Patents by Inventor Manuel Allen Revez Ferreira

Manuel Allen Revez Ferreira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment Of Cognitive Impairment With Alpha-N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5 (ST6GALNAC5) Inhibitors
    Publication number: 20230034093
    Abstract: The present disclosure provides methods of treating subjects having cognitive impairment or at risk of developing cognitive impairment, and methods of identifying subjects having an increased risk of developing cognitive impairment.
    Type: Application
    Filed: June 30, 2022
    Publication date: February 2, 2023
    Inventors: Jonathan Marchini, Manuel Allen Revez Ferreira, Giovanni Coppola, Goncalo Abecasis, Aris Baras
  • Methods Of Treating A Metabolic Disorder With Mitogen-Activated Protein Kinase Kinase Kinase 15 (MAP3K15) Inhibitors
    Publication number: 20230025878
    Abstract: The present disclosure provides methods of treating a subject having a metabolic disorder or is at risk of developing a metabolic disorder or preventing a subject from developing a metabolic disorder, and methods of identifying subjects having an increased risk of developing a metabolic disorder.
    Type: Application
    Filed: June 30, 2022
    Publication date: January 26, 2023
    Inventors: Manuel Allen Revez Ferreira, Joshua Backman, Alexander Li, Luca Andrea Lotta, Goncalo Abecasis, Aris Baras
  • Treatment of Hypertension With Solute Carrier Family 9 Isoform A3 Regulatory Factor 2 (SLC9A3R2) Inhibitors
    Publication number: 20230027007
    Abstract: The present disclosure provides methods of treating subjects having hypertension, coronary heart disease, and/or atrial fibrillation or at risk of developing hypertension, coronary heart disease, and/or atrial fibrillation, methods of identifying subjects having an increased risk of developing hypertension, coronary heart disease, and/or atrial fibrillation, and methods of detecting Solute Carrier Family 9 Isoform A3 Regulatory Factor 2 (SLC9A3R2) variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: June 30, 2022
    Publication date: January 26, 2023
    Inventors: Manuel Allen Revez Ferreira, Joshua Backman, Alexander Li, Luca Andrea Lotta, Goncalo Abecasis, Aris Baras, Jonas Nielsen
  • Methods Of Treating Asthma With Solute Carrier Family 27 Member 3 (SLC27A3) Inhibitors
    Publication number: 20230023182
    Abstract: The present disclosure provides methods of treating a subject having asthma or at risk of developing asthma, and methods of identifying subjects having an increased risk of developing asthma.
    Type: Application
    Filed: June 30, 2022
    Publication date: January 26, 2023
    Inventors: Manuel Allen Revez Ferreira, Joshua Backman, Alexander Li, Goncalo Abecasis, Julie Horowitz, Katherine Siminovitch, Aris Baras
  • Methods Of Treating Skin Cancer With Histidine Ammonia-Lyase (HAL) Agonists
    Publication number: 20230016750
    Abstract: The present disclosure provides methods of treating subjects having skin cancer or at risk of developing skin cancer, and methods of identifying subjects having an increased risk of developing skin cancer.
    Type: Application
    Filed: July 5, 2022
    Publication date: January 19, 2023
    Inventors: Manuel Allen Revez Ferreira, Joshua Backman, Alexander Li, Michael Kessler, Eric Jorgenson, Aris Baras, Goncalo Abecasis
  • Treatment Of Obesity With G-Protein Coupled Receptor 75 (GPR75) Inhibitors
    Publication number: 20220411870
    Abstract: The present disclosure provides methods of treating subjects having obesity, methods of identifying subjects having an increased risk of developing obesity, methods of detecting human G-protein coupled receptor 75 variant nucleic acid molecules and variant polypeptides, and GPR75 variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: May 19, 2022
    Publication date: December 29, 2022
    Inventors: Luca Andrea Lotta, Manuel Allen Revez Ferreira, Aris Baras, Parsa Akbari, Olukayode Sosina
  • Materials And Methods Of Treating MHC-1-Opathy Risk Haplotypes
    Publication number: 20220323581
    Abstract: The present disclosure provides methods of treating subjects having an immune disorder by administering to the subject a therapeutically effective amount of an Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) inhibitor in combination with an HLA-A29 or HLA-B27 inhibitory nucleic acid molecule.
