Abstract: Disclosed herein are viewing systems configured for viewing an image of a biological object illuminated with light and a viewing device (e.g., loupes, glasses, etc.) and methods for operation thereof. The viewing device comprises a plurality of viewing modes: a white light mode, a fluorescent light mode, and an overlay mode, and a shutter that opens and closes in accordance with the viewing mode. An overlay image is an image of the biological object when the biological object is illuminated with both white light and fluorescent light, causing the overlay image to be an overlay of the white light image and the fluorescent light image. The disclosed systems and methods allow a user (e.g., a surgeon, medical staff, etc.) to preserve the ergonomics offered by eyewear while providing fluorescent viewing capabilities, particularly with visible fluorescent dyes.

Abstract: A method for multi-link wireless transmission of medical images includes establishing a wireless communication connection between a medical data source and a medical data sink, the wireless communication connection comprising a first wireless communication link and a second wireless communication link; transmitting the medical images from the medical data source to the medical data sink via the wireless communication connection, wherein the medical images are transmitted via the first wireless communication link and the second wireless communication link; determining data loss over the first wireless communication link; and reconstructing at least one of the medical images using data transmitted via the second wireless communication link to correct for the data loss over the first wireless communication link.

Abstract: The present invention generally relates to medical imaging, and more specifically to transmitting and tracking the transmission of medical image data and associated metadata. An exemplary method for transmitting and tracking the transmission of medical image data from a first device to a second device comprises receiving, at the first device, a video frame and frame-specific metadata; in response to receiving the video frame and the frame-specific metadata, generating, at the first device, device identification data of the first device; generating a set of one or more data structures in accordance with a predefined data specification, wherein the set of one or more data structures comprises the frame-specific metadata and the device identification data; and transmitting, by the first device, the set of one or more data structures along with the video frame to the second device.

Abstract: The present disclosure relates to system architectures for real-time processing and displaying of medical imaging data with no or reduced latency. An exemplary system for generating a video of a surgery can comprise: a processor configured to execute a plurality of instructions for a machine-learning model stored on a memory and a programmable circuit communicatively coupled with the processor. The programmable circuit is programmed to: receive surgical video data comprising a current frame; provide data related to the current frame to the processor; receive overlay data generated by the machine-learning model based on a previous frame captured before the current frame; generate, by a mixer of the programmable circuit, a composite frame based on the current frame and the overlay data; and output the composite frame for display as a part of the video of the surgery.

Abstract: Techniques for fluorescence imaging are provided. A tissue region comprising a target fluorophore is illuminated with an excitation light in a wavelength range of 380-490 nm. First image data of the tissue is captured at an image sensor, wherein the first image comprises an autofluorescence contribution from the tissue and a fluorescence emission contribution from the target fluorophore, wherein the first image data comprises red channel data and green channel data. A corrected fluorescence image is generated, based on the first image data, wherein generating the fluorescence image comprises subtracting a second component based on one of the green channel data or the red channel data from a first component based on the other of the green channel data or the red channel data.

Abstract: An exemplary system for acquiring surgical imaging data comprises a surgical imaging device for generating Pulse Amplitude Modulation (PAM)-encoded surgical imaging data, wherein the PAM-encoded surgical imaging data comprises a plurality of pulses, and each pulse of the plurality of pulses is configured to have one of more than two amplitude levels; an imaging processor for receiving data corresponding to the PAM-encoded surgical imaging data; and a galvanic isolation component between the surgical imaging device and the imaging processor.

Abstract: The present disclosure relates to techniques for imaging tissue of a subject. An exemplary method comprises transitioning the liquid crystal light shutter to the closed state to prevent the global shutter imager from receiving visible light; illuminating the tissue of the subject with the fluorescence excitation illumination source to accumulate charge at a plurality of pixels of the global shutter imager, while the liquid crystal light shutter is in the closed state; reading a set of accumulated charge at the plurality of pixels of the global shutter imager to produce a set of imaging data; and generating a fluorescence image frame based on the set of imaging data.

Abstract: An exemplary method of imaging tissue of a subject using a rolling shutter imager to provide a video stream comprises: sequentially resetting a plurality of rows of pixels of the rolling shutter imager from a first row to a last row; transitioning a liquid crystal shutter from a closed state to an open state; after the liquid crystal shutter is transitioned into the open state and after resetting the last row, illuminating the tissue of the subject with an illumination light for an illumination period to accumulate charge at the plurality of rows of pixels, and after the illumination period ends, sequentially reading the accumulated charge at the rows of pixels from the first row to the last row; generating an image frame from the sequentially read accumulated charge at the plurality of rows of pixels; and adding the image frame to the video stream.

Abstract: The present disclosure relates to techniques for imaging tissue of a subject. An exemplary method comprises transitioning a (liquid crystal) light shutter to an open state to allow reflected light from illuminating the tissue of the subject with a visible-light illumination source to accumulate charge at a plurality of rows of pixels of an imager; transitioning the light shutter to a closed state to prevent the imager from receiving visible light; during a first readout period, reading accumulated charge to produce a first set of imaging data; while the light shutter is in the closed state, illuminating the tissue of the subject with a fluorescence excitation illumination source; during a second readout period after the first readout period, reading accumulated charge to produce a second set of imaging data; and generating image frames based on the first set of imaging data and the second set of imaging data.

