Abstract: A system includes a medical device for implanting in a valve of a subject, the implantable medical device having a self-expanding frame; and a holder configured to retain the frame of the implantable medical device in a constricted configuration and to control expansion of the frame. The holder has a controllably constrictable and expandable loop, wherein the loop is disposed about at least a portion of the self-expanding frame such that constriction or expansion of the first loop controls constriction or expansion of the frame.

Abstract: The invention features modular implantable ventricular assist devices configured to be, at least in part, assembled within a patient. The devices generally include a pump assembly and an expandable frame. The frame is configured to engage tissue of a patient when implanted. The pump assembly is configured to be operably coupled to the frame when the frame is implanted and in the expanded configuration.

Abstract: Heart valve delivery systems and methods for providing a clinician with feedback during a stented prosthetic heart valve delivery procedure. Feedback is provided using piezochromatic indicators incorporated into elements of the delivery device, such as the handle assembly, shaft assembly and capsule to indicate when detrimental forces, or forces nearing those that are detrimental, are being applied to the delivery device during the prosthetic heart valve loading, delivery or deployment procedure. Other embodiments incorporate a feedback indicator to indicate that a delivery device has previously been used and is not in a new condition.

Abstract: A sealing system for sealing a valve component in a radially expanded deployed configuration to a wall of a native valve includes a valve component and an expandable sealing ring. The valve component has an inflow portion and outflow portion and includes a frame and a prosthetic valve coupled to the frame. The frame defines a central passage with the prosthetic valve disposed therein. The expandable sealing ring is configured to be inserted in a compressed configuration within the central passage of the valve component with the valve component in the radially expanded deployed configuration. The expandable sealing ring is configured to be radially expanded to apply a radially outward force to the valve component, forcing the frame radially outward toward the wall of the native valve.

Abstract: A sealing system for sealing a valve component in a radially expanded deployed configuration includes a valve component and an expandable sealing component. The valve component includes a frame and a prosthetic valve coupled to the frame. The frame defines a central passage with the prosthetic valve disposed therein. The expandable sealing component includes a sealing frame and a skirt coupled to the sealing frame. The expandable sealing component is configured to be inserted in a compressed configuration within the central passage of the valve component with the valve component in the radially expanded deployed configuration. The expandable sealing component is configured to be radially expanded partially within the valve component, with a first portion disposed within the valve component and a second portion disposed longitudinally outside the valve component. The sealing frame may include a first ring and a second ring.

Abstract: A system includes a medical device for implanting in a valve of a subject, the implantable medical device having a self-expanding frame; and a holder configured to retain the frame of the implantable medical device in a constricted configuration and to control expansion of the frame. The holder has a controllably constrictable and expandable loop, wherein the loop is disposed about at least a portion of the self-expanding frame such that constriction or expansion of the first loop controls constriction or expansion of the frame.

Abstract: The invention features modular implantable ventricular assist devices configured to be, at least in part, assembled within a patient. The devices generally include a pump assembly and an expandable frame. The frame is configured to engage tissue of a patient when implanted. The pump assembly is configured to be operably coupled to the frame when the frame is implanted and in the expanded configuration.

Abstract: Methods and systems for automated language detection for domain names are disclosed. In some embodiments, a method for detecting a language of an Internationalized Domain Name (IDN) comprises receiving, by an I/O interface, a string of characters for the IDN; receiving training data, including a plurality of multi-gram analyses for a set of languages; analyzing, by a processor, the string of characters based on the training data, wherein the analyzing includes extracting a set of multi-grams from the string of characters and comparing the extracted set of multi-grams with the training data; detecting the language of the IDN based on results of the analyzing. In some embodiments, the method further comprises comparing the detected language of the IDN with a user selected language and using the IDN to generate a domain name, if the comparing indicates that the detected language of the IDN is consistent with the user selected language.

Abstract: Embodiments hereof relate to a delivery system for a transcatheter valve prosthesis, the delivery system having an integral centering mechanism to circumferentially center both the delivery system and the valve prosthesis within a vessel at the target implantation site. The centering mechanism may include expandable wings that may be selectively aligned with openings formed through a sidewall of an outer shaft of the delivery system, a coiled wing that may be selectively exposed through an opening formed through a sidewall of an outer shaft of the delivery system, a plurality of elongated filaments extending through a plurality of lumens of an outermost shaft of the delivery system that may be selectively deployed or expanded, an outer shaft that includes at least one pre-formed deflection segment formed thereon, a tool having a deployable lever arm, and/or a plurality of loops deployable via simultaneous longitudinal and rotational movement.

