Patents by Inventor Marcel P. Bruchez
Marcel P. Bruchez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7144458Abstract: Nanocrystals are synthesized with a high degree of control over reaction conditions and hence product quality in a flow-through reactor in which the reaction conditions are maintained by on-line detection of characteristic properties of the product and by adjusting the reaction conditions accordingly. The coating of nanocrystals is achieved in an analogous manner.Type: GrantFiled: December 2, 2003Date of Patent: December 5, 2006Assignee: Invitrogen CorporationInventors: Donald A. Zehnder, Marcel P. Bruchez, Joseph A. Treadway, Jonathan P. Earhart
-
Patent number: 7129048Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide and/or an amplification product therefrom are provided. The methods comprise contacting a sample suspected of containing the target polynucleotide with a polynucleotide that can bind specifically thereto; this polynucleotide is conjugated to a substrate, preferably an encoded bead conjugate. An amplification reaction can first be used to produce the amplification product from the target polynucleotide so that it can be used to indirectly assay for the target polynucleotide. An amplification product detection complex and method of forming the same are also provided. The methods are particularly useful in multiplex settings where a plurality of targets are present. Amplification product assay complexes and amplification product assay arrays are also provided, along with methods of forming the same. Kits comprising reagents for performing such methods are also provided.Type: GrantFiled: November 17, 2003Date of Patent: October 31, 2006Assignee: Invitrogen CorporationInventors: Marcel P. Bruchez, Jennifer Lai, Vince Phillips, Andrew R. Watson, Edith Wong
-
Publication number: 20040247517Abstract: Nanocrystals are synthesized with a high degree of control over reaction conditions and hence product quality in a flow-through reactor in which the reaction conditions are maintained by on-line detection of characteristic properties of the product and by adjusting the reaction conditions accordingly. The coating of nanocrystals is achieved in an analogous manner.Type: ApplicationFiled: December 2, 2003Publication date: December 9, 2004Applicant: Quantum Dot Corporation, a corporation of the state of CaliforniaInventors: Donald A. Zehnder, Marcel P. Bruchez, Joseph A. Treadway, Jonathan P. Earhart
-
Publication number: 20040171039Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide and/or an amplification product therefrom are provided. The methods comprise contacting a sample suspected of containing the target polynucleotide with a polynucleotide that can bind specifically thereto; this polynucleotide is conjugated to a substrate, preferably an encoded bead conjugate. An amplification reaction can first be used to produce the amplification product from the target polynucleotide so that it can be used to indirectly assay for the target polynucleotide. An amplification product detection complex and method of forming the same are also provided. The methods are particularly useful in multiplex settings where a plurality of targets are present. Amplification product assay complexes and amplification product assay arrays are also provided, along with methods of forming the same. Kits comprising reagents for performing such methods are also provided.Type: ApplicationFiled: November 17, 2003Publication date: September 2, 2004Applicant: Quantum Dot CorporationInventors: Marcel P. Bruchez, Jennifer Lai, Vince Phillips, Andrew R. Watson, Edith Wong
-
Publication number: 20040166505Abstract: The use of semiconductor nanocrystals as detectable labels in various chemical and biological applications is disclosed. The methods find use for detecting a single analyte, as well as multiple analytes by using more than one semiconductor nanocrystal as a detectable label, each of which emits at a distinct wavelength.Type: ApplicationFiled: July 30, 2003Publication date: August 26, 2004Applicant: Quantum Dot CorporationInventors: Marcel P. Bruchez, R. Hugh Daniels, Stephen A. Empedocles, Vince E. Phillips, Edith Y. Wong, Donald A. Zehnder
-
Publication number: 20040023261Abstract: Methods, compositions and articles of manufacture for encoding a cell with semiconductor nanocrystals and/or other fluorophors are provided. The encoded cells can be subjected to functional assays in mixed populations, and an assay result can be determined and associated with individual cells by virtue of their code. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed. The methods are used in screening methods for G protein coupled receptors (GPCRs), for identifying the ligands and functions of orphan GPCRs, and for screening for modulators of GPCRs. Kits comprising reagents for performing such methods are also provided.Type: ApplicationFiled: February 26, 2003Publication date: February 5, 2004Inventors: Marcel P. Bruchez, R. Hugh Daniels, Jennifer Dias, Larry C. Mattheakis, Jianquan Liu
-
Patent number: 6682596Abstract: Nanocrystals are synthesized with a high degree of control over reaction conditions and hence product quality in a flow-through reactor in which the reaction conditions are maintained by on-line detection of characteristic properties of the product and by adjusting the reaction conditions accordingly. The coating of nanocrystals is achieved in an analogous manner.Type: GrantFiled: December 26, 2001Date of Patent: January 27, 2004Assignee: Quantum Dot CorporationInventors: Donald A. Zehnder, Marcel P. Bruchez, Joseph A. Treadway, Jonathan P. Earhart
