Patents by Inventor Marc Bohner
Marc Bohner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11377352Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH), the granules comprising interconnected pores with a minimum mean diameter of 3 microns, to a first incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; (b) subjecting the granules to a second incubation in an alkaline aqueous solution having a pH-value of more than 10 and optionally PO43? ions; (c) filtering and drying the obtained porous granules of calcium deficient hydroxyapatite; and wherein (d) the sum of the amounts of PO43? ions present in the first and second incubation is at least as large as the amount of SO42? ions of the granules used for step (a).Type: GrantFiled: October 16, 2018Date of Patent: July 5, 2022Assignees: Bioventus, LLC, Mathys AG BettlachInventors: Alex De Gasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
-
Patent number: 10807869Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) to an incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; whereby the granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) comprise interconnected pores with a minimum mean diameter of 3 microns; (b) washing with water the granules obtained after incubation of step a); (c) drying the obtained porous granules of calcium deficient hydroxyapatite; whereby (d) the amount-of PO43? ions present in the incubation of step a) is at least as large as the amount of SO42? ions of the granules used for step (a).Type: GrantFiled: October 4, 2018Date of Patent: October 20, 2020Assignees: Mathys AG Bettlach, Bioventus, LLCInventors: Alex De Gasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
-
Publication number: 20190047862Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH), the granules comprising interconnected pores with a minimum mean diameter of 3 microns, to a first incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; (b) subjecting the granules to a second incubation in an alkaline aqueous solution having a pH-value of more than 10 and optionally PO43? ions; (c) filtering and drying the obtained porous granules of calcium deficient hydroxyapatite; and wherein (d) the sum of the amounts of PO43? ions present in the first and second incubation is at least as large as the amount of SO42? ions of the granules used for step (a).Type: ApplicationFiled: October 16, 2018Publication date: February 14, 2019Inventors: Alex De Gasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
-
Publication number: 20190031511Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) to an incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; whereby the granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) comprise interconnected pores with a minimum mean diameter of 3 microns; (b) washing with water the granules obtained after incubation of step a); (c) drying the obtained porous granules of calcium deficient hydroxyapatite; whereby (d) the amount-of P43? ions present in the incubation of step a) is at least as large as the amount of SO42? ions of the granules used for step (a).Type: ApplicationFiled: October 4, 2018Publication date: January 31, 2019Inventors: Alex De Gasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
-
Patent number: 10150672Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) to an incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; whereby the granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) comprise interconnected pores with a minimum mean diameter of 3 microns; (b) washing with water the granules obtained after incubation of step a); (c) drying the obtained porous granules of calcium deficient hydroxyapatite; whereby (d) the amount-of PO43? ions present in the incubation of step a) is at least as large as the amount of SO42? ions of the granules used for step (a).Type: GrantFiled: June 22, 2015Date of Patent: December 11, 2018Assignee: Bioventus, LLC.Inventors: Alex DeGasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
-
Patent number: 10131543Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH), the granules comprising interconnected pores with a minimum mean diameter of 3 microns, to a first incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; (b) subjecting the granules to a second incubation in an alkaline aqueous solution having a pH-value of more than 10 and optionally PO43? ions; (c) filtering and drying the obtained porous granules of calcium deficient hydroxyapatite; and wherein (d) the sum of the amounts of PO43? ions present in the first and second incubation is at least as large as the amount of SO42? ions of the granules used for step (a).Type: GrantFiled: June 23, 2014Date of Patent: November 20, 2018Assignees: Bioventus, LLC., Mathys AG BettlachInventors: Alex DeGasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
