Patents by Inventor Manuel Debono
Manuel Debono has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7790744Abstract: Provided are compounds of the formula (1): wherein R? is hydrogen, methyl or NH2C(O)CH2—; R? and R?? are independently methyl or hydrogen; R adn Ry are independently hydroxy or hydrogen; R1 is hydroxy, hydrogen, or hydroxysulfonyloxy; R7 is hydroxy, hydrogen, hydroxysulfonyloxy or phosphonooxy; R2 is a novel acyl side chain. Also provided are novel formulations, methods of inhibiting fungal and parasitic activity, and a process for preparing dideoxy (R?H) forms of the compounds.Type: GrantFiled: March 10, 2005Date of Patent: September 7, 2010Assignee: Eli Lilly and CompanyInventors: Frederick J. Burkhardt, Manuel Debono, Jeffrey S. Nissen, William Wilson Turner, Jr.
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Publication number: 20050181984Abstract: Provided are compounds of the formula (1): wherein R? is hydrogen, methyl or NH2C(O)CH2—; R? and R?? are independently methyl or hydrogen; R adn Ry are independently hydroxy or hydrogen; R1 is hydroxy, hydrogen, or hydroxysulfonyloxy; R7 is hydroxy, hydrogen, hydroxysulfonyloxy or phosphonooxy; R2 is a novel acyl side chain. Also provided are novel formulations, methods of inhibiting fungal and parasitic activity, and a process for preparing dideoxy (R?H) forms of the compounds.Type: ApplicationFiled: March 10, 2005Publication date: August 18, 2005Inventors: Frederick Burkhardt, Manuel Debono, Jeffrey Nissen, William Turner
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Patent number: 6916784Abstract: Provided are compounds of the formula (1): wherein R? is hydrogen, methyl or NH2C(O)CH2—; R? and R?? are independently methyl or hydrogen; R adn Ry are independently hydroxy or hydrogen; R1 is hydroxy, hydrogen, or hydroxysulfonyloxy; R7 is hydroxy, hydrogen, hydroxysulfonyloxy or phosphonooxy; R2 is a novel acyl side chain. Also provided are novel formulations, methods of inhibiting fungal and parasitic activity, and a process for preparing dideoxy (R?H) forms of the compounds.Type: GrantFiled: February 27, 2003Date of Patent: July 12, 2005Assignee: Eli Lilly and CompanyInventors: Frederick J. Burkhardt, Manuel Debono, Jeffrey S. Nissen, William W. Turner, Jr.
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Patent number: 6743777Abstract: Provided are compounds of the formula (1): wherein R′ is hydrogen, methyl or NH2C(O)CH2—; R″ and R′″ are independently methyl or hydrogen; R adn Ry are independently hydroxy or hydrogen; R1 is hydroxy, hydrogen, or hydroxysulfonyloxy; R7 is hydroxy, hydrogen, hydroxysulfonyloxy or phosphonooxy; R2 is a novel acyl side chain. Also provided are novel formulations, methods of inhibiting fungal and parasitic activity, and a process for preparing dideoxy (R=H) forms of the compounds.Type: GrantFiled: February 27, 2002Date of Patent: June 1, 2004Assignee: Eli Lilly and CompanyInventors: Frederick J. Burkhardt, Manuel Debono, Jeffrey S. Nissen, William W. Turner, Jr.
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Publication number: 20030220236Abstract: Provided are compounds of the formula (1): 1Type: ApplicationFiled: February 27, 2003Publication date: November 27, 2003Inventors: Frederick J. Burkhardt, Manuel Debono, Jeffrey S. Nissen, William W. Turner
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Patent number: 6384013Abstract: Provided are compounds of the formula (1): wherein R′ is hydrogen, methyl or NH2C(O)CH2—; R″ and R′″ are independently methyl or hydrogen; R and Ry are independently hydroxy or hydrogen; R1 is hydroxy, hydrogen, or hydroxysulfonyloxy; R7 is hydroxy, hydrogen, hydroxysulfonyloxy or phosphonooxy; R2 is a acyl side chain. Also provided are formulations, methods of inhibiting fungal and parasitic activity, and a process for preparing dideoxy (R═H) forms of the compounds.Type: GrantFiled: April 14, 1999Date of Patent: May 7, 2002Assignee: Eli Lilly and CompanyInventors: Frederick J. Burkhardt, Manuel Debono, Jeffrey S. Nissen, William W. Turner, Jr.
