Abstract: Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.

Abstract: Described herein are compounds and chemical entities of Formula (I), methods of their synthesis, compositions comprising them, and their use in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.

Abstract: Described herein are compounds and chemical entities of Formula (I), methods of their synthesis, compositions comprising them, and their use in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.

Abstract: Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.

Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.

Abstract: A cutting device for perforating a running fibrous material web transversely to the web running direction has a first row of blades with a plurality of tips. A displacement device moves the row of blades with a motion component in the web running direction and a motion component perpendicular to the web running direction. Transverse separation by perforation and subsequent tearing is improved, particularly for heavy fibrous material webs (>250 g/mm2), by providing a second row of blades, which has a plurality of tips and which is also displaceable by a displacement device approximately simultaneously with the first row of blades. Cuts are made in the running fibrous web at a spacing distance between the cuts made by the first row of blades and the cuts made by the second row of blades in the web running direction of at least 1 mm, preferably at least 3 mm.

Abstract: Described herein are compounds and chemical entities of Formula I, methods of their synthesis, compositions comprising them, and their use in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.

Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analyzed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.

Abstract: A clutch assembly includes an input shaft, an output shaft, at least one first friction plate mounted to the input shaft, and at least one second friction plate mounted to the output shaft and spaced apart from the at least one first friction plate. The clutch assembly also includes a rheological fluid positioned between the at least one first friction plate and the at least one second friction plate, and a fluid activator configured to increase a viscosity of the rheological fluid to provide increased torque transfer from the at least one first friction plate to the at least one second friction plate.

Abstract: An air compressor includes a first compressor stage and at least one motor. The first compressor stage includes a first housing, a first drive plate, and a plurality of first pistons. The first drive plate is positioned in the first housing and includes an odd number of first lobes. The plurality of first pistons each contact the first drive plate at different locations relative to top dead center on the first lobes. The at least one motor is operable to rotate the first drive plate to move the plurality of first pistons to generate a volume of compressed air in the first housing.

Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.

Abstract: A building is provided with a hood for drawing fumes produced in a metallurgical environment, comprising: a main hood body defining a hood conduit having a decreasing cross-section between an inlet and an outlet openings for the fumes coming from the metallurgical environment; a header for collecting fumes coming from the outlet opening of the main hood body; one or more pipes for conveying fumes outside said header. Portions of said main hood body form walls of said one or more pipes.

Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.

Abstract: Reagents and compositions for use in reactions catalysed by luciferase enzymes, and in particular for use in luciferase-based gene reporter assays are described. The invention also provides methods and compositions for, inter alia, increasing the sensitivity and/or improving the kinetics of luciferase-catalysed reactions.

Abstract: The present invention provides methods for screening a pharmaceutical agent for its ability to modulate long term memory formation, performance of a hippocampal-dependent cognitive task or Gpr12 function. The present invention also provides methods for modulating long term memory formation or performance of a hippocampal-dependent cognitive task by modulating Gpr12-dependent protein expression. The present invention further provides methods for treating a defect in long term memory formation by inhibiting Gpr12 function and methods for treating a defect in performance of a hippocampal-dependent cognitive task by inhibiting Gpr12 function.

Abstract: A floor-cleaning machine which can be driven over the floor, includes a driven brush for sweeping the floor to be cleaned. The brush picks up dirt and debris from the floor and carries it, assisted by forced air flow, in an overhead motion and through a transfer duct to a pair of dirt containers in the form of buckets located side-by-side at the rear of the machine. A manual linkage at the rear of the machine moves a pivoted carrier frame which holds the dirt containers, between a raised use position in which the upper rims of the dirt containers are sealed to the machine for collection of debris, and a lowered access position for removal of the containers. Each container is independently accessible for emptying, and includes a bail-type handle pivotally attached such that a bucket, the opening of which faces forwardly and upwardly in the use position, extends generally horizontal when removed, to avoid spillage.

Abstract: The present invention provides methods for screening a pharmaceutical agent for its ability to modulate long term memory formation, performance of a hippocampal-dependent cognitive task or Gpr12 function. The present invention also provides methods for modulating long term memory formation or performance of a hippocampal-dependent cognitive task by modulating Gpr12-dependent protein expression. The present invention further provides methods for treating a defect in long term memory formation by inhibiting Gpr12 function and methods for treating a defect in performance of a hippocampal-dependent cognitive task by inhibiting Gpr12 function.

Abstract: The disclosed invention relates to cell based screening assays that are useful to identify compounds that enhance memory in normal and memory impaired individuals.

Abstract: Disclosed herein are methods for determining the amount or activity of one or more luciferases and methods for measuring the luminescent signal generated by one or more luciferases in a sample, the methods comprising incubating the sample with a reactive substrate(s) of the luciferase(s) to be analysed and a reducing agent to inactivate a first luciferase, wherein the first luciferase, in its native form, is a secreted luciferase.

Abstract: Reagents and compositions for use in reactions catalysed by luciferase enzymes, and in particular for use in luciferase-based gene reporter assays are described. The invention also provides methods and compositions for, inter alia, increasing the sensitivity and/or improving the kinetics of luciferase-catalysed reactions.