Abstract: Procedure for the purification of biodegradable thermoplastic polymer particles for medical and/or pharmaceutical use without the use of organic solvents, as well as the particles obtained themselves, and the use of polymeric particles obtained by this procedure to manufacture parenteral administered medicinal products and/or implantable medical devices.

Abstract: The application is directed to compounds of formulae (IA) and (IB) and their salts and solvates, wherein R1a, R2a, R3a, A1, A2, A3, R1b, R2b, R3b, B1, and B2 are as set forth in the specification, as well as to methods for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of, e.g., lysosomal storage diseases, such as Gaucher's disease, and ?-synucleinopathies, such as Parkinson's disease.

Abstract: The application is directed to compounds of formulae (IA) and (IB): (IA) and (IB), and their salts and solvates, wherein R1a, R2a, A1, A2, A3, A4, R1b, R2b, B1, B2, B3, and G are as set forth in the specification, as well as to methods for their preparation, N pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of, e.g., lysosomal storage diseases, such as Krabbe's disease, and ?-synucleinopathies, such as Parkinson's disease.

Abstract: Compositions and methods for protecting insect pollinators against the harmful cognitive effects of pesticides are disclosed. The compositions are suitable for administration to or ingestion by an insect pollinator and contain one or more phenolic compounds, such as the flavonoids quercetin, rutin, kaempferol and p-coumaric acid in an effective amount to protect against pesticide-induced impairment of a cognitive function of the insect pollinator. Methods of using such compositions for preventing or reducing pesticide-induced impairment of cognitive functions including learning, memory, decision-making, motor activity, and navigation in an insect pollinator are also provided. The compositions and methods protect insect pollinators including honeybees and bumblebees against neurotoxic pesticides with different pharmacodynamics including neonicotinoids, such as Imidacloprid, fipronil, and pyrethroids, such as deltamethrin.

Abstract: The present invention relates to crystalline forms of 5-[5-[2-isopropylcyclopropyl]-6-methyl-pyridazin-3-yl]-1H-pyrimidine-2,4-dione, and pharmaceutical compositions comprising them, which inhibit the activity of CD73 and are useful for treating cancer.

Abstract: The application is directed to compounds of formula (I):(I), and formula (IA):(IA) and their salts and solvates, wherein R1, R2, R3, R4, R5, n, A1, A2, A3, and Y are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of conditions associated with the alteration of the activity of ?-galactosidase, specially galactosidase beta-1 or GLB 1, including GM 1 gangliosidoses and Morquio syndrome, type B.

Abstract: An airborne system and method for the characterization and measurement of radiating systems or antennas (5), including: an aerial module (1) including a unit for measuring electromagnetic emissions (11), which captures the electromagnetic field (E) radiated by the radiating system or antenna (5), and a positioning and guiding system (13) with an accuracy equal to or less than 3 cm; and a ground station (2) including a unit (23) for processing the electromagnetic emission measurements, which processes the measurements using a set of algorithms for processing electromagnetic emission measurements (25). Also, a method for measuring and characterizing radiating systems or antennas (5). The invention is suitable for use in sectors that require antennas to be characterized and measured, such as, for example, radar and radio navigation facilities, terrestrial- and satellite-based telecommunications systems, or terrestrial broadcasting facilities.

Abstract: The present invention relates to cPLA2e inducing agents and cPLA2e inducing agents for use as a medicament, particularly for use in the treatment of a cognitive disorder and/or disease associated with a cognitive disorder, for example dementia, and more specifically age-related dementia and/or Alzheimer's disease.

Abstract: The disclosure provides a process of making the compound of Formula I, and pharmaceutically acceptable salts thereof; and the process of making the intermediate of Formula III; wherein PG is as defined as set forth in the specification.

Abstract: The application is directed to compounds of formula (I): and their salts and solvates, wherein R1, R2, R3, A1, A2, A3, and n are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of a lysosomal storage disease, such as Gaucher's, and other diseases or disorders that are synucleinopathies.

