Abstract: A polarizing screen includes an arrangement of at least one, electrically conductive, polarizing cell, which at least one cell is frequency- and polarization-selective, for transforming the polarization of the electric component E of the transverse electromagnetic (TEM) wave, received with linear polarization, into an electromagnetic wave with circular polarization. The four lateral walls of each section of waveguide forming a polarizing cell are each open over their entire length due to a median continuous slot, parallel to the direction of propagation of the incident electromagnetic wave, so as to form four angled electrically conductive plates.

Abstract: A sterile procedure for the filing of solids into pharmaceutical containers and the sealing thereof under sterile conditions is provided. Exemplary containers include syringes, vials, capsules, ampoules, single-dose devices or cartridges. The containers can be filled with powder, granules, nanoparticles or microparticles. After sealing, the containers are airtight. More specifically, the procedure minimizes adherence of those solids to the interior surfaces of the containers during the filling and sealing steps, thus ensuring airtightness of the seal and precision of the weight of the solid dispensed into the containers.

Abstract: The disclosure provides a process of making the compound of Formula I, and pharmaceutically acceptable salts thereof: and the process of making the intermediate of Formula III: wherein PG is as defined as set forth in the specification.

Abstract: The present disclosure relates to a method of treating or preventing a disease or disorder selected from the group consisting of a central nervous system disorder, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, a chronic granulomatous disorder, a polycystic ovary syndrome, a thyroid carcinoma, a thyroid autoimmune disorder, a pituitary adenoma, atherosclerosis, hypertension, a skin disease, an inflammation and autoimmune disease, an inflammatory respiratory disease, and a mitochondrial disease by administering 5-[[4-[2-[5-acetylpyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione or a salt thereof to a subject in need thereof. The disclosure also relates to 5-[[4-[2-[5-acetylpyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione for use in a pharmaceutical composition or in the manufacture of a medicament for the treatment or prevention of a mitochondrial disease.

Abstract: Cap for drink bottle or similar recipient that comprises a base element comprising a drinking nozzle and a substantially tubular portion adapted to be secured to a neck of the bottle or recipient, a covering element comprising a flip top adapted to hermetically seal the drinking nozzle of the base element, and anti-tamper means of the top adapted to provide a visual indication of whether the top has already been removed for a first time from the drinking nozzle; the covering element comprises a tubular portion adapted to be secured to the outside of the substantially tubular portion of the base element, and the anti-tamper means of the top comprise an interlocking element extended from a lower edge of the top; wherein, the interlocking element is adapted to latch through the inside a front window of the tubular portion.

Abstract: Disclosed are electrochemical devices, such as lithium metal batteries using a solid state electrolyte. A means is disclosed to achieve relevant charging rates without short-circuiting a cell of the electrochemical device by limiting the electrode area, positioning the electrode where least defect population exist and controlling the external variables for stable lithium electrodeposition. Also disclosed is a method for visualizing metal propagation from an anode into a solid state electrolyte during cycling of an electrochemical cell comprising the anode and the solid state electrolyte.

Abstract: Described here are devices for closing one or more tissues, and handles for controlling these devices. Generally, the devices described here comprise a snare loop assembly, wherein the snare loop assembly comprises a snare and a suture loop, and a handle for controlling the snare loop assembly. In some variations the snare loop assembly may comprise a retention member that may releasably connect the suture loop to the snare. In other variations the devices comprise one or more force-reducing suture locks to help prevent the suture loop from inadvertently disengaging from the snare loop assembly. In still other variations, the excess-suture management features. The handles described here may be configured to remove excess suture from a suture loop, and may also be configured to release the suture loop from the snare loop assembly.

Abstract: Airborne systems and methods for the detection, location and obtaining of images of buried objects and for the characterization of the composition of the subsoil. The systems comprise at least one aerial module with a radar unit that emits and/or captures radar signals and a positioning and guidance system with an accuracy equal to or less than 3 cm, and a ground station with a flight control system and a radar signal processing unit where radar signal processing algorithms are applied. The invention also comprises a method for the detection, localization and obtaining of images of buried objects and a method for the characterization of the composition of the subsoil. Applicable in sectors where it is necessary to perform the detection of buried objects, as for example in civil applications (detection of antipersonnel mines), pipeline inspection or in archaeology.

Abstract: On example of a fluid dispensing system includes an unfiltered water container body defining an internal storage volume configured to hold a volume of water, a fluid outlet arranged for fluid communication with the internal storage volume, and a filter element positioned in the internal storage volume. With this configuration, a water dispensing process can be performed in which a single continuous stream of unfiltered water from the unfiltered water container body can pass through the filter element and be dispensed from the unfiltered water container body as a stream of filtered water. A water soluble tablet with an additive is positioned in the internal storage volume downstream of the filter medium such that the filtered water can pass out of the filter element and into contact with the water soluble tablet before being dispensed from the fluid outlet.