-
Patent number: 9907654Abstract: The invention relates to a bone substitute (1) comprising A) a container (2) made of a porous casing (4) which is at least partly provided with openings; and B) a plurality of filler elements (5) which are not connected to one another and which are enclosed in the container (2); wherein C) the filler elements (5) consist of interconnected particles with an average diameter Dp; and D) the openings of the casing (4) are interconnected pores or channels with an average diameter of DM.Type: GrantFiled: December 11, 2012Date of Patent: March 6, 2018Assignee: Dr. H.C. Robert Mathys StiftungInventors: Andre Butscher, Marc Bohner, Nicola Döbelin
-
Publication number: 20170197833Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) to an incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; whereby the granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) comprise interconnected pores with a minimum mean diameter of 3 microns; (b) washing with water the granules obtained after incubation of step a); (c) drying the obtained porous granules of calcium deficient hydroxyapatite; whereby (d) the amount-of PO43? ions present in the incubation of step a) is at least as large as the amount of SO42? ions of the granules used for step (a).Type: ApplicationFiled: June 22, 2015Publication date: July 13, 2017Inventors: Alex De Gasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
-
Publication number: 20170158510Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH), the granules comprising interconnected pores with a minimum mean diameter of 3 microns, to a first incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; (b) subjecting the granules to a second incubation in an alkaline aqueous solution having a pH-value of more than 10 and optionally PO43? ions; (c) filtering and drying the obtained porous granules of calcium deficient hydroxyapatite; and wherein (d) the sum of the amounts of PO43? ions present in the first and second incubation is at least as large as the amount of SO42? ions of the granules used for step (a).Type: ApplicationFiled: June 23, 2014Publication date: June 8, 2017Inventors: Alex De Gasparo, Noemie Van Garderen, Marc Bohner
-
Patent number: 9611173Abstract: A calcium phosphate cement composition that includes the following two components: A) one or several calcium phosphate powders suspended in an aqueous solution including inhibitor cations inhibiting a reaction of the calcium phosphate powders with water, the inhibitor cations being selected from Mg2+, Sr2+ and Ba2+ at a concentration greater than 0.01 M; and B) an aqueous solution including Ca2+ cations at a concentration greater than 0.1 M. This calcium phosphate cement compositions can be safely stored for years yet still retain its full reactivity when mixed.Type: GrantFiled: April 22, 2013Date of Patent: April 4, 2017Assignee: Mathys AG BettlachInventors: Nicola Döbelin, Hanna Tiainen, Marc Bohner
-
Publication number: 20160075599Abstract: A calcium phosphate cement composition that includes the following two components: A) one or several calcium phosphate powders suspended in an aqueous solution including inhibitor cations inhibiting a reaction of the calcium phosphate powders with water, the inhibitor cations being selected from Mg2+, Sr2+ and Ba2+ at a concentration greater than 0.01 M; and B) an aqueous solution including Ca2+ cations at a concentration greater than 0.1 M. This calcium phosphate cement compositions can be safely stored for years yet still retain its full reactivity when mixed.Type: ApplicationFiled: April 22, 2013Publication date: March 17, 2016Inventors: Nicola Döbelin, Hanna Tiainen, Marc Bohner
-
Patent number: 9205174Abstract: A bone graft substitute in the form of an implantable three-dimensional scaffold that includes calcium phosphate and has pores. The scaffold is impregnated with a calcium and/or phosphate containing substance, and the dissolution rate DRS of the scaffold is slower than the dissolution rate DRD of the calcium and/or phosphate containing substance.Type: GrantFiled: May 21, 2014Date of Patent: December 8, 2015Assignee: MATHYS AG BETTLACHInventors: Marc Bohner, Reto Luginbühl
-
