Abstract: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.

Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Abstract: An anti-E1 ion channel antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.

Abstract: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.

Abstract: The gastight sealing device associated with a functional clearance existing between two sectors of a turbomachine includes an annular plate wound up on itself over at least one turn, covering functional clearance.

Abstract: Analog beamformers for continuous wave ultrasonic receivers, typically realized in integrated circuit form and using a direct quadrature baseband conversion architecture for CW Doppler to eliminate a second down conversion mixer and second synthesizer. The beamformers use integrated mixers and LO's for phase steering, and dedicated ring counters for each channel for lower noise. Input filtering may be provided with switchable RF input low pass filters. The integrated circuit includes the ultrasound signal VGA and beamformer on the same chip. An auxiliary channel may be included for a self-test mode. Also a programmable bit soft shutdown feature, programmable via the serial port, allows disabling individual channels. Various other features are disclosed including cascading of multiple integrated circuits for a much greater number of channels.

Abstract: The present invention relates to a fermentation process comprising a fermentation step of growing a strain of Corynebacterium diphtheria in medium in a fermenter under conditions of agitation sufficient to maintain a homogenous culture and limited aeration such that pO2 within the culture falls to less than 4% for the majority of the fermentation step.

Abstract: Analog control integrated FET based variable resistors and attenuators using the variable resistors having a wide range of monotonic and substantially linear attenuation with control voltage for use in circuits having AC signals of AC signal frequencies. The variable resistors comprise field effect devices (FETs) biased to operate in their linear region and having their bodies and gates coupled to a reference voltage and a control voltage, respectively, through impedances, typically resistors, having impedances that are higher than the impedances of parasitic capacitances at the signal frequencies. This allows the body and gate of each FET to vary in voltage with the signal to maintain the bias of the FETs in the presence of large signals. Various embodiments are disclosed.

Abstract: A composition comprising a) 5 to 25% by weight of a fluorescent whitening agent of the formula (1), wherein R1 and R2 independently represent C1-C4alkyl, C2-C4hydroxyalkyl or together complete a morpholine ring and M is an alkaline or alkaline earth metal, b) 0.5 to 5% by weight of a swellable layered silicate which is hectorite and/or vermiculite, c) water and, optionally, d) further adjuvants and the use thereof for the fluorescent whitening of paper in the pulp mass, in coatings or in the size press or metering size press.

Abstract: The present invention relates to compounds having formula (1): wherein each R1 represents, independently, a linear C1-C4-alkylene residue which is unsubstituted or substituted by hydroxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-hydroxy- or alkoxy-alkoxy, —OCOM, —OCOC1-C4-alkyl, or an amino acid residue from which a hydrogen atom on the amino group has been removed; each R2 represents, independently, a linear C1-C4-alkylene residue which is unsubstituted or substituted by hydroxy, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-hydroxy- or alkoxy-alkoxy, —OCOM, —OCOC1-C4-alkyl, —CO2M, CO2C1-C4-alkyl SO3M or phenoxy which is unsubstituted or substituted by halogen, C1-C4-alkyl or C1-C4-alkoxy, —CO2M or CO2C1-C4-alkyl, NH3 or mono- or disubstituted amino; or phenyl which is unsubstituted or substituted by 1 to 3 SO3M, SO2NHC1-C4-alkyl, —SO2NH2, —CO2M, —CO2M, —CO2C1-C4-alkyl, —CONH2, —CONHC1-C4-alkyl, —NHCOC1-C4-alkyl or mono- or disubstituted amino groups;

Abstract: A system and method is provided for booking work for allocating work assignments to a worker.

Abstract: A sealing device is disclosed comprising a least one sealing leaf maintained axially in position by a retaining bracket which comprises a first end bearing on the sealing leaf and a bent-back second end engaged in a groove in a structural element. The sealing leaf is preferably retained radially in position by lugs which are bent so as to engage below lugs provided on the retaining bracket. When the sealing device comprises at least two adjacent sealing leaves placed edge to edge, the device also comprises a cover sheet so disposed between the sealing leaves and the retaining bracket as to cover the joint between the two adjacent leaves.

Abstract: The invention provides a turbomachine including a device for supplying pressurized gas, the gas being bled from the compressor of the turbomachine via a bleed orifice and cooled in a cooling cavity disposed within the compressor rotor upstream of the bleed orifice. This arrangement has the effect of cooling the bled gas by heat transfer through the outer wall of the compressor rotor to the gas stream which is being compressed by the compressor upstream of the bleed orifice, and has the result of reducing the drop in the performance of the compressor as a result of the gas being bled off.

Abstract: A method of reducing the gap between a liner and a turbine distributor of a turbojet engine. The method allows for the improvement of the seal on the inside of the distributor of the high pressure turbine at the lower platform. The method includes the steps of: applying a protective deposit to the lower part of the external surface of the liner, before carrying out a filling by diffusion brazing between the liner and the distributor. The protective deposit, preferably a anti-adherent ceramic, makes it possible for the braze to avoid fixing the liner onto the distributor at the lower platform level. The method also has applications to turbojet engines.

Abstract: A cooling system is disclosed for cooling the platforms of turbine blades fixed to the periphery of a turbine rotor, each turbine blade having an airfoil portion, a platform with opposite longitudinal edges, a root portion affixed to the turbine rotor, and a shank portion connecting the root portion to the platform. Adjacent turbine blades are located such that a longitudinal edge of one platform is adjacent to a longitudinal edge of an adjacent platform. A cavity is formed bounded by a portion of the periphery of the turbine rotor, the shank portions of the adjacent turbine blades, and the platforms of the adjacent turbine blades. A cooling air passage supplies cooling air to the cavity. One or more cooling channels are formed in a side of the platform facing the turbine rotor, each cooling channel having a cooling air collector at an end located adjacent to the air supply passage and communicating with the cavity.

Abstract: This seal (6) running between gaps (6) between two stator sectors of a gas urbine engine is made up of several thin flexible slabs, capable of sliding one over the other, which gives a better seal.

Abstract: There is described a liquid preparation comprising:a) 10 to 40 % by weight of the fluorescent whitening agent having the formula: ##STR1## wherein M is hydrogen, an alkali metal, ammonium or magnesium; b) 10 to 85% by weight of polyethylene glycol having a mean molecular weight in the range of from 150 to 500;c) 0 to 75% by weight of water; andd) 0 to 20% by weight of one or more auxiliary compounds; each based on the total weight of the liquid preparation.The new formulation is suitable for the fluorescent whitening of paper or detergents, and is stable over a wide range of temperature.

Abstract: Device for cooling the external part of a turbine disk (2) by means of an external fresh air current (circuit II) without mixing with the warmer ventilation from the center of the disk (circuit I). A part (30) through which ducts (31, 32) pass that intersect without interruption, prevents mixing of substantially perpendicular streams in front of a part (22) of the disk (2) and a mixture which reduces the cooling efficiency.

Abstract: A cranium is firstly produced form an epoxy resin, whose thickness is adapted so that the compressive strength at a given point is the same as at the corresponding point of a real cranium. This is followed by the fitting of the soft parts, i.e. the brain, eyeballs, flats of the ear and nasal pyramid. These members are made from a silicone to which a variable quantity of oil has been added to ensure that their hardness is the same as that of the corresponding real organs. The cranium is then placed on a support permitting the correct orientation thereof in the mould where the skin is cast.