez Ferreira, Kishor Devalaraja-Narashimha, Lori Morton
  • Treatment Of Lung Conditions With Integrin Subunit Alpha 1 (ITGA1) Inhibitors
    Publication number: 20230192864
    Abstract: The present disclosure provides methods of treating subjects having a lung disease such as a fibrotic lung disease, pulmonary fibrosis, interstitial lung disease, chronic obstructive pulmonary disease (COPD), or asthma, or at risk of developing a lung disease, and methods of identifying subjects having an increased risk of developing a lung disease.
    Type: Application
    Filed: December 16, 2022
    Publication date: June 22, 2023
    Inventors: Manuel Allen Revez Ferreira, Julie E. Horowitz, Katherine Siminovitch, Goncalo Abecasis, Aris Baras, Maria Cristina Suciu
  • Kelch domain containing 7B (KLHDC7B) variants and uses thereof
    Patent number: 11674177
    Abstract: The present disclosure provides methods of treating subjects having hearing loss, methods of identifying subjects having an increased risk of developing hearing loss, and methods of detecting Kelch Domain Containing 7B (KLHDC7B) variant nucleic acid molecules and variant polypeptides.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: June 13, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Aris Baras, Meghan Drummond Samuelson, Goncalo Abecasis
  • Methods Of Treating Metabolic Disorders And Cardiovascular Disease With Inhibin Subunit Beta E (INHBE) Inhibitors
    Publication number: 20230172963
    Abstract: The present disclosure provides methods of treating a subject having metabolic disorders and/or cardiovascular diseases, methods of identifying subjects having an increased risk of developing a metabolic disorder and/or a cardiovascular disease, and methods of detecting human Inhibin Subunit Beta E variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: August 31, 2022
    Publication date: June 8, 2023
    Inventors: Luca Andrea Lotta, Parsa Akbari, Olukayode Sosina, Manuel Allen Revez Ferreira, Aris Baras
  • Methods Of Treating Chronic Kidney Disease (CKD) With Inhibitors Of Protective Loss-Of-Function Genes
    Publication number: 20230107173
    Abstract: The present disclosure provides methods of treating a subject having a kidney disease or preventing a subject from developing a kidney disease, and methods of identifying subjects having an increased risk of developing a kidney disease.
    Type: Application
    Filed: September 22, 2022
    Publication date: April 6, 2023
    Inventors: Mary E. Haas, Luca Andrea Lotta, Aris Baras, Manuel Allen Revez Ferreira, Adam E. Locke, Joshua Backman
  • Treatment Of Psychiatric Disorders And Psychiatric Disorder-Associated MRI Phenotypes With Stabilin 1 (STAB1) Inhibitors
    Publication number: 20230108957
    Abstract: The present disclosure provides methods of treating subjects having psychiatric disorders and/or psychiatric disorder-associated MRI phenotypes, and methods of identifying subjects having an increased risk of developing psychiatric disorders and/or psychiatric disorder-associated MRI phenotypes.
    Type: Application
    Filed: September 29, 2022
    Publication date: April 6, 2023
    Inventors: Manuel Allen Revez Ferreira, Veera Rajagopal, Giovanni Coppola, Jonathan Marchini, Aris Baras
  • Treatment Of Glaucoma With Rho Guanine Nucleotide Exchange Factor 12 (ARHGEF12) Inhibitors
    Publication number: 20230099109
    Abstract: The present disclosure provides methods of treating subjects having glaucoma or elevated intraocular pressure (IOP), methods of identifying subjects having an increased risk of developing glaucoma or developing elevated IOP, methods of detecting human Rho Guanine Nucleotide Exchange Factor 12 (ARHGEF12) variant nucleic acid molecules and variant polypeptides, and ARHGEF12 variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: September 28, 2022
    Publication date: March 30, 2023
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Aris Baras, Claudia Schurmann
  • Treatment Of Inflammatory Diseases With RAS Protein Activator Like 3 (RASAL3) Inhibitors
    Publication number: 20230074721
    Abstract: The present disclosure provides methods of treating subjects having an inflammatory disease, and methods of identifying subjects having an increased risk of developing an inflammatory disease.
    Type: Application
    Filed: August 24, 2022
    Publication date: March 9, 2023
    Inventors: Manuel Allen Revez Ferreira, Joshua Backman, Alexander Li, Lauren Gurski, Julie E. Horowitz, Katherine Siminovitch, Goncalo Abecasis, Aris Baras
  • Modulation Of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2)-Mediated Immune Response
    Publication number: 20230059929
    Abstract: The present disclosure provides methods of treating subjects having an immune disorder by administering a therapeutically effective amount of an Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) inhibitor to the subject, and optionally an Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) agonist or inhibitor and/or an HLA-Aw19 inhibitor, and also provides methods of identifying subjects having an increased risk for developing an MHC-I-opathy.
    Type: Application
    Filed: July 23, 2021
    Publication date: February 23, 2023
    Inventors: Sahar Gelfman, Ann Ligocki, Giovanni Coppola, Aris Baras, Arden Moscati, Eli A. Stahl, Jack A. Kosmicki, Manuel Allen Revez Ferreira, Carmelo Romano
  • Treatment of Varicose Veins With Piezo Type Mechanosensitive Ion Channel Component 1 (PIEZO1) Agonists
    Publication number: 20230041060
    Abstract: The present disclosure provides methods of treating subjects having varicose veins or at risk of developing varicose veins, methods of identifying subjects having an increased risk of developing varicose veins, and methods of detecting Piezo Type Mechanosensitive Ion Channel Component 1 (PIEZO1) variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: July 5, 2022
    Publication date: February 9, 2023
    Inventors: Manuel Allen Revez Ferreira, Joshua Backman, Alexander Li, Aris Baras, Goncalo Abecasis
  • Treatment Of Psoriasis With Interferon Induced Helicase C Domain 1 (IFIH1) Inhibitors
    Publication number: 20230037582
    Abstract: The present disclosure provides methods of treating subjects having psoriasis, and methods of identifying subjects having an increased risk of developing psoriasis.
    Type: Application
    Filed: June 9, 2022
    Publication date: February 9, 2023
    Inventors: Julie E. Horowitz, Manuel Allen Revez Ferreira, Katherine Siminovitch, Aris Baras, Lori Khrimian, Katia Karalis