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Patent number: 6111067Abstract: A82846-related glycopeptide compounds are prepared by treating an antibiotic selected from A82846 components A, B and C with trifluoroacetic acid to remove 1) the .alpha.-L-O-4-epi-vancosaminyl group attached to the disaccharide; 2) the (.alpha.-L-O-4-epi-vancosaminyl-.beta.-O-glucosyl) disaccharide group or 3) both the disaccharide group and the .alpha.-L-O-4-epi-vancosaminyl group attached to the peptide core from these antibiotics. The compounds have antibacterial activity, especially against Gram-positive microorganisms.Type: GrantFiled: December 21, 1993Date of Patent: August 29, 2000Assignee: Eli Lilly and CompanyInventors: Manuel Debono, R. Michael Molloy, Ramakrishnan Nagarajan, Amelia A. Schabel
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Patent number: 5965525Abstract: Provided are compounds of the formula (1): ##STR1## wherein R' is hydrogen, methyl or NH.sub.2 C(O)CH.sub.2 --;R" and R'" are independently methyl or hydrogen;R and R.sup.y are independently hydroxy or hydrogen;R.sub.1 is hydroxy, hydrogen, or hydroxysulfonyloxy;R.sub.7 is hydroxy, hydrogen, hydroxysulfonyloxy or phosphonooxy;R.sub.2 is a novel acyl side chain. Also provided are novel formulations, methods of inhibiting fungal and parasitic activity, and a process for preparing dideoxy (R=H) forms of the compounds.Type: GrantFiled: May 24, 1995Date of Patent: October 12, 1999Assignee: Eli Lilly and CompanyInventors: Frederick J. Burkhardt, Manuel Debono, Jeffrey S. Nissen, William W. Turner, Jr.
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Patent number: 5932543Abstract: Provided are compounds of the formula (1): ##STR1## wherein R' is hydrogen, methyl or NH.sub.2 C(O)CH.sub.2 --;R" and R'" are independently methyl or hydrogen;R and R.sup.Y are independently hydroxy or hydrogen;R.sub.1 is hydroxy, hydrogen, or hydroxysulfonyloxy;R.sub.7 is hydroxy, hydrogen, hydroxysulfonyloxy or phosphonooxy;R.sub.2 is a novel acyl side chain. Also provided are novel formulations, methods of inhibiting fungal and parasitic activity, and a process for preparing dideoxy (R=H) forms of the compounds.Type: GrantFiled: June 12, 1997Date of Patent: August 3, 1999Assignee: Eli Lilly and CompanyInventors: Frederick J. Burkhardt, Manuel Debono, Jeffrey S. Nissen, William W. Turner, Jr.
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Patent number: 5912226Abstract: Two new groups of A-21978C cyclic peptides, anhydro- and isomer-A21978C peptide derivatives, have antibacterial activity and are useful as intermediates. The two groups are prepared via transpeptidation of the parent cyclic peptides. Pharmaceutical formulations containing the new peptides as active ingredients and methods of treating infections caused by susceptible Gram-positive bacteria with the formulations are also provided.The invention also provides an antibacterial composition containing the new drug substance LY 146032 in substantially pure form.Type: GrantFiled: December 16, 1991Date of Patent: June 15, 1999Assignee: Eli Lilly and CompanyInventors: Patrick J. Baker, Manuel Debono, Khadiga Z. Farid, R. Michael Molloy
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Patent number: 5534420Abstract: New glycopeptides prepared by biotransformation of a vancomycin-type antibiotic by an Acinomadura citrea culture (NRRL 18382), which are useful intermediates, and methods of preparing the biotransformed intermediates by adding a vancomycin-type glycopeptide to a growing culture of Actinomadura citrea NRRL 18382 and continuing fermentation under submerged aerobic conditions, are provided.Type: GrantFiled: May 18, 1995Date of Patent: July 9, 1996Assignee: Eli Lilly and CompanyInventors: Manuel Debono, Robert M. Logan, Gary G. Marconi, R. Michael Molloy, Milton J. Zmijewski, Jr.