-
Patent number: 6653080Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide and/or an amplification product therefrom are provided. The methods comprise contacting a sample suspected of containing the target polynucleotide with a polynucleotide that can bind specifically thereto; this polynucleotide is conjugated to a substrate, preferably an encoded bead conjugate. An amplification reaction can first be used to produce the amplification product from the target polynucleotide so that it can be used to indirectly assay for the target polynucleotide. An amplification product detection complex and method of forming the same are also provided. The methods are particularly useful in multiplex settings where a plurality of targets are present. Amplification product assay complexes and amplification product assay arrays are also provided, along with methods of forming the same. Kits comprising reagents for performing such methods are also provided.Type: GrantFiled: March 22, 2001Date of Patent: November 25, 2003Assignee: Quantum Dot CorporationInventors: Marcel P. Bruchez, Jennifer Lai, Vince Phillips, Andrew R. Watson, Edith Wong
-
Patent number: 6630307Abstract: The use of semiconductor nanocrystals as detectable labels in various chemical and biological applications is disclosed. The methods find use for detecting a single analyte, as well as multiple analytes by using more than one semiconductor nanocrystal as a detectable label, each of which emits at a distinct wavelength.Type: GrantFiled: June 21, 2001Date of Patent: October 7, 2003Assignee: Quantum Dot CorporationInventors: Marcel P. Bruchez, R. Hugh Daniels, Stephen A. Empedocles, Vince E. Phillips, Edith Y. Wong, Donald A. Zehnder
-
Publication number: 20030165951Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide and/or an amplification product therefrom are provided. The methods comprise contacting a sample suspected of containing the target polynucleotide with a polynucleotide that can bind specifically thereto; this polynucleotide is conjugated to a substrate, preferably an encoded bead conjugate. An amplification reaction can first be used to produce the amplification product from the target polynucleotide so that it can be used to indirectly assay for the target polynucleotide. An amplification product detection complex and method of forming the same are also provided. The methods are particularly useful in multiplex settings where a plurality of targets are present. Amplification product assay complexes and amplification product assay arrays are also provided, along with methods of forming the same. Kits comprising reagents for performing such methods are also provided.Type: ApplicationFiled: December 30, 2002Publication date: September 4, 2003Applicant: Quantum Dot CorporationInventors: Marcel P. Bruchez, Jennifer H. Lai, Vince E. Phillips, Andrew R. Watson, Edith Y. Wong
-
Patent number: 6500622Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide and/or an amplification product therefrom are provided. The methods comprise contacting a sample suspected of containing the target polynucleotide with a polynucleotide that can bind specifically thereto; this polynucleotide is conjugated to a substrate, preferably an encoded bead conjugate. An amplification reaction can first be used to produce the amplification product from the target polynucleotide so that it can be used to indirectly assay for the target polynucleotide. An amplification product detection complex and method of forming the same are also provided. The methods are particularly useful in multiplex settings where a plurality of targets are present. Amplification product assay complexes and amplification product assay arrays are also provided, along with methods of forming the same. Kits comprising reagents for performing such methods are also provided.Type: GrantFiled: March 22, 2001Date of Patent: December 31, 2002Assignee: Quantum Dot CorporationInventors: Marcel P. Bruchez, Jr., Jennifer H. Lai, Vince E. Phillips, Andrew R. Watson, Edith Y. Wong
-
Publication number: 20020155507Abstract: Methods, compositions and articles of manufacture for encoding a cell with semiconductor nanocrystals and/or other fluorophors are provided. The encoded cells can be subjected to functional assays in mixed populations, and an assay result can be determined and associated with individual cells by virtue of their code. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed. The methods are used in screening methods for G protein coupled receptors (GPCRs), for identifying the ligands and functions of orphan GPCRs, and for screening for modulators of GPCRs. Kits comprising reagents for performing such methods are also provided.Type: ApplicationFiled: October 5, 2001Publication date: October 24, 2002Inventors: Marcel P. Bruchez, R. Hugh Daniels, Jennifer Dias, Larry C. Mattheakis
-