    Type: Application
    Filed: April 6, 2022
    Publication date: October 13, 2022
    Inventors: Sahar Gelfman, Ann Ligocki, Giovanni Coppola, Aris Baras, Arden Moscati, Eli A. Stahl, Jack A. Kosmicki, Manuel Allen Revez Ferreira, Carmelo Romano
  • Methods Of Treating Metabolic Disorders And Cardiovascular Disease With Inhibin Subunit Beta E (INHBE) Inhibitors
    Publication number: 20220313726
    Abstract: The present disclosure provides methods of treating a subject having metabolic disorders and/or cardiovascular diseases, methods of identifying subjects having an increased risk of developing a metabolic disorder and/or a cardiovascular disease, and methods of detecting human Inhibin Subunit Beta E variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: April 1, 2022
    Publication date: October 6, 2022
    Inventors: Luca Andrea Lotta, Parsa Akbari, Olukayode Sosina, Manuel Allen Revez Ferreira, Aris Baras
  • Treatment Of Liver Disease With Ring Finger Protein 213 (RNF213) Inhibitors
    Publication number: 20220307033
    Abstract: The present disclosure provides methods of treating subjects having a liver disease, and methods of identifying subjects having an increased risk of developing a liver disease.
    Type: Application
    Filed: March 1, 2022
    Publication date: September 29, 2022
    Inventors: Luca Andrea Lotta, Niek Verweij, Manuel Allen Revez Ferreira, Aris Baras
  • Methods Of Treating Metabolic Disorders And Cardiovascular Disease With Inhibin Subunit Beta E (INHBE) Inhibitors
    Publication number: 20220184114
    Abstract: The present disclosure provides methods of treating a subject having metabolic disorders and/or cardiovascular diseases, methods of identifying subjects having an increased risk of developing a metabolic disorder and/or a cardiovascular disease, and methods of detecting human Inhibin Subunit Beta E variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: December 13, 2021
    Publication date: June 16, 2022
    Inventors: Luca Andrea Lotta, Parsa Akbari, Olukayode Sosina, Manuel Allen Revez Ferreira, Aris Baras
  • Treatment of obesity with G-protein coupled receptor 75 (GPR75) inhibitors
    Patent number: 11359246
    Abstract: The present disclosure provides methods of treating subjects having obesity, methods of identifying subjects having an increased risk of developing obesity, methods of detecting human G-protein coupled receptor 75 variant nucleic acid molecules and variant polypeptides, and GPR75 variant nucleic acid molecules and variant polypeptides.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: June 14, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Luca Andrea Lotta, Manuel Allen Revez Ferreira, Aris Baras, Parsa Akbari, Olukayode Sosina
  • Methods Of Identifying Subjects Having An Increased Risk Of Developing A Coronavirus Infection And Treatment Thereof
    Publication number: 20220177982
    Abstract: Methods of treating subjects having a coronavirus infection, and methods of identifying subjects having an increased risk of a coronavirus infection are provided herein.
