Abstract: The present invention relates to the use of multiple doses of Cladribine combined with beta interferon for the treatment of multiple sclerosis in patients who are refractory to at least one conventional therapy.

Abstract: Provided herein are oligonucleotides, trimeric peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease in a subject in need thereof, comprising administering to the subject oligonucleotides, trimeric peptides, and peptide-oligonucleotide-conjugates described herein. A synthetic method provides for the generation of a library of cell-penetrating peptides conjugated to an antisense oligonucleotide, and a machine learning-based generator-predictor-optimizer loop for the generation of novel peptide sequences capable of enhanced delivery of oligonucleotide cargo from the library of conjugates.

Abstract: A method for slowing diabetes development in a diabetic or prediabetic individual or reducing a risk of diabetes development in an individual at risk of developing diabetes comprises administering Bifidobacterium animalis subsp. lactis CECT 8145 (BPL1) and a carbohydrate blend to the individual. The carbohydrate blend comprises a source of at least one carbohydrate that provides rapidly available glucose, a source of at least one carbohydrate that provides slowly available glucose, and a source of at least one non-digestible carbohydrate or resistant starch. A nutritional composition comprises protein, fat, the carbohydrate blend, and BPL1.

Abstract: Generating security configurations for data-centric communications system methods and systems are provided for visually modeling and validating cybersecurity configurations. Computer implemented and software operable methods provide a level of automation not possible in a manual fashion and provides a significant level of efficiency, accuracy and effectiveness regarding (cyber) security between data producers and consumers in data exchange systems. In a specific example, the method details methods for generating security configurations for Data Distributed Service (DDS) systems. The methods can be extended by implementing operable translation code for interpreting STRIDE threat security policies and translating them into, respectively, the security policies or DDS security policies.

Abstract: A method of enhancing muscle performance in a subject in need of improved physical performance comprises administering an exosome-enriched product comprising intact bovine milk-derived exosomes to the subject in need thereof. A method of reducing chronic fatigue in a subject recovering or recovered from a viral infection comprises administering an exosome-enriched product comprising intact bovine milk-derived exosomes to the subject.

Abstract: A method of improving insulin production in a subject in need thereof comprises administering a nutritional composition comprising lysine, arginine, and beta-hydroxy-beta-methylbutyrate (HMB) to the subject. A method of improving insulin secretion in a subject in need thereof comprises administering a nutritional composition comprising lysine, arginine, and HMB to the subject. A nutritional composition comprises about 0.01 to about 15 wt % HMB, about 0.03 to about 40 wt % lysine, and about 0.02 to about wt % arginine.

Abstract: A method of improving joint health in a subject in need thereof comprises administering an exosome-enriched product comprising intact bovine milk-derived exosomes to the subject in need thereof.

Abstract: Unlike point-to-point request/reply systems, where data is exchanged between pairs of endpoints, in publish-subscribe systems the publisher entity may have to send data to many subscribing entities (subscribers), which can range from a handful to hundreds, thousands, or more. These systems may be used for critical applications that require security. Security requires an authentication phase where the publisher can securely identify subscribers and determine they have the necessary permissions to receive the information they send. Likewise, the subscribers need to authenticate the publishers to ensure they are entitled to produce the information they send. With this invention, a method is provided for performing secure and scalable distribution of symmetric keys from a publisher to one or more subscribers in publish-subscribe system. In addition, a method is provided for performing secure and scalable distribution of cached data samples from a publisher to one or more subscribers in a publish-subscribe system.

Abstract: A method of increasing height in a pediatric subject comprises enterally administering an exosome-enriched product comprising intact bovine milk-derived exosomes to the pediatric subject in need thereof. A method of promoting linear bone growth in a pediatric subject comprises enterally administering an exosome-enriched product comprising intact bovine milk-derived exosomes to the pediatric subject in need thereof. A method of obtaining an exosome-enriched product from cheese whey comprises subjecting the cheese whey to microfiltration (MF), ultrafiltration (UF), and diafiltration (DF) steps, wherein the MF, UF, and DF steps employ, successively, membranes with cut off values which gradually decrease in size with each filtration step, wherein the cheese whey is sweet cheese whey and has a pH from about 6.0 to about 6.5.

Abstract: The present invention provides a method for obtaining an ethanolic extract from mature seeds of Solanum melongena, preferably defatted, characterized in that they are extracted with a hydroalcoholic solution containing 50% ethanol, at acid PH, preferably under a nitrogen atmosphere and for short periods of time, no longer than 1-2 h. The extracts obtained from different varieties of Solanum melongena have a high polyphenol content and show potent antitumor activity against colon adenocarcinoma, pancreatic adenocarcinoma and glioblastoma multiforme cell lines, even against chemotherapy-resistant lines, but with low toxicity to human hepatocytes. Therefore, the extracts of the invention are proposed for use in the treatment of colon adenocarcinoma, pancreatic adenocarcinoma and glioblastoma multiforme, including those resistant to currently used chemotherapies.