Abstract: A polarizing screen includes an arrangement of at least one, electrically conductive, polarizing cell, which at least one cell is frequency- and polarization-selective, for transforming the polarization of the electric component E of the transverse electromagnetic (TEM) wave, received with linear polarization, into an electromagnetic wave with circular polarization. The four lateral walls of each section of waveguide forming a polarizing cell are each open over their entire length due to a median continuous slot, parallel to the direction of propagation of the incident electromagnetic wave, so as to form four angled electrically conductive plates.

Abstract: Described here are devices for closing one or more tissues, and handles for controlling these devices. Generally, the devices described here comprise a snare loop assembly, wherein the snare loop assembly comprises a snare and a suture loop, and a handle for controlling the snare loop assembly. In some variations the snare loop assembly may comprise a retention member that may releasably connect the suture loop to the snare. In other variations the devices comprise one or more force-reducing suture locks to help prevent the suture loop from inadvertently disengaging from the snare loop assembly. In still other variations, the excess-suture management features. The handles described here may be configured to remove excess suture from a suture loop, and may also be configured to release the suture loop from the snare loop assembly.

Abstract: A system for improving network data communications performance between end-user devices and content origin servers. A plurality of accelerators are distributed across a network and communicate with end-user devices and content origin servers. Software development kits installed on end-user devices monitor control channel data traffic between the end-user devices and accelerators. Various data traffic efficiency approaches are implemented by the software development kits on the end-user devices and the plurality of accelerators resulting in improved data communications links between the end-user devices and the content origin servers.

Abstract: A dynamic approach to optimizing configuration of network parameters is presented. By gathering operational contexts and aggregating optimized network performance data against a baseline, a training data set may be generated. Client-side policies are determined, in part, by applying machine learning techniques on the training data set to achieve desired outcomes. Data delivery strategies are compiled at user devices to deliver content using the optimized network configuration values based on the operating contexts.

Abstract: The present invention relates to a method for the preparation of a humic substance-coated bioactive compound, to humic acid-encapsulated bioactive compound particles and to compositions comprising humic acid-encapsulated bioactive compound particles. The invention has its main application in the field of agriculture.

Abstract: The application is directed to compounds of formula (I):(I), and formula (IA):(IA) and their salts and solvates, wherein R1, R2, R3, R4, R5, n, A1, A2, A3, and Y are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of conditions associated with the alteration of the activity of ?-galactosidase, specially galactosidase beta-1 or GLB 1, including GM 1 gangliosidoses and Morquio syndrome, type B.

Abstract: A system for and method of gravimetric filling of a solid product in sterile conditions in a pharmaceutical container of small dimensions including syringes, vials, capsules, ampoules, single-dose devices, inhalers, bottles, carpules, well(s) of blister pack(s), sachets or bags with solid substances selected from the group formed by powder, lyophilizate, granules, pellets, nanoparticles or microparticles. More particularly, it relates to a process for the gravimetric filling of pharmaceutical containers with one or more sterile solid pharmaceutical substances or sterile excipients dosed and prepared in an aseptic environment.

Abstract: The invention relates to an airborne system and method for the characterization and measurement of radiating systems or antennas, comprising: an aerial module including a unit for measuring electromagnetic emissions, which captures the electromagnetic field radiated by the radiating system or antenna, and a positioning and guiding system with an accuracy equal to or less than 3 cm; and a ground station including a unit for processing the electromagnetic emission measurements, which processes the measurements using a set of algorithms for processing electromagnetic emission measurements. The invention also relates to a method for measuring and characterising radiating systems or antennas. The invention is suitable for use in sectors that require antennas to be characterised and measured, such as, for example, radar and radio navigation facilities, terrestrial and satellite-based telecommunications systems, or terrestrial broadcasting facilities.

Abstract: The disclosure provides a process of making the compound of Formula I, and pharmaceutically acceptable salts thereof: and the process of making the intermediate of Formula III: wherein PG is as defined as set forth in the specification.

Abstract: Method of diagnosing fibromyalgia based on microRNAs. The invention provides a method for the molecular diagnosis of fibromyalgia patients, based on the analysis of the possible alteration of the levels of specific microRNAs in peripheral blood mononuclear cells. The method comprises the analysis of the levels of the microRNAs miR-223, miR-451, miR-338, miR-143 and miR-145 and the diagnosis of fibromyalgia when at least one, or preferably several thereof have decreased levels with respect to a reference value, which preferably is the level of each microRNA in healthy individuals. Three additional microRNAs are also provided, miR-21, miR-1260b and miR-1908, which can be used as negative controls to confirm the diagnosis. The method facilitates an objective diagnosis of fibromyalgia based on molecular markers that are determined from a sample such as blood, which is easy to obtain and process.

Abstract: The application is directed to compounds of formula (I): and their salts and solvates, wherein R1, R2, R3, A1, A2, A3, and n are as set forth in the specification, as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or prevention of a lysosomal storage disease, such as Gaucher's, and other diseases or disorders that are synucleinopathies.