Publication number: 20020144644Abstract: Nanocrystals are synthesized with a high degree of control over reaction conditions and hence product quality in a flow-through reactor in which the reaction conditions are maintained by on-line detection of characteristic properties of the product and by adjusting the reaction conditions accordingly. The coating of nanocrystals is achieved in an analogous manner.Type: ApplicationFiled: December 26, 2001Publication date: October 10, 2002Applicant: Quantum Dot CorporationInventors: Donald A. Zehnder, Marcel P. Bruchez, Joseph A. Treadway, Jonathan P. Earhart
-
Publication number: 20020083888Abstract: Nanocrystals are synthesized with a high degree of control and hence product quality control in a flow-through reactor in which the reaction conditions are maintained by on-line detection of characteristic properties of the product and by adjusting the reaction conditions accordingly. The coating of nanocrystals is achieved in an analogous manner.Type: ApplicationFiled: December 28, 2000Publication date: July 4, 2002Inventors: Donald A. Zehnder, Marcel P. Bruchez, Joseph A. Treadway
-
Publication number: 20020039732Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide and/or an amplification product therefrom are provided. The methods comprise contacting a sample suspected of containing the target polynucleotide with a polynucleotide that can bind specifically thereto; this polynucleotide is conjugated to a substrate, preferably an encoded bead conjugate. An amplification reaction can first be used to produce the amplification product from the target polynucleotide so that it can be used to indirectly assay for the target polynucleotide. An amplification product detection complex and method of forming the same are also provided. The methods are particularly useful in multiplex settings where a plurality of targets are present. Amplification product assay complexes and amplification product assay arrays are also provided, along with methods of forming the same. Kits comprising reagents for performing such methods are also provided.Type: ApplicationFiled: March 22, 2001Publication date: April 4, 2002Inventors: Marcel P. Bruchez, Jennifer Lai, Vince E. Phillips, Andrew R. Watson, Edith Wong
-
Publication number: 20020034747Abstract: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide and/or an amplification product therefrom are provided. The methods comprise contacting a sample suspected of containing the target polynucleotide with a polynucleotide that can bind specifically thereto; this polynucleotide is conjugated to a substrate, preferably an encoded bead conjugate. An amplification reaction can first be used to produce the amplification product from the target polynucleotide so that it can be used to indirectly assay for the target polynucleotide. An amplification product detection complex and method of forming the same are also provided. The methods are particularly useful in multiplex settings where a plurality of targets are present. Amplification product assay complexes and amplification product assay arrays are also provided, along with methods of forming the same. Kits comprising reagents for performing such methods are also provided.Type: ApplicationFiled: March 22, 2001Publication date: March 21, 2002Inventors: Marcel P. Bruchez, Jennifer H. Lai, Vince E. Phillips, Andrew R. Watson, Edith Y. Wong
-
Publication number: 20020009728Abstract: Methods for assaying a sample for a probe polynucleotide are provided. The methods comprise forming a complex between a target on a substrate, the probe polynucleotide that binds to the target, and a conjugate comprising a semiconductor nanocrystal that binds to the probe polynucleotide by way of a tag sequence on the probe polynucleotide. The complex is formed when the probe polynucleotide is present in the sample. The methods are useful in any technique in which the detection of a target that can bind to a probe polynucleotide is desired, for example in fluorescence in situ hybridization. The methods are particularly useful in multiplex settings such as hybridization to microarrays where a plurality of targets are present. Assay complexes produced by such methods and kits useful for performing such methods are also provided.Type: ApplicationFiled: January 18, 2001Publication date: January 24, 2002Applicant: Quantum Dot CorporationInventors: Michael Bittner, Edith Y. Wong, Marcel P. Bruchez
-
Publication number: 20010034034Abstract: The use of semiconductor nanocrystals as detectable labels in various chemical and biological applications is disclosed. The methods find use for detecting a single analyte, as well as multiple analytes by using more than one semiconductor nanocrystal as a detectable label, each of which emits at a distinct wavelength.Type: ApplicationFiled: June 21, 2001Publication date: October 25, 2001Applicant: Quantum Dot CorporationInventors: Marcel P. Bruchez, R. Hugh Daniels, Stephen A. Empedocles, Vince E. Phillips, Edith Y. Wong, Donald A. Zehnder
-
Patent number: 6274323Abstract: The use of semiconductor nanocrystals as detectable labels in various chemical and biological applications is disclosed. The methods find use for detecting a single analyte, as well as multiple analytes by using more than one semiconductor nanocrystal as a detectable label, each of which emits at a distinct wavelength.Type: GrantFiled: May 5, 2000Date of Patent: August 14, 2001Assignee: Quantum Dot CorporationInventors: Marcel P. Bruchez, R. Hugh Daniels, Stephen A. Empedocles, Vince E. Phillips, Edith Y. Wong, Donald A. Zehnder