Patents by Inventor Marco Villa

Marco Villa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of L-5-(2-acetoxy-propionylamino)-2,4,6-triiodo-isophthalic acid dichloride
    Patent number: 5362905
    Abstract: An improvement to a process for the preparation of L-5-(2-acetoxy-propionylamino)-2,4,6-triiodo-isophthalic acid dichloride by reacting 5-amino-2,4,6-triiodo-isophthalic acid dichloride with L-2-acetoxy-propionyl-chloride, is described.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: November 8, 1994
    Assignee: Zambon Group S.p.A.
    Inventors: Marco Villa, Maurizio Paiocchi, Aldo Di Caterino
  • Intermediates for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers
    Patent number: 5284966
    Abstract: Intermediates for transforming (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R)-enantiomers are described. The final compounds are useful intermediates for the synthesis of antibiotics like Chloramphenicol, Thiamphenicol and Florfenicol.
    Type: Grant
    Filed: December 18, 1992
    Date of Patent: February 8, 1994
    Assignee: Zambon Group S.p.A.
    Inventors: Marco Villa, Claudio Giordano, Silvia Cavicchioli, Silvio Levi
  • Process for the dehalogenation of naphthalene derivatives
    Patent number: 5268491
    Abstract: A process for the selective dehalogenation in position 5 of the naphthalenic nucleus of compounds of formula ##STR1## (wherein X, X.sub.1 and R have the meanings reported in the description) by treatment with a dehalogenating agent selected among hydrogen sulfide, aliphatic thiols or mixtures thereof in an inert anhydrous solvent at acid pH.
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: December 7, 1993
    Assignee: Zambon Group S.p.A.
    Inventors: Marco Villa, Paolo Cavalleri
  • Process for the stereochemical inversion of (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R) enantiomers
    Patent number: 5202484
    Abstract: A four step process for transforming (2S,3S)-2-amino-3-phenyl-1,3-propanediols into their (2R,3R)-enantiomers is described. The final compounds are useful intermediates for the synthesis of antibiotics like Chloramphenicol, Thiamphenicol and Florfenicol. The starting products generally are discard products in the synthesis of said antibiotics.
    Type: Grant
    Filed: October 19, 1990
    Date of Patent: April 13, 1993
    Assignee: Zambon Group S.p.A.
    Inventors: Marco Villa, Claudio Giordano, Silvia Cavicchioli, Silvio Levi
  • Trioxy bicyclic compounds useful for preparing optically active carboxylic acids
    Patent number: 5084569
    Abstract: A stereoconvergent process is described for preparing optically active alpha-arylalkanoic acids using as starting substance a diastereoisomeric mixture of ketals of formula ##STR1## in which the substitutents have the meanings given in the description. The described process leads to the formation of a single enantiomer.
    Type: Grant
    Filed: March 15, 1990
    Date of Patent: January 28, 1992
    Assignee: Zambon SpA
    Inventors: Marco Villa, Claudio Giordano, Graziano Castaldi, Silvia Cavicchioli
  • Process for preparing naproxen
    Patent number: 5053533
    Abstract: A process for preparing alpha-arylalkanoic acids is described, and more specifically a process which is particularly convenient from the industrial aspect for the synthesis of S(+)2-(6-methoxy-2-naphthyl)-1-propionic acid.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: October 1, 1991
    Assignee: Zambon Group SpA
    Inventors: Claudio Giordano, Marco Villa
  • Carboxylic acid synthesis process
    Patent number: 4937379
    Abstract: A process is described for preparing alpha-arylalkanoic acids, which comprises preparing and subsequently rearranging ketals of formula ##STR1## (in which Ar, R, R.sub.1, R.sub.2 and R.sub.4 have the meanings given in the description).The ketals of formula II are prepared from the corresponding alpha-hydroxyketals.The rearrangement reaction is conducted under mild conditions.
    Type: Grant
    Filed: July 30, 1987
    Date of Patent: June 26, 1990
    Assignee: Zambon S.p.A.
    Inventors: Claudio Giordano, Marco Villa
  • Stereoconvergent process for preparing optically active carboxylic acids
    Patent number: 4922009
    Abstract: A stereoconvergent process is described for preparing optically active alpha-arylalkanoic acids using as starting substance a diastereoisomeric mixture of ketals of formula ##STR1## in which the substituents have the meanings given in the description. The described process leads to the formation of a single enantiomer.
    Type: Grant
    Filed: December 23, 1987
    Date of Patent: May 1, 1990
    Assignee: Zambon SpA
    Inventors: Marco Villa, Claudio Giordano, Graziano Castaldi, Silvia Cavicchioli