Abstract: What is disclosed is an endoscopic surgical instrument with a hose-shaped outside jacket, in which a likewise hose-shaped inside jacket is supported relatively displaceable, on whose distal end section a sleeve or shaft-shaped instrument head is formed or mounted. In the instrument head is fixed a needle-shaped RF electrode electrically-insulated, whose electrical supply line is routed through the inside jacket, and which projects freely beyond the distal end of the instrument head in the axial direction. In the instrument head is formed a flush channel, extending at least axially, opening at both instrument head ends.

Abstract: The present invention provides a method for obtaining feedback parameters related to the state of a dielectric elastomer (DE). The method comprises introducing a small-scale oscillation to the voltage difference between electrodes of the DE, monitoring or repeatedly measuring several measurable electrical characteristics of the DE, deriving other relevant data from the measurements, deriving an equation for a plane of best fit through the relevant data when defined as orthogonal axes, and deriving the feedback parameters from coefficients of the plane equation. The method thus provides important feedback regarding the capacitance, leakage current and/or electrode resistance of the DE. Also disclosed are a computer program and a system adapted to perform the method.

Abstract: The invention provides an electric circuit device including a conductive element configured to provide an electrical input to an electrical component, the resistivity of the conductive element being variable based at least on the extent of deformation thereof, and a deformable body coupled directly or indirectly to, or integral with, the conductive element such that deformation of the body causes the conductive element to deform, thereby varying the resistance thereof and altering the input to the electrical component. Said devices may be used singularly or in combination as logic elements within electrical circuits, providing drive and/or control functionality. Particular embodiments provide improved electrostatic generators.

Abstract: The present invention relates to devices, and methods for using the devices, to create and secure a tissue fold during an endoluminal medical procedure. The devices and methods may be used for folding and securing, for example, a fundus wall onto an esophagus wall or esophageal tissue in the region of the lower esophageal sphincter (LES) to reduce the diameter of the esophagus opening in that region. One aspect of the invention includes forming the tissue fold by closing a grasping arm that is pivotably connected to an overtube that has been positioned at the juncture of the fundus wall and esophagus wall. A further aspect of the invention includes tissue clips configured to be inserted and positioned through an endoluminal device.

Abstract: The invention relates to transformers. More particularly, the invention relates to transformers using (preferably electrostatic and more preferably dielectric elastomer) transducers such as generators and actuators. The invention further provides a priming circuit therefor.

Abstract: A medical implant is disclosed, said implant having a flexible hollow body (1) which can be implanted inside the stomach (8) of a patient and which has a first tube-like end section (2) and a second tube-like end section (3), wherein the first tube-like end section (2) is dimensioned such that it can be fitted into the esophagus (7) of the patient, and the second tube-like end section (3) is dimensioned such that it can be connected to the small intestine loop (9) of the patent in a sealing manner.

Abstract: A floor and carpet sweeper has a pair of side-by-side brush assemblies rotated in opposite rotational directions with a battery operated electric motor operable to pickup dust, dirt and debris materials from a surface and deposit the materials into a replacement filter box.

Abstract: A medical implant is disclosed, said implant having a flexible hollow body (1) which can be implanted inside the stomach (8) of a patient and which has a first tube-like end section (2) and a second tube-like end section (3), wherein the first tube-like end section (2) is dimensioned such that it can be fitted into the esophagus (7) of the patient, and the second tube-like end section (3) is dimensioned such that it can be connected to the small intestine loop (9) of the patent in a sealing manner.

Abstract: The invention provides compounds of the formula (I): and salts, tautomers, solvates and N-oxides thereof; wherein Q is CH or N; X is N, N+—O? or CR3; Y is N, N+—O? or CR3a; R1 and R2 are independently selected from hydrogen and various substituents as defined in the claims; or R1 and R2 together with the atoms to which they are attached, link to form an optionally substituted carbocyclic or heterocyclic aromatic or non-aromatic ring of 4 to 7 members; R3 is selected from hydrogen and various substituents; and R3a is selected from hydrogen and various substituents as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds. The compounds of formula (I) have activity as inhibitors of CDK kinases and are useful in the treatment of inter alia proliferative diseases such as cancers.

Abstract: A system and method is provided for determining the capacitance between electrodes of an artificial muscle or dielectric elastomer actuator (DEA). The method comprises measuring the voltage difference between the electrodes of the DEA, the first derivative of that voltage with respect to time, and the total instantaneous current through the DEA, then calculating the capacitance of the DEA as the difference between the total instantaneous current through the DEA and the product of the voltage between the electrodes and an error term, divided by the first derivative of the voltage between the electrodes with respect to time. The capacitance may then be used to derive estimates of the leakage current, charge upon the DEA, and/or the physical state of the DEA, thereby implementing self-sensing to allow closed-loop feedback control of DEA actuation.

Abstract: An array of actuators is provided which is adapted for sequential actuation by way of mechano-sensitivity propagating actuation through the array, triggering each actuator upon deformation thereof caused by an adjacent actuator or a load in the form of a fluid or a solid object. Actuation is thus coordinated with minimal computational overhead. Also provided is an actuator suitable for use in such an array, a method of controlling an actuator, and a method of controlling an array of mechano-sensitive actuators.

