Abstract: Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale production. Also provided herein are variant human IgG1 Fc molecules lacking or with highly reduced effector function and high stability despite lacking glycosylation at N297. Also, provided herein are linker peptides that are glycosylated when expressed in mammalian cells.

Abstract: An apparatus includes an introducer defining an inner volume, a catheter, and a guide member. The having a proximal end portion and a distal end portion, with the catheter defining a lumen extending through the proximal end portion and the distal end portion of the catheter, and with the catheter configured to move between a first position, in which the catheter is disposed within the introducer, and a second position, in which at least the distal end portion of the catheter is distal to the introducer. The guide member is coupled to the introducer, with the guide member defining a lumen. A portion of the catheter is received within the lumen of the guide member when the catheter is in the first position, and the distal end portion of the catheter is distal to the guide member when the catheter is in the second position.

Abstract: In some embodiments, a method may include display of a data summary view of a set of events that correspond to query results of a query. Each event of the set of events may include data items of a plurality of event attributes. In embodiments, the data summary view can include various summary reports. Each summary report can include summary entries and a summary graph that each present a summary of data items of a selected event attribute, of the plurality of event attributes. At least one summary report can include summary entries that are selectable by a user. The method may further include filtering the set of event, in response to, and based on, selection of one or more of the selectable summary entries by the user and updating of at least the first and second summary graphs to correspond to the filtered set of events.

Abstract: Systems and methods described herein may provide a system that enables game play or other application sessions from a set of candidate game hosts and environments to consumption devices of a user's choice while the user moves about their home between the different environments. The system may employ methods to determine where a user is located within the home, availability and selection of candidate game hosting and target environments, homing and direction of related I/O and audio-visual (AV) content for consumption. The solution accommodates multiple users simultaneously within the home, whether in single player, multiplayer using the same screen, or multiplayer using separate screen games. The solution may configure AV and input/output (I/O) such that multiple users can consume one or multiple games in the home simultaneously, whether in separate locations or when seated together in front of the same consumption device.

Abstract: An electronic hinge system is provided, including a first component and a second component. The first component may include a first enclosure, a first substrate extending within the first enclosure, a first connector, and a plurality of curved elements disposed in the first connector. The first substrate may have electrically conductive elements and microelectronic devices electrically connected with the electrically conductive elements. The curved elements may be electrically conductive and spaced apart from one another. Each curved element may be electrically connected with a respective one of the electrically conductive elements of the first component. The second component may include a second enclosure and a second connector disposed at an end of the second enclosure. The first connector may be configured to mate with the second connector, such that when the first component is engaged with the second component, the first connector is rotationally coupled with the second connector.

Abstract: The present invention relates to a novel robot drive train that is robust, and low cost. The drive train is capable of ascending obstacles greater than the height of its wheels, protects the robot against shocks/vibration, and is highly maneuverable, such as able to execute a zero-point turn. To control the bogie in a variety of scenarios, a novel mechanism is used to selectively limit the articulation range of the bogie and/or programmatically apply a preload to the bogie axle.

Abstract: Apparatus for monitoring an axle of a wheelset assembly of a railway vehicle, the apparatus comprising a wireless sensor node fitted to a wheelset assembly, the wheelset assembly comprising an axle mounted between opposed wheels, each wheel being fitted to a respective opposite end of the axle, the wireless sensor node comprising a vibration energy harvester for converting mechanical energy from vibration in the wheelset assembly into electrical energy, a sensor for measuring a parameter, and a wireless transmitter for wirelessly transmitting the measured parameter or data associated therewith, and the apparatus further comprising a processor for processing the measured parameter to produce processed data, wherein the sensor is an accelerometer mounted to an end of the axle and the sensor and processor are arranged respectively to measure and process an axle percussion vibration frequency in the form of resonant vibration along the axle.

Abstract: The present invention relates to a novel robot drive train that is robust, and low cost. The drive train is capable of ascending obstacles greater than the height of its wheels, protects the robot against shocks/vibration, and is highly maneuverable, such as able to execute a zero-point turn. To control the bogie in a variety of scenarios, a novel mechanism is used to selectively limit the articulation range of the bogie and/or programmatically apply a preload to the bogie axle.