Abstract: The disclosure relates to a method and an imaging device for multi-color imaging using frequency-modulated illumination. The method comprises a step of providing electromagnetic radiation with a plurality of different wavelengths, comprising a step of modulating each wavelength with a different modulation frequency, a step of illuminating a target with the modulated electromagnetic radiation, in particular for excitation of a target, a step of sensing electromagnetic radiation emitted from the target, in particular the luminescence, more in particular the fluorescence, and a step of processing the data obtained in the step of sensing.

Abstract: The present invention relates to a toilet cleaner comprising a cleaning agent, wherein said cleaning agent is included at a percentage between 50% and 80% by weight, and also comprising an effervescent agent at a percentage between 10% and 30% by weight. The cleaner is preferably in the form of solid granules, and it also comprises a foaming agent. The present invention allows providing a cleaner in solid form which can be applied directly in the toilet bowl and readily metered, giving the user a perception of cleanliness.

Abstract: The invention provides TRF1 inhibitors and compositions comprising them for the treatment of a brain cancer, such as a glioblastoma, and particularly a glioblastoma multiforme (GBM). PI3K inhibitors can be among the TRF1 inhibitors used. The compositions can comprise more than one TRF1 inhibitor, being particularly advantageous that at least one of the inhibitors is a PI3K inhibitor and that at least a second possible TRF1 inhibitor present is selected from the group an RTK inhibitor, a MEK inhibitor, an ERK inhibitor, an HSP90 inhibitor, docetaxel and gemcitabine, because such compositions show a synergic effect. The invention also relates to a method for identifying compounds candidates to be used for treating glioblastoma or other cancers, which method is based on the identification of the compound as a TRF1 inhibitor.

Abstract: Cap for drink bottle or similar recipient that comprises a base element comprising a drinking nozzle and a substantially tubular portion adapted to be secured to a neck of the bottle or recipient, a covering element comprising a flip top adapted to hermetically seal the drinking nozzle of the base element, and anti-tamper means of the top adapted to provide a visual indication of whether the top has already been removed for a first time from the drinking nozzle; the covering element comprises a tubular portion adapted to be secured to the outside of the substantially tubular portion of the base element, and the anti-tamper means of the top comprise an interlocking element extended from a lower edge of the top; wherein, the interlocking element is adapted to latch through the inside a front window of the tubular portion.

Abstract: A circularly polarized radiating element includes at least one excitation aperture for a wave that is linearly polarized with what is referred to as an excitation first polarization, a frequency selective surface and a metasurface comprising a two-dimensional and periodic array of metasurface cells, the excitation aperture opening onto the metasurface, the metasurface cells all being oriented identically with respect to the excitation polarization and configured to: reflect an incident wave having the excitation polarization in order to form a reflected wave polarized with the excitation polarization, and depolarize and reflect the incident wave in order to form a reflected wave polarized with the orthogonal polarization, having a phase difference substantially equal to ±90° with respect to the reflected wave polarized with the excitation polarization, and having an amplitude substantially equal to the amplitude of a wave radiated by the frequency selective surface, generated from the reflected wave polarized

Abstract: The disclosure relates to a method and an imaging device for multi-color imaging using frequency-modulated illumination. The method comprises a step of providing electromagnetic radiation with a plurality of different wavelengths, comprising a step of modulating each wavelength with a different modulation frequency, a step of illuminating a target with the modulated electromagnetic radiation, in particular for excitation of a target, a step of sensing electromagnetic radiation emitted from the target, in particular the luminescence, more in particular the fluorescence, and a step of processing the data obtained in the step of sensing.

Abstract: The application is directed to compounds of formula (I): and their salts and solvates, wherein R1, R2, R3, A1, A2, A3, and n are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of a lysosomal storage disease, such as Gaucher's, and other diseases or disorders that are synucleinopathies.

Abstract: The production of an oxygen-absorbent composition is provided, having: (a) a porous silica encapsulation matrix; and (b) a composition containing an oxygen-absorbent compound selected from fatty acids, unsaturated esters or compounds containing same, and, optionally, a catalyst based on an inorganic salt of a transition metal, wherein the composition (b) is encapsulated in the porous silica matrix (a). The composition can form part of the structure of the packaging for oxidation sensitive products or be placed in the surrounding atmosphere to reduce the concentration of oxygen. A method for encapsulating the active compound or the active compound together with a catalyst, and subsequently incorporating same into polymer matrices is also provided.