Patents by Inventor Marc Bohner
Marc Bohner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110041735Abstract: Calcium phosphate particles having A) a specific surface area (SSA) larger than 0.1 m2/g; B) a mean diameter smaller than 5 mm; C) a Ca/P molar ratio superior to 0.95; and wherein D) said particles have been subjected as a last processing step to a heat treatment at a temperature superior to 400° C. for a period of time such that the specific surface area (SSA) of said particles after the heat treatment is not decreased by more than 10% compared to the SSA before said heat treatment.Type: ApplicationFiled: May 2, 2008Publication date: February 24, 2011Applicant: DR. H.C. ROBERT MATHYS STIFTUNGInventor: Marc Bohner
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Publication number: 20110034391Abstract: The shaped article is obtained via a cementitious reaction of a particulate composition reactive with water, whereby said reaction is obtained between said composition and an aqueous, liquid or gaseous phase. The particles of the shaped article are present in the form of interlocked particles, whereby the interlocking of said particles is obtained in a 100% water-saturated atmosphere.Type: ApplicationFiled: October 18, 2010Publication date: February 10, 2011Applicants: DR. H.C. ROBERT MATHYS STIFTUNG, SYNTHES GMBHInventors: Marc Bohner, Anna Malsy
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Publication number: 20100055018Abstract: The method relates to the production of essentially pyrogene-free calcium phosphate starting from one or more calcium phosphate educts having a Ca/P molar ratio in the range of 1.00 to 2.00 and being formed in a pre-determined shape which remains essentially the same during the following procedural steps: A) transforming said educt(s) at least partly to beta-tricalcium phosphate (?-TCP), alpha-tricalcium phosphate (?-TCP), tetracalciumphosphate.(TetCP) or a mixture thereof at a temperature above 600° C.; B) cooling down the material obtained in step A with said ?-TCP, ?-TCP, TetCP or a mixture thereof to below 600° C.; C) reacting the material obtained in step B with said ?-TCP, ?-TCP, TetCP or a mixture thereof with water in gas or liquid phase or in an aqueous Solution at a temperature above room temperature to obtain an end-product which is essentially pyrogene-free.Type: ApplicationFiled: April 13, 2007Publication date: March 4, 2010Applicant: DR. H.C. ROBERT MATHYS STIFTUNGInventor: Marc Bohner
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Patent number: 7670419Abstract: A hydraulic cement based on calcium phosphate for surgical use comprising A) a first component comprising powder particles of calcium phosphate; and B) a second component comprising water. The calcium phosphate comprises anhydrous, amorphous calcium phosphate (ACP) and the ACP is obtained by milling a calcium phosphate synthesized above 500° C. The cement according to the invention has the advantage of being very fast setting compared to prior art calcium phosphate cements. The setting reaction is finished much faster although the initial part of the reaction proceeds at the same speed as with known cements.Type: GrantFiled: March 8, 2004Date of Patent: March 2, 2010Assignee: Dr. H.C. Robert Mathys StiftungInventor: Marc Bohner
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Publication number: 20090220475Abstract: The bone repair material comprises the following components: A) a first granular component with a diameter larger than 20 ?m chosen from the group of: calcium phosphate, calcium pyrophosphate, or calcium sulfate dihydrate; B) a second component chosen from the group of apatite powder with a particle diameter smaller than 1 ?m, (preferably smaller than 100 nm); and B) a third component comprising water or an aqueous solution, whereby C) the volume fraction of the second and third component represents at least 35 volume-% of the total bone repair material.Type: ApplicationFiled: November 15, 2005Publication date: September 3, 2009Applicants: DR. H.C. ROBERT MATHYS STIFTUNG, SYNTHES GMBHInventors: Marc Bohner, Andrea Montali, Yvonne Bruderer
