Abstract: The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

Abstract: A material deposition unit includes a radiation unit designed to emit electromagnetic radiation in a directed manner onto a workpiece along a beam axis, and a powder discharge device that has multiple powder discharge units configured to discharge powder in a directed form onto the workpiece through powder-outlet openings. The material deposition unit further includes a powder division unit having multiple powder channels. A number of powder channels corresponds to a number of powder discharge units. The powder division unit is designed to distribute a central powder stream guided to a feed channel uniformly over the powder channels. Each respective powder channel is connected to a respective powder discharge unit by an exchangeable connecting element. At least one powder discharge unit has an exchangeable powder discharge element, which is elongate, has a first end and a second end, and is arranged at least partially within the corresponding powder discharge unit.

Abstract: A system for execution of limit trades on decentralized exchanges comprising a computer service system configured for receiving from a client device a limit order for swapping a desired quantity of a first digital asset for a second digital asset at a desired target price. A smart contract on a blockchain network is then generated corresponding to the order. By depositing the desired quantity of the first digital asset the smart contracts creates a single-sided liquidity pool on the blockchain network. For real-time monitoring of price feeds the smart contract interacts with a decentralized oracle system. On finding one or more matches for the swapping at said target price the position is filled using liquidity pool. User receives the exact number of the second digital asset which the user wanted at the target price in exchange of the first digital asset without any price impact, liquidity fee or slippage.

Abstract: A closure assembly (10) for plastic containers comprises a neck insert (12) and a closure cap or plug (26). The closure assembly is configured to be fixed and sealed to the container either by insert-molding or by ultrasonic welding.

Abstract: The present invention relates to a swimming pool structure having at least one edge zone and a water collection, filtering and recirculation circuit, the latter including at least one well zone (WZ) for falling water, at least one filter mounted in the well zone and designed to intercept the water falling into it.

Abstract: An example sterilization indicator (102) includes a cover (122), an indicator (102), and a seal (142). The cover (122) defines at least a portion of a cavity (138). The indicator (102) is disposed within the cavity (138). The indicator (102) is configured to fluidly couple with an internal cavity (110) of a sterilization package (package) and indicate an exposure to a sterilant. The seal (142) is configured to form a microorganism barrier between an exterior of the cover (122) and an internal cavity (110) of a sterilization package (100).

Abstract: Systems and methods are described herein to estimate or calculate an execution time for a compute cluster to execute a task based on the number of cores the compute cluster has relative to the number of cores present in a heterogeneous compute cluster for which the time to complete the task was previously measured. In some examples, minimum and maximum scaling ratios are calculated for compute clusters having a different number of cores than a compute cluster for which the time to complete the task has been measured.

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: Described is a method for making an object using an additive manufacturing device comprising actuators which act in conjunction to make the object. The method includes: receiving a design of the object, the design including at least one three-dimensional representation of the object, receiving at least one construction parameter indicating a physical characteristic of the object to be made, extracting from a memory at least one value associated with said at least one construction parameter and/or associated with the three-dimensional representation of the object, said at least one value indicating a command which can be set for the actuators of the additive manufacturing device, modifying the design of the object as a function of said at least one extracted value, generating a set of commands as a function of said design, and controlling said actuators by means of said set of commands.

Abstract: A method in which a medium viscous to highly viscous fluid and/or a medium viscous to highly viscous suspension are/is mixed by means of an agitator device that is driven by a drive shaft, wherein the fluid and/or the suspension are/is brought into a multi-dimensional flow by means of a close-clearance stirring blade (14) of the agitator device, and a flow resistance is minimized along a shaft direction in a shaft proximity.

Abstract: The present application generally relates to a method for training a machine learning, ML, model using class incremental learning, and to a computer-implemented method and apparatus for using the trained machine learning, ML, model. The method may learn how to update semantic representations of old concepts (classes) by modelling drift of semantic representations.

Abstract: Sensorised wheel hub unit and a method for detecting, in real time, forces and moments applied to an outer ring of the wheel hub unit in which piezoresistive ceramic plates are made of one piece with welded metal plates housed within respective recesses formed in an outer surface of the outer ring over respective races for rolling elements that there is a gap between the plates and a base wall of each recess; the temperature of the outer ring and the amplitude and frequency of first electrical signals (S1) associated with the sensors relating to the same race are analysed to determine a frequency value equal to the frequency of the first signal having the maximum amplitude and as many amplitude values (D1-Dn) as there are sensors associated with that race and each equal to the maximum amplitude of the first signal from each sensor, corrected according to temperature.