    Type: Application
    Filed: December 3, 2021
    Publication date: June 9, 2022
    Inventors: Jack Kosmicki, Julie Horowitz, Manuel Allen Revez Ferreira, Goncalo Abecasis, Aris Baras, Amy Damask
  • Synaptojanin 2 (SYNJ2) Variants And Uses Thereof
    Publication number: 20220064735
    Abstract: The present disclosure provides methods of treating patients having hearing loss, methods of identifying subjects having an increased risk of developing hearing loss, methods of detecting human Synaptojanin-2 (SYNJ2) variant nucleic acid molecules and variant polypeptides, and SYNJ2 variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: November 12, 2021
    Publication date: March 3, 2022
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Aris Baras, Meghan Drummond Samuelson, Goncalo Abecasis
  • Treatment Of Sepsis With PCSK9 And LDLR Modulators
    Publication number: 20220064652
    Abstract: The present disclosure provides methods of treating subjects having sepsis, SIRS, septic shock, and/or MODS, methods of identifying subjects having an increased risk of developing sepsis, SIRS, septic shock, and/or MODS, and methods of detecting Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and/or Low Density Lipoprotein Receptor (LDLR) variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: August 25, 2021
    Publication date: March 3, 2022
    Inventors: Julie Horowitz, Luca Andrea Lotta, Manuel Allen Revez Ferreira, Amy Damask, Charles Paulding, Garen Manvelian, Michael Cantor, Aris Baras
  • Treatment Of Obesity In Subjects Having Variant Nucleic Acid Molecules Encoding Calcitonin Receptor (CALCR)
    Publication number: 20220049308
    Abstract: The present disclosure provides methods of treating subjects having obesity and/or increased body mass index (BMI), and methods of identifying subjects having an increased risk of developing obesity and/or BMI.
    Type: Application
    Filed: August 13, 2021
    Publication date: February 17, 2022
    Inventors: Luca Andrea Lotta, Parsa Akbari, Manuel Allen Revez Ferreira, Aris Baras
  • Treatment Of Obesity With G-Protein Coupled Receptor 75 (GPR75) Inhibitors
    Publication number: 20220042101
    Abstract: The present disclosure provides methods of treating subjects having obesity, methods of identifying subjects having an increased risk of developing obesity, methods of detecting human G-protein coupled receptor 75 variant nucleic acid molecules and variant polypeptides, and GPR75 variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: June 21, 2021
    Publication date: February 10, 2022
    Inventors: Luca Andrea Lotta, Manuel Allen Revez Ferreira, Aris Baras, Parsa Akbari, Olukayode Sosina
  • Solute Carrier Family 26 Member 5 (SLC26A5) Variants And Uses Thereof
    Publication number: 20210371930
    Abstract: The present disclosure provides methods of treating a subject having hearing loss, methods of identifying a subject having an increased risk of developing hearing loss, and methods of detecting Solute Carrier Family 26 Member 5 (SLC26A5) variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: May 5, 2021
    Publication date: December 2, 2021
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Aris Baras, Meghan Drummond Samuelson, Goncalo Abecasis
  • Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) Variants And Uses Thereof
    Publication number: 20210353709
    Abstract: Methods of treating obesity and methods of identifying susceptibility of an obese subject to treatment with an agonist of the leptin-melanocortin signaling pathway are provided herein.
    Type: Application
    Filed: May 3, 2021
    Publication date: November 18, 2021
    Inventors: Luca Andrea Lotta, Manuel Allen Revez Ferreira
  • Kelch Domain Containing 7B (KLHDC7B) Variants And Uses Thereof
    Publication number: 20210348228
    Abstract: The present disclosure provides methods of treating subjects having hearing loss, methods of identifying subjects having an increased risk of developing hearing loss, and methods of detecting Kelch Domain Containing 7B (KLHDC7B) variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: May 4, 2021
    Publication date: November 11, 2021
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Aris Baras, Meghan Drummond Samuelson, Goncalo Abecasis
  • Fascin-2 (FSCN2) Variants And Uses Thereof
    Publication number: 20210300976
    Abstract: The present disclosure provides methods of treating subjects having hearing loss, methods of identifying subjects having an increased risk of developing hearing loss, and methods of detecting human Fascin-2 (FSCN2) variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: March 5, 2021
    Publication date: September 30, 2021
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Aris Baras, Meghan Drummond Samuelson, Goncalo Abecasis