Abstract: There is described a wood optimization system for a production line. The wood optimization system generally having a conveyor moving wood products across a handling area; a wood product selector positioned proximate to a selected wood product in the handling area; and a computer vision system along the production line having a camera imaging the handling area, a processor communicatively coupled to the camera, and a computer-readable memory having program code that when executed by the processor perform the steps of: receiving from the camera an image representing at least a portion of the handling area; finding the wood product selector in the image; identifying the selected wood product in the image as the wood product of the plurality being most proximate to the wood product selector; receiving an instruction associated to the selected wood product; and implementing the instruction into optimization data associated to the selected wood product.

Abstract: A skate (e.g., an ice skate) or other footwear for a user, in which a skate boot or other foot-receiving structure for receiving a foot of the user may be configured to enhance power transfer of the user (e.g., for push-off and skating straight), agility of the user (e.g., for turns), and/or other aspects of performance of the user, such as by comprising a sole region that is configured to be disposed under the user's foot and includes different materials strategically distributed (e.g., in a longitudinal direction of the skate boot or other foot-receiving structure) or otherwise implements these enhancements.

Abstract: Novel forms of 2-amino-9-[(2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-14-(6-amino-9H-purin-9)-yl)-15,16-difluoro-2,10-dihydroxy-2,10-disulfidooctahydro-12H-5.8-methanofuro[3,2-1][1,3,6,9,11,2,10]pentaoxa-diphosphacyclotetradecin-7-yl]-1,9-dihydro-6H-purin-6-one, which include crystalline salts and hydrates of 2-amino-9)-[(2R,5R,7R,8,S,10R,12aR,14R,15S,15aR,16R)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-dihydroxy-2,10-disulfido-octahydro-12H-5,8-methanofuro[3,2-1][1,3,6,9,11,2,10]pentaoxa-diphosphacyclotetradecin-7-yl]-1,9-dihydro-6H-purin-6-one, may be useful as inductors of type I interferon production, specifically as STING active agents.

Abstract: A method and a system for noise discrimination, the method comprising measuring noise levels of a noise source, measuring noise levels at a target location positioned at a distance from the noise source, measuring wind speed and direction in an area comprising the noise source and the target location, filtering transient short-duration events from the noise levels measured at the noise source, yielding filtered noise levels of the noise source, filtering transient short-duration events from the noise levels measured at the target location, yielding filtered noise levels of the target location, measuring a sound transfer function between the noise source and the target location using the filtered noise levels, comparing the measured sound transfer function with a reference transfer function; and when the difference between the measured transfer function and the reference transfer function is above a predetermined threshold, determining a probability that noise at the location originates from the noise source.

Abstract: The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (O—{[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl}O,O-dihydrogen phosphorothioate, also known as 2?-(S)-fluoro-thio-adenosine monophosphate or 2?-F-thio-AMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

Abstract: A skate (e.g., an ice skate) or other footwear for a user, in which a skate boot or other foot-receiving structure for receiving a foot of the user may be configured to enhance power transfer of the user (e.g., for push-off and skating straight), agility of the user (e.g., for turns), and/or other aspects of performance of the user, such as by comprising a sole region that is configured to be disposed under the user's foot and includes different materials strategically distributed (e.g., in a longitudinal direction of the skate boot or other foot-receiving structure) or otherwise implements these enhancements.

Abstract: A skate (e.g., an ice skate) or other footwear for a user, in which a skate boot or other foot-receiving structure for receiving a foot of the user may be configured to enhance power transfer of the user (e.g., for push-off and skating straight), agility of the user (e.g., for turns), and/or other aspects of performance of the user, such as by comprising a sole region that is configured to be disposed under the user's foot and includes different materials strategically distributed (e.g., in a longitudinal direction of the skate boot or other foot-receiving structure) or otherwise implements these enhancements.

Abstract: A skate (e.g., an ice skate) or other footwear for a user, in which a skate boot or other foot-receiving structure for receiving a foot of the user may be configured to enhance power transfer of the user (e.g., for push-off and skating straight), agility of the user (e.g., for turns), and/or other aspects of performance of the user, such as by comprising a sole region that is configured to be disposed under the user's foot and includes different materials strategically distributed (e.g., in a longitudinal direction of the skate boot or other foot-receiving structure) or otherwise implements these enhancements.

Abstract: Various embodiments of electronic flares are described which generally comprise a light module that is disposed along a portion of a housing and includes at least one light source for emitting light according to a lighting mode, a power source for providing power to the light module, a circuit board that is disposed within the housing and is electrically coupled to the power source and light module, the circuit board including a controller for providing power to the light module according to the selected lighting mode when the electronic flare is activated; and a switch having an external switch portion and an internal switch portion coupled to one another, the external switch portion being disposed along an outer portion of the housing and the internal switch portion being operatively coupled to the circuit board, the external switch portion being rotatably movable by a user to one or more positions where each position is associated with a different lighting mode allowing the user to select the lighting mode

Abstract: Various embodiments of electronic flares are described which generally comprise a light module that is disposed along a portion of a housing and includes at least one light source for emitting light according to a lighting mode, a power source for providing power to the light module, a circuit board that is disposed within the housing and is electrically coupled to the power source and light module, the circuit board including a controller for providing power to the light module according to the selected lighting mode when the electronic flare is activated; and a switch having an external switch portion and an internal switch portion coupled to one another, the external switch portion being disposed along an outer portion of the housing and the internal switch portion being operatively coupled to the circuit board, the external switch portion being rotatably movable by a user to one or more positions where each position is associated with a different lighting mode allowing the user to select the lighting mode

Abstract: A method and a system for noise discrimination, the method comprising measuring noise levels of a noise source, measuring noise levels at a target location positioned at a distance from the noise source, measuring wind speed and direction in an area comprising the noise source and the target location, filtering transient short-duration events from the noise levels measured at the noise source, yielding filtered noise levels of the noise source, filtering transient short-duration events from the noise levels measured at the target location, yielding filtered noise levels of the target location, measuring a sound transfer function between the noise source and the target location using the filtered noise levels, comparing the measured sound transfer function with a reference transfer function; and when the difference between the measured transfer function and the reference transfer function is above a predetermined threshold, determining a probability that noise at the location originates from the noise source.

Abstract: This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK2 kinase is involved.

Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Abstract: The disclosure is directed at a method and system for improving situational awareness and accuracy of a user with a firearm. The system includes a blank firing laser attachment which is mounted to an end of the firearm and emits a laser when the trigger is pulled.

Abstract: This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

Abstract: This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK2 kinase is involved.

Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.