Abstract: A sensing module for monitoring dosage delivery of a vaporized material, and a portable vaporization unit including the sensing module, include a light sensor that detects disruptions in a light path across a vapor channel, the disruptions caused by the vaporized material flowing through the vapor channel. The light sensor includes a UV light source, which may emit 370 nm wavelength light, and a UV light detector that converts intensity of incident light in the light path into a signal. A microprocessor of the sensing module compares the signal to a baseline measurement to determine the concentration of a medicament in the vapor; then, using the flow rate and activation time of the device, the microprocessor determines the dosage and can perform monitoring and reporting actions based on the dosage. A measuring circuit measures fluctuations in resistance/impedance of a vaporization element to further determine flow rate and/or dosage.

Abstract: A coupler lock device is configured for use with a self-latching trailer coupler securing a hitch ball in the coupler socket. The coupler lock device has a housing that includes a top panel portion defining a cavity configured so that, when the housing is secured in position over the trailer coupler, the housing top panel prevents seating of the hitch ball in the coupler socket by restricting upward movement of the release lever when an attempt is made to insert the hitch ball into the coupler socket. Also, when the housing is secured in position over the trailer coupler with a hitch ball seated in the coupler socket, the housing top panel prevents removal of the coupler socket from the hitch ball by restricting upward movement of the release lever that would otherwise release the coupler socket from the hitch ball.

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: Polymers for gene therapy. The present invention relates to a polymer, more specifically a polyphosphazene polymer, that is useful for gene therapy. The invention also relates to a complex comprising the polymer, the method for producing same and uses thereof.

Abstract: The present invention relates to a cyclopropenium salt bearing an electron withdrawing group suitable for use as a reagent in cyclopropenylation reactions of formula (I). The invention also relates to a process for their preparation, the use thereof as cyclopropenylation reagent, to an electrophilic aromatic substitution process of cyclopropenylation, and to a process for cyclopropenylation of organometallic substrates using said reagents.

Abstract: The present invention relates to bispecific antigen binding molecules targeting (i) IL-13 or IL-13R and (ii) OX40L or OX40, pharmaceutical compositions comprising the same, and methods of treatment using the same, e.g. in treating a dermatological disease or condition such as atopic dermatitis.

Abstract: An adapter for a trailer coupler assembly includes an elongated riser member configured to be removably mounted to a vertical channel of a trailer coupler. The riser member has a transverse cross-section generally in the shape of an I-beam having a first channel portion and an opposing second channel portion. The first channel portion includes a generally U-shaped transverse cross-section and is configured to be removably mounted to a vertical channel of a trailer coupler assembly at one of a plurality of longitudinal positions along a length of the vertical channel of the trailer coupler assembly. The opposing second channel portion includes a generally U-shaped transverse cross-section configured to hold a trailer coupler.

Abstract: An improved hitch ball mount includes a draw bar shank having vibration-isolating member disposed over a portion of an outer surface of a draw bar rod. The vibration-isolating member comprises a vibration-absorbing material, and the draw bar shank is sized to fit closely within a receiver tube of a receiver hitch assembly so that the vibration-isolating member contacts the interior of the receiver tube when the draw bar is positioned within the receiver tube. The vibration-absorbing material can comprise a layer of composite or rubberized material. The vibration-isolating member can be a removable sleeve that can be slidingly positioned over the draw bar rod or it can be a layer of vibration-absorbing material molded over a portion of the draw bar rod. In some embodiments, one or more protrusions can be disposed on the outer surface of the draw bar rod.

Abstract: The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human IL-36 cytokines, IL-36?, IL-36?, and/or IL-36?, and block the IL-36 stimulated signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided.

Abstract: An adapter for a trailer coupler assembly includes an elongated riser member configured to be removably mounted to a vertical channel of a trailer coupler. The riser member has a transverse cross-section generally in the shape of an I-beam having a first channel portion and an opposing second channel portion. The first channel portion includes a generally U-shaped transverse cross-section and is configured to be removably mounted to a vertical channel of a trailer coupler assembly at one of a plurality of longitudinal positions along a length of the vertical channel of the trailer coupler assembly. The opposing second channel portion includes a generally U-shaped transverse cross-section configured to hold a trailer coupler.