Abstract: A method of reducing or delaying the onset of fatty liver disease in a subject comprises enterally administering at least one human milk oligosaccharide (HMO) to a subject in need thereof in an amount effective to reduce hepatic lipid accumulation. In a specific embodiment, the at least one HMO is administered in an amount effective to reduce de novo lipogenesis in the subject. The at least one HMO can be administered to the subject directly or in a nutritional composition.

Abstract: A method of obtaining an exosome-enriched product comprises providing a whey-containing bovine milk fraction, conducting a first centrifugation of the whey-containing bovine milk fraction to obtain a whey middle fraction, conducting a second centrifugation of the whey middle fraction at an increased speed to obtain a concentrated whey fraction, filtering the concentrated whey fraction to obtain a filtered whey fraction, and conducting a third centrifugation of the filtered whey fraction at a further increased speed to obtain an exosome-enriched product. The exosome-enriched product comprises intact exosomes and less than 5 wt % casein based on the total weight of protein in the exosome-enriched product. Nutritional compositions comprise protein, carbohydrate, and/or fat, and exosomes provided by addition of the exosome-enriched product. A method of improving insulin sensitivity in a subject comprises administering a nutritional composition comprising the exosome-enriched product.

Abstract: A method of preventing, reducing, or delaying the onset of fatty liver disease in a subject comprises enterally administering intact bovine milk-derived exosomes consisting of endogenous cargo to a subject in need thereof in an amount effective to reduce hepatic lipid accumulation. In a specific embodiment, the intact bovine milk-derived exosomes consisting of endogenous cargo can be administered in an amount effective to reduce de novo lipogenesis in the subject. The intact bovine milk-derived exosomes consisting of endogenous cargo can be administered to the subject directly or in a nutritional composition.

Abstract: The method includes the steps of loading ground coffee in a dispensing chamber; pressing said ground coffee present in the dispensing chamber by means of a piston (1) for the compaction thereof; dispensing the ground coffee; supplying the brewed coffee to a user; and determining if the position of the piston (1) varies depending on the amount of ground coffee that is loaded in said dispensing chamber.

Abstract: Methods of decreasing muscle atrophy and/or promoting muscle regeneration in a subject at risk of muscle atrophy comprise orally administering a nutritional composition comprising at least one of protein, fat and carbohydrate, and bovine milk-isolated exosomes comprising intact exosomes. In specific embodiments, the subject suffers from malnutrition, acquired immune deficiency syndrome (AIDS), cancer, diabetes, chronic obstructive pulmonary disease (COPD), amyotrophic lateral sclerosis (ALS), non-alcoholic fatty liver disease (NAFLD), or a burn injury, or has undergone clinical corticosteroid treatment.

Abstract: A replacement system for a tire supporting a vehicle includes a processor in electronic communication with an electronic system of the vehicle, and an electronic memory capacity for storing tire identification information. The processor receives the tire identification information and vehicle data. A prediction model is in electronic communication with the processor and receives the tire identification information and the vehicle data. An identification of a replacement tread depth for the tire is included in the prediction model, and the model determines an estimation of remaining available distance for the tire to reach the replacement tread depth. The model estimates remaining available time to reach the replacement tread depth from the estimation of remaining available distance. A residual correction module optimizes the estimation of the remaining available time for the tire to reach the replacement tread depth, and a notification of a replacement lead time is generated by the system.

Abstract: The present invention relates to a composition comprising the bioactive molecules esculetin and euphorbetin, which present antitumor activity, so it may be used for the treatment and/or prevention of cancer, especially for colorectal, pancreatic and glioblastoma. Furthermore, it relates to a drug delivery system composed of nanoparticles of calcium phosphate functionalized with said bioactive molecules, preferably obtained from a Euphorbia extract. The invention also refers to the obtaining of an ethanolic extract of plant origin from defatted flour of mature seed of Euphorbia.

Abstract: The present invention faces the issue of authorizing redirection services in PCC architecture and provides for a PCRF server adapted to determine redirection per service in an IP-CAN session, a PCEF device adapted to receive redirection information per service basis, to determine redirection per service request and to trigger the redirection; and a method of authorizing a redirection service in a PCC architecture, comprising: upon an IP-CAN session establishment or modification, a PCEF device requesting control rules; a PCRF server determining services requiring redirection and answering with control rules and redirection information per service basis; installing at the PCEF device the control rules and redirection information; upon a first request for a service, the PCEF device determining the service redirection and returning a redirection message with a redirection identifier; and upon completion of the service redirection, the first request for the service reaching the PCEF, the PCEF verifying the service