Abstract: A fluid channel assembly for a connector of a charging gun for an electric vehicle is provided. The fluid channel assembly includes a fluid channel network for cooling a contact pin of the charging gun. The fluid channel network is arranged around the contact pin and is in direct or indirect contact with the contact pin. Further, the fluid channel assembly includes a fluid inlet connected to the fluid channel network via a first single fluid transfer channel. The fluid inlet is configured to receive a coolant through a charging cable and to inject the coolant into the fluid channel network. A fluid outlet connected to the fluid channel network via a second single fluid transfer channel is provided. The fluid outlet is configured to receive the coolant from the fluid channel network and to inject the coolant into the charging cable.

Abstract: The present invention provides compounds of the formula: wherein A, Z, G, R1, R2, and R4 are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and pharmaceutically acceptable salts thereof for treating patients for cancer.

Abstract: A computing system including a processor configured to receive atomistic molecular dynamics simulation data of training-time conformers of an atomistic structure of a molecule. The processor is further configured to compute coarse-grained molecular dynamics simulation data based at least in part on the atomistic molecular dynamics simulation data. The coarse-grained molecular dynamics simulation data is computed at least in part by converting the atomistic structure into a coarse-grained structure. The processor is further configured to train a denoising diffusion model using the coarse-grained molecular dynamics simulation data. At the denoising diffusion model, the processor is further configured to receive a runtime conformer of the coarse-grained structure and generate a coarse-grained force field estimate associated with the runtime conformer.

Abstract: A sheave (100) for a passenger conveyor system is provided. The sheave (100) comprises a sheave axis (150) about which the sheave (100) rotates; a cylindrical sleeve (105); and a bearing (120a, 120b) centred on and arranged to rotate about the sheave axis (150). The cylindrical sleeve (105) includes an outer surface (110) including a groove (155) arranged to receive a belt; and an inner surface (115) defining a cylindrical cavity (122) centred on the sheave axis (150). The bearing (120a, 120b) includes an outer race (125a), an inner race (130a) and one or more rolling elements (135a) therebetween, wherein the outer race (125a) comprises a protrusion (140) arranged to hold the bearing (120a, 120b) within the cylindrical cavity (122) due to engagement between the protrusion (140) and the inner surface of the cylindrical sleeve (115).

Abstract: The present invention relates to a disinfection composition and a process for disinfection hard surface. This invention is especially useful for remove bacteria and virus.

Abstract: A coupler lock device is configured for use with a self-latching trailer coupler securing a hitch ball in the coupler socket. The coupler lock device has a housing that includes a top panel portion defining a cavity configured so that, when the housing is secured in position over the trailer coupler, the housing top panel prevents seating of the hitch ball in the coupler socket by restricting upward movement of the release lever when an attempt is made to insert the hitch ball into the coupler socket. Also, when the housing is secured in position over the trailer coupler with a hitch ball seated in the coupler socket, the housing top panel prevents removal of the coupler socket from the hitch ball by restricting upward movement of the release lever that would otherwise release the coupler socket from the hitch ball.

Abstract: Polymers for gene therapy. The present invention relates to a polymer, more specifically a polyphosphazene polymer, that is useful for gene therapy. The invention also relates to a complex comprising the polymer, the method for producing same and uses thereof.

Abstract: The present invention relates to bispecific antigen binding molecules targeting (i) IL-13 or IL-13R and (ii) OX40L or OX40, pharmaceutical compositions comprising the same, and methods of treatment using the same, e.g. in treating a dermatological disease or condition such as atopic dermatitis.

Abstract: The present invention relates to a cyclopropenium salt bearing an electron withdrawing group suitable for use as a reagent in cyclopropenylation reactions of formula (I). The invention also relates to a process for their preparation, the use thereof as cyclopropenylation reagent, to an electrophilic aromatic substitution process of cyclopropenylation, and to a process for cyclopropenylation of organometallic substrates using said reagents.

Abstract: An adapter for a trailer coupler assembly includes an elongated riser member configured to be removably mounted to a vertical channel of a trailer coupler. The riser member has a transverse cross-section generally in the shape of an I-beam having a first channel portion and an opposing second channel portion. The first channel portion includes a generally U-shaped transverse cross-section and is configured to be removably mounted to a vertical channel of a trailer coupler assembly at one of a plurality of longitudinal positions along a length of the vertical channel of the trailer coupler assembly. The opposing second channel portion includes a generally U-shaped transverse cross-section configured to hold a trailer coupler.

