Abstract: Porous implantable devices for housing one or more therapeutic agents are disclosed herein. The implantable devices include a porous outer wall defining an interia or void. The interior void houses a carrier material carrying a first therapeutic agent. The implantable devices are made by patterning at least a portion of a polymerizable substrate into a polymerized three-dimensional porous outer wall surrounding an interior void. This can be achieved by two-photon polymerization techniques. A first therapeutic agent is then added to the interior void, which is then sealed. Methods of treating diseases using the implantable devices are disclosed herein. The methods include implanting the implantable device at a target area and locally releasing a therapeutically effective dosage of a first therapeutic agent from the interior void. The implantable devices can also be used in methods of screening potentially therapeutic agents for desired biological responses.

Abstract: The invention relates to a method and a system for moving and labelling reels (R1, R2, R3, R4, . . . Rn) of a web material such as paper or nonwoven in which each reel has a central core piece (3) which is hollow and around which the web material is wound. A robot arm (6) is inserted into the central core piece (3) of at least one reel (R1) and is then used to move the (R1) from a first position (P1) to a second position (P2) and to fix an inner label (15) onto the central core piece (3). According to the invention, the inner label (15) is placed on the robot arm (6) before the robot arm (6) is inserted into the central core piece (3) and the robot arm (6) is used both to fix the inner label (15) to the central core piece (3) and to move the at least one reel (R1).

Abstract: In one embodiment, a method includes, by a computing system of a vehicle, determining a first temperature of a control unit of the vehicle, wherein the control unit and one or more components of the vehicle are interconnected through a thermal network, determining a thermal objective for the control unit based on the first temperature of the control unit, selecting, based on the thermal objective for the control unit, at least a first component from the one or more components, and sending one or more signals to one or more actuators within the thermal network to enable a heat-transfer fluid to flow between (1) a first portion of the thermal network thermally coupled to the control unit and (2) a second portion of the thermal network thermally coupled to the selected first component.

Abstract: There is described a web alignment device for aligning a web comprising an engagement surface for supporting the web, a clamp assembly for clamping the web on at least a clamp portion of the engagement surface, an alignment control assembly for controlling a correct alignment of the web. The alignment control assembly comprises a control unit for generating a trigger signal if the web is correctly aligned, a first sensor device for detecting and/or determining a desired position of a first section of the web and to send at least a first signal to the control unit if the first section is positioned in the desired position, and a second sensor device for detecting and/or determining a desired position of a second section of the web and to send a second signal to the control unit if the second section is positioned in the desired position.

Abstract: Prior to the rolling of a flat rolling material (2) on a rolling line that includes a number of roll stands (1), a control system (3) receives actual variables (I) and target variables (Z) of the material (2). The control system (3) determines desired values (S*) for the roll stands (1), based on the actual (I) and target variables (Z) in combination with a model (10) of the rolling line, such that expected variables (E1) of the material (2) after its rolling are aligned as far as possible with the target variables (Z) and transfers the desired values (S*) to the roll stands (1) such that the material (2) is rolled according to the desired values (S*). The target variables (Z) comprise at least one freely selectable, discrete characteristic variable (K1 to K5, K2? to K4?, K2? to K4?) defining the contour (K) of the flat rolling material (2).

Abstract: There may be provided a computer-implemented method. It may be implemented using a blockchain such as, for example, the Bitcoin blockchain. The computer-implemented method includes: i) joining a congress by transferring, by a node operating in a proof-of-work blockchain network, one or more digital assets to a congress pool having one or more other digital assets associated with other members of a congress; ii) detecting, by the node, a special transaction of digital assets on the proof-of-work blockchain network to an address associated with the congress pool, the special transaction satisfying determined criteria; and iii) minting, by the node, one or more digital assets on a proof-of-stake blockchain network in response to detecting the special transaction.

Abstract: An integrated circuit may include a power transistor coupled between a supply pin and an output pin; a current sensing circuit configured to sense a load current passing through the power transistor and to provide a respective current sense signal; a first configuration pin; a current output circuit configured to provide a diagnosis current at a current output pin; a diagnosis pin for receiving a diagnosis request signal; and a control circuit configured to: select a characteristic curve representing a current versus time characteristic dependent on a external circuit connected to the first configuration pin; generate a drive signal for the power transistor dependent on the selected characteristic curve and the current sense signal; and control—dependent on a pulse pattern of the diagnosis request signal—the current output circuit to set the value of the diagnosis current such that it represents the load current or the selected characteristic curve.

Abstract: A front-load laundry appliance includes a drum that is rotationally operable within a tub about a generally horizontal rotational axis. A plurality of lifters are coupled to an interior surface of the drum. A fluid delivery path is at least partially defined within the drum and the plurality of lifters. A fluid delivery system delivers fluid into the fluid delivery path in a direction parallel to the generally horizontal rotational axis.

Abstract: A voltage reference circuit includes a first circuit block configured to generate a proportional to absolute temperature current, the first circuit block comprising a current mirror amplifier, a second circuit block coupled to the first circuit block and configured to generated a complimentary to absolute temperature current, and a third circuit block coupled to both the first circuit block and the second circuit block. The second circuit block includes a multi-stage common-source amplifier. The third circuit block is configured to combine the proportional to absolute temperature current and the complimentary to absolute temperature current to generate a reference voltage at an output of the voltage reference circuit.