Abstract: An exemplary method of imaging tissue of a subject using a rolling shutter imager to provide a video stream comprises: sequentially resetting a plurality of rows of pixels of the rolling shutter imager from a first row to a last row; transitioning a liquid crystal shutter from a closed state to an open state; after the liquid crystal shutter is transitioned into the open state and after resetting the last row, illuminating the tissue of the subject with an illumination light for an illumination period to accumulate charge at the plurality of rows of pixels, and after the illumination period ends, sequentially reading the accumulated charge at the rows of pixels from the first row to the last row; generating an image frame from the sequentially read accumulated charge at the plurality of rows of pixels; and adding the image frame to the video stream.

Abstract: An exemplary method of imaging tissue of a subject using a rolling shutter imager to provide a video stream comprises: sequentially resetting a plurality of rows of pixels of the rolling shutter imager from a first row to a last row; transitioning a liquid crystal shutter from a closed state to an open state; after the liquid crystal shutter is transitioned into the open state and after resetting the last row, illuminating the tissue of the subject with an illumination light for an illumination period to accumulate charge at the plurality of rows of pixels, and after the illumination period ends, sequentially reading the accumulated charge at the rows of pixels from the first row to the last row; generating an image frame from the sequentially read accumulated charge at the plurality of rows of pixels; and adding the image frame to the video stream.

Abstract: A system for processing and displaying medical imaging data onto an electronic display is configured to: access a plurality of data portions corresponding to a frame of the one or more video frames stored in memory; process the plurality of data portions using a single instruction multiple data (SIMD) processing architecture such that each data portion of the plurality of data portions is separately processed in parallel using one or more common instructions; and transmit the processed plurality of data portions to an electronic display; and a second processor, wherein the second processor is communicatively coupled to the first processor, and wherein the second processor is configured to coordinate one or more operations of the first processor.

Abstract: Disclosed herein are viewing systems configured for viewing an image of a biological object illuminated with light and a viewing device (e.g., loupes, glasses, etc.) and methods for operation thereof. The viewing device comprises a plurality of viewing modes: a white light mode, a fluorescent light mode, and an overlay mode, and a shutter that opens and closes in accordance with the viewing mode. An overlay image is an image of the biological object when the biological object is illuminated with both white light and fluorescent light, causing the overlay image to be an overlay of the white light image and the fluorescent light image. The disclosed systems and methods allow a user (e.g., a surgeon, medical staff, etc.) to preserve the ergonomics offered by eyewear while providing fluorescent viewing capabilities, particularly with visible fluorescent dyes.

Abstract: An exemplary method of imaging tissue of a subject using a rolling shutter imager to provide a video stream comprises: sequentially resetting a plurality of rows of pixels of the rolling shutter imager from a first row to a last row; transitioning a liquid crystal shutter from a closed state to an open state; after the liquid crystal shutter is transitioned into the open state and after resetting the last row, illuminating the tissue of the subject with an illumination light for an illumination period to accumulate charge at the plurality of rows of pixels, and after the illumination period ends, sequentially reading the accumulated charge at the rows of pixels from the first row to the last row; generating an image frame from the sequentially read accumulated charge at the plurality of rows of pixels; and adding the image frame to the video stream.

Abstract: The present disclosure relates to system architectures for real-time processing and displaying of medical imaging data with no or reduced latency. An exemplary system for generating a video of a surgery can comprise: a processor configured to execute a plurality of instructions for a machine-learning model stored on a memory and a programmable circuit communicatively coupled with the processor. The programmable circuit is programmed to: receive surgical video data comprising a current frame; provide data related to the current frame to the processor; receive overlay data generated by the machine-learning model based on a previous frame captured before the current frame; generate, by a mixer of the programmable circuit, a composite frame based on the current frame and the overlay data; and output the composite frame for display as a part of the video of the surgery.

Abstract: A device for providing reference information in laser speckle medical imaging of tissue of a subject can include a support that includes a marker for image recognition and a speckle target region that is nontransparent to light in a first illumination wavelength range and that generates a speckle pattern when illuminated with light in the first wavelength range. The support can be configured to be attachable to tissue of the subject.

Abstract: A device for providing reference information in laser speckle medical imaging of tissue of a subject can include a support that includes a marker for image recognition and a speckle target region that is nontransparent to light in a first illumination wavelength range and that generates a speckle pattern when illuminated with light in the first wavelength range. The support can be configured to be attachable to tissue of the subject.

Abstract: An exemplary method of imaging tissue of a subject using a rolling shutter imager to provide a video stream comprises: sequentially resetting a plurality of rows of pixels of the rolling shutter imager from a first row to a last row; transitioning a liquid crystal shutter from a closed state to an open state; after the liquid crystal shutter is transitioned into the open state and after resetting the last row, illuminating the tissue of the subject with an illumination light for an illumination period to accumulate charge at the plurality of rows of pixels, and after the illumination period ends, sequentially reading the accumulated charge at the rows of pixels from the first row to the last row; generating an image frame from the sequentially read accumulated charge at the plurality of rows of pixels; and adding the image frame to the video stream.

Abstract: A device for providing reference information in laser speckle medical imaging of tissue of a subject can include a support that includes a marker for image recognition and a speckle target region that is nontransparent to light in a first illumination wavelength range and that generates a speckle pattern when illuminated with light in the first wavelength range. The support can be configured to be attachable to tissue of the subject.

Abstract: Methods and systems for imaging tissue of a subject are disclosed, and involve illuminating the tissue with a coherent light having a coherent wavelength, acquiring image data of the tissue using a color image sensor, and processing the image data using laser speckle contrast analysis while correcting for differences in sensitivity of color pixels at the coherent wavelength to generate a perfusion image of the tissue. The perfusion image is then displayed to the user. Also disclosed are methods and systems for correcting for ambient light and for acquiring white light images along with laser speckle images.