Abstract: Generally, an airline operations computing system accomplishes rule checking in an efficient and useful manner and provides functionality that allows multiple different users to accomplish schedule changes in a manner that minimizes conflicts between different schedulers. In addition, an airline operations computing system includes a common rules engine that is used by multiple different optimizer and decision support systems of the airline operations computing system.

Abstract: Provided herein are small molecule triazolothienopyrimidine compounds that inhibit urea transport activity of solute transporters, particularly the UT-B transporter. The compounds described herein are useful for increasing solute clearance in states of fluid overload and for treating refractory edema associated with cardiovascular, renal, and metabolic diseases, disorders, and conditions.

Abstract: A delivery device for implanting a prosthetic heart valve. The device includes an inner shaft assembly, an outer sheath and a connector assembly. The inner shaft assembly defines a guide wire lumen. The outer sheath is slidably received over the inner shaft assembly, and forms an exit port proximate a distal end thereof. The connector assembly establishes a guide wire passageway between the guide wire lumen and the exit port. The connector assembly is configured to permit sliding movement of the outer sheath relative to the inner shaft assembly when deploying the prosthetic heart valve. The connector assembly can include first and second tubes that are slidable relative to one another in facilitating movement of the outer sheath relative to the inner shaft assembly.

Abstract: Methods and systems for automated language detection for domain names are disclosed. In some embodiments, a method for detecting a language of an Internationalized Domain Name (IDN) comprises receiving, by an I/O interface, a string of characters for the IDN; receiving training data, including a plurality of multi-gram analysis for a set of languages; analyzing, by a processor, the string of characters based on the training data, wherein the analyzing includes extracting a set of multi-grams from the string of characters and comparing the extracted set of multi-grams with the training data; detecting the language of the IDN based on results of the analyzing. In some embodiments, the method further comprises comparing the detected language of the IDN with a user selected language and using the IDN to generate a domain name, if the comparing indicates that the detected language of the IDN is consistent with the user selected language.

Abstract: The invention features modular implantable ventricular assist devices configured to be, at least in part, assembled within a patient. The devices generally include a pump assembly and an expandable frame. The frame is configured to engage tissue of a patient when implanted. The pump assembly is configured to be operably coupled to the frame when the frame is implanted and in the expanded configuration.

Abstract: A heart valve therapy system including a delivery device and a stented valve. The delivery device includes an outer sheath, an inner shaft, an optional hub assembly, and a plurality of tethers. In a delivery state, a stent frame of the prosthesis is crimped over the inner shaft and maintained in a compressed condition by the outer sheath. The tethers are connected to the stent frame. In a partial deployment state, the outer sheath is at least partially withdrawn, allowing the stent frame to self-expand. Tension in the tethers prevents the stent frame from rapidly expanding and optionally allowing recapture. Upon completion of the stent frame expansion, the tethers are withdrawn.

Abstract: Provided herein are small molecule triazolothienopyrimidine compounds that inhibit urea transport activity of solute transporters, particularly the UT-B transporter. The compounds described herein are useful for increasing solute clearance in states of fluid overload and for treating refractory edema associated with cardiovascular, renal, and metabolic diseases, disorders, and conditions.

Abstract: A pump for use in anal irrigation includes a control unit integrated in the pump. The control unit includes a cylindrical housing element and a valve element fitted in the housing. The valve element and the housing element are adapted for rotating with respect to each other between a position allowing the pump to pump air into a balloon, a position allowing the pump to pump air into a reservoir bag and an evacuation position. The control unit is actuated by a handle attached to the rotatable valve element. The handle extends radially out from the rotatable valve element and the cylindrical housing.

Abstract: A system includes a medical device for implanting in a valve of a subject, the implantable medical device having a self-expanding frame; and a holder configured to retain the frame of the implantable medical device in a constricted configuration and to control expansion of the frame. The holder has a controllably constrictable and expandable loop, wherein the loop is disposed about at least a portion of the self-expanding frame such that constriction or expansion of the first loop controls constriction or expansion of the frame.

Abstract: Method and system for routing EPP requests over a network are provided. A routing system includes multiple frontend service interfaces, one or more gateways, a management server, and a backend service platform that provides multiple application services. The frontend service interfaces are addressable using virtual IP addresses (“VIP”) and can be provided by the gateways. The routing system defines a many-to-many mapping between the frontend service interfaces and a set of services provided by the backend service platform. A requestor can send a request over EPP to a targeted service interface to access one or more backend services, by sending the request to a target IP or domain name that corresponds to a VIP associated with the targeted service interface. Using the many-to-many mapping and the VIP of the targeted service interface, the routing system can identify backend services sought by the request and provide the requestor with access to the backend services.