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Patent number: 5451403Abstract: Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C.sub.1-6 -alkyl ether and C.sub.1-6 -alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A.sub.2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A.sub.2 inhibitors that are also useful as antiinflammatory agents.Type: GrantFiled: April 28, 1994Date of Patent: September 19, 1995Assignee: Eli Lilly and CompanyInventors: Dennis R. Berry, Anne H. Dantzig, Manuel Debono, Robert Hamill, R. Michael Molloy, Raymond C. Yao
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Patent number: 5350579Abstract: Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C.sub.1-6 -alkyl ether and C.sub.1-6 -alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A.sub.2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A.sub.2 inhibitors that are also useful as antiinflammatory agents.Type: GrantFiled: August 9, 1993Date of Patent: September 27, 1994Assignee: Eli Lilly and CompanyInventors: Dennis R. Berry, Anne H. Dantzig, Manuel Debono, Robert Hamill, R. Michael Molloy, Raymond C. Yao
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Patent number: 5278064Abstract: Fermentation product A87689 is produced by a strain of Amycolatopsis mediterranei selected from NRRL 18815 and NRRL 18851, or an A87689-producing mutant thereof. A87689, its C.sub.1-6 -alkyl ether and C.sub.1-6 -alkanoyl ester derivatives and pharmaceutically acceptable salts thereof are phospholipase A.sub.2 inhibitors that are useful as antiinflammatory agents. Fermentation products known as BU-3889V, its components and pharmaceutically acceptable salts thereof, are phospholipase A.sub.2 inhibitors that are also useful as antiinflammatory agents.Type: GrantFiled: May 4, 1992Date of Patent: January 11, 1994Assignee: Eli Lilly and CompanyInventors: Dennis R. Berry, Anne H. Dantzig, Manuel Debono, Robert Hamill, R. Michael Molloy, Raymond C. Yao
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Patent number: 5110800Abstract: Three new groups of 9-N-substituted derivatives of erythromycylamine with superior oral activity against Gram-positive pathogens, new processes for preparing derivatives of erythromycylamine and aliphatic aldehydes by controlling the pH of the reaction and by catalytic hydrogenation, and pharmaceutical compositions and methods using the new compounds are provided.Type: GrantFiled: August 18, 1989Date of Patent: May 5, 1992Assignee: Eli Lilly and CompanyInventors: Rosanne Bonjouklian, Manuel Debono, Herbert A. Kirst, Julie A. Wind
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Patent number: 4820694Abstract: New 3'" and/or 4'"-modified macrocin and 3" and/or 4"-modified-lactenocin derivatives of formula 1 have significant antibacterial activity. Compositions positions containing and methods of using these derivatives are also provided.Type: GrantFiled: September 29, 1986Date of Patent: April 11, 1989Assignee: Eli Lilly and CompanyInventors: Manuel Debono, Herbert A. Kirst, James P. Leeds
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Patent number: 4820695Abstract: C-20-Dihydro-deoxy-(cyclic amino)-derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, lactenocin, 2"'-O-demethylmacrocin and 2"-O-demethyllactenocin, which inhibit pathogenic bacteria, especially gram-positive bacteria, Pasteurella species, and Mycoplasma species, and pharmaceutical compositions thereof, are provided.Type: GrantFiled: May 28, 1987Date of Patent: April 11, 1989Assignee: Eli Lilly and CompanyInventors: Manuel Debono, Herbert A. Kirst
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Patent number: RE39071Abstract: Two new groups of A-21978C cyclic peptides, anhydro- and isomer-A21978C peptide derivatives, have antibacterial activity and are useful as intermediates. The two groups are prepared via transpeptidation of the parent cyclic peptides. Pharmaceutical formulations containing the new peptides as active ingredients and methods of treating infections caused by susceptible Gram-positive bacteria with the formulations are also provided. The invention also provides an antibacterial composition containing the new drug substance LY 146032 in substantially pure form.Type: GrantFiled: April 11, 2000Date of Patent: April 18, 2006Assignee: Eli Lilly and CompanyInventors: Patrick J. Baker, Manuel Debono, Khadiga Z. Farid, R. Michael Molloy
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Patent number: RE32310Abstract: A-21978C cyclic peptide derivatives of the formula ##STR1## wherein R is a substituted benzoyl group of the formula ##STR2## R.sup.2 is C.sub.8 -C.sub.15 alkyl; X is hydrogen, chloro, bromo, iodo, nitro, C.sub.1 -C.sub.3 alkyl, hydroxy, C.sub.1 -C.sub.3 alkoxy, or C.sub.1 -C.sub.3 alkylthio; and R.sup.1 is hydrogen or an amino-protecting group; and the salts thereof, are useful new semisynthetic antibacterial agents or intermediates to such agents.Type: GrantFiled: September 23, 1985Date of Patent: December 16, 1986Assignee: Eli Lilly and CompanyInventor: Manuel Debono
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Patent number: RE32311Abstract: A-21978C cyclic peptide derivatives of the formula ##STR1## wherein R is hydrogen, a specified aminoacyl or N-alkanoylaminoacyl group, 8-methyldecanoyl, 10-methyldodecanoyl, 10-methylundecanoyl, the specific C.sub.10 -alkanoyl group of A-21978C.sub.0 or the specific C.sub.12 -alkanoyl groups of A-21978C factors C.sub.4 and C.sub.5 or an amino-protecting group; and R.sup.1 is hydrogen, an amino-protecting group, or a specified aminoacyl or N-alkanoylaminoacyl group; provided that, when R is other than aminoacyl or N-alkanoylaminoacyl, R.sup.1 must be aminoacyl or N-alkanoylaminoacyl; and, when R.sup.1 is an amino-protecting group, R must be aminoacyl or N-alkanoylaminoacyl; and the salts thereof, are useful as antibacterial agents or as intermediates to antibacterial agents.Type: GrantFiled: September 25, 1985Date of Patent: December 16, 1986Assignee: Eli Lilly and CompanyInventor: Manuel Debono