Abstract: A spectrometer device includes an optical interference filter which is designed to filter specific wavelength ranges of an incident light beam on passage through the optical interference filter. The spectrometer device also includes a detector device which is designed to detect the filtered light beam. Further, the spectrometer device includes a focusing device with a reflective surface. The focusing device is designed to focus the filtered light beam onto the detector device by reflection on the surface.

Abstract: A spectrometer apparatus is disclosed that includes at least one light source for irradiating a sample with light, an optical detection device for detecting light scattered by the sample, at least one optical filter device, which is arranged in front of and/or behind the sample, a contact sensor device for determining a contact between the sample and the spectrometer apparatus and for outputting a corresponding output signal, a control device for controlling the light source and the detection device in response to the output signal. The control device is designed such that the control device modifies at least one operating parameter of the light source and the detection device, when the output signal indicates the contact between the sample and the spectrometer apparatus. A method for operating a spectrometer apparatus is disclosed as well.

Abstract: A system is disclosed herein for providing a kinetic assessment and preparation of a prosthetic joint comprising one or more prosthetic components. The system comprises a prosthetic component including sensors and circuitry configured to measure load, position of load, and joint alignment. The system further includes a remote system for receiving, processing, and displaying quantitative measurements from the sensors. The kinetic assessment measures joint alignment under loading that will be similar to that of a final joint installation. The kinetic assessment can use trial or permanent prosthetic components. Furthermore, adjustments can be made to the applied load magnitude, position of load, and joint alignment by various means to fine-tune an installation. The kinetic assessment increases both performance and reliability of the installed joint by reducing error that is introduced by elements that load or modify the joint dynamics not taken into account by prior assessment methods.

Abstract: An intraoperative surgical system for knee arthroplasty may be configured and/or reconfigurable to allow the surgical system to be inserted into different sized joint spaces during a surgical procedure. For example, the surgical system may include a sensor support body defining a platform, a force sensor, and a plurality of sensor covers each being configured to be detachably attached to the sensor support body. Each of the sensor covers can vary from each other in at least one characteristic. A selected one of the sensor covers can be placed over the platform, sandwiching the force sensor between the platform and sensor cover, to define a joint insertion block configured to be inserted into a tibiofemoral joint for measuring a force between a tibia and a femur defining the tibiofemoral joint.

Abstract: Systems and techniques can be provided to generate sensorized insights into the characteristics of a knee joint space during a knee replacement procedure. In some implementations, a sensor support body carrying one or more sensors can be used to measure and inform the clinician of the varus/valgus angles of the tibia and femur, allowing the clinician to adjust the surgical procedure to accommodate the measured angles. The clinician may simulate changes to the load balance across the knee joint in response to potential dimensional changes to the knee joint prior to actually surgically implementing the changes.

Abstract: An intraoperative surgical system can be used for knee arthroplasty. The system may include a sensor support body defining a platform, a force sensor positioned on the platform, and a sensor cover positioned over the platform of the sensor support body thereby sandwiching the force sensor between the platform and the sensor cover. The sensor cover can be detachably coupled to the sensor support body. The platform, the force sensor, and the sensor cover can collectively define a joint insertion block configured to be inserted into a tibiofemoral joint for measuring a force between a tibia and a femur defining the tibiofemoral joint.

Abstract: A method of performing knee arthroplasty may involve resecting each of a tibia and a femur defining a tibiofemoral joint and inserting a sensor support body carrying a force sensor into the joint with both the tibia and the femur resected. The method can involve measuring a force across the tibiofemoral joint without a prosthetic trial component installed on either of the bones to provide a full-gap force measurement. The method may further involve installing a prosthetic trial component on the tibia and/or the femur and inserting the sensor support body carrying the force sensor into the tibiofemoral joint with the prosthetic trial component installed. The method can further include measuring the force across the tibiofemoral joint to provide a trialing force measurement.

Abstract: A system is disclosed herein for providing a kinetic assessment and preparation of a prosthetic joint comprising one or more prosthetic components. The system comprises a prosthetic component including sensors and circuitry configured to measure load, position of load, and joint alignment. The system further includes a remote system for receiving, processing, and displaying quantitative measurements from the sensors. The kinetic assessment measures joint alignment under loading that will be similar to that of a final joint installation. The kinetic assessment can use trial or permanent prosthetic components. Furthermore, adjustments can be made to the applied load magnitude, position of load, and joint alignment by various means to fine-tune an installation. The kinetic assessment increases both performance and reliability of the installed joint by reducing error that is introduced by elements that load or modify the joint dynamics not taken into account by prior assessment methods.

Abstract: The invention provides methods of making immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions generated by such methods.

Abstract: This disclosure provides methods of making immune effector cells (for example, T cells, NK cells) that comprise (i) a nucleic acid molecule that encodes a controllable chimeric antigen receptor (CCAR) or (ii) a nucleic acid molecule that encodes a CAR and a regulatory molecule, and compositions generated by such methods.