Abstract: A method for monitoring precipitation of magnetospheric particles includes detecting charged magnetospheric particles by a particles detector, processing the detection data to associate a respective estimate or measurement of kinetic energy with the detected magnetospheric particles, obtaining a first count value NH associated with a relatively higher estimate or measurement of kinetic energy, obtaining a second count value NL associated with a relatively lower estimate or measurement of kinetic energy, detecting a relative variation of the second count value NL with respect to the first count value NH, determining that an impulsive event of precipitation of charged magnetospheric particles (MPP event) in the magnetosphere occurred, assigning to the MPP event geomagnetic longitude and time, defining one or more groups of MPP events occurred in a time range at a same geomagnetic longitude, and identifying a group of MPP events indicative of an activity of terrestrial origin.

Abstract: A compostable material for packaging food products comprising a coffee-based granular material and at least one binding agent selected from methylcellulose, methylcellulose derivatives, mixtures thereof.

Abstract: Sensorised wheel hub unit and a method for detecting, in real time, forces and moments applied to an outer ring of the wheel hub unit in which piezoresistive ceramic plates are made of one piece with welded metal plates housed within respective recesses formed in an outer surface of the outer ring over respective races for rolling elements that there is a gap between the plates and a base wall of each recess; the temperature of the outer ring and the amplitude and frequency of first electrical signals (S1) associated with the sensors relating to the same race are analysed to determine a frequency value equal to the frequency of the first signal having the maximum amplitude and as many amplitude values (D1-Dn) as there are sensors associated with that race and each equal to the maximum amplitude of the first signal from each sensor, corrected according to temperature.

Abstract: OPERATION AND FUNCTIONING METHOD OF AN ASSEMBLY AND CONTROL SYSTEM FOR ACCUMULATORS IN WORKSTATIONS, using a radio-base station rack, comprising processing center provided, at least with a battery presence sensor, at least a radio-base station rack door opening and closing sensor and an audible alarm device, allowed for use in equipment containing locks, both electromechanical and electromagnetic, and comprising the startup, verification, work and maintenance steps of an assembly and control system operation and functioning of accumulators in workstations.

Abstract: A method performed by a wireless device (12) comprises receiving (500), from a network node (18) in a wireless communication network (10), signaling (20) that indicates one or more report triggering measurement objects (22) and one or more report content measurement objects (24). The one or more report triggering measurement objects (22) are one or more objects of measurements whose results (22R) are to be evaluated by the wireless device (12) for determining whether to log or send a measurement report (16). The one or more report content measurement objects (24) are one or more objects of measurements whose results (22R) are to be reported by the measurement report (16). The signaling (20) is configurable to indicate at least one report content measurement object (24) that is different from each of the one or more report triggering measurement objects (22) indicated by the signaling (20).

Abstract: A light source comprises at least one light-emitting component, in particular a component emitting ultraviolet light and/or a semiconductor component, and a line system, through which a cooling fluid can flow in a flow direction, for controlling the temperature of the at least one light-emitting component, and also a first and a second cooling-fluid pressure sensor, which are arranged one after the other in the line system in the flow direction, and an electronics unit which is connected to the first and second cooling-fluid pressure sensors and configured to determine at least one diagnostic, control and/or regulating value on the basis of pressures captured by the first cooling-fluid pressure sensor and by the second cooling-fluid pressure sensor.

Abstract: A method for the content capture of an environment of a vehicle is disclosed. The method uses an artificial intelligence neural network, on the basis of a point cloud generated by an environment sensor of the vehicle. The method involves performing reference measurements by the environment sensor to capture reference objects depending on positions in the environment in relation to the environment sensor, generating confidence values depending on positions in the environment in relation to the environment sensor on the basis of the reference measurements by the environment sensor to capture the reference objects, training the artificial intelligence for the content capture of the environment on the basis of training point clouds for the environment sensor, capturing the environment by the environment sensor to generate the point cloud, and processing the point cloud generated by the environment sensor using the trained artificial intelligence for the content capture of the environment.

Abstract: A composite web includes a mass of meltblown fibres including an elastomer and a hydrophilic additive, melted and blown together, and a particulate material dispersed among the fibres and at least partly adherent thereto.