Abstract: A tow hitch assembly includes a draw bar and a hitch ball mount pivotally supported by the draw bar. A compression spring is disposed longitudinally between the draw bar and the hitch ball mount. The compression spring exerts a force that opposes a downward pivoting motion of the hitch ball mount when weight is placed on the hitch ball mount. The compression spring cooperates with an indicator configured to indicate to a user whether the weight placed on the hitch ball mount is within a predetermined weight range. The compression spring is removable and replaceable with a second compression spring that has a different spring constant. The second compression spring cooperates with the indicator to indicate to a user whether the weight placed on the hitch ball mount is within a second, different predetermined weight range.

Abstract: A sheave (100) for a passenger conveyor system is provided. The sheave (100) comprises a sheave axis (150) about which the sheave (100) rotates; a cylindrical sleeve (105); and a bearing (120a, 120b) centred on and arranged to rotate about the sheave axis (150). The cylindrical sleeve (105) includes an outer surface (110) including a groove (155) arranged to receive a belt; and an inner surface (115) defining a cylindrical cavity (122) centred on the sheave axis (150). The bearing (120a, 120b) includes an outer race (125a), an inner race (130a) and one or more rolling elements (135a) therebetween, wherein the outer race (125a) comprises a protrusion (140) arranged to hold the bearing (120a, 120b) within the cylindrical cavity (122) due to engagement between the protrusion (140) and the inner surface of the cylindrical sleeve (115).

Abstract: A user input device (202), for providing an input to an elevator controller is disclosed. The user input device (202) includes a plurality of input regions (204A-204F) each of which correspond to a different input command; and a single touchless sensor (216) arranged to detect the presence of an object in any of the plurality of input regions (204A-204F).

Abstract: A device manufactured using CAD/CAM, including an upper splint (1) with followers (19) and various lower splints (2) including contact surfaces (3a) on which the followers (19) contact, so that on exchanging lower splints for others, according to a manufacturing sequence, they cause different controlled mandibular advancements. The contact surfaces (3a) reproduce a movement from the contact of the followers (19) on said contact surfaces (3a). The device is customised for each patient according to a set of anatomical parameters, and a series of input data measured by doctors, which personalise the device to achieve opening movement with single protrusive advancement in each of the lower splints (2).

Abstract: A coupler lock device is configured for use with a self-latching trailer coupler securing a hitch ball in the coupler socket. The coupler lock device has a housing that includes a top panel portion defining a cavity configured so that, when the housing is secured in position over the trailer coupler, the housing top panel prevents seating of the hitch ball in the coupler socket by restricting upward movement of the release lever when an attempt is made to insert the hitch ball into the coupler socket. Also, when the housing is secured in position over the trailer coupler with a hitch ball seated in the coupler socket, the housing top panel prevents removal of the coupler socket from the hitch ball by restricting upward movement of the release lever that would otherwise release the coupler socket from the hitch ball.

Abstract: An aqueous dispersion comprising: (a) at least one of an acrylic polymer and an inorganic pigment; (b) 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one; and (c) an alkyl acetoacetate.

Abstract: An aqueous composition comprising: (a) 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one; and (b) an aromatic acid anhydride comprising from 6 to 30 carbon atoms.

Abstract: A tow hitch assembly includes a draw bar and a hitch ball mount pivotally supported by the draw bar. A compression spring is disposed longitudinally between the draw bar and the hitch ball mount. The compression spring exerts a force that opposes a downward pivoting motion of the hitch ball mount when weight is placed on the hitch ball mount. The compression spring cooperates with an indicator configured to indicate to a user whether the weight placed on the hitch ball mount is within a predetermined weight range. The compression spring is removable and replaceable with a second compression spring that has a different spring constant. The second compression spring cooperates with the indicator to indicate to a user whether the weight placed on the hitch ball mount is within a second, different predetermined weight range.

Abstract: An apparatus for simulating a vehicle traveling on a road and towing a trailer, wherein the apparatus includes a scale model towing vehicle and trailer combination positioned on a moving belt of a treadmill. The apparatus has a speed control and a remote control steering mechanism to demonstrate how the vehicle/trailer towing combination will react to vehicle operator inputs under varying conditions, including variations in weight distribution of the trailer load.

Abstract: The present invention relates compounds useful as reagents for the diazomethylation reaction, their preparation and the use thereof as reagents in a method for the diazomethylation reaction of aromatic substrates. It relates in particular to a compound of formula (I) wherein E is an electron withdrawing group.