Abstract: The present invention relates to a cyclopropenium salt bearing an electron withdrawing group suitable for use as a reagent in cyclopropenylation reactions of formula (I). The invention also relates to a process for their preparation, the use thereof as cyclopropenylation reagent, to an electrophilic aromatic substitution process of cyclopropenylation, and to a process for cyclopropenylation of organometallic substrates using said reagents.

Abstract: The present invention relates to bispecific antigen binding molecules targeting (i) IL-13 or IL-13R and (ii) OX40L or OX40, pharmaceutical compositions comprising the same, and methods of treatment using the same, e.g. in treating a dermatological disease or condition such as atopic dermatitis.

Abstract: An adapter for a trailer coupler assembly includes an elongated riser member configured to be removably mounted to a vertical channel of a trailer coupler. The riser member has a transverse cross-section generally in the shape of an I-beam having a first channel portion and an opposing second channel portion. The first channel portion includes a generally U-shaped transverse cross-section and is configured to be removably mounted to a vertical channel of a trailer coupler assembly at one of a plurality of longitudinal positions along a length of the vertical channel of the trailer coupler assembly. The opposing second channel portion includes a generally U-shaped transverse cross-section configured to hold a trailer coupler.

Abstract: A method of detecting an islanding operation of an electrical power generating system coupled to a power grid provided. The method includes monitoring a frequency that is indicative of an AC frequency on the power grid and monitoring reactive power on a coupling of the electrical power generating system to the power grid. The monitored frequency is processed to determine a rate of change of frequency, and the monitored reactive power is processed to determine a rate of change of reactive power. A detection parameter is determined from the determined rate of change of frequency and the determined rate of change of reactive power. An islanding operation of the electrical power generating system is detected if the detection parameter exceeds an islanding threshold value.

Abstract: An improved hitch ball mount includes a draw bar shank having vibration-isolating member disposed over a portion of an outer surface of a draw bar rod. The vibration-isolating member comprises a vibration-absorbing material, and the draw bar shank is sized to fit closely within a receiver tube of a receiver hitch assembly so that the vibration-isolating member contacts the interior of the receiver tube when the draw bar is positioned within the receiver tube. The vibration-absorbing material can comprise a layer of composite or rubberized material. The vibration-isolating member can be a removable sleeve that can be slidingly positioned over the draw bar rod or it can be a layer of vibration-absorbing material molded over a portion of the draw bar rod. In some embodiments, one or more protrusions can be disposed on the outer surface of the draw bar rod.

Abstract: In various embodiments, a process for obtaining a generated dataset with a predetermined bias for evaluating algorithmic fairness of a machine learning model includes receiving an input dataset and generating an anonymized reconstructed dataset based at least on the input dataset. The process includes introducing a predetermined bias into the generated dataset, forming an evaluation dataset based at least on the generated dataset with the predetermined bias, and outputting the evaluation dataset. In various embodiments, a process for training a generative model includes configuring a generative model and receiving training data, where the training data includes a tabular dataset. The process includes using computer processor(s) and the received training data to train the generative model, where the generative model is sampled to generate a dataset with a predetermined bias.

Abstract: The present invention provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human IL-36 cytokines, IL-36?, IL-36?, and/or IL-36?, and block the IL-36 stimulated signaling pathways. Compositions comprising such binding proteins and methods of making and using such binding proteins are also provided.

Abstract: A sensing module for monitoring dosage delivery of a vaporized material, and a portable vaporization unit including the sensing module, include a light sensor that detects disruptions in a light path across a vapor channel, the disruptions caused by the vaporized material flowing through the vapor channel. The light sensor includes a UV light source, which may emit 370 nm wavelength light, and a UV light detector that converts intensity of incident light in the light path into a signal. A microprocessor of the sensing module compares the signal to a baseline measurement to determine the concentration of a medicament in the vapor; then, using the flow rate and activation time of the device, the microprocessor determines the dosage and can perform monitoring and reporting actions based on the dosage. A measuring circuit measures fluctuations in resistance/impedance of a vaporization element to further determine flow rate and/or dosage.

Abstract: The disclosure relates to systems and methods for improving the manufacturing of silk solutions and powders containing silk fibroin obtained from silkworm cocoons. The solutions and powders can be used to improve the post-harvest preservation of perishables and to improve the performance of packaging, including biodegradable packaging.

Abstract: The disclosure relates to systems and methods for improving the manufacturing of silk solutions and powders containing silk fibroin obtained from silkworm cocoons. The solutions and powders can be used to improve the post-harvest preservation of perishables and to improve the performance of packaging, including biodegradable packaging.