Abstract: A method of selecting a scanning sequence of a laser beam in a selective laser solidification process, in which one or more objects are formed layer-by-layer by, repeatedly, depositing a layer of powder on a powder bed and scanning a plurality of laser beams over the deposited powder to selectively solidify the powder layers, wherein a gas flow is passed over the powder bed in a gas flow direction. The method including selecting a scanning sequence for the plurality of laser beams to include the simultaneous exposure of an upstream point together with a downstream point located downstream of a flow of debris carried from the upstream point by the gas flow, the downstream and upstream points selected for simultaneous exposure based upon the downstream point being within a maximum separation distance from the upstream point.

Abstract: Systems, methods, and non-transitory computer readable media are configured to determine a likelihood of a user choosing to reveal a given content item when contents of the content item are obscured. The likelihood can be determined based at least in part on a trained machine learning model. An extent by which to obscure the content item based at least in part on the likelihood can be determined. Subsequently, an obscured version of the content item can be provided for display. The content item can be obscured based at least in part on the determined extent.

Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.

Abstract: A system and method is disclosed for identifying demographics of an audience (e.g., customers, shoppers and the like) using machine learning and delivering relative content to the audience. In one embodiment, a processing unit receives images and/or audio of an audience and uses a machine learning logic to identify audience demographical characteristics. Demographical characteristics are used to select and deliver audio entertainment, and/or audio information, and/or visual entertainment and/or visual information to the audience that is relevant to the audience. In other embodiments, demographic information is used to analyze audience or customer demographics based on time periods (hour, day, week, etc.), location(s), and/or point of sale data.

Abstract: A system and method is disclosed for identifying demographics of an audience (e.g., customers, shoppers and the like) using machine learning and delivering relative content to the audience. In one embodiment, a processing unit receives images and/or audio of an audience and uses a machine learning logic to identify audience demographical characteristics. Demographical characteristics are used to select and deliver audio entertainment, and/or audio information, and/or visual entertainment and/or visual information to the audience that is relevant to the audience. In other embodiments, demographic information is used to analyze audience or customer demographics based on time periods (hour, day, week, etc.), location(s), and/or point of sale data.

Abstract: An electronic hinge system is provided, including a first component and a second component. The first component may include a first enclosure, a first substrate extending within the first enclosure, a first connector, and a plurality of curved elements disposed in the first connector. The first substrate may have electrically conductive elements and microelectronic devices electrically connected with the electrically conductive elements. The curved elements may be electrically conductive and spaced apart from one another. Each curved element may be electrically connected with a respective one of the electrically conductive elements of the first component. The second component may include a second enclosure and a second connector disposed at an end of the second enclosure. The first connector may be configured to mate with the second connector, such that when the first component is engaged with the second component, the first connector is rotationally coupled with the second connector.

Abstract: A system and method is disclosed for identifying demographics of an audience (e.g., customers, shoppers and the like) using machine learning and delivering relative content to the audience. In one embodiment, a processing unit receives images and/or audio of an audience and uses a machine learning logic to identify audience demographical characteristics. Demographical characteristics are used to select and deliver audio entertainment, and/or audio information, and/or visual entertainment and/or visual information to the audience that is relevant to the audience. In other embodiments, demographic information is used to analyze audience or customer demographics based on time periods (hour, day, week, etc.), location(s), and/or point of sale data.

Abstract: The present invention relates to a novel robot drive train that is robust, and low cost. The drive train is capable of ascending obstacles greater than the height of its wheels, protects the robot against shocks/vibration, and is highly maneuverable, such as able to execute a zero-point turn. To control the bogie in a variety of scenarios, a novel mechanism is used to selectively limit the articulation range of the bogie and/or programmatically apply a preload to the bogie axle.

Abstract: An electronic hinge system is provided, including a first component and a second component. The first component may include a first enclosure, a first substrate extending within the first enclosure, a first connector, and a plurality of curved elements disposed in the first connector. The first substrate may have electrically conductive elements and microelectronic devices electrically connected with the electrically conductive elements. The curved elements may be electrically conductive and spaced apart from one another. Each curved element may be electrically connected with a respective one of the electrically conductive elements of the first component. The second component may include a second enclosure and a second connector disposed at an end of the second enclosure. The first connector may be configured to mate with the second connector, such that when the first component is engaged with the second component, the first connector is rotationally coupled with the second connector.