Abstract: A system is disclosed herein for providing a kinetic assessment and preparation of a prosthetic joint comprising one or more prosthetic components. The system comprises a prosthetic component including sensors and circuitry configured to measure load, position of load, and joint alignment. The system further includes a remote system for receiving, processing, and displaying quantitative measurements from the sensors. The kinetic assessment measures joint alignment under loading that will be similar to that of a final joint installation. The kinetic assessment can use trial or permanent prosthetic components. Furthermore, adjustments can be made to the applied load magnitude, position of load, and joint alignment by various means to fine-tune an installation. The kinetic assessment increases both performance and reliability of the installed joint by reducing error that is introduced by elements that load or modify the joint dynamics not taken into account by prior assessment methods.

Abstract: A system is disclosed herein for providing a kinetic assessment and preparation of a prosthetic joint comprising one or more prosthetic components. The system comprises a prosthetic component including sensors and circuitry configured to measure load, position of load, and joint alignment. The system further includes a remote system for receiving, processing, and displaying quantitative measurements from the sensors. The kinetic assessment measures joint alignment under loading that will be similar to that of a final joint installation. The kinetic assessment can use trial or permanent prosthetic components. Furthermore, adjustments can be made to the applied load magnitude, position of load, and joint alignment by various means to fine-tune an installation. The kinetic assessment increases both performance and reliability of the installed joint by reducing error that is introduced by elements that load or modify the joint dynamics not taken into account by prior assessment methods.

Abstract: The invention provides immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions and methods thereof.

Abstract: Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The anti-PD-L1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.

Abstract: Antibody molecules that specifically bind to TIM-3 are disclosed. The antibody molecules can be used to treat or prevent cancerous or infectious conditions and disorders.

Abstract: Dosage regimens for antibody molecules that specifically bind to LAG-3 are disclosed. The antibody molecules can be used to treat or prevent cancerous or infectious conditions and disorders.

Abstract: A nerve modulation device includes a first ultrasound transducer and a second ultrasound transducer. The first and second ultrasound transducers are configured to emit a first and second ultrasound waves, respectively, that exhibit different frequencies. The first and second ultrasound transducers can emit the first and second ultrasound waves in directions that are selected to cause the first and second ultrasound waves to intersect with each other at an intersection site that is at or near a selected nerve. At the intersection site, the first and second ultrasound waves can non-linearly interact to form an acoustic wave exhibiting a frequency that is less than the frequencies of the first and second ultrasound waves. The acoustic wave can modulate a selected nerve.

Abstract: A system is disclosed herein for providing a kinetic assessment and preparation of a prosthetic joint comprising one or more prosthetic components. The system comprises a prosthetic component including sensors and circuitry configured to measure load, position of load, and joint alignment. The system further includes a remote system for receiving, processing, and displaying quantitative measurements from the sensors. The kinetic assessment measures joint alignment under loading that will be similar to that of a final joint installation. The kinetic assessment can use trial or permanent prosthetic components. Furthermore, adjustments can be made to the applied load magnitude, position of load, and joint alignment by various means to fine-tune an installation. The kinetic assessment increases both performance and reliability of the installed joint by reducing error that is introduced by elements that load or modify the joint dynamics not taken into account by prior assessment methods.

Abstract: A system is disclosed herein for providing a kinetic assessment and preparation of a prosthetic joint comprising one or more prosthetic components. The system comprises a prosthetic component including sensors and circuitry configured to measure load, position of load, and joint alignment. The system further includes a remote system for receiving, processing, and displaying quantitative measurements from the sensors. The kinetic assessment measures joint alignment under loading that will be similar to that of a final joint installation. The kinetic assessment can use trial or permanent prosthetic components. Furthermore, adjustments can be made to the applied load magnitude, position of load, and joint alignment by various means to fine-tune an installation. The kinetic assessment increases both performance and reliability of the installed joint by reducing error that is introduced by elements that load or modify the joint dynamics not taken into account by prior assessment methods.

Abstract: An orthopedic implant having a three-axis accelerometer is disclosed. The three-axis accelerometer is used to detect micro-motion in the implant. The micro-motion can be due to loosening of the implant. The implant is configured to couple to the muscular-skeletal system. In one embodiment, the implant is configured to couple to bone. An impact force is imparted to the bone or implant. The impact force can be provided via a transducer coupled to the implant. In the example, the impact force is imparted along a single axis. The three-axis accelerometer measures the impact force along each axis. Resultant peaks of the quantitative measurement and the frequencies at which they occur are measured. The peaks and frequencies of the measurements correspond to micro-motion. Typically, the frequency of interest is less than 1 KHz to determine if micro-motion is occurring.