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Publication number: 20090028954Abstract: The precursor is used for the preparation of a pasty bone replacement material by admixture of a liquid. The precursor comprises a biocompatible substance swellable by the action of water or of an aqueous solution thereby forming a hydrogel; and solid particles made of a substance which is suitable as a bone replacement material. The swellable substance is in the form of discrete particles having a mean dimension in the range of 18 ?m to 2000 ?m.Type: ApplicationFiled: December 22, 2006Publication date: January 29, 2009Applicant: MATHYS AG BETTLACHInventors: Marc Bohner, Giancarlo Rizzoli
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Publication number: 20080206300Abstract: The shaped article is obtained via a cementitious reaction of a particulate composition reactive with water, whereby said reaction is obtained between said composition and an aqueous, liquid or gaseous phase. The particles of the shaped article are present in the form of interlocked particles, whereby the interlocking of said particles is obtained in a 100% water-saturated atmosphere.Type: ApplicationFiled: June 9, 2005Publication date: August 28, 2008Inventors: Marc Bohner, Anna Malsy
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Publication number: 20080208354Abstract: The solid precursor is used for the preparation of a pasty bone replacement material by admixture of a liquid. The precursor comprises calcium-containing ceramic particles and a hydrogel or a substance which can be swelled into a hydrogel; whereby said precursor has been obtained by wet autoclaving and subsequent drying.Type: ApplicationFiled: May 23, 2006Publication date: August 28, 2008Applicant: MATHYS AG BETTLACHInventors: Marc Bohner, Giancarlo Rizzoli
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Patent number: 7393405Abstract: A hydraulic cement is based on calcium phosphate for surgical use, and includes three components. The first component includes ?-tricalcium phosphate powder particles. The second, component includes calcium sulphate dehydrate. The third component includes water. Furthermore the hydraulic cement does not contain more calcium sulfate hemihydrate (CSH) than 10% of the total amount of the calcium sulphate dihydrate (CSD).Type: GrantFiled: May 13, 2003Date of Patent: July 1, 2008Inventor: Marc Bohner
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Publication number: 20070233149Abstract: The invention relates to an injection device (1), especially for bone cement, comprising A) a syringe base (3) having a longitudinal axis (2), a front end (6), a connecting piece (8) disposed on the front end (6) and having a coaxial bore (21), and a coaxial cavity (4); B) an injection plunger (5), coaxially displaceable in the cavity (4); and C) a cannula (13) which can be linked with the connecting piece (8) and which has a center bore (14) and a rear end (15). The injection device is characterized in that D) the syringe base (3), on its front end (6), has a transition segment (22) having a bore (9) linking the cavity (4) with the bore (21) in the connecting piece (8), E) the bore (9) in the transition segment (22) and the center bore (14), at least on the rear end (15) of the cannula (13), having the same orthogonal cross-sectional area q relative to the longitudinal axis (2).Type: ApplicationFiled: February 6, 2004Publication date: October 4, 2007Applicant: DR. H. C. ROBERT MATHYS STIFTUNGInventors: Marc Bohner, Paul Heini
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Publication number: 20070186818Abstract: A hydraulic cement based on calcium phosphate for surgical use comprising A) a first component comprising powder particles of calcium phosphate; and B) a second component comprising water. The calcium phosphate comprises anhydrous, amorphous calcium phosphate (ACP) and the ACP is obtained by milling a calcium phosphate synthesized above 500° C. The cement according to the invention has the advantage of being very fast setting compared to prior art calcium phosphate cements. The setting reaction is finished much faster although the initial part of the reaction proceeds at the same speed as with known cements.Type: ApplicationFiled: March 8, 2004Publication date: August 16, 2007Applicant: DR. H.C. ROBERT MATHYS STIFTUNGInventor: Marc Bohner