Publication number: 20150297349Abstract: The invention relates to a bone substitute (1) comprising A) a container (2) made of a porous casing (4) which is at least partly provided with openings; and B) a plurality of filler elements (5) which are not connected to one another and which are enclosed in the container (2); wherein C) the filler elements (5) consist of interconnected particles with an average diameter DP; and D) the openings of the casing (4) are interconnected pores or channels with an average diameter of DM.Type: ApplicationFiled: December 11, 2012Publication date: October 22, 2015Inventors: Andre BUTSCHER, Marc BOHNER, Nicola DOBELIN
-
Patent number: 9125966Abstract: The bone repair material comprises the following components: A) a first granular component with a diameter larger than 20 ?m chosen from the group of: calcium phosphate, calcium pyrophosphate, or calcium sulfate dihydrate; B) a second component chosen from the group of apatite powder with a particle diameter smaller than 1 ?m, (preferably smaller than 100 nm); and B) a third component comprising water or an aqueous solution, whereby C) the volume fraction of the second and third component represents at least 35 volume-% of the total bone repair material.Type: GrantFiled: November 15, 2005Date of Patent: September 8, 2015Assignees: DR. H.C. ROBERT MATHYS STIFTUNG, DEPUY SYNTHES PRODUCTS, INC.Inventors: Marc Bohner, Andrea Montali, Yvonne Bruderer
-
Patent number: 9050390Abstract: A kneadable and moldable bone-replacement material includes a mixture of calcium-containing ceramic particles and a hydrogel or a substance which can be swelled into a hydrogel. The ceramic particles are of fully synthetic origin and the individual ceramic particles have a structure which is at least partially cohesive and porous. In addition, the majority of the ceramic particles have a non-spheric shape.Type: GrantFiled: December 9, 2013Date of Patent: June 9, 2015Assignee: DePuy Synthes Products, LLCInventors: Giancarlo Rizzoli, Thierry Stoll, Reto Luginbuhl, Marc Bohner
-
Publication number: 20140257514Abstract: A bone graft substitute in the form of an implantable three-dimensional scaffold that includes calcium phosphate and has pores. The scaffold is impregnated with a calcium and/or phosphate containing substance, and the dissolution rate DRS of the scaffold is slower than the dissolution rate DRD of the calcium and/or phosphate containing substance.Type: ApplicationFiled: May 21, 2014Publication date: September 11, 2014Applicant: Mathys AG BettlachInventors: Marc Bohner, Reto Luginbühl
-
Publication number: 20140093571Abstract: A kneadable and moldable bone-replacement material includes a mixture of calcium-containing ceramic particles and a hydrogel or a substance which can be swelled into a hydrogel. The ceramic particles are of fully synthetic origin and the individual ceramic particles have a structure which is at least partially cohesive and porous. In addition, the majority of the ceramic particles have a non-spheric shape.Type: ApplicationFiled: December 9, 2013Publication date: April 3, 2014Inventors: Giancarlo Rizzoli, Thierry Stoll, Reto Luginbuhl, Marc Bohner
-
Patent number: 8603184Abstract: A kneadable and moldable bone-replacement material includes a mixture of calcium-containing ceramic particles and a hydrogel or a substance which can be swelled into a hydrogel. The ceramic particles are of fully synthetic origin and the individual ceramic particles have a structure which is at least partially cohesive and porous. In addition, the majority of the ceramic particles have a non-spheric shape.Type: GrantFiled: April 2, 2003Date of Patent: December 10, 2013Assignee: DePuy Synthes Products, LLCInventors: Giancarlo Rizzoli, Thierry Stoll, Reto Luginbuehl, Marc Bohner
-
Publication number: 20120330436Abstract: A bone graft substitute in the form of an implantable three-dimensional scaffold that includes calcium phosphate and has pores. The scaffold is impregnated with a calcium and/or phosphate containing substance, and the dissolution rate DRS of the scaffold is slower than the dissolution rate DRD of the calcium and/or phosphate containing substance.Type: ApplicationFiled: March 9, 2010Publication date: December 27, 2012Applicant: MATHYS AG BETTLACHInventors: Marc Bohner, Reto Luginbuhl
-
Patent number: 8287641Abstract: Calcium phosphate particles having A) a specific surface area (SSA) larger than 0.1 m2/g; B) a mean diameter smaller than 5 mm; C) a Ca/P molar ratio superior to 0.95; and wherein D) said particles have been subjected as a last processing step to a heat treatment at a temperature superior to 400° C. for a period of time such that the specific surface area (SSA) of said particles after the heat treatment is not decreased by more than 10% compared to the SSA before said heat treatment.Type: GrantFiled: May 2, 2008Date of Patent: October 16, 2012Assignee: Dr. H.C. Robert Mathys StiftungInventor: Marc Bohner