Abstract: A medical capsule including an electrical circuit and an internal power source for selectively supplying the electrical circuit with electrical energy, wherein at least a photosensitive element is provided for initiating a supply of electrical energy to the electrical circuit when a light signal having a predetermined intensity is irradiated and the invention related to a system comprising a medical capsule in a package, and an extracorporeal device including a light source for emitting a light beam, wherein the package of the medical capsule is adapted and provided to be permeable for the predetermined intensity.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-8 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A process for manufacturing a viscoelastic injection agent having first and second poloxamers and at least one other component, the process including: a) mixing a first injection agent by mixing a the first poloxamer with the second poloxamer and a third amount of the at least one other component to obtain a predetermined amount of the injection agent; b) determining the viscosity of the injection agent obtained in step at different temperatures at a predetermined shear rate to obtain a present viscosity-over-temperature-curve; c) verifying if a maximum viscosity of the present viscosity-over-temperature-curve lays at a predetermined specific temperature range in a predetermined maximum viscosity range depending on the predetermined shear rate; and d) mixing a new injection agent, having amended at least the first amount of the first poloxamer and/or the second amount of the second poloxamer based on determined properties of the first injection agent

Abstract: Arming apparatus is installable between twin arming units (101, 102) of an ejector release unit in a military aircraft, and a single fuzing unit (74) of a store (78). The arming apparatus comprises sequentially breakable links (221, 222, 223) which ensure reliable ejection of the store in an armed state, or jettisoning of the store in an unarmed state, as desired.

Abstract: Arming apparatus is installable between twin arming units of an ejector release unit in a military aircraft, and a single fuzing unit of a store. The arming apparatus comprises sequentially breakable links which ensure reliable ejection of the store in an armed state, or jettisoning of the store in an unarmed state, as desired.

Abstract: The present invention relates to a braiding machine with at least two impellers for displacing at least one clapper, wherein the clapper is made at least partially of a ferromagnetic material and wherein each of the impellers has at least one clapper receiver comprising a plurality of electromagnets, wherein the electromagnets enclose a partial circumference of the clapper of about 50° to about 120°.

Abstract: A portable bioelectric impedance monitor and methods using the monitor can measure and monitor extracellular fluid levels and/or cardiac signals. The monitor may include a tetrapolar electrode array lead with four electrodes arranged sequentially and axially along the lead, and circuitry coupled with the at least four electrodes configured to measure bioelectric impedance extracellular fluid and/or cardiac signals in a human subject at various frequencies. The electrodes are adhered to a human subject/patient on the patient's torso or one of the patient's limbs. One embodiment includes a Tetrapolar Analog Front End Patient Interface circuit configured to convert two electrode operation of a commercial Impedance Converter, Network Analyzer into a tetrapolar operation for excitation and impedance measurement of the human subject.

Abstract: A dry weight measurement system and method uses multiple frequency bioimpedance measurements. In one embodiment, the dry weight measurement system may be used to monitor dialysis patients.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A medical capsule is equipped with a sensor device having light emitting and light receiving elements. The sensor device can detect blood on the basis of light absorption properties of the blood. The capsule has a casing forming a recess or gap at its outer surface. The recess has a pre-selected width which represents a fixed measuring track between the light emitting and light receiving elements being arranged at opposing sides of the recess or gap when seen in its width direction. The medical capsule also has a shielding plate/layer/membrane arranged at least at or near the bottom of the recess or gap and extending along the width direction of the recess or gap preferably to exceed the recess at both sides into its width direction to prohibit emitted light from bypassing the recess via the casing material of the capsule.

Abstract: Arming apparatus is installable between twin arming units of an ejector release unit in a military aircraft, and a single fuzing unit of a store. The arming apparatus comprises sequentially breakable links which ensure reliable ejection of the store in an armed state, or jettisoning of the store in an unarmed state, as desired.

Abstract: The present invention relates to a switch for sorting, deflecting, and supplying ferromagnetic elements. Here, the switch comprises at least two electromagnets, which are embodied curved or circular. The magnets may be installed fixed in the switch, on the one hand, or supported on an axis, on the other hand. The ferromagnetic elements are moved by a conveying element through the switches. Advantageously the switch can also be used to control bobbins in a braiding machine. Here, the bobbin can be transferred to another impeller. This way new options are generated with regard to flexibility of braids. Further, this invention offers a considerable reduction of braiding time in case of complex braids.

Abstract: Provided herein are inhibitors of transmembrane protein 16A (TMEM 16A), a Ca2+-activated CI? channel expressed widely in mammalian epithelia, as well as in vascular smooth muscle and some tumors and electrically excitable cells. TMEM16A inhibitors have potential utility for treatment or management of disorders of epithelial fluid and mucus secretion, hypertension, some cancers, pain, and other diseases.

Abstract: Computer-aided process for creating a braiding program is disclosed herein.

Abstract: A medical capsule including an electrical circuit and an internal power source for selectively supplying the electrical circuit with electrical energy, wherein at least a photosensitive element is provided for initiating a supply of electrical energy to the electrical circuit when a light signal having a predetermined intensity is irradiated and the invention related to a system comprising a medical capsule in a package, and an extracorporeal device including a light source for emitting a light beam, wherein the package of the medical capsule is adapted and provided to be permeable for the predetermined intensity.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: The disclosure relates to a spacer in the form of an attachment (15) to be mounted to an endoscope (1), said attachment being formed like a cap, enclosing a spatial volume (16) and being made of an insulating material. The attachment (15) is further equipped with a mounting device/adapter (6) designed to be coupled to a distal end of the endoscope (1). The attachment (15) comprises an area (11) designed to be in contact with a target tissue and further forms an aperture (12) enclosing a surface area (12a). Within the spatial volume, there is arranged an electrode (9) comprising a distal (9b) and a proximal (9a) end, the distal (9b) end of the electrode (9) having a predetermined minimum distance to the closest point of the surface area (12a).

Abstract: A minimally invasive surgical implant-cutting instrument of the bipolar type, operated with direct current, with an instrument head which is located at the distal end of an instrument shank, wherein at least two mutually opposing instrument branches, preferably of the linear type, are arranged on the instrument head and between them define a cutting gap for receiving an electrically conductive implant or implant section between them. The electrodes are formed on the mutually facing longitudinal sides of the branches or these are each equipped with at least one electrode, which electrodes are in turn shaped at their mutually facing longitudinal sides to form a cutting edge in order to effect a quasi-linear or punctiform physical contact engagement with the electrically conductive implant or implant section for an electrical short circuit of the mutually opposing electrodes.