Patents by Inventor Marcel Hibert
Marcel Hibert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11046657Abstract: A subject of the present invention is a compound having the general formula (I): a pharmaceutically acceptable salt thereof or a tautomeric form thereof, wherein A, B3, B4, B5, Y, X, B1 and B2 are as defined in any one of claims 1 to 10. Another subject of the invention is the compound as defined above for use as a medicament, in particular for preventing and/or treating inflammation and inflammatory diseases, immune and auto-immune diseases, pain related diseases, genetic diseases and/or cancer.Type: GrantFiled: July 13, 2017Date of Patent: June 29, 2021Assignees: Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite de Strasbourg, Universite Paris-Sud, Centre International de Recherche aux Frontieres de la ChimieInventors: Dominique Bonnet, Nelly Frossard, Jean-Luc Galzi, Christophe Guignabert, Marcel Hibert, Frédéric Simonin, Sylviane Muller
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Publication number: 20200181093Abstract: A subject of the present invention is a compound having the general formula (I): a pharmaceutically acceptable salt thereof or a tautomeric form thereof, wherein A, B3, B4, B5, Y, X, B1 and B2 are as defined in any one of claims 1 to 10. Another subject of the invention is the compound as defined above for use as a medicament, in particular for preventing and/or treating inflammation and inflammatory diseases, immune and auto-immune diseases, pain related diseases, genetic diseases and/or cancer.Type: ApplicationFiled: July 13, 2017Publication date: June 11, 2020Applicants: Centre National de la Recherche Scientifique (CNRS, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Strasbourg, Universite Paris-Sud, Centre International de Recherche aux Frontieres d e la ChimieInventors: Dominique Bonnet, Nelly Frossard, Jean-Luc Galzi, Christophe Guignabert, Marcel Hibert, Frédéric Simonin, Sylviane Muller
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Patent number: 9663493Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: GrantFiled: June 29, 2016Date of Patent: May 30, 2017Assignees: Northwestern University, Universite De Strasbourg, Centre National De La Recherche Scientifique (CNRS)Inventors: D. Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Patent number: 9527819Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: GrantFiled: December 3, 2014Date of Patent: December 27, 2016Assignees: NORTHWESTERN UNIVERSITY, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: D. Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Publication number: 20160326139Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: ApplicationFiled: June 29, 2016Publication date: November 10, 2016Applicants: NORTHWESTERN UNIVERSITY, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: D. Martin WATTERSON, Linda VAN ELDIK, Jacques HAIECH, Marcel HIBERT, Jean-Jacques BOURGUIGNON, Anastasia VELENTZA, Wenhui HU, Magdalena ZASADZKI
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Publication number: 20150175555Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: ApplicationFiled: December 3, 2014Publication date: June 25, 2015Applicants: NORTHWESTERN UNIVERSITY, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: D. Martin WATTERSON, Linda VAN ELDIK, Jacques HAIECH, Marcel HIBERT, Jean-Jacques BOURGUIGNON, Anastasia VELENTZA, Wenhui HU, Magdalena ZASADZKI
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Patent number: 8933076Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for, research, drug screening, and therapeutic applications.Type: GrantFiled: June 8, 2012Date of Patent: January 13, 2015Assignees: Centre National de la Recherche Scientifique (CNRS), Northwestern University, Universite de StrasbourgInventors: D. Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Publication number: 20140186872Abstract: The present invention provides compounds having the formula A: (A) or pharmaceutically acceptable salt thereof, wherein W, R1, R2 and R5 are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as cytotoxic agents towards proliferating and/or quiescent cancer stem cells, and thus are useful, for example, for the treatment of cancer.Type: ApplicationFiled: June 6, 2012Publication date: July 3, 2014Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE- CNRS, UNIVERSITE DE STRASBOURGInventors: Marie Feve, Maria Zeniou-Meyer, Jacques Haiech, Herve Chneiweiss, Marie-Claude Kilhoffer, Samir Mameri, Marcel Hibert
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Patent number: 8367672Abstract: The invention relates to novel chemical compounds and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: GrantFiled: November 2, 2005Date of Patent: February 5, 2013Assignees: Universite de Strasbourg, Northwestern University, Centre National de la Recherche Scientifique (CNRS)Inventors: D. Martin Watterson, Linda J. Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Publication number: 20120245125Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for, research, drug screening, and therapeutic applications.Type: ApplicationFiled: June 8, 2012Publication date: September 27, 2012Applicants: Northwestern UniversityInventors: D. Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Patent number: 8088774Abstract: A novel class of pyridazine compositions and related methods of use.Type: GrantFiled: July 7, 2010Date of Patent: January 3, 2012Assignees: Northwestern University, Universite de Strasbourg, Centre National de la Recherche Scientifique, A Scientific Research CentreInventors: Daniel Martin Watterson, Anu R. Sawkar, Thomas J. Lukas, Salida Mirzoeva, Linda J. Van Eldik, Marcel Hibert, Anastasia Velentza, Magdalena Zasadzki, Jacques Haiech, Jean-Jacques Bourguignon
