Abstract: An apparatus is disclosed for storing and changing needles for a medicament delivery device having a medicament container, including a fixed mount for connecting the apparatus with the medicament delivery device, a needle holder displaceable along a circuitous path and connecting a plurality of needles displaceably disposed thereon, and a guide member for guiding displacement of the needle holder, the guide member being disposed about the fixed mount. The apparatus also includes a user interface rotatably disposed about the fixed mount and having at least one internal engaging structure for displacing the needle holder along the circuitous path.

Abstract: An apparatus is disclosed for storing and changing needles for connection with a medicament delivery device, comprising an inner housing, a reservoir disposed within the inner housing, and a needle holder disposed within the inner housing, for fluidly connecting a medicament container of the medicament delivery device with the reservoir. The apparatus also includes a plurality of patient needles displaceably disposed on the needle holder, and an outer housing displaceably disposed about the inner housing and providing a user interface to individually select one of the plurality of patient needles, connect the selected needle with the reservoir, expose the selected needle outside of the apparatus for injection, and store the selected needle.

Abstract: There is provided a silicone rubber composition comprising an organopolysiloxane having a viscosity of at least 250,000 mPa·s at 250C, treated filler, and an organic peroxide curing agent. The composition is substantially free of reinforcing silica fillers and is characterised in that the filler comprises a mixture of aluminium trihydroxide and kaolin in a ratio of from 1:3 to 4:1.

Abstract: Therapeutic agents suitable for use as artificial platelets are described. The agents comprise a fibrinogen binding precursor bound to an insoluble carrier, wherein the fibrinogen binding precursor can be converted by a wound site specific agent, such as thrombin, to a fibrinogen binding component bound to the carrier. The fibrinogen binding component has increased ability to bind fibrinogen compared to the fibrinogen binding precursor. The agents may be used to treat patients with deficiencies in their own platelets, such as hereditary or acquired defects of platelet numbers (thrombocytopenia) or function (thrombasthenia).

Abstract: A method for implanting a transcorneal implant having a cap, a foot, and a body connecting the cap and the foot, the body having a lesser circumference than either the cap or the foot, the method including the operations: creating a first corneal incision to create a tunnel, such that the a far end of the first incision enters the anterior chamber; creating a second corneal incision opening a roof of the tunnel to an end point past the far end of the first incision and creating flaps; guiding the implant to the end point, so that the foot of the implant is under the flaps; rotating the implant until the foot is entirely within the anterior chamber; and rotating the implant back to a neutral position, such that a portion of the foot is beneath a floor of the tunnel.

Abstract: The present invention describes novel methods for the stabilization of mRNA. These alterations increase stability of mRNA and enable its use in sense RNA therapy to transiantly express proteins in a cell. Accordingly, the present invention is directed to methods for making such modifications, compositions comprising such modifications, and the use of such compositions in treating disease states.

Abstract: A method of implanting a transcorneal shunt into a cornea, the shunt having a head and a foot, each having a hole therein, the method including the operations of engaging an insertion tool with a foot hole of the shunt; making an entry incision in the cornea; inserting the shunt, while still engaged with the insertion tool, through the entry incision; making an implant incision in the cornea; inserting the head of the shunt through the implant incision to position and seat the shunt; and releasing the shunt from the insertion tool.

Abstract: The present invention provides an injectable pharmaceutical product comprising an agent, the agent comprising an insoluble carrier to which is bound a peptide, the peptide being capable of binding fibrinogen such that the agent binds via the bound fibrinogen to activated platelets in preference to inactive platelets, and wherein the peptide is not fibrinogen.

Abstract: The present invention relates in part to a method of manufacturing zinc-glycerol complexes and the zinc-glycerol complexes so produced, which unexpectedly results in microfine zinc-glycerol complex particles which have a mean particle length (i.e., major axis) of less than about 1.0 micron. The zinc-glycerol complex particles of the invention also generally maintain a hexagonal crystalline structure, thereby retaining superior lubricity and tactile properties. The invention also provides pharmaceutical and/or therapeutic compositions comprising microfine zinc-glycerol complex particles, and methods for using such compositions.

Abstract: The present invention relates to a gel composition, comprising first and second gel-forming moieties which bind reversibly to one another to form a gel. The binding of the moieties is sensitive to the level of an analyte, and either or both of the gel-forming moieties are attached to cross-linked particulate entities such that the interstices between the entities allow gel-sol and sol-gel transformation, and yet are not so small that the analyte cannot diffuse therethrough. The invention also provides drug delivery systems and sensors for detecting an analyte utilising such a gel.

Abstract: A system and method for locating the subscriber of a telephony product in which a best guess location is assigned to each subscriber of the telephony product. Under certain predetermined conditions, the telephony product directs incoming phone calls to a subscriber by first attempting to locate the subscriber at the best guess location. If the best guess location does not successfully answer or is not attempted first, an alternate search method is used.

Abstract: The present invention describes novel methods for the stabilization of mRNA. These alterations increase stability of mRNA and enable its use in sense RNA therapy to transiantly express proteins in a cell. Accordingly, the present invention is directed to methods for making such modifications, compositions comprising such modifications, and the use of such compositions in treating disease states.

Abstract: A method for the preparation of hydrophobic fumed silicas which are useful, for example, as reinforcing fillers in rubber compositions. The method comprises two steps, where in the first step an aqueous suspension of fumed silica is contacted with an organosilicon compound in the presence of a catalytic amount of an acid to effect hydrophobing of the fumed silica. In the preferred method the first step is conducted in the presence of a water miscible organic solvent which facilitates hydrophobing of the fumed silica with the organosilicon compound and the fumed silica has a BET surface area greater than 50 m.sup.2 /g. In the second step the aqueous suspension of the fumed silica is contacted with a water-immiscible organic solvent at a solvent to silica weight ratio greater than 0.1:1 to effect separation of the hydrophobic fumed silica from the aqueous phase. In a preferred process the hydrophobic fumed silica has a surface area within a range of about 100 m.sup.2 /g to 750 m.sup.2 /g.