Patents by Inventor Marc F. Schwartz

Marc F. Schwartz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression of O-glycosylated therapeutic proteins in prokaryotic microorganisms
    Patent number: 8198045
    Abstract: The invention relates to methods of producing an O-glycosylated soluble therapeutic protein in a prokaryotic microorganism by co-expressing the therapeutic protein and a heterologous glycosyltransferase that transfers a sugar moiety to an amino acid acceptor on the therapeutic protein.
    Type: Grant
    Filed: April 19, 2007
    Date of Patent: June 12, 2012
    Assignee: BioGeneriX AG
    Inventors: Shawn DeFrees, Marc F. Schwartz, Karl Johnson
  • Expression of soluble, active eukaryotic glycosyltransferases in prokaryotic organisms
    Patent number: 8137928
    Abstract: The present invention provides enhanced methods of producing soluble, active eukaryotic glycosyltransferases in prokaryotic microorganisms that have an oxidizing environment.
    Type: Grant
    Filed: March 24, 2006
    Date of Patent: March 20, 2012
    Assignee: BioGeneriX
    Inventors: Marc F. Schwartz, Tarik Soliman
  • Expression of soluble therapeutic proteins
    Patent number: 8043833
    Abstract: The present invention provides enhanced methods of producing soluble, active fibroblast growth factor-20 (FGF-20), FGF-21, neurotrophin-3 (NT-3), growth hormone (GH), granulocyte colony stimulating factor (G-CSF), or glucocerebrosidase proteins in microorganisms that have an oxidizing environment.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: October 25, 2011
    Assignee: Novo Nordisk A/S
    Inventors: Marc F. Schwartz, Bingyuan Wu, Aliakbar Mobasseri, Shawn A. DeFrees, Tarik Soliman, Karl F. Johnson
  • EXPRESSION OF SOLUBLE, ACTIVE EUKARYOTIC GLYCOSYLTRANSFERASES IN PROKARYOTIC ORGANISMS
    Publication number: 20110223646
    Abstract: The present invention provides enhanced methods of producing soluble, active eukaryotic glycosyltransferases in prokaryotic microorganisms that have an oxidizing environment.
    Type: Application
    Filed: March 28, 2011
    Publication date: September 15, 2011
    Applicant: BIOGENERIX AG
    Inventors: Marc F. Schwartz, Tarik Soliman
  • EXPRESSION OF SOLUBLE, ACTIVE EUKARYOTIC GLYCOSYLTRANSFERASES IN PROKARYOTIC ORGANISMS
    Publication number: 20100143969
    Abstract: The present invention provides enhanced methods of producing soluble, active eukaryotic glycosyltransferases in prokaryotic microorganisms that have an oxidizing environment.
    Type: Application
    Filed: March 24, 2006
    Publication date: June 10, 2010
    Applicant: Neose Technologies, Inc.
    Inventors: Marc F. Schwartz, Tarik Soliman
  • EXPRESSION OF O-GLYCOSYLATED THERAPEUTIC PROTEINS IN PROKARYOTIC MICROORGANISMS
    Publication number: 20090311744
    Abstract: The invention relates to methods of producing an O-glycosylated soluble therapeutic protein in a prokaryotic microorganism by co-expressing the therapeutic protein and a heterologous glycosyltransferase that transfers a sugar moiety to an amino acid acceptor on the therapeutic protein.
    Type: Application
    Filed: April 19, 2007
    Publication date: December 17, 2009
    Inventors: Shawn DeFrees, Marc F. Schwartz, Karl Johnson
  • EXPRESSION OF SOLUBLE FACTOR VIII PROTEINS IN BACTERIA
    Publication number: 20090305349
    Abstract: The present invention provides enhanced methods of producing soluble Factor VIII proteins in microorganisms that have an oxidizing environment.
    Type: Application
    Filed: October 31, 2006
    Publication date: December 10, 2009
    Inventors: Marc F. Schwartz, Shawn Defrees, Karl Johnson
  • EXPRESSION OF SOLUBLE THERAPEUTIC PROTEINS
    Publication number: 20090298121
    Abstract: The present invention provides enhanced methods of producing soluble, active fibroblast growth factor-20 (FGF-20), FGF-21, neurotrophin-3 (NT-3), growth hormone (GH), granulocyte colony stimulating factor (G-CSF), or glucocerebrosidase proteins in microorganisms that have an oxidizing environment.
    Type: Application
    Filed: September 6, 2006
    Publication date: December 3, 2009
    Inventors: Marc F. Schwartz, Bingyuan Wu, Aliakbar Mobasseri, Shawn A. DeFrees, Tarik Soliman, Karl F. Johnson