Abstract: Processes of manufacturing polymeric microspheres facilitate the generation of polymeric microspheres of size ranges smaller than 600 microns diameter by forming beads of a predetermined size from a starting material which may include a template polymer, and subsequently contacting the beads with a structural polymer. After crosslinking of the structural polymer has taken place, the template polymer may be removed to form the finished microspheres.

Abstract: Particles and related methods are disclosed. In some embodiments, a method of making particles can include forming a stream of a mixture including first and second materials, exposing the stream to a vibration, and treating the stream to form particles. The vibration can have, for example, a sinusoidal, triangular, and/or sawtooth waveform.

Abstract: Processes of manufacturing polymeric microspheres facilitate the generation of polymeric microspheres of size ranges smaller than 600 microns diameter by forming beads of a predetermined size from a starting material which may include a template polymer, and subsequently contacting the beads with a structural polymer. After crosslinking of the structural polymer has taken place, the template polymer may be removed to form the finished microspheres.

Abstract: Embolization, as well as related particles and methods, are described.

Abstract: A device for introducing an embolic coil into a catheter comprises an elongated body defining a longitudinal passage extending therethrough from a first opening at a proximal end thereof to a second opening at a distal end thereof, the elongated body being including a mating portion for conforming to a size and shape of an opening in a hub of a catheter to mate therewith and an embolic coil introducer sheath including a coil receiving lumen extending therethrough, a distal tip of the introducer sheath being dimensioned to be received within a proximal end of the longitudinal passage. Similarly, a method of implanting an embolic coil, comprises inserting a stabilizer into a catheter hub so that a flexible mating portion substantially conforms to a shape of an inner surface of the hub wherein the stabilizer includes a passage extending therethrough from a proximal opening to a distal opening thereof.

Abstract: Embolization, as well as related compositions and methods, are disclosed.

Abstract: A delivery catheter for delivering material(s) into the body of a mammal can include a first elongated member and a second elongated member. At least a portion of the second elongated member can be slidably disposed within a lumen of the first elongated member. The delivery catheter can mix two materials and then introduce the mixed materials into the body of a mammal.

Abstract: The invention relates to bulking agents and apparatus and methods for using the disclosed bulking agents. The bulking agents can be used to treat such conditions as urinary and fecal incontinence, gastro-esophageal reflux, aneurismal blockages, and cosmetic deformities. The invention also relates to an injection method that reduces the injection pressure required to place the bulking agents.

Abstract: A method of treating tissue includes placing substantially spherical polymer particles in the tissue. The particles include an interior region having relatively large pores and a first region substantially surrounding the interior having fewer relatively large pores than the interior region.

Abstract: A delivery catheter for delivering material(s) into the body of a mammal can include a first elongated member and a second elongated member. At least a portion of the second elongated member can be slidably disposed within a lumen of the first elongated member. The delivery catheter can mix two materials and then introduce the mixed materials into the body of a mammal.

Abstract: A drug delivery particle including a reservoir region having primarily large pores and a metering region. The particle can be highly spherical.

Abstract: Processes of manufacturing polymeric microspheres facilitate the generation of polymeric microspheres of size ranges smaller than 600 microns diameter by forming beads of a predetermined size from a starting material which may include a template polymer, and subsequently contacting the beads with a structural polymer. After crosslinking of the structural polymer has taken place, the template polymer may be removed to form the finished microspheres.

Abstract: Embolic polymer particles are described.

Abstract: A delivery catheter for delivering material(s) into the body of a mammal can include a first elongated member and a second elongated member. At least a portion of the second elongated member can be slidably disposed within a lumen of the first elongated member. The delivery catheter can mix two materials and then introduce the mixed materials into the body of a mammal.