Abstract: An improved hitch ball mount includes a draw bar shank having vibration-isolating member disposed over a portion of an outer surface of a draw bar rod. The vibration-isolating member comprises a vibration-absorbing material, and the draw bar shank is sized to fit closely within a receiver tube of a receiver hitch assembly so that the vibration-isolating member contacts the interior of the receiver tube when the draw bar is positioned within the receiver tube. The vibration-absorbing material can comprise a layer of composite or rubberized material. The vibration-isolating member can be a removable sleeve that can be slidingly positioned over the draw bar rod or it can be a layer of vibration-absorbing material molded over a portion of the draw bar rod. In some embodiments, one or more protrusions can be disposed on the outer surface of the draw bar rod.

Abstract: The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human IL-36 cytokines, IL-36?, IL-36?, and/or IL-36?, and block the IL-36 stimulated signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided.

Abstract: An adapter for a trailer coupler assembly includes an elongated riser member configured to be removably mounted to a vertical channel of a trailer coupler. The riser member has a transverse cross-section generally in the shape of an I-beam having a first channel portion and an opposing second channel portion. The first channel portion includes a generally U-shaped transverse cross-section and is configured to be removably mounted to a vertical channel of a trailer coupler assembly at one of a plurality of longitudinal positions along a length of the vertical channel of the trailer coupler assembly. The opposing second channel portion includes a generally U-shaped transverse cross-section configured to hold a trailer coupler.

Abstract: A tow hitch assembly includes a draw bar and a hitch ball mount pivotally supported by the draw bar. A compression spring is disposed longitudinally between the draw bar and the hitch ball mount. The compression spring exerts a force that opposes a downward pivoting motion of the hitch ball mount when weight is placed on the hitch ball mount. The compression spring cooperates with an indicator configured to indicate to a user whether the weight placed on the hitch ball mount is within a predetermined weight range. The compression spring is removable and replaceable with a second compression spring that has a different spring constant. The second compression spring cooperates with the indicator to indicate to a user whether the weight placed on the hitch ball mount is within a second, different predetermined weight range.

Abstract: A sheave (100) for a passenger conveyor system is provided. The sheave (100) comprises a sheave axis (150) about which the sheave (100) rotates; a cylindrical sleeve (105); and a bearing (120a, 120b) centred on and arranged to rotate about the sheave axis (150). The cylindrical sleeve (105) includes an outer surface (110) including a groove (155) arranged to receive a belt; and an inner surface (115) defining a cylindrical cavity (122) centred on the sheave axis (150). The bearing (120a, 120b) includes an outer race (125a), an inner race (130a) and one or more rolling elements (135a) therebetween, wherein the outer race (125a) comprises a protrusion (140) arranged to hold the bearing (120a, 120b) within the cylindrical cavity (122) due to engagement between the protrusion (140) and the inner surface of the cylindrical sleeve (115).

Abstract: A user input device (202), for providing an input to an elevator controller is disclosed. The user input device (202) includes a plurality of input regions (204A-204F) each of which correspond to a different input command; and a single touchless sensor (216) arranged to detect the presence of an object in any of the plurality of input regions (204A-204F).

Abstract: A device manufactured using CAD/CAM, including an upper splint (1) with followers (19) and various lower splints (2) including contact surfaces (3a) on which the followers (19) contact, so that on exchanging lower splints for others, according to a manufacturing sequence, they cause different controlled mandibular advancements. The contact surfaces (3a) reproduce a movement from the contact of the followers (19) on said contact surfaces (3a). The device is customised for each patient according to a set of anatomical parameters, and a series of input data measured by doctors, which personalise the device to achieve opening movement with single protrusive advancement in each of the lower splints (2).

Abstract: A coupler lock device is configured for use with a self-latching trailer coupler securing a hitch ball in the coupler socket. The coupler lock device has a housing that includes a top panel portion defining a cavity configured so that, when the housing is secured in position over the trailer coupler, the housing top panel prevents seating of the hitch ball in the coupler socket by restricting upward movement of the release lever when an attempt is made to insert the hitch ball into the coupler socket. Also, when the housing is secured in position over the trailer coupler with a hitch ball seated in the coupler socket, the housing top panel prevents removal of the coupler socket from the hitch ball by restricting upward movement of the release lever that would otherwise release the coupler socket from the hitch ball.

Abstract: An aqueous dispersion comprising: (a) at least one of an acrylic polymer and an inorganic pigment; (b) 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one; and (c) an alkyl acetoacetate.

Abstract: An aqueous composition comprising: (a) 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one; and (b) an aromatic acid anhydride comprising from 6 to 30 carbon atoms.