Abstract: In one embodiment, the present invention may include a method of performing microdrilling surgery including directing a distal portion of a cannulated guide having an angle of curvature adjacent to a defect site; directing a drill, including a drill head and a flexible shaft, through the cannulated guide from a proximal portion of the guide through the distal portion and towards the defect site; drilling at least one hole into the defect site; and removing the drill and cannulated guide from the defect site and allowing blood or bone marrow to flow into the at least one hole towards the defect site.

Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.

Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.

Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.

Abstract: A method for the repair of a cartilage defect in a patient in need thereof, including implanting an implant into the cartilage defect, wherein the implant may comprise at least a first material, wherein the first material may be porous and may be a scaffold that is expandable or compressible. The invention also includes an implant for the repair of a cartilage defect in a patient in need thereof, the implant may include at least a first material and a second material, wherein the first material may be porous and may be a scaffold that is expandable or compressible, and wherein the first material may surround the second material.

Abstract: The present invention relates to a tissue defect repair implant including a porous material, wherein the material is expandable or compressible. The implant may be a scaffold, and may also be formed of a material such as, for example, collagen or demineralized bone matrix. Another aspect of the invention may be a method for the repair of a tissue defect in a patient in need thereof, including implanting an implant between two adjacent tissues, wherein the implant may include a porous material which is expandable or compressible. The two tissues may be soft tissue and hard tissue, and alternatively, the two tissues may be soft tissue, and may further be the same or different soft tissues.

Abstract: Disclosed are methods of enhancing recovery from joint surgery, comprising administering to the joint during surgery a composition comprising stem or progenitor cells in an amount effective to enhance recovery, and a pharmaceutically acceptable carrier.

Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.

Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.

Abstract: The present invention relates to a method for repairing cartilage defects in a patient. According to the current invention, a porous material having at least expandable or compressible properties is implanted into a cartilage defect.

Abstract: The invention is directed to the repair of articular cartilage in joints and includes an articular cartilage graft, a method of producing the articular cartilage graft, and a method of repairing an articular cartilage defect using the articular cartilage graft. In its preferred embodiment, the articular cartilage graft of the present invention comprises a collagen portion with structure or architecture similar to, or substantially the same as, native human articular cartilage.

Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.

Abstract: A power supply method an apparatus for powering electrical equipment, the electrical equipment operated by using current peaks. The electrical equipment may be connected via at least one capacitive element to a voltage converter which may be connected to a storage battery. The voltage converter may be current-regulated from a reference current. The reference current may correspond to an average current between two peaks (generally corresponding to one cycle of operation). The reference current may be calculated in a predictive manner and the reference current may include a correction factor. The voltage output from the voltage converter may be maintained between an upper limit and a lower limit.

Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.

Abstract: The present invention is directed to methods and compositions for manufacturing a bone graft substitute. A powder compaction process is utilized to generate a shaped product comprised of a bone material and in some embodiments a processing aid is utilized to facilitate compaction of the bone material and/or for release of the product from the die. In one aspect of the present invention, the manufacturing process comprises a withdrawal press having a shelf die, a lower punch, and an upper punch, wherein at least both the shelf die and lower punch are configured to impart at least part of the shape of the particle upon the material.

Abstract: A power supply method for powering electrical equipment (1) operating on current peaks and connected via at least one capacitive element (5) to a voltage converter (6) connected to a storage battery (3), the voltage converter being current-regulated from a reference current corresponding to a mean current between two peaks.

Abstract: Embodiments of the present invention include apparatuses and methods for delivering one or more particles. In some embodiments, shaped particles are stacked in a tube and dispensed from the tube into a wound such as a bone void.

Abstract: The present invention is directed to methods and compositions for manufacturing a bone graft substitute. A powder compaction process is utilized to generate a shaped product comprised of a granulated bone material, such as demineralized bone matrix. In addition, a processing aid is utilized to facilitate compaction of the granulated bone material and for release of the product from the die.

Abstract: A prosthetic device having at least part of its surface comprising a diffusion-hardened, in-situ formed oxidation or nitridation layer and with at least another part of its surface comprising a coating of bioceramic, preferably hydroxyapatite. The bone in-growth and on-growth promoting bioceramic further works synergistically with the diffusion-hardened surface in realizing a longer service life prosthetic.

Abstract: An electricity distribution network for a motor vehicle, the network having at least two pieces of equipment connected to a storage battery, at least one of the pieces of equipment operates in a pulse mode likely to create oscillations in the network at a resonant frequency thereof, the network includes at least one resistive element and capacitor that are associated in series and that are of resistance and capacitance determined so that the resistance of the resistive element is equal to a damping resistance for the network.