Abstract: Methods and compositions are described herein that inhibit FAK/ATK interactions. Such methods and compositions are useful for inhibiting cell adhesion and cancer metastasis.

Abstract: Exemplary embodiments of the present disclosure include apparatus and methods to identify endometrial tissue.

Abstract: A system for testing functionality of die on a wafer including a plurality of contacts includes a support structure and a plurality of probes mounted to the support structure in an array. A configuration of each of the plurality of probes varies based on a position of the probe within the array to maintain uniform engagement between the plurality of probes and a corresponding plurality of contacts across the array.

Abstract: A liquid indicating article is disclosed. It can have a single layer, but generally will have at least two layers bonded together, wherein a visible layer masks a second colored layer and the visible layer becomes at least semitransparent when wet.

Abstract: A multilayer optical adhesive including a first viscoelastic or elastomeric adhesive layer and a second viscoelastic or elastomeric adhesive layer. A crosslinked or soluble resin layer may be disposed between the first viscoelastic or elastomeric adhesive layer and the second viscoelastic or elastomeric adhesive layer or the first viscoelastic or elastomeric adhesive layer may be immediately adjacent to the second viscoelastic or elastomeric adhesive layer. An interface between immediately adjacent layers is structured and there is a difference in refractive indices across the interface.

Abstract: An eye treatment positions a mask device over first and second eyes. A posterior side of the mask device is proximate to the face and the anterior side is distal from the face. The mask device includes an outer wall extending between the anterior and posterior sides and defining a chamber extending across the first and second eyes. The anterior side includes a first transmission region that allows a photoactivating light for the first eye to be delivered into a first section of the chamber positioned over the first eye. The anterior side includes a second transmission region that allows a photoactivating light for the second eye to be delivered into the second section positioned over the second eye. The system includes at least one gas source storing a gas that is different than ambient air. The system includes a gas delivery system that delivers the gas into the chamber.

Abstract: A wake generator for placement in a wind tunnel between a wind source and a test object includes a first frame member having a first track formed thereon, where the first track has a shape including a first side that is substantially rounded and a second side that is substantially flat. The wake generator may include a mounting plate disposed within a perimeter of the first track, where the mounting plate is rotatable relative to the first frame member about a first axis. The wake generator may allow for better simulation of unsteady turbine wakes that influence cooling flow. The wake generator may also include a plurality of bars slidably engaged to the mounting plate and structurally configured to traverse along the first track when the mounting plate is rotated about the first axis.

Abstract: An apparatus includes an outer bearing member defining a cavity and an inner bearing member disposed within the cavity. The inner bearing member includes a spherical surface and a rod attachment opening defined in the spherical surface. The apparatus also includes an elastomeric material disposed within the cavity adjacent to the spherical surface.

Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.

Abstract: A flexible system capable of utilizing data from different monitoring techniques and capable of providing assistance to patients with diabetes at several scalable levels, ranging from advice about long-term trends and prognosis to real-time automated closed-loop control (artificial pancreas). These scalable monitoring and treatment strategies are delivered by a unified system called the Diabetes Assistant (DiAs) platform. The system provides a foundation for implementation of various monitoring, advisory, and automated diabetes treatment algorithms or methods. The DiAs recommendations are tailored to the specifics of an individual patient, and to the patient risk assessment at any given moment.

Abstract: An example tool includes a housing; an inclined handle coupled to, and extending obliquely from, a top portion of the housing, where the inclined handle has a first trigger button and a second trigger button; and an interlocking mechanism disposed in the inclined handle. The interlocking mechanism is configured to disable one of the first trigger button or the second trigger button while the other of the first trigger button or the second trigger button is triggered.

Abstract: The disclosed apparatus may include (1) at least one alignment pin that (A) is placed proximate to a component on a circuit board and (B) is secured proximate to the component on the circuit board and (2) at least one heatsink that (A) is placed atop the component after completion of a reflow process in which the component is soldered to the circuit board, (B) is aligned by the alignment pin such that the heatsink resides in a specific position atop the component, and (C) absorbs heat dissipated by the component when the component is operational. Various other apparatuses, systems, and methods are also disclosed.

