Abstract: A computer-implemented method of evaluating the performance of a trajectory planner in simulation comprises miming first instances of a scenario in a simulator, the first instances run with a first set of parameterizations of the scenario, the trajectory planner used to control an ego agent responsive in each scenario instance; evaluating performance of the trajectory planner in each scenario instance, thereby computing a set of test results for the first set of scenario parameterizations; identifying at least one target parameterization of the first set based on the set of test results; and based on the target parameterization, determining a second set of parameterizations of the scenario for miming second instances of the scenario for exploring a subspace of the parameter space in the vicinity of the target parameterization.

Abstract: The present invention primarily relates to a process for production of one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulphuric compounds, the process comprising providing a culture medium comprising one or more components supporting growth of a fungus from the phylum Basidiomycota and being convertable to one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulfur aroma compounds; cultivating a fungus from the phylum Basidiomycota in or on the culture medium under conditions that support the growth of the fungus and formation of the one or more flavourings, and optionally recovering the one or more flavourings.

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: A bumper crossmember comprising a wave structure oriented in the vertical direction (z direction), wherein the wave structure comprises at least three apex structures which extend in the bumper crossmember longitudinal direction and are adjacent in the vertical direction. This crossmember comprises a first length section that follows its longitudinal extent, at least one second length section that follows its longitudinal extent, and at least one transition section that is arranged respectively between these length sections. In the second length section, the wave structure is inverted with respect to the first length section, in that the opening direction of the apex structures switches in the transition section. In the transition section, there is at least one additional apex-forming structure, the apex of which is offset in the frontal direction (x direction) with respect to a frontal plane (yz-plane) in which at least two apex structures that are adjacent in the longitudinal sections lie.

Abstract: A method for pre-authorizing a delivery transaction is disclosed. A transaction value can be pre-authorized such that resources can be delivered. After the resources are delivered, a user can determine whether to continue with processing the transaction.

Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: A soundproof fume discharge conduit adapted to be arranged between a ventilation system and an outlet chimney, the conduit defining a fume path therein, wherein at least one side surface of the conduit is provided with at least two protrusions, each protrusion internally defining a respective step-shaped recess, whereby the path is provided with at least two step-shaped recesses adapted to reflect sound waves propagating along the path, and wherein the step shape of each recess is defined by two first walls, which are incident at a first end thereof, and at least one wall of the two first walls is coated with a first sound absorbing material.

Abstract: In some embodiments, the invention relates to methods and reagents for the identification of compounds that traverse he cell membrane of an animal cell. In some embodiments, the invention provides additional methods for determining if a candidate compound that traverses an animal cell membrane is able to modulate an intracellular target, as well as reagents and kits for reagents and kits for performing the disclosed methods.

Abstract: The present invention relates to a silicone-gel-coated, adhesive layer structure, a method for the production thereof as well as the use thereof. The layer structure comprises a porous backing material, an intermediate layer applied to one side of the porous backing material and an adhesive layer made of a silicone gel applied to the intermediate layer.

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: The present invention relates to a silicone-gel-coated, adhesive layer structure, a method for the production thereof as well as the use thereof. The layer structure comprises a porous backing material, an intermediate layer applied to one side of the porous backing material and an adhesive layer made of a silicone gel applied to the intermediate layer.

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.

Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.

Abstract: A soundproof fume discharge conduit adapted to be arranged between a ventilation system and an outlet chimney, the conduit defining a fume path therein, wherein at least one side surface of the conduit is provided with at least two protrusions, each protrusion internally defining a respective step-shaped recess, whereby the path is provided with at least two step-shaped recesses adapted to reflect sound waves propagating along the path, and wherein the step shape of each recess is defined by two first walls, which are incident at a first end thereof, and at least one wall of the two first walls is coated with a first sound absorbing material.

Abstract: A remote station and method for rendering a ground plane over video feed are provided. The remote station comprises a processor, a communication interface for communicating with an unmanned vehicle (UV), and a non-transitory memory device storing a communications module. The communications module comprises machine-readable instructions that, when executed by the processor, causes the processor to render a ground plane over video feed. The method comprises receiving a video feed from a camera on a UV, receiving from the UV telemetry information of the camera, receiving from the camera a zoom factor of the camera, calculating a horizon of the camera at a UV controller of the UV, and rendering the horizon as an overlay image on the video feed at a display of the UV controller.

Abstract: Splice variants associated with neomorphic SF3B1 mutations are described herein. This application also relates to methods of detecting the described splice variants, and uses for diagnosing cancer, evaluating modulators of SF3B1, and methods of treating cancer associated with mutations in SF3B1.

Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.

Abstract: The present invention relates to a reel for a plaster strip roll with one or two side discs and/or a cover/protective ring for a plaster strip roll, which optionally has a tear-off edge, as well as the production thereof. The reel or the cover/protective ring, respectively, comprises an antimicrobially effective substance, wherein, on the outer surface of the reel or of the cover/protective ring, respectively, there is contact between the antimicrobially effective substance and the environment.