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Publication number: 20060041033Abstract: An injectable mixture for substituting bone tissue in situ comprises: A) a two-component powder/liquid bone cement which upon mixing forms a self-hardening cement paste; and B) a third component consisting of a liquid which essentially is non-miscible with the cement paste and which is suitable to be washed out after hardening of said mixture in situ, resulting in a porous bone substituting material; and C) an X-ray contrast agent which is an organic substance. The injectable bone substitute material for bone augmentation has adaptable mechanical properties, an optimal radio-opacity without any inorganic X-ray contrast agent and therefore good biocompatibility.Type: ApplicationFiled: August 12, 2005Publication date: February 23, 2006Inventors: Adrian Bisig, Marc Bohner, Erich Schneider
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Publication number: 20050241535Abstract: A hydraulic cement is based on calcium phosphate for surgical use, and includes three components. The first component includes ?-tricalcium phosphate powder particles. The second component includes calcium sulphate dehydrate. The third component includes water. Furthermore the hydraulic cement does not contain more calcium sulfate hemihydrate (CSH) than 10% of the total amount of the calcium sulphate dihydrate (CSD).Type: ApplicationFiled: May 13, 2003Publication date: November 3, 2005Applicant: DR. H.C. ROBERT MATHYS STIFTUNDInventor: Marc Bohner
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Publication number: 20050124720Abstract: A kneadable and moldable bone-replacement material includes a mixture of calcium-containing ceramic particles and a hydrogel or a substance which can be swelled into a hydrogel. The ceramic particles are of fully synthetic origin and the individual ceramic particles have a structure which is at least partially cohesive and porous. In addition, the majority of the ceramic particles have a non-spheric shape.Type: ApplicationFiled: April 2, 2003Publication date: June 9, 2005Applicant: Mathys Medizinaltechnik AGInventors: Giancarlo Rizzoli, Thierry Stoll, Reto Luginbuhl, Marc Bohner
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Patent number: 6733582Abstract: A brushite cement for surgical purposes includes a first component including a basic calcium phosphate, a second component including an acidic phosphate, a third component including water, and a fourth component including a source of magnesium used to stabilize an end-product of the setting reaction between the components. The solubility of the source of magnesium is smaller than 100 g/L. The components are chosen in such an amount that (i) the pH of the cement past during setting is lower than 6.0; and (ii) the end-product of the setting reaction comprises dicalcium phosphate dihydrate.Type: GrantFiled: July 2, 2002Date of Patent: May 11, 2004Assignees: Dr. H. C. Robert Mathys Stiftung, Stratec Medical AGInventors: Marc Bohner, Sandro Matter
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Patent number: 6642285Abstract: A composition including a hydraulic cement for implantation in a human or animal body. The hydraulic cement includes a first component, a second component, and a third component. The first component includes a calcium source while the second component includes water. The third component is a hydrophobic liquid. The composition hardens after mixing of the components, and results in a cement with open macroporosity enabling a rapid bone ingrowth.Type: GrantFiled: July 19, 2001Date of Patent: November 4, 2003Assignees: Stratec Medical AGInventor: Marc Bohner
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Patent number: 6425949Abstract: The cement for surgical purposes includes three components. The first component includes beta tertiary calciumphosphate &bgr;-Ca3(PO4)2(&bgr;-TCP) particles; and monocalcium phosphate Ca(H2PO4)2(MCPA) or monocalcium phosphate monohydrate Ca(H2PO4).H2O (MCPM) particles or phosphoric acid. The second component includes water. The third component includes particles having an average diameter which is larger than the average diameter of the beta tertiary calciumphosphate &bgr;-Ca3(PO4)2(&bgr;-TCP) particles of the first component. Upon mixing of the three components a hardened mass comprising brushite CaHPO4.2H2O (DCPD) is formed. The &bgr;-TCP particles have a specific surface area of less than 10,000 m2/g and a Ca/P atomic ratio different from 1.50. The component constitutes 1 to 99 volume-percent of the hardened mass.Type: GrantFiled: July 7, 2000Date of Patent: July 30, 2002Assignees: Dr. H. C. Robert Mathys Stiftung, Stratec Medical AGInventors: Jacques Lemaitre, Marc Bohner, Pascale Van Landuyt