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Patent number: 8063047Abstract: The invention relates to novel chemical compounds of Formula I compositions and methods of using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: GrantFiled: May 12, 2008Date of Patent: November 22, 2011Assignees: Centre National de la Recherche Scientifique (CNRS), Northwestern University, Universite de StrasbourgInventors: Martin Watterson, Linda Van El Dik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Veleniza, Wenhui Hu, Magdaena Zasadzki
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Patent number: 7888357Abstract: A novel class of pyridazine compositions and related methods of use.Type: GrantFiled: October 26, 2005Date of Patent: February 15, 2011Assignees: Northwestern University, Universite de Strasbourg, Centre National de la Recherche ScientifiqueInventors: Daniel Martin Watterson, Anastasia Velentza, Magdalena Zasadzki, Jacques Haiech, Jean-Jacques Bourguignon, Anu R. Sawkar, Thomas J. Lukas, Salida Mirzoeva, Linda J. Van Eldik, Marcel Hibert
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Publication number: 20100317665Abstract: A novel class of pyridazine compositions and related methods of use.Type: ApplicationFiled: July 7, 2010Publication date: December 16, 2010Inventors: D.M. Watterson, Anastasia Velentza, Magdalena Zasadzki, Jacques Halech, Jean-Jacques Bourguignon, Anu R. Sawkar, Thomas J. Lukas, Salida Mirzoeva, Linda J. Van Eldik, Marcel Hibert
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Publication number: 20090170749Abstract: The present invention relates to novel pseudopeptide compounds of defined formula, capable of interacting with the PEA-15 protein and to the use thereof in screening methods and to a method of diagnosing pathological conditions which may involve PEA-15.Type: ApplicationFiled: December 15, 2006Publication date: July 2, 2009Applicant: Institut National De La Sante Et De La Recherche Medicale (Inserm)Inventors: Marcel Hibert, Hadjila Chabane, Dominique Bonnet, Jacques Haiech, Francois Renault-Mihara, Hervé M. Chneiweiss
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Publication number: 20090029985Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: ApplicationFiled: May 12, 2008Publication date: January 29, 2009Inventors: Martin Watterson, Linda Van El Dik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Valeniza, Wenhui Hu, Magdena Zasadzki
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Publication number: 20080318899Abstract: The invention relates to novel chemical compounds and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: ApplicationFiled: November 2, 2005Publication date: December 25, 2008Inventors: Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdelena Zasadzki
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Publication number: 20070249013Abstract: The invention concerns the use of a collection of traceable cationic compounds for determining ligands of a receptor whose ligand is unknown or whose ligand useful for specific affinity binding studies is unknown, said traceable cationic compounds being characterized in that they comprise at least one basic amino acid residue providing the cationic type to said compound and a tracer group, in particular a fluorophor, a colouring agent or a quencher.Type: ApplicationFiled: June 15, 2005Publication date: October 25, 2007Inventors: Marcel Hibert, Christel Franchet, Galzi Jean-Luc, Franc Pattus, Fabrice Guillier
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Publication number: 20060194259Abstract: A method for isolating an allosteric effector of a receptor, by determining the variation of the dissociation kinetics of the complex formed between the receptor and one of its ligands in the presence of the allosteric effector, as compared to the kinetics dissociation, in the absence of the effector, and/or the amplitude of the linkage formed between the receptor and the ligand in the presence of the allosteric effector, as compared to the amplitude in the absence of the effector. The receptor and ligand are being involved in at least one biological response, and the allosteric effector is capable of modulating at least one of the responses. The receptor is marked by at least one fluorescent protein, and the ligand by a molecule capable of absorbing light, or by a fluorescent substance.Type: ApplicationFiled: June 16, 2003Publication date: August 31, 2006Inventors: Jean-Luc Galzi, Marcel Hibert, Jean-Jacques Bourguignon, Emalina Maillet
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Publication number: 20060073472Abstract: A novel class of pyridazine compositions and related methods of use.Type: ApplicationFiled: October 26, 2005Publication date: April 6, 2006Inventors: D. Watterson, Anastasia Velentza, Magdalena Zasadzki, Jacques Haiech, Jean-Jacques Bourguignon, Anu Sawkar, Thomas Lukas, Salida Mirzoeva, Linda Van Eldik, Marcel Hibert