Abstract: An apparatus, method and computer program product for modifying a surface of a component is provided. In use, a surface of a component is translated relative to at least one jet for a period of time to form a plurality of features thereon.

Abstract: A full-thickness resection system comprises a flexible endoscope and a stapling mechanism, wherein the endoscope is slidably received through at least a portion of the stapling mechanism. The stapling mechanism comprises an anvil and a stapling head mounted to the anvil so that the anvil and the stapling head are moveable with respect to one another between a tissue receiving position and a stapling position and wherein a gap formed between the stapling head and the anvil is larger in the tissue receiving position than it is in the stapling position. A position adjusting mechanism is provided for moving the anvil and the stapling head between the tissue receiving and stapling positions and a staple firing mechanism sequentially fires a plurality of staples from the stapling head across the gap against the anvil and through any tissue received in the gap and a knife cuts a portion of tissue received within the gap.

Abstract: A resection device comprising a cup-shaped cap for a shaft-type inserting means is disclosed which is fixed at the distal end of the shaft-type inserting means or is formed at the same and includes an expanding sleeve portion to which a spring-biased tissue clip is attached which can be withdrawn by means of a releasing or withdrawing device over the distal front edge of the cap. In accordance with the invention, inside the expanding sleeve portion a cutting device is arranged which is held at the inner wall of the expanding sleeve portion at a predetermined axial distance from the distal front edge of the cap.

Abstract: A method of fabricating a substrate processing chamber component involves forming a component having a textured surface and sweeping a jet of pressurized fluid across the textured surface of the component. The jet of fluid is pressurized sufficiently high to dislodge substantially all the particles from the textured surface. The method can be applied to dislodge grit particles from textured exposed surfaces formed by electromagnetic energy beam scanning and grit blasting. The method can also be applied to remove loosely adhered coating particles from the textured surfaces of coated components.

Abstract: The present application relates to a medical gripping device (1) with a flexible shaft (2) with a front end (13) and a rear end (14) and a web (5) comprising at least one web element, wherein the web (4) is attached to the front end (3) of the shaft (2). The medical gripping device additionally has at least two branches (5, 6) which are hinged on the web (4), and at least two at least partly flexible control mechanisms (7, 151, 155, 8, 152, 156) which are at least partly arranged in the shaft (2), wherein each individual branch (5, 6) can be moved individually with respect to the web (4) by means of its individual control mechanism (7, 151, 155, 8, 152, 156). Furthermore, the medical gripping device has a grip (150) at the rear end (14) of the flexible shaft (2), by mans of which grip the medical gripping device (1) can be held and actuated.

Abstract: The present invention relates to an endoscope cap with a holding and withdrawal device for a tissue clip (4) that can be placed onto a spreading sleeve (3) of the endoscope cap (1). The endoscope cap comprises an end groove (7) that opens at the front edge of the spreading sleeve (3) and that slits open the cap wall on both sides, and a withdrawal thread or web (11) that radially traverses the end groove (7) in a forward axial cap section and that is introduced or can be introduced slideably into an endoscope channel for actuation thereof at a radial inside of the endoscope cap (1).

Abstract: A proctological instrument is disclosed comprising an instrument handle to which at its proximal end a bending-resistant tubular shaft is mounted at the distal end of which a cap is fixed or formed to which a tissue clip adapted to be withdrawn from the cap by means of a releasing or withdrawing device is attached in a preferably spring-elastic manner. In accordance with the invention, the tubular shaft is offset at its distal end portion in an area directly ahead of the cap and/or the cap itself is offset at a predetermined fixed angle so that the withdrawing direction for the clip defined by the cap is aligned at the angle with respect to the tubular shaft axis.

Abstract: Endoscopic devices and methods used for fastening multiple tissue layers, such as, for example, an endoscopic fundoplication procedure, are disclosed. The device may include, for example, an elongated tubular member having a proximal end for extending outside of the body and a distal end for positioning proximate the multiple tissue layers, a grasper configured for positioning proximate the distal end of the tubular member and for grasping at least one of the multiple tissue layers, a device coupled to the distal end of the tubular member for folding the multiple tissue layers together, a tissue fastener configured to be inserted into the tissue layers to hold the tissue layers together, and a fastener head for inserting the tissue fastener into the tissue layers.

Abstract: A full-thickness resection system comprises a flexible endoscope and a stapling mechanism, wherein the endoscope is slidably received through at least a portion of the stapling mechanism. The stapling mechanism comprises an anvil and a stapling head mounted to the anvil so that the anvil and the stapling head are moveable with respect to one another between a tissue receiving position and a stapling position and wherein a gap formed between the stapling head and the anvil is larger in the tissue receiving position than it is in the stapling position. A position adjusting mechanism is provided for moving the anvil and the stapling head between the tissue receiving and stapling positions and a staple firing mechanism sequentially fires a plurality of staples from the stapling head across the gap against the anvil and through any tissue received in the gap and a knife cuts a portion of tissue received within the gap.