Abstract: An example shearing head includes a first member and a second member being rotatable about a pin. The first member has a shearing surface forming a substantially right angle with a first lateral surface of the first member. The second member has a shearing surface forming a substantially right angle with a second lateral surface of the second member. The second member includes a first distal surface and a second distal surface forming a substantially right angle. The first distal surface and the second distal surface are substantially perpendicular to the second lateral surface. The second member includes a third lateral surface opposing the second lateral surface and a retainer is attached to the second member. A first surface of the retainer contacts the first distal surface, a second surface of the retainer contacts the second distal surface, and the third lateral surface contacts a third surface of the retainer.

Abstract: A liquid indicating article is disclosed. It can have a single layer, but generally will have at least two layers bonded together, wherein a visible layer masks a second colored layer wherein the visible layer is a wicking material that becomes semitransparent when wet, wherein the colored layer is a permeable adhesive that bonds to the mask layer.

Abstract: A cutting head for a power tool. The cutting head includes a first jaw having a first blade mounting surface and a second jaw having a second blade mounting surface. The second jaw is rotatably coupled to the first jaw. The cutting head also includes a first blade removably coupled to the first blade mounting surface of the first jaw and a second blade removably coupled to the second blade mounting surface of the second jaw. A first cutting edge of the first blade is substantially co-planar with a second cutting edge of the second blade. During a cutting action, the first jaw and the second jaw rotate with respect to one another to bring the first cutting edge closer to the second cutting edge.

Abstract: A method, system and related computer program product for tracking the probability of hypoglycemia from routine self-monitoring of blood glucose (SMBG) data in patients with diabetes. A specific bivariate probability distribution of low BG events based jointly on the Low BG Index (LBGI) and the Average Daily Risk Range (ADRR) is used to predict hypoglycemia probability of occurrence from inputted SMBG data. The SMBG data is retrieved from a series of SMBG data of a patient available from the patient's glucose meter and allows tracking of the probability for future hypoglycemia over a predetermined duration, e.g. a 24 or 48 hour period. The tracking includes presentation of visual and/or numerical output, as well as construction of hypoglycemia risk trajectories that would enable warning messages for crossing of predefined thresholds, such as 50% likelihood for upcoming hypoglycemia below 50 mg/dl.

Abstract: A tray for dispensing product containers, particularly yogurt containers, which vary widely in size and shape and frequently are stacked several high. The tray is of adjustable width and of extruded construction. The tray comprises two main components, one forming a bottom part and a high wall, the other forming a bottom part and a low wall. The high wall has a flanged track running lengthwise and the low wall has a T-shaped rail for reception in the flanged track of an adjacent tray. An array of trays are thus connected such that the high wall of one tray serves as a second high wall for an adjacent connected tray while allowing a tray to be pulled forward, supported by its neighbors, for restocking. A pusher and pull strip are provided in which an L-shaped pusher can be reversely oriented and thereby optimized for round or rectangular containers.

Abstract: A simulation environment for in silico testing of monitoring methods, open-loop and closed-loop treatment strategies in type 1 diabetes. Some exemplary principal components of the simulation environment comprise, but not limited thereto, the following: 1) a “population” of in silico “subjects” with type 1 diabetes in three age groups; 2) a simulator of CGM sensor errors; 3) a simulator of insulin pumps and discrete insulin delivery; 4) an interface allowing the input of user-specified treatment scenarios; and 5) a set of standardized outcome measures and graphs evaluating the quality of the tested treatment strategies. These components can be used separately or in combination for the preclinical evaluation of open-loop or closed-loop control treatments of diabetes.

Abstract: A technique for treating diabetes that recognizes patient insulin sensitivity is a time-varying physiological parameter. The described techniques for treating diabetes include measuring interstitial fluid glucose concentration, reading insulin delivery data, determining patient insulin sensitivity based on the interstitial fluid glucose concentration and insulin delivery data, and a time-varying physiological parameter, and dispensing an insulin dose from an insulin delivery device based on the determined patient insulin sensitivity.