Abstract: The present invention addresses to a system and methodology for evaluating the deposition in tubes of the furnaces of delayed coking unit (DCU) in order to reduce the costs involved with premature shutdowns. With this system, load rankings are obtained, influences of certain loads on processing are evaluated, and additives that reduce deposition are further evaluated. Consequently, the results obtained by such a system allow greater flexibility for the follow-up engineer to optimize his delayed coking unit in order to increase load or increase the unit campaign time, drastically reducing costs in premature shutdowns, or increasing its return by increasing load and shutdowns, since the load is limited by the degree of deposit formation, and that directly affects the wall temperature.

Abstract: An adapter for a trailer coupler assembly includes an elongated riser member configured to be removably mounted to a vertical channel of a trailer coupler. The riser member has a transverse cross-section generally in the shape of an I-beam having a first channel portion and an opposing second channel portion. The first channel portion includes a generally U-shaped transverse cross-section and is configured to be removably mounted to a vertical channel of a trailer coupler assembly at one of a plurality of longitudinal positions along a length of the vertical channel of the trailer coupler assembly. The opposing second channel portion includes a generally U-shaped transverse cross-section configured to hold a trailer coupler.

Abstract: A tow hitch assembly includes a draw bar and a hitch ball mount pivotally supported by the draw bar. A compression spring is disposed longitudinally between the draw bar and the hitch ball mount. The compression spring exerts a force that opposes a downward pivoting motion of the hitch ball mount when weight is placed on the hitch ball mount. The compression spring cooperates with an indicator configured to indicate to a user whether the weight placed on the hitch ball mount is within a predetermined weight range. The compression spring is removable and replaceable with a second compression spring that has a different spring constant. The second compression spring cooperates with the indicator to indicate to a user whether the weight placed on the hitch ball mount is within a second, different predetermined weight range.

Abstract: A sheave (100) for a passenger conveyor system is provided. The sheave (100) comprises a sheave axis (150) about which the sheave (100) rotates; a cylindrical sleeve (105); and a bearing (120a, 120b) centred on and arranged to rotate about the sheave axis (150). The cylindrical sleeve (105) includes an outer surface (110) including a groove (155) arranged to receive a belt; and an inner surface (115) defining a cylindrical cavity (122) centred on the sheave axis (150). The bearing (120a, 120b) includes an outer race (125a), an inner race (130a) and one or more rolling elements (135a) therebetween, wherein the outer race (125a) comprises a protrusion (140) arranged to hold the bearing (120a, 120b) within the cylindrical cavity (122) due to engagement between the protrusion (140) and the inner surface of the cylindrical sleeve (115).

Abstract: A user input device (202), for providing an input to an elevator controller is disclosed. The user input device (202) includes a plurality of input regions (204A-204F) each of which correspond to a different input command; and a single touchless sensor (216) arranged to detect the presence of an object in any of the plurality of input regions (204A-204F).

Abstract: A device manufactured using CAD/CAM, including an upper splint (1) with followers (19) and various lower splints (2) including contact surfaces (3a) on which the followers (19) contact, so that on exchanging lower splints for others, according to a manufacturing sequence, they cause different controlled mandibular advancements. The contact surfaces (3a) reproduce a movement from the contact of the followers (19) on said contact surfaces (3a). The device is customised for each patient according to a set of anatomical parameters, and a series of input data measured by doctors, which personalise the device to achieve opening movement with single protrusive advancement in each of the lower splints (2).

Abstract: A coupler lock device is configured for use with a self-latching trailer coupler securing a hitch ball in the coupler socket. The coupler lock device has a housing that includes a top panel portion defining a cavity configured so that, when the housing is secured in position over the trailer coupler, the housing top panel prevents seating of the hitch ball in the coupler socket by restricting upward movement of the release lever when an attempt is made to insert the hitch ball into the coupler socket. Also, when the housing is secured in position over the trailer coupler with a hitch ball seated in the coupler socket, the housing top panel prevents removal of the coupler socket from the hitch ball by restricting upward movement of the release lever that would otherwise release the coupler socket from the hitch ball.

Abstract: An aqueous dispersion comprising: (a) at least one of an acrylic polymer and an inorganic pigment; (b) 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one; and (c) an alkyl acetoacetate.

Abstract: An aqueous composition comprising: (a) 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one; and (b) an aromatic acid anhydride comprising from 6 to 30 carbon atoms.

Abstract: A tow hitch assembly includes a draw bar and a hitch ball mount pivotally supported by the draw bar. A compression spring is disposed longitudinally between the draw bar and the hitch ball mount. The compression spring exerts a force that opposes a downward pivoting motion of the hitch ball mount when weight is placed on the hitch ball mount. The compression spring cooperates with an indicator configured to indicate to a user whether the weight placed on the hitch ball mount is within a predetermined weight range. The compression spring is removable and replaceable with a second compression spring that has a different spring constant. The second compression spring cooperates with the indicator to indicate to a user whether the weight placed on the hitch ball mount is within a second, different predetermined weight range.