Abstract: Nominal values of parameters, and perturbations of the nominal values, that are associated with previously defined radiation treatment plans are accessed. For each treatment field of the treatment plans, a field-specific planning target volume (fsPTV) is determined based on those perturbations. At least one clinical target volume (CTV) and at least one organ-at-risk (OAR) volume are also delineated. Each OAR includes at least one sub-volume that is delineated based on spatial relationships between each OAR and the CTV and the fsPTV for each treatment field. Dose distributions for the sub-volumes are determined based on the nominal values and the perturbations. One or more dose prediction models are generated for each sub-volume. The dose prediction model(s) are trained using the dose distributions.

Abstract: A double suction impeller is disclosed. In at least one embodiment, the impeller is configured for centrifugal pumps and hydraulic power recovery turbines. The impeller's flow-path arrangement comprises inter-blade channels, intersecting each other at the impeller's outer diameter and defining a variable cross section shape, so that the equivalent number of blades is at least doubled with respect to a conventional configuration obtained by the coupling of two single suction impellers and an improved control over the velocity of the flow within the inter-blade channels is achieved.

Abstract: A method for producing smoking articles, in particular cigarettes, each comprising a respective first tobacco rod portion; the method comprises the step of cutting a second rod portion, which is four times the length of the first rod portion, crosswise so as to obtain third rod portions, which are twice the length of the first rod portion; the third rod portions are offset and aligned so as to be fed in succession; the speed at which the third rod portions are conveyed before the offsetting procedure is smaller than the speed at which they are conveyed after the offsetting procedure.

Abstract: A tool container system includes a first tool container and a second tool container. The first tool container has a first base, a first cover pivotably attached to the first base by a first hinge portion, a first base locking member coupled to the base, a first cover locking member coupled to the first cover, and a first latch coupled to the first base and moveable between a first unlocked position in which the first cover is movable relative to the first base between a closed position and an open position, and a first locked position in which the first latch engages the first cover locking member and the first cover is locked to the first base in the closed position. The second tool container is stackable on the first cover of the first tool container and having a second locking member.

Abstract: A wheel hub having an axis of symmetry and including a flange transverse to the axis of symmetry and provided with a plurality of fixing holes for attaching a wheel, a tubular body extending axially from the flange for supporting a rolling bearing, and a centering device arranged on a side of the flange opposite to that of the tubular body and in a position concentric with the axis of symmetry of the wheel hub, for retaining a wheel rim or a brake disc. The centering device being provided with a given number of flattened areas extending circumferentially and axially on a respective continuous tubular body projecting axially from the flange.

Abstract: The vehicle odometry and motion direction system and method is described. The vehicle odometry and motion direction system and method determines if the first ground speed data is acceptable. Ground speed data is calculated for all targets within a radar's field of view and targets ground speed data is processed to determine second ground speed data. The vehicle odometry and motion direction system and method determines trusted ground speed data using first ground speed data and second ground speed data and adjusts the trusted ground speed data due to errors in radar Doppler speed data.

Abstract: The invention relates to an adhesive film which comprises a layer of an adhesive that comprises one or more polymers and at least one peroxide, characterized in that the adhesive comprises at last 50% by weight of thermoplastic polymers that do not have C?C multiple bonds, in that at least one peroxide has the general structural formula R—O—O—R?, wherein R and R? each represent organyl groups or together represent a cyclic organyl group, and in that the peroxide in solution has a 1-minute half-life temperature of less than 200° C. In a preferred embodiment, the thermoplastic polymer is a polyurethane and the peroxide is a dicumyl peroxide.

Abstract: A device for the quantification of cellular and non-cellular components in a blood sample including detection electrodes including a first electrode connected with a first input to receive a first signal in input and a second electrode, reference electrodes including a first electrode connected with a second input configured to receive a second signal in input of opposite polarity to the first input signal and a second electrode connected to the second electrode of said detection electrodes, in a common point wherefrom an output signal is picked up, a ferromagnetic concentrator that cooperates with an external magnetic field external to effectuate concentration of said components on said detection electrodes, a substrate configured to house said detection electrodes, reference electrodes, and concentrator; a support configured to collect a blood sample, and a spacer element to confine in the substrate plane the blood sample and to distance said substrate from said support.

Abstract: A system stores data, such as sensor data or other operational data, on a plurality of storage volumes in a sequence so as to allow for interpolations or other approximations of the data using a subset of the storage volumes in response to a request for information regarding that data. For example, a plurality of devices connect to the system to provide operational data, which is then stored in a specified sequence on a specified set of volumes. In response to a request for operational information regarding some or all of the devices, the system reads at least one of the volumes, and approximates the values of the data over a specified period of time. In some embodiments, the data may be buffered prior to storage, and a jitter analyzer determines whether the incoming data is anomalous relative to a baseline, which may be determined using related data sets.

Abstract: A simulated track inductor mount including a base configured to be fixed against a supporting surface and an inductor hub attached to and extending from the base. The inductor hub includes one or more surfaces defining a margin and being configured to engage with an inner surface of the simulated track inductor, and the one or more surfaces are fixed to a camming tab configured to flex to removably seat the simulated track inductor on the inductor hub.

Abstract: An end-to-end automatic speech recognition (ASR) system includes: a first encoder configured for close-talk input captured by a close-talk input mechanism; a second encoder configured for far-talk input captured by a far-talk input mechanism; and an encoder selection layer configured to select at least one of the first and second encoders for use in producing ASR output. The selection is made based on at least one of short-time Fourier transform (STFT), Mel-frequency Cepstral Coefficient (MFCC) and filter bank derived from at least one of the close-talk input and the far-talk input. If signals from both the close-talk input mechanism and the far-talk input mechanism are present for a speech segment, the encoder selection layer dynamically selects between the close-talk encoder and the far-talk encoder to select the encoder that better recognizes the speech segment. An encoder-decoder model is used to produce the ASR output.