Patents by Inventor Maria Laura Gennaro

Maria Laura Gennaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions And Methods For Immunodominant Antigens of Mycobacterium Tuberculosis
    Publication number: 20110245099
    Abstract: Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen M. tuberculosis and their use in vaccines, therapeutic agents, and various diagnostic tests. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter.
    Type: Application
    Filed: March 31, 2011
    Publication date: October 6, 2011
    Inventors: Philip Felgner, Xiaowu Liang, Maria Laura Gennaro
  • Proteins expressed by and not by BCG and their use as diagnostic reagents and vaccines
    Patent number: 8021832
    Abstract: The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: September 20, 2011
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventor: Maria Laura Gennaro
  • Antibody profiles characteristic of tuberculosis state
    Patent number: 7993657
    Abstract: Serum antibody assays capable of distinguishing cases of inactive TB from cases of active TB include a combination of at least three M. tuberculosis protein antigens, at least one for which a positive response is consistent with inactive TB and at least one for which a negative response is consistent with inactive TB. Preferred assays further distinguish other TB classes. Also, antigen kits for performing such assays.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: August 9, 2011
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventor: Maria Laura Gennaro
  • Proteins expressed by mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents and vaccines
    Patent number: 7932373
    Abstract: The invention provides polypeptides encoded by open reading frames present in the genome of Mycobacterium tuberculosis but absent from the genome of BCG and diagnostic and prophylactic methodologies using these polypeptides.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: April 26, 2011
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventor: Maria Laura Gennaro
  • Compositions and methods for immunodominant antigens of
    Patent number: 7927818
    Abstract: Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen M. tuberculosis and their use in vaccines, therapeutic agents, and various diagnostic tests. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: April 19, 2011
    Inventors: Philip Felgner, Xiaowu Liang, Maria Laura Gennaro
  • Proteins expressed by and not by BCG and their use as diagnostic reagents and vaccines
    Patent number: 7709211
    Abstract: The invention provides polypeptides encoded by open reading frames present in the genome of Mycobacterium tuberculosis but absent from the genome of BCG and diagnostic and prophylactic methodologies using these polypeptides.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: May 4, 2010
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventor: Maria Laura Gennaro
  • Proteins Expressed by Mycobacterium Tuberculosis and not by BCG and their use as Diagnostic Reagents and Vaccines
    Publication number: 20100016415
    Abstract: The present invention is directed to reagents useful for generating immune responses to Mycobacterium tuberculosis and for diagnosing infection and disease in a subject that has been exposed to M. tuberculosis.
    Type: Application
    Filed: July 15, 2009
    Publication date: January 21, 2010
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventor: Maria Laura Gennaro
  • Compositions And Methods For Immunodominant Antigens of Mycobacterium Tuberculosis
    Publication number: 20090285847
    Abstract: Contemplated compositions, devices, and methods are drawn to various antigens from the pathogen M. tuberculosis and their use in vaccines, therapeutic agents, and various diagnostic tests. In particularly preferred aspects, the antigens are immunodominant and have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and/or have a known association with a disease parameter.
    Type: Application
    Filed: May 13, 2009
    Publication date: November 19, 2009
    Inventors: Philip Felgner, Xiaowu Liang, Maria Laura Gennaro
  • Secreted proteins of and their use as vaccines and diagnostic reagents
    Patent number: 7595383
    Abstract: The invention provides mycobacterium tuberculosis polypeptides and genes encoding them for use in diagnostic and prophylactic methodologies.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: September 29, 2009
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Maria Laura Gennaro, Manuel J. Gomez
  • Proteins expressed by and not by BCG and their use as diagnostic reagents and vaccines
    Patent number: 7579141
    Abstract: The invention provides polypeptides encoded by open reading frames present in the genome of Mycobacterium tuberculosis but absent from the genome of BCG and diagnostic and prophylactic methodologies using these polypeptides.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: August 25, 2009
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventor: Maria Laura Gennaro