Abstract: Methods and systems for determining a temperature of goods in a temperature controlled unit are disclosed. Raw temperature data is received for a first iteration. The raw temperature data indicates an air temperature inside the temperature controlled unit at the first iteration. A property value for a good stored in the temperature controlled unit is obtained. Based on the raw temperature data for the first iteration and the property value for the good, a first adjusted stored goods temperature is determined for the good. The first adjusted stored goods temperature for the good represents a first internal temperature of the good. Additional iterations are performed, where raw temperature data is received for a second iteration. Based on the raw temperature for the second iteration and the property value for the good, a second adjusted stored goods temperature is determined.

Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Abstract: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.

Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Abstract: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.

Abstract: The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Abstract: The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Abstract: Disclosed in some examples are methods, systems, and machine-readable mediums to collect GNSS corrections reliably via multiple network links. In some examples, the GNSS corrections obtained via multiple network links are processed via a voting algorithm that determines the optimal instance of the correction to forward to the Client.

Abstract: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.

Abstract: An anti-E1 ion channel antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.

Abstract: The present invention relates to improved processes for culturing bacteria, in particular to processes for perfusion suspension culturing of bacteria in a fermenter, wherein the culture medium including the bacteria is circulated over a separation system in alternating tangential flow, wherein the separation system removes a filtrate containing inhibitory metabolites from the culture medium.

Abstract: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.

Abstract: An anti-E1 ion channel antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.

Abstract: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.

Abstract: Disclosed in some examples are methods, systems and machine readable mediums to efficiently stream data across restricted networks. In some examples, this streamed data may be sent more efficiently using lower overhead protocols such as UDP. In order to bypass the aforementioned limitations on these lower overhead protocols, the client may send a periodic update message to the server. This update message maintains the openings in the network firewalls and updates the server on the client's status. This update message may be sent much less frequently than a typical TCP acknowledgement, and the lower overhead protocol may be a protocol that does not retransmit lost or corrupted packets—thereby eliminating unnecessary overhead. In some examples this streamed data may be GNSS correction data. In some examples, the client may be behind one or more network firewalls.

Abstract: The present invention relates to a fermentation process comprising a fermentation step of growing a strain of Corynebacterium diphtheriae in medium in a fermenter under conditions of agitation sufficient to maintain a homogenous culture and limited aeration such that pO2 within the culture falls to less than 4% for the majority of the fermentation step.

Abstract: Methods and systems for determining a temperature of goods in a temperature controlled unit are disclosed. Raw temperature data is received for a first iteration. The raw temperature data indicates an air temperature inside the temperature controlled unit at the first iteration. A property value for a good stored in the temperature controlled unit is obtained. Based on the raw temperature data for the first iteration and the property value for the good, a first adjusted stored goods temperature is determined for the good. The first adjusted stored goods temperature for the good represents a first internal temperature of the good. Additional iterations are performed, where raw temperature data is received for a second iteration. Based on the raw temperature for the second iteration and the property value for the good, a second adjusted stored goods temperature is determined.

Abstract: A bearing lining has a bearing backing layer provided with a coating comprising a first overlay layer and a second overlay layer, the first overlay layer being provided between the bearing backing layer and the second overlay layer. The first and second overlay layers each comprise a matrix material and a soft-phase material that is substantially insoluble in the matrix and dispersed within the matrix as soft-phase particles. The first overlay layer comprises a higher proportion by weight of a grain size